February 27, 2025 • 37 mins
In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden and Steve Reiter explore various aspects of heart health and longevity. They discuss the effects of sweeteners on heart function, delve into Takotsubo syndrome, and highlight the importance of fitness metrics. The conversation also covers the role of GLP-1s in treating heart disease, the benefits of dietary salt substitutes, and innovative approaches to brain and heart health at Gladden Longevity in Dallas, TX.
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Takeaways
· The heart responds directly to artificial sweeteners and sugar.
· Eating can be stressful, impacting heart health.
· Takotsubo syndrome, or broken heart syndrome, is on the rise.
· Fitness metrics like push-ups can indicate heart health.
· GLP-1 medications can aid in weight loss and heart health.
· Potassium-rich foods can improve heart function and lower blood pressure.
· Heart disease can be prevented with lifestyle changes.
· Innovative treatments are emerging for brain and heart health.
· Stress management is crucial for heart health.
· Body composition is more important than weight alone.
· Dementia might be optional.
Chapters
00:00 Introduction to Longevity and Heart Health
01:54 The Impact of Sweeteners on Heart Function
07:55 Understanding Takotsubo Syndrome
18:04 Physical Fitness and Heart Health
23:00 The Role of GLP-1 in Heart Disease
26:51 Dietary Salt Substitutes and Heart Health
31:38 Innovations in Brain and Heart Health
Articles, News and Supplements mentioned
Heart Health
SWEET TASTE RECEPTORS IN THE HEART: A NEW PATHWAY FOR CARDIAC REGULATION: https://www.google.com/url?sa=t&source=web&rct=j&opi=89978449&url=https://medicalxpress.com/news/2025-02-sweet-receptors-heart-pathway-cardiac.html&ved=2ahUKEwjz8aD7q9-LAxVwRzABHfm_I9gQFnoECBMQAQ&usg=AOvVaw1TchSQH8L0OOc0rbJ-24qx
BROKEN HEART SYNDROME ON THE RISE IN WOMEN: https://psychcentral.com/news/broken-heart-syndrome-is-on-the-rise-in-women
BROKEN HEART SYNDROME AFFECTING MEN THE WORST: https://www.tctmd.com/news/following-takotsubo-men-have-worse-outcomes-are-more-likely-die-women
LATEST INSIGHTS AND QUESTIONS ABOUT TAKOTSUBO SYNDROME: https://www.acc.org/latest-in-cardiology/articles/2024/12/01/42/cover-story-takotsubo-syndrome-expanding-insights-unanswered-questions
IF YOU CAN DO THIS MANY PUSH-UPS, YOUR HEART IS HEALTHIER THAN YOU THINK: https://www.eatthis.com/push-up-test-heart-health-check/
GLP-1 RAs MEDICATIONS BEING USED TO TREAT HEART DISEASE: https://www.theguardian.com/australia-news/2025/feb/18/weight-loss-drug-wegovy-approved-to-treat-heart-disease-in-overweight-and-obese-australian-patients-tga
DIETARY SALT SUBSTITUTES
Mark as Played
Transcript
Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
(00:02):
Welcome to the Gliden Longevity Podcast with Dr.
Jeffrey Gladden, where our passion is helping you become an AJAX.
On this show, we want to help you optimize your life energy, longevity, health, and humanperformance with impactful and actionable information.
By answering four questions, how good can we be?
How do we make 100 the new 30?
(00:22):
How do we live well beyond 120?
And how do we live young for a lifetime?
I'm Steve Ryder and Dr.
Gladden.
is February.
Yeah.
American heart month.
Valentine's was just last weekend from the time that we're recording this.
Any special plans with MOOC?
yeah, we had a lovely time.
(00:43):
Yeah, we, I've surprised her with a booking a hotel for Saturday night and a littleboutique hotel here in town.
And, yeah.
So we had, we had what we call a festival of joy where we just kind of hang out togetherand yeah, just have a lot of really cool conversations, a lot of, sweet time together and
(01:05):
that was good.
yeah, super fun.
How about you?
I would just relaxed.
made, I made some soup rather than go out.
made some soup.
is my girlfriend's favorite soups.
Both of them one Friday night and one Saturday night.
And that was our, Valentine's weekend.
kind of relax and chill and hanging out with the boys and.
(01:27):
Cool.
Awesome.
I love it.
Yeah, no, all good.
Yeah.
So it's a birthday month for me too.
I've got a birthday coming up a week from Friday.
So that's cool.
And my son and grandson are coming in town for the first grandfather, father, son weekendtogether.
He's six years old.
So I'm really looking forward to kind of breaking the ice on the on the guys weekends kindof scenario.
(01:52):
So that'll be super fun.
Nice.
Nice.
So American heart month and we have some articles and a paper.
Let's start out with sweet taste receptors in the heart.
A new pathway for cardiac regulation.
(02:14):
Yeah.
