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May 22, 2025 16 mins
This is Episode 18, Part B: Fractionation - Dose Rate Effects.In our last episode, we laid the groundwork by exploring the "Four Rs of Radiobiology" – Repair, Reassortment, Repopulation, and Reoxygenation – which explain the benefits of delivering radiation in multiple fractions. Today, we're going to zoom in on another critical parameter that profoundly influences biological outcome: the dose rate, or how quickly a given dose of radiation is delivered. We'll see how, in general, slower delivery allows for more cellular repair, leading to increased survival. But we'll also uncover a fascinating exception known as the "Inverse Dose Rate Effect" and explore why some cells actually become more sensitive at certain low dose rates. Finally, we'll touch upon how Linear Energy Transfer, or L E T, interacts with these dose rate
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