The Oxygen Hemoglobin Dissociation Curve, also known as the Oxyhemoglobin Dissociation Curve, is a critical concept. Understanding this provides a foundation for a number of pathophysiologic processes key in the understanding of physiology.
In this podcast, we dive into these concepts. We start by discussing what makes up oxygen content in the blood and how that differs between the arterial system and venous system. We discuss gas exchange of oxygen and carbon dioxide at the capillary level. We then define key concepts like oxygen content (with the equation), dissolved oxygen (PaO2), oxygen saturation (SaO2, SpO2). We dive into red blood cells, hemoglobin (subunits), oxygen binding capacity of hemoglobin, tense vs relaxed states, tissue-lung interface, and more. After that, we use all of these concepts to establish what the normal oxyhemoglobin dissociation curve is before discussing abnormal including left shifts, right shifts, Bohr's Law, and more!
Introduction to Capillary Gas Exchange, Arterial vs Venous Systems, Oxygen Content
Defining Oxygen Content, Oxygen Saturation (SaO2, SpO2), Dissolved Oxygen (PaO2)
ed Blood Cells, Hemoglobin Structure (subunits), Oxygen Binding Capacity, Tense vs Relaxed, Lung Tissue Interface
Relationship Between SaO2 (SpO2) and PaO2 or Oxygen Saturation and Dissolved Oxygen
Normal Oxyhemoglobin Dissociation Curve
Right Shift, Left Shift, Bohr's Law, Bringing it all Together
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