From what I, from what I gathered on this, it's, know, if you're drinking artificialsweeteners, it can cause your heart to be a little irregular.
Is that right?
Well, not exactly.
think what's interesting is we think that all heart rate response and strength ofcontraction is controlled by, you know, either the nervous system, right?
(02:36):
Putting more epinephrine down the sympathetic nervous system pathway to increase heartrate and increase force of contraction or through hormones that are released from the
adrenal glands, more adrenaline, you know, things epinephrine that do a similar kind ofthing, dopamine.
What this is pointing out though, is that they found that when they gave an artificialsweetener, spartamine, and I'm sure that it's probably true for sugar as well, that the
(03:05):
heart actually responds directly to that molecule and increases heart rate and force ofcontraction, which is interesting.
So it's kind of like, you know, we've had this conversation before about, think thateating is restorative, but it's actually has a stress component to it, right?
Which is one of the reasons that
Eating one meal a day has been associated with increased mortality, 80 % increasedmortality over eating three meals a day.
(03:30):
And we know fasting is good, but we know that we've come to understand that eating isactually stressful.
So if you're eating sugar or sweets or even artificial sweeteners, it looks like you'restimulating your heart to have an increased force of contraction and an increased heart
rate.
Right.
So that can be a good thing.
(03:51):
If you have underlying heart disease, right, like you've had bypass or a stent or youhaven't had those, but you've got a significant blockage or something like that.
It's interesting to know that eating the sugar not only is destroying the glycocalyx inyour arteries, right?
That keeps your arteries healthy and allows them to dilate appropriately and not developplaque and lower blood pressure, et cetera, improve sexual function, athletic performance,
(04:15):
brain function.
But it's also directly now.
stimulating the heart and that's kind of new information that sugar would actuallydirectly stimulate the heart in terms of force of contraction and heart rate.
So that's kind of cool.
What would be your general recommendations about this?
Well, you have an option, I would go for a run because your heart's ready to go.
(04:40):
You know, I think if you're if your heart's healthy, it's just and you're and you're anathlete.
There was an interesting study that was done where if you took carbohydrate, let's justsay sugar and you didn't swallow it, you simply put it in your mouth and swished it around
for, I don't know, 15 seconds or so and spit it out.
(05:03):
And then rinse your mouth out with water.
You actually had improved athletic performance just because the body perceived that it hadtaken in carbohydrate.
Yeah, that's crazy.
Isn't that wild?
So you didn't actually give your body more fuel.
just sort of tricked it to thinking it got more fuel.
(05:25):
And because of that, everything got better.
So it just goes to show you in that case that the nervous system really is kind of.
keeping the lid on everything, right?
It won't let you, if it thinks you're overstressing your muscles, too much exercise, toomuch oxidative stress, it'll shut things down.
If it feels like you're depleting your nutrient resources, it shuts things down.
(05:47):
If it thinks the force on the muscle in the bone is too great, right?
It might break the bone or whatever, it shuts things down, right?
So it won't really allow you to lift a weight that's.
You know, heavy enough to kind of break a bone unless you've got really fragile bones.
But anyway, the point is, you've got sort of the central nervous system control, over whatit allows your body to do.
(06:10):
And when you proceed, when your central nervous system perceives that you've just gottencarbohydrate says, okay.
We're good to go.
So it loosens things up and enables you to kind of, you know, run another three miles orwhatever.
Right.
So that's kind of, kind of interesting.
So I remember when I got, when I tried out levels, the continuous glucose monitor, a postmeal walk or hike really helped to blunt that glucose response.
(06:41):
And so I would assume you factor in the benefit of blood, of bringing that response down,but the benefit of, you know, the, the increased cardio output, would that be
Yeah.
Something that you would recommend even more.
There's a couple of things going on there.
We know that after a meal, particularly after dinner, society has us still sort ofbelieving that dinner should be a big meal, right?
(07:08):
Where we know from a health perspective, it probably shouldn't be a big meal.
It should be something.
Could be something.
But the bigger meal should be lunch or even a mix between breakfast and lunch.
But if you go out for that walk afterwards, number one, when you're exercising, you tendto slow
Food digestion and absorption, right?
(07:28):
So that's one thing.
The second thing is you're also sort of burning off some calories at the same time So youkind of get kind of get a benefit for both and to your point since your body now Feels
like it's replete with calories You know, it's kind of ready to go and your heart's kindof ready to go anyway, so it's you just have to understand that if you have heart disease
(07:53):
You're pushing blood into your gut
to digest the food, which is one form of exercise for the heart.
And then you're pushing blood to your muscles to be able to get you to exercise, which isanother form.
So you're kind of doubling up on the exercise.
So even though you're just going for a walk, you're kind of getting a more potent form ofexercise that way, which if you have heart disease could be too much, but if you're
(08:16):
healthy, could be a really great way to go about it.
