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November 3, 2025 20 mins

If you've been told you have premature ovarian insufficiency (POI), it can feel final as if your ovaries have stopped working and your only hope is donor eggs. But the truth is more complex. Research shows that spontaneous ovulation is still possible. In this episode, we're looking at POI through both a conventional and functional fertility lens, exploring what it really means for your pregnancy potential, and how timing, preparation, and immune balance all matter.

You'll learn:

  • The difference between menopause and POI and why ovarian function can "flicker" back on
  • What autoimmune activity, gut health, and toxins have to do with ovarian function
  • The realistic chances of natural pregnancy with POI and how to detect spontaneous ovulation
  • When hormone therapy or IVF with your own eggs might make sense
  • Why donor eggs often lead to high success rates when functional foundations are addressed

Sarah Clark is the founder of Fab Fertile Inc. and the host of Get Pregnant Naturally. Her team specializes in functional approaches for low AMH, high FSH, diminished ovarian reserve, premature ovarian insufficiency, recurrent miscarriage and helping couples prepare their bodies for pregnancy success naturally or with IVF.

This episode is especially for you if:

  • You've been told POI or "early menopause" means you'll never get pregnant
  • You're considering IVF or donor eggs and want to understand your options
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