From Stress to Strength: How to Rewire Your Brain with Jamey Maniscalco

In this transformative episode of Mind Over Matter, neuroscientist and Manifest Wellness founder Jamey Maniscalco breaks down why stress isn’t the villain we’ve made it out to be. With over a decade studying stress and the brain, Jamey shares how your mindset about stress—more than the stress itself—can affect your health, decision-making, and longevity. Learn about the science behind stress hormones like cortisol and DHEA, how to shift into a “stress-is-enhancing” mindset, and three actionable tools to stop mental rumination in its tracks. Whether you’re battling anxiety or looking to optimize your performance, this episode delivers brain-backed strategies for lasting change.

About the Guest: Jamey Maniscalco is a neuroscientist, professor, and founder of Manifest Wellness Co., a platform helping individuals build sustainable wellness habits rooted in neuroscience. With a background in stress physiology and behavioral health, she bridges science with practical tools to empower personal transformation. Jamey is on a mission to make complex science actionable and accessible for everyone.

Key Takeaways:

• A “stress-is-enhancing” mindset can increase resilience, reduce anxiety, and even lower mortality risk.

• Stress hormones like DHEA can boost brain growth and emotional stability—when harnessed correctly.

• Simple practices like mindfulness, exercise, and quality sleep support a healthier stress response.

• Reframing stress, identifying its purpose, and recognizing its growth potential are keys to mental mastery.

• Rumination is a brain loop we can disrupt through de-catastrophizing, journaling, and reclaiming control.

Connect with Jamey Maniscalco:

• Download the free Wellness Habit Starter Guide: Manifest Wellness Guide

• Book a free 25-minute consultation or learn more: www.manifestwellness.co

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