So yeah, we like going for a walk after eating in the evening.
So we have two articles about Takotsubo.
Is how pronounce it?
Yeah, it's Hakusubo.
Takasubo syndrome.
Broken heart.
(08:38):
Talk about that because it looks like it's on the rise.
Yeah.
well, it's probably on the rise, for a couple of different reasons, but also, since it wasfirst described back in the nineties in Japan, it's now become more universally
recognized.
(08:59):
And I think a lot of it was not recognized previously.
Right.
So it's hard to know if it's an incidence in occurrence or an incidence in observation ofit.
Right.
Yeah.
appreciation of it.
So,
But yeah, Takasubo is interesting.
I saw a number of cases when I was, you know, doing interventional cardiology work andbasically boils down to what's referred to as broken heart syndrome, where the heart is
(09:25):
exposed to stress and it could be psychological stress.
Could be physical stress, could be a combination of the two.
It seems to affect women about 90 % of the time, 10 % of the time in men, can occur in menand it's sense to happen in women that are post-menopausal.
And so my hypothesis is that the female heart is not structurally quite as strong as aman's heart.
(09:51):
Just, you know, just like their bicep isn't structurally quite as strong as a man's bicep.
The sex is just kind of a hormonal effect, if you will.
And then when women are post-menopausal and depleted of hormones, they lose muscle mass.
Men do the same thing, but they have a little more to start with.
And the heart becomes a little more vulnerable to the effects of high stress.
(10:16):
So the high stress, you know, it's it's it's typically characterized as a psychologicalstress, like, you know, the loss of a loved one or, you know, a tsunami hits a village or,
you know, something that's, you know, heartbreaking, if you will.
And all of the release of catecholamines into the system, the epinephrine, the dopamine,norepinephrine, all that dumps in and it overwhelms the heart in terms of
(10:40):
what it's asking the heart to do, right?
Speeding it up, forcing it to contract more vigorously, things like that in response toall those stress hormones and the nervous system as well.
And the heart just kind of shuts down, right?
And so what happens is it kind of balloons out and instead of going from pumping out about60 % of the blood with each beat that it's been filled up with, it doesn't pump out every
(11:03):
last drop, but pumps out about 55, 60, 65 % of the blood.
It may drop down to pumping out 15%.
Right.
Yeah.
What does that cause?
heart failure causes heart failure where you're not pumping enough blood and the bloodbacks up into your lungs and people get pulmonary edema and they can die from that.
(11:26):
it's like acute heart failure.
It's also associated, depending times, with chest pain.
So there's kind of a pain response to it as well, kind of like a heart attack.
it many times is diagnosed, somebody comes in with acute heart attack symptoms, but theydon't show
some of the classic findings of heart attack on the EKG.
(11:46):
It's different kind of EKG and I'm not going to the EKG details because we don't havepictures to show people, but it can be determined that it's not an acute heart attack.
And when you take them to the cath lab, you see that the arteries are typically clear.
There's no clot, there's no plaque, but the heart muscle itself is very weak and itballoons out.
(12:06):
If you can imagine the body of an octopus, how it's kind of that big body now it has allthe eight
legs coming off, tentacles coming off.
The heart kind of looks like that.
It just looks like it's ballooned out and hardly contracts.
So that's how it got to name Takasubo.
It can also happen with physical stress and it can also happen with, let's say you're aninpatient and you just had your gallbladder out or you just had a major surgery and you're
(12:36):
under a lot of physical stress as well as emotional stress.
can occur in that setting as well.
So yeah, Takasubo, it's an interesting thing.
really only accounts for probably two, three, four, five percent of people that are seenin an emergency room, probably more around two percent.
Again, women more than men.
yeah.
(12:57):
Interesting.
What's the treatment?
the treatment, it tends to get better.
Reduced.
Yeah.
In our world, reducing stress.
When a heart is strong enough doing low dose beta blockade to block the beta receptorsthat this is where the epinephrine, norepinephrine things are reacting, alpha and beta
(13:23):
blockers like Corag, Corvetilol, kind of rest the heart, kind of remove that.
stimulus from the heart, it allows it to regain strength.
And then you can do regenerative things here too, right?
This is a place where some of the regenerative factors, whether it's stem cells orplacental derived trophic factors and cord blood factors and things like that can all be
(13:49):
beneficial.
And then improving hormone levels can be helpful.
You know, where you do get testosterone and estrogen back.
which makes all the tissues more sturdy, you will, enables them to manage that stress.
So there's two things here.
One to try to prevent it.
One, I would do hormone replacement therapy so that you're, you know, you don't lose themuscle mass, both not only in your arms and your legs, but in your heart.
(14:15):
the second is monitoring how your body manages stress.
And we're really big, have become big fans of brain tap, which is a device that's a visorand headphones that
you know, uses binaural beats and photobiomodulation through the eyes and the ears toactually entrain your brain into a particular waveform like alpha for meditation or theta
(14:38):
for deep meditation or delta for sleep.
