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August 6, 2025 62 mins

Standard blood tests barely scratch the surface.

Ryan Smith shares how TruDiagnostic’s TruAge & TruHealth tests use over 1,700 biomarkers from just a drop of blood to measure biological age, hormone health, immunity & more. Go beyond standard labs & start bioharmonizing with cutting-edge precision so you can make decisions that actually impact how you feel & age.

Meet our guest

Ryan Smith studied Biochemistry at Transylvania University before founding Tailor Made Compounding, which became one of the fastest-growing healthcare companies in the U.S. After exiting in 2020, he launched several ventures, including TruDiagnostic, a CLIA-certified lab specializing in methylation-based diagnostics for longevity & preventive health.

TruDiagnostic leads the field with one of the largest private epigenetic databases, over 13,000 patients, & active participation in 30+ clinical research studies. Ryan remains a key figure in advancing functional medicine through innovative health data solutions.

Thank you to our partners Key takeaways
  • Biological age gives a clearer picture of health risk than birthdate by showing how your body is actually aging
  • Lifestyle basics like exercise, clean eating, stress reduction & social connection remain top tools for aging well
  • Some biological age tests are more reliable thanks to stronger prediction power & actionable results
  • Longevity interventions can now be ranked using technology that tracks measurable improvements over time
  • Leading tests don’t just score your age but give clear next steps to improve healthspan & lifespan
  • DNA methylation data offers biomarker proxies that sometimes outperform traditional blood tests
  • Methylation-based tests bring better precision & consistency than standard lab results affected by daily shifts
  • Immune system strength plays a major role in aging by influencing inflammation & clearing damaged cells
  • Supplement & lifestyle tracking tools now show whether specific changes are actually improving key health markers
  • TruAge tests work well for most while biohackers may benefit more from deeper panels like the TruHealth test
Episode Highlights

3:29 What Biological Age Really Tells You

10:12 Inside TruDiagnostic’s Testing Framework

11:39 Key Lifestyle & Supplement Insights from the Data

15:10 How to Interpret Your Report & Take Action

30:12 Understanding Your Immune & Metabolic Health

45:29 Practical Application & Future of Epigenetic Testing

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