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September 23, 2025 60 mins
A couple years ago, Charlie Marsh lit a fire under Python tooling with Ruff and then uv. Today he’s back with something on the other side of that coin: pyx.

Pyx isn’t a PyPI replacement. Think server, not just index. It mirrors PyPI, plays fine with pip or uv, and aims to make installs fast and predictable by letting a smart client talk to a smart server. When the client and server understand each other, you get new fast paths, fewer edge cases, and the kind of reliability teams beg for. If Python packaging has felt like friction, this conversation is traction. Let’s get into it.

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Charlie Marsh on Twitter: @charliermarsh
Charlie Marsh on Mastodon: @charliermarsh

Astral Homepage: astral.sh
Pyx Project: astral.sh
Introducing Pyx Blog Post: astral.sh
uv Package on GitHub: github.com
UV Star History Chart: star-history.com

Watch this episode on YouTube: youtube.com
Episode #520 deep-dive: talkpython.fm/520
Episode transcripts: talkpython.fm

Theme Song: Developer Rap
🥁 Served in a Flask 🎸: talkpython.fm/flasksong

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