And you can actually train your nervous system to receive a stressful quote unquotestressful input and yet have more equanimity around it, not be as impacted by it.
There's also some interesting cognitive insights about that too.
(14:59):
in terms of how to manage stress.
So one of them is, many times the reason we feel stress is because we are identified orassociated or attached to a particular outcome.
Right.
And if we, if we don't, if we unattach ourselves from the outcome, right.
(15:24):
This is kind of a perspective shift.
Yes.
You see, then all of a sudden, stress can be decreased dramatically, particularly when ouridentity is caught up in it.
Like, I, know, I'm here to do this job and you know, I didn't get something done on timeor whatever.
now it's like, there's a threat to me, my own identity.
I'm attached to that outcome.
(15:44):
Right.
Yeah.
And so.
A lot of stress comes from that and the inside of realizing that, I will actually be afree individual if I, it's, it's not a question of not caring.
It's not a question of not connecting.
It's not even a question of not loving or participating or really trying hard.
It's just not identifying with the outcome and attaching our identity and our self-worthand everything else to that outcome.
(16:09):
Right.
That's really important to learn to separate that.
Right.
And then that will really help.
manage stress dramatically,
It's massive.
It's massive.
Once I started to do that, I noticed my overall stress levels significantly decrease.
Hey, whatever happens, happens.
Yeah.
And it's not even, yeah, I mean, it can be that, and it doesn't mean you don't even careabout the outcome.
(16:33):
Like you want a good thing to happen, but if it doesn't happen, it's like, but it's not,it's not me.
It's like, well, what can I do to be helpful here?
Right.
And so you get away from that being caught up with your identity tied to it.
I once heard this speaker in the Christian communities give this thought, and it's neverask the why question because it'll never be answered.
(16:57):
Instead, ask, what does this mean and what must I do?
And changing that kind of perspective can be massive.
Yeah.
Yeah, that's right.
What I find is that when you are not attached to an outcome, right, like in this podcast,for example, I'm not attached to an outcome as much as I love this podcast and I love
(17:19):
having these conversations and I care about the audience, right.
But I'm not attached to the outcome.
My identity is not attached to the outcome.
Yeah.
And what that does is it frees me up psychically to do the podcast and not be fatigued ortired at the end of it.
Right.
Or it also frees me up to be more, either both thoughtful or creative in my responses, mythoughts.
(17:42):
So it actually it's, you know, we talk about freedom all the time, right?
We talk about freedom and yet everybody signs up for indentured servitude, right?
They tie themselves to a job and a salary and a, and, and for me to be a good person, I'vegot to do this and perform at that.
You see what I'm saying?
We all sign ourselves up for indentured servitude.
(18:04):
And yet we can free ourselves from all that.
And this is how you do it, is by unattaching.
And that decreases stress and that will protect you from Takasubo.
So that's my take on Takasubo.
Dr.
Gladden dropping truth bombs.
Next article we've got, if you can do this many pushups, your heart is healthier than youthink.
(18:27):
Dr.
Gladden, truth or myth?
What do you do to improve your heart health?
Well, there are many, many, many, many metrics like this, right?
You could say the longer you can hold a plank, the longer you can hang from a bar, themore pull-ups you can do, the higher your VO2 max, really the stronger your hand grip
(18:49):
strength is, right?
So all of these things are really similar measures, if you will, of just total overallbody fitness.
And I think
What we're saying here is something obvious.
If you're fit, you do better, right?
You have more physiologic reserve.
(19:10):
So you have the ability to be more anti-fragile, which is a really important concept,right?
So fragility, of course, is when something unexpected happens, we're damaged by it.
Strength is, resilience is the ability to actually absorb that and recover from it.
(19:30):
And then basically being
really sturdy, so to speak, or strong means that you're not even impacted in the firstplace, right?
anyway, I think when we think about the body and being in shape, you just want to be inthe best shape that you can.
(19:52):
And I will tell you that some insights I've had are that you never can get in shape in agym.
And you can never get in shape without a What I mean by that is that when you train,you're not training your muscles.
Everybody goes to the gym because they're going to train today.
(20:12):
It's upper body today.
It's legs today.
It's this actually being fit.
or whatever.
Being fit is actually having a nervous system that is fast and responsive and agile andquick and balanced and all those kinds of things and powerful and strong, right?
And to generate all that force.
And so you're really, if you focus on the fact that you're training your nervous system,you'll realize that you can't sit on a machine or do a limited range of motion something
(20:41):
and really train the nervous system to be fast, agile, strong, quick and balanced, right?
It's not gonna happen.
Even if you're doing
you curls on one leg.
You have to put yourself in an environment that's unpredictable.
And the only way you get that is to get outside.
You've got the wind, you've got the rain, you've got the boulder in front of you.
