The Shocking Truth About POI and Autoimmune Diseases

What if your Premature Ovarian Insufficiency (POI) wasn't just about your ovaries but about your immune system turning against them?

Most women with POI are told it's simply early menopause. The conversation stops at hormone replacement or donor eggs. But new research shows that for many women, POI has autoimmune roots. When that's the case, treatment, prognosis, and even pregnancy potential all look very different.

In this episode, we explore how the immune system can drive POI, the red flags most doctors miss, and which labs uncover what's really happening inside your body. You'll also hear how a functional fertility approach can calm immune dysfunction and support natural ovarian activity.

You'll learn:

• The latest evidence connecting autoimmunity and Premature Ovarian Insufficiency

• Red flags that suggest POI may be immune-driven rather than purely ovarian

• The key labs to request for thyroid, gut, and immune system assessment

• Why conventional HRT isn't enough and how bioidentical hormones fit in

• Functional fertility strategies that support hormone balance and ovarian function

Sarah Clark is the founder of Fab Fertile Inc. and the host of Get Pregnant Naturally. Her team specializes in functional approaches for low AMH, high FSH, diminished ovarian reserve, premature ovarian insufficiency, recurrent miscarriage and helping couples prepare their bodies for pregnancy success naturally or with IVF.

This episode is for you if:

• • You've been diagnosed with POI, low AMH, or high FSH and want to understand what's driving it

  • You or your family have autoimmune conditions like thyroid disease, celiac, type 1 diabetes, or lupus

  • You've had irregular cycles, miscarriages, or failed IVF transfers, and feel like something deeper is being missed

Not sure where to start? Download our most popular resource: The Ultimate Guide to Getting Pregnant This Year If You Have Low AMH/High FSH. It breaks everything down step by step to help you understand your options and take action.

For personalized support to improve pregnancy success, book a call here.

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TIMESTAMPS

00:00 – What if POI isn't just early menopause?
Why many women are misdiagnosed and how autoimmunity can drive premature ovarian insufficiency.

02:00 – Conventional vs. functional fertility approaches to POI
How standard care stops at HRT or donor eggs, while functional fertility looks at what's really driving ovarian decline.

04:00 – Understanding POI beyond the ovaries
How deeper health issues like immune, thyroid, and gut imbalances can affect ovarian function and fertility potential.

06:00 – The autoimmune patterns seen in women with low AMH and high FSH
How family history, Hashim