Season 1: The Science of Aging | Episode 10: Regeneration & Reversal
Welcome to Deep Dive, where we transform complex research into actionable insights. In this episode, we delve into what seems like science fiction but is becoming reality: age reversal. We'll explore a groundbreaking 2020 study that reversed vision loss in old mice by introducing specific genetic tools, suggesting that aging damage might not be permanent. But as we unpack the potential of age regeneration therapies, including telomerase therapy and stem cell rejuvenation, we must weigh the incredible promise against serious risks such as cancer and loss of cell identity.
Our exploration covers the intricate landscape of cutting-edge science, starting with the nuts and bolts of cellular reprogramming and the revolutionary Yamanaka factors. We address the critical challenges in safely reprogramming cells, along with the broader implications for human trials. You'll also hear about the much-discussed young blood research and the dilution hypothesis, and how understanding the systemic factors in blood may influence aging.
We conclude with a thorough discussion on the safety protocols required for human trials, underlining the necessity of balancing rejuvenation's potential with ethical responsibilities. Join us for a fascinating deep dive into the possibilities and perils of pushing the boundaries of aging research.
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