You've got the tree that fell down in front of you, whatever it is, you've got to haveyour skiing, your walking, your hiking, your running, whatever, biking, whatever it is,
(21:08):
you got to have unpredictability to train your nervous system to be adaptable to thesethings.
And I think that's why you can never really get in shape in a gym.
And I think you also need a gym because you do need to sit there and do some, some squatsand you do some leg presses and some other stuff to actually build up just pure strength,
if you will, which is also a nervous system situation.
(21:30):
But when you carry that strength into the unexpected environment of the outdoors, now youhave the fun of like, yeah, I'm strong.
I can pedal up this hill.
Right.
But now I've got to dodge that and hop this and whatever else.
So anyway, that's how I think about it.
What's your normal ratio of strength training outside all of that and how has it evolvedover the last number of years?
(21:53):
Yeah, well, it's a function of the weather to some extent, and it's a function of thestatus of my body.
So if I'm injured, it's a little harder for me to do certain things outside.
So I'm a little bit more confined to a gym, but even in a gym, I'll try to make itunpredictable and I'll get outside as soon as I can.
(22:18):
If I have access to the outside,
I will be outside probably five days a week and I'll be in a gym two days a week would beabout the right ratio.
When the weather's bad or it's cold or this or, know, and it's, I can't get out and runfor either a scheduling reason or something, you know, in reality, it probably works out
(22:39):
to where I get outside three days a week and I'm inside four days a week, but I'm stilloutside as much as I can be.
Yeah.
GLP-1s are being used to treat heart disease.
I can assume you have some thoughts about this.
(23:00):
Yeah.
Well, I JLP ones were basically, mimic, you know, the hormones that are secreted when weeat that, you know, basically indicate that we're full.
And so they decrease appetite.
They, and so they've been used for controlling blood sugars in the sense of decreasingappetite.
Also, they do seem to improve insulin sensitivity and improve beta cell function andthings like that.
(23:28):
And so.
You know, they really were developed for diabetes.
but then it was found that, people are actually losing weight on these drugs.
So then it became weight loss.
At the same time, people were realizing that when diabetics would take JLP once they had alower incidence of heart attacks, right.
(23:48):
And strokes.
And so there was been a cardiovascular benefit, right?
There's an impact on lipid levels and, and, the way the heart responds to certainstresses.
So.
It's really important to know that you're kind of enhancing a normal function in the body.
The problem is that it's like anything.
(24:10):
If you push it too hard, you start to get the negative effects.
And so we see people that are, have become reliant on GLP-1s and GL1s to basically, youknow, lose weight.
And what we find many times, because we measure everybody's
body composition is that they're losing muscle instead of fat and they can be losing bonedensity.
(24:34):
Now there are papers published on this as well.
So while it's useful, particularly for diabetics and for decreasing cardiovascular eventsin diabetics and even in non-diabetics, and it's also good for preserving kidney function,
they have to be used cautiously at the same time.
(24:55):
And so
We're fans of, of going about it a little bit differently.
We'll use GLP once to kind of jumpstart a situation if somebody wants to lose weight, butwe actually think that a five day fast mimicking diet is really a great jumpstart.
it resets the gut, bio resets or taste buds resets or appetite.
(25:19):
and then from there you can use Mimeo.
We've had a podcast on Mimeo, right?
Which basically.
has PEA and OEA and spermidine in it, a little bit of niacin.
And the PEA and OEA, the OEA in particular, decreases appetite.
So if you take three or four of those, now you're getting the benefits of appetitesuppression without loss of bone density or muscle mass.
(25:45):
And you're getting spermidine, which is increasing basically autophagy in your cells andyou're increasing reverse cholesterol transport.
So that's like a magical formula for keeping your arteries healthy.
So we're big fans of that.
And then there are also probiotics out there now that have GLP, that increased GLP-1activity.
(26:10):
And acromansia is one that is good for improving blood sugar control.
So my point is if you're on a GLP-1 and you're listening to this, there are ways to getyou off of it.
not lose ground and actually gain ground in terms of muscle mass, bone density and whereyou really want to be.
I think it's super important for people not to focus on the number on a scale.
(26:32):
It's really body composition you want.
And if you're serious about your health, get a scale that has a body composition componentto it.
I think withings has one of those, I in body makes a scale.
I think there's different ones out there.
You can resource.
but if you
How accurate are those?
Obviously it's not as...
How accurate are those?
Obviously it's not as...
really matter.
It doesn't really matter in a sense.
(26:55):
It matters.
Well, my point is it matters.
They're not as accurate as the DEXA scan, right?
But they're accurate enough that you can see changes in a positive direction.
if muscle mass is going up, muscle mass is going up.
If fat, percent body fat's going down, percent body fat's going down.
It doesn't matter if it's 18 % or 22 % even.
(27:16):
It's the fact that it's moving in the right direction.
