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August 27, 2025 72 mins

Could saying no actually be your best longevity strategy?

Blair LaCorte reveals why avoiding over-optimization and focusing on system biology, compassion, and purpose instead leads to authentic biosynergy and lasting vitality.

Meet our guest

Blair LaCorte is a dynamic business executive whose career spans entertainment, aviation, AI, technology, aerospace, consulting, investing & military logistics. He has held CEO & C-level roles at leading companies like PRG, XOJET/Vista, TPG, Autodesk & Oracle, while also taking startups such as AEye Technologies & VerticalNet to IPO. Currently an astronaut-in-training with Virgin Galactic & Vice Chairman of the Buck Institute, Blair continues to drive innovation, growth & global impact.

Thank you to our partners Key takeaways
  • Tech is for control, not a cure all Forgetting biology leads to problems, not progress
  • Over optimizing health with gadgets causes new problems Step back & look at the whole picture
  • Scientific knowledge & personal belief both affect your biology & well being more than most realize
  • Staying healthy is better than only reacting to sickness Small daily choices matter more than silver bullets
  • Focus on what works for you Test, observe, & stick with what fits your life & makes you feel good
  • Relationships lower stress & boost your immune system Loneliness is a major health risk at any age
  • Some stress helps growth Chronic unbroken stress harms your body Find ways to activate & calm yourself
  • Knowing health tips isn’t enough Build habits you enjoy, ideally with friends or community support, for lasting results
  • No two people are alike Track your own changes & work out routines & diets that fit you specifically
  • Modern testing makes it easier to spot issues early Keep personal health records to track your biomarkers over time
Episode highlights

04:19 Why Technology Alone Won’t Save Your Health

21:17 The Real Framework for Habit Change That Works

28:50 What Truly Multiplies Healthspan Results

36:44 Practical Ways to Strengthen Connection & Reduce Stress

46:28 How to Personalize Health in a Complex World

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