The Neuroscience of Mindfulness with Jamey Maniscalco

In this episode of Soul Sparks, host Saima welcomes Jamey Maniscalco, neuroscientist, educator, and founder of Manifest Wellness, to explore the science behind mindfulness. Jamey demystifies how mindfulness rewires the brain through neuroplasticity, explaining why consistent practice builds emotional regulation, focus, and self-awareness. He also discusses why behavioral change feels hard, how the brain craves instant gratification, and how even small, daily mindful moments can spark lasting transformation. Drawing on neuroscience, growth mindset principles, and real-world examples, Jamey offers actionable strategies for anyone struggling to stay consistent with mindfulness.

About the Guest:Jamey Maniscalco is a neuroscientist, professor at Regis University, and founder of Manifest Wellness. He specializes in translating cutting-edge brain science into practical wellness habits that people can use daily. His work focuses on neuroplasticity, behavioral change, emotional regulation, and the neuroscience of mindfulness.

Key Takeaways:

• Mindfulness reshapes the brain by strengthening attention, emotional regulation, and interoception.

• Neuroplasticity allows for lifelong brain change — even small, consistent habits have a big impact.

• Behavioral change struggles often stem from our brain's preference for short-term gratification.

• Growth mindset empowers us to embrace learning and change, regardless of age or past experiences.

• Simple mindful moments like conscious breathing or mindful toothbrushing can build mindfulness without formal meditation.

• Nature, even in small doses, plays a powerful role in stress reduction and cognitive restoration.

Connect with Jamey Maniscalco:

• Website: manifestwellnessco

• Email: jamey@manifestwellnessco

• LinkedIn, Instagram, Facebook: Search “Manifest Wellness”

 

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