So yes, you want to try to get one that's been
know, verified and accurate.
But the point is it's really the change that you're looking for.
So, yeah.
(29:20):
Well, you mentioned artery health and our last article is dietary salt substitutes toprevent heart attack, stroke and death.
Basically it's talking about using potassium rich salt as a salt alternative.
Dr.
Gladden, what are your thoughts?
I'd never heard of this.
(29:41):
Yeah, well, it turns out that, yeah, there's some really interesting things around salt,right?
So we all grew up with, you know, Morton salt, iodide salt, right?
And then we got away from that because everybody got infatuated with sea salt and Celticsalt and things like that, which is great because it is many salts.
It's not just sodium chloride.
It's actually many different minerals.
(30:02):
And having all those minerals is actually really good because a lot of the time in ourpasteurized world, we don't get all those minerals.
So using those kinds of salts are helpful.
What's also known though, is that potassium rich foods help lower blood pressure and raisepotassium.
And likewise, if you put some potassium chloride into your sodium chloride, or even somepotassium chloride into your Celtic sea salt, to where you're getting some potassium, some
(30:28):
extra potassium, that's been shown to actually relax tension in the arteries and lowerblood pressure, improve heart function and...
improve arterial function.
So you can get potassium from, you know, things like potatoes, or they're higher inpotassium than bananas, for example, sweet potatoes and white potatoes.
(30:48):
And if you want to refrigerate a baked potato overnight and turn it into a resistantstarch, you don't get all the carbs from it.
You get resistant starch that feeds your gut biome and you're still getting the potassium.
So there are many ways to boost potassium.
You don't have that necessarily get a salt substitute to boost potassium.
You do it with food.
But the idea of having more potassium is a smart idea for hard function.
(31:12):
We know that too much sodium pushes us into higher blood pressure and things like that.
So it's not that salt is bad, especially if you're getting all the minerals from like aCeltic sea salt or something, but too much pure sodium chloride is not what you're after.
Dr.
Gladden, February, what's the latest?
(31:34):
What's new?
What are you excited for in the next month?
Um, well, we're, we're basically, um, starting a new brain optimization program here.
So we're super excited about that.
We're, coupling many of the technologies that we have here, both diagnostically andtherapeutically.
(31:55):
And we've always used a Dale Bredesen's protocol here in terms of, you know, fixing the 36holes in the roof that are associated with dementia.
Yeah.
And so.
We've been all over that, but now we have a number of things that actually are veryadditive to that in terms of regenerative therapies, trans-cranial magnetic stimulation
and peptides and no tropics and regenerative technologies like placental derived exosomesand stem cells and things like that.
(32:25):
So you put all that together.
It's pretty magical plasma freezes to kind of clear out the trash and the inflammation.
And then we have.
genetic testing to actually understand who's at risk for what kind of dementia, thingslike that.
And now we're just getting a hold of a new product called TB006, which is a monoclonalantibody that binds a molecule called galectin 3.
(32:49):
And galectin 3 is a major player in enhancing inflammation in the brain.
It basically turns on the microglia in the brain, which are the immune cells in the brain.
And it cross-links all these proteins that are in the brain also that kind of theseneurofibrillary tangles and things like that, that actually increase inflammation in the
(33:12):
brain.
And pretty much all neurodegenerative diseases have a common denominator ofneuroinflammation or brain inflammation, right?
So hydrogen is great for decreasing the oxidative stress associated withneuroinflammation.
Using something like TB006 to bind up, collect in three and decrease
(33:32):
the inflammatory response improves cognitive ability.
So even somebody that has pretty profound dementia can improve 63%, which has never beenshown before.
And people with milder forms of cognitive impairment can improve 240%.
So it's like you start to put these things together, know, hormone optimization andthyroid and all the things we know how to do here.
(33:55):
I mean, we're at a point where, you know, I've thought for a long time that heart diseaseis optional.
And now we're thinking that dementia is optional.
And the other thing that we're doing on the cardiovascular front is we have access becausecardiovascular disease does affect brains as well, both via strokes and, and multi-infarct
dementia where there's little, little emboli that go into the brain and cause microinfarcts, if you will, or micro strokes.
(34:21):
We have access to something called Capodex, which is cyclodextrin that mines upcholesterol and pulls it out of plaque.
So, you can actually pull.
cholesterol out of plaque for the first time, not just try to decrease cholesterol, butactually pull it out.
that's the exciting part.
The less exciting part is the fact that you, you, use it as an enema, daily for, but it'sonly about five or six CCs.
(34:45):
but, we're super excited about that too, right?
mean, if you have, if you had significant blockage, it'd be like, yeah, I'll do that.
Right.
I want to get rid of that.
So we're, running trials on all these things.
we're involved.
These are all under.
IRB approved trials to sort of collect data and see what happens.
But we're very excited about the whole field around both brain and heart health.
(35:07):
Yeah.
