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May 6, 2025 64 mins

What if you could reverse the age of your heart...without leaving home? 


In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer of Timeline, to reveal groundbreaking science that targets cardiovascular aging at the cellular level. You’ll discover how mitochondrial decline drives heart failure, why postmenopausal women face skyrocketing cardiac risks, and how one powerful molecule, Urolithin A, can rejuvenate your heart’s energy systems. 


Dr. Singh shares clinical research showing how Urolithin A improves mitochondrial function, boosts endurance, and may even reverse biological aging markers in the heart. You’ll also learn how simple lifestyle biohacks, combined with cellular nutrition, can protect your cardiovascular health and extend your healthspan. 


What You’ll Learn in This Episode: 

• The link between mitochondrial decline and heart failure 

• Why women’s cardiac risk skyrockets after menopause 

• How Urolithin A stimulates mitophagy and energy renewal 

• New human clinical data on reversing cardiac aging markers 

• Biohacking strategies to fortify your cardiovascular health 

• How to optimize endurance, recovery, and heart resilience 


 THANK YOU TO OUR SPONSORS! 

-STEMREGEN | Head to https://www.stemregen.co/dave for 20% off your first order.  

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. 


 

Resources:  

Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ 

Timeline Website –  https://www.timeline.com/partners/dave-asprey 

Timeline Instagram - https://www.instagram.com/timeline_longevity/ 

2025 Biohacking Conference: https://biohackingconference.com/2025 

Danger Coffee: https://dangercoffee.com 

Dave Asprey’s Website: https://daveasprey.com 

Dave Asprey’s Linktree: https://linktr.ee/daveasprey 

Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com 

Own an Upgrade Labs: https://ownanupgradelabs.com 

Upgrade Labs: https://upgradelabs.com 

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 


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