Well, listeners, if you are interested in heart health, Dr.
Gladden has a tincture called the blood vessel formula.
Use podcast 10 to get 10 % off your order in the checkout.
And listeners, if you are interested in fighting dementia, if you're interested inunderstanding more heart health, if you're interested in getting better care of your heart
(35:35):
with Dr.
Gladden,
Go to gladdenlonggevity.com, fill out the form, reach out, someone will call you.
And Dr.
Gladden, there are ways in which to help get this paid.
You guys have creative ways to make sure that.
yeah.
Yeah.
People, people invest in themselves, free tax and things like that.
So there's lots of ways to do that.
(35:56):
And, yeah, the blood vessel formula is really, way for you to get the benefits of all themed training herbs without having to eat a bushel of basil and arugula every day.
Right.
So kind of regular per se, but, summer savory and things like that.
Sometimes that are hard to get ahold of.
and then we have a mushroom formula also that's, five different mushrooms as the tincturethat, all turn off inflammation.
(36:19):
So we use this in general for inflammatory control, if you will, but those two togetherwork really well.
yeah.
Listeners also, if you have a question for Dr.
Gladden, submit it.
Podcast at gladdenlongevity.com.
That's podcast at gladdenlongevity.com.
Dr.
Gladden.
(36:40):
Yes, sir.
I see you next month, my man.
All right, great to see you, Steve.
you
Thank you for listening to this week's episode of the Gladden Longevity Podcast.
If you would like more information on what we've discussed or other topics, pleasereference the show notes or go to gladdenlongevitypodcast.com.
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(37:04):
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Welcome to the Gliden Longevity Podcast with Dr.
Jeffrey Gladden, where our passion is helping you become an AJAX.
On this show, we want to help you optimize your life energy, longevity, health, and humanperformance with impactful and actionable information.
By answering four questions, how good can we be?
How do we make 100 the new 30?
(00:22):
How do we live well beyond 120?
And how do we live young for a lifetime?
I'm Steve Ryder and Dr.
Gladden.
is February.
Yeah.
American heart month.
Valentine's was just last weekend from the time that we're recording this.
Any special plans with MOOC?
yeah, we had a lovely time.
(00:43):
Yeah, we, I've surprised her with a booking a hotel for Saturday night and a littleboutique hotel here in town.
And, yeah.
So we had, we had what we call a festival of joy where we just kind of hang out togetherand yeah, just have a lot of really cool conversations, a lot of, sweet time together and
(01:05):
that was good.
yeah, super fun.
How about you?
I would just relaxed.
made, I made some soup rather than go out.
made some soup.
is my girlfriend's favorite soups.
Both of them one Friday night and one Saturday night.
And that was our, Valentine's weekend.
kind of relax and chill and hanging out with the boys and.
(01:27):
Cool.
Awesome.
I love it.
Yeah, no, all good.
Yeah.
So it's a birthday month for me too.
I've got a birthday coming up a week from Friday.
So that's cool.
And my son and grandson are coming in town for the first grandfather, father, son weekendtogether.
He's six years old.
So I'm really looking forward to kind of breaking the ice on the on the guys weekends kindof scenario.
(01:52):
So that'll be super fun.
Nice.
Nice.
So American heart month and we have some articles and a paper.
Let's start out with sweet taste receptors in the heart.
A new pathway for cardiac regulation.
(02:14):
Yeah.
From what I, from what I gathered on this, it's, know, if you're drinking artificialsweeteners, it can cause your heart to be a little irregular.
Is that right?
Well, not exactly.
think what's interesting is we think that all heart rate response and strength ofcontraction is controlled by, you know, either the nervous system, right?
(02:36):
Putting more epinephrine down the sympathetic nervous system pathway to increase heartrate and increase force of contraction or through hormones that are released from the
adrenal glands, more adrenaline, you know, things epinephrine that do a similar kind ofthing, dopamine.
What this is pointing out though, is that they found that when they gave an artificialsweetener, spartamine, and I'm sure that it's probably true for sugar as well, that the
(03:05):
heart actually responds directly to that molecule and increases heart rate and force ofcontraction, which is interesting.
So it's kind of like, you know, we've had this conversation before about, think thateating is restorative, but it's actually has a stress component to it, right?
Which is one of the reasons that
Eating one meal a day has been associated with increased mortality, 80 % increasedmortality over eating three meals a day.
(03:30):
And we know fasting is good, but we know that we've come to understand that eating isactually stressful.
So if you're eating sugar or sweets or even artificial sweeteners, it looks like you'restimulating your heart to have an increased force of contraction and an increased heart
rate.
Right.
So that can be a good thing.
(03:51):
If you have underlying heart disease, right, like you've had bypass or a stent or youhaven't had those, but you've got a significant blockage or something like that.
It's interesting to know that eating the sugar not only is destroying the glycocalyx inyour arteries, right?
That keeps your arteries healthy and allows them to dilate appropriately and not developplaque and lower blood pressure, et cetera, improve sexual function, athletic performance,
(04:15):
brain function.
But it's also directly now.
stimulating the heart and that's kind of new information that sugar would actuallydirectly stimulate the heart in terms of force of contraction and heart rate.
So that's kind of cool.
What would be your general recommendations about this?
Well, you have an option, I would go for a run because your heart's ready to go.
(04:40):
You know, I think if you're if your heart's healthy, it's just and you're and you're anathlete.
There was an interesting study that was done where if you took carbohydrate, let's justsay sugar and you didn't swallow it, you simply put it in your mouth and swished it around
for, I don't know, 15 seconds or so and spit it out.
(05:03):
And then rinse your mouth out with water.
You actually had improved athletic performance just because the body perceived that it hadtaken in carbohydrate.
Yeah, that's crazy.
Isn't that wild?
So you didn't actually give your body more fuel.
just sort of tricked it to thinking it got more fuel.
(05:25):
And because of that, everything got better.
So it just goes to show you in that case that the nervous system really is kind of.
keeping the lid on everything, right?
It won't let you, if it thinks you're overstressing your muscles, too much exercise, toomuch oxidative stress, it'll shut things down.
If it feels like you're depleting your nutrient resources, it shuts things down.
(05:47):
If it thinks the force on the muscle in the bone is too great, right?
It might break the bone or whatever, it shuts things down, right?
So it won't really allow you to lift a weight that's.
You know, heavy enough to kind of break a bone unless you've got really fragile bones.
But anyway, the point is, you've got sort of the central nervous system control, over whatit allows your body to do.
(06:10):
And when you proceed, when your central nervous system perceives that you've just gottencarbohydrate says, okay.
We're good to go.
So it loosens things up and enables you to kind of, you know, run another three miles orwhatever.
Right.
So that's kind of, kind of interesting.
So I remember when I got, when I tried out levels, the continuous glucose monitor, a postmeal walk or hike really helped to blunt that glucose response.
(06:41):
And so I would assume you factor in the benefit of blood, of bringing that response down,but the benefit of, you know, the, the increased cardio output, would that be
Yeah.
Something that you would recommend even more.
There's a couple of things going on there.
We know that after a meal, particularly after dinner, society has us still sort ofbelieving that dinner should be a big meal, right?
(07:08):
Where we know from a health perspective, it probably shouldn't be a big meal.
It should be something.
Could be something.
But the bigger meal should be lunch or even a mix between breakfast and lunch.
But if you go out for that walk afterwards, number one, when you're exercising, you tendto slow
Food digestion and absorption, right?
(07:28):
So that's one thing.
The second thing is you're also sort of burning off some calories at the same time So youkind of get kind of get a benefit for both and to your point since your body now Feels
like it's replete with calories You know, it's kind of ready to go and your heart's kindof ready to go anyway, so it's you just have to understand that if you have heart disease
(07:53):
You're pushing blood into your gut
to digest the food, which is one form of exercise for the heart.
And then you're pushing blood to your muscles to be able to get you to exercise, which isanother form.
So you're kind of doubling up on the exercise.
So even though you're just going for a walk, you're kind of getting a more potent form ofexercise that way, which if you have heart disease could be too much, but if you're
(08:16):
healthy, could be a really great way to go about it.
So yeah, we like going for a walk after eating in the evening.
So we have two articles about Takotsubo.
Is how pronounce it?
Yeah, it's Hakusubo.
Takasubo syndrome.
Broken heart.
(08:38):
Talk about that because it looks like it's on the rise.
Yeah.
well, it's probably on the rise, for a couple of different reasons, but also, since it wasfirst described back in the nineties in Japan, it's now become more universally
recognized.
(08:59):
And I think a lot of it was not recognized previously.
Right.
So it's hard to know if it's an incidence in occurrence or an incidence in observation ofit.
Right.
Yeah.
appreciation of it.
So,
But yeah, Takasubo is interesting.
I saw a number of cases when I was, you know, doing interventional cardiology work andbasically boils down to what's referred to as broken heart syndrome, where the heart is
(09:25):
exposed to stress and it could be psychological stress.
Could be physical stress, could be a combination of the two.
It seems to affect women about 90 % of the time, 10 % of the time in men, can occur in menand it's sense to happen in women that are post-menopausal.
And so my hypothesis is that the female heart is not structurally quite as strong as aman's heart.
(09:51):
Just, you know, just like their bicep isn't structurally quite as strong as a man's bicep.
The sex is just kind of a hormonal effect, if you will.
And then when women are post-menopausal and depleted of hormones, they lose muscle mass.
Men do the same thing, but they have a little more to start with.
And the heart becomes a little more vulnerable to the effects of high stress.
(10:16):
So the high stress, you know, it's it's it's typically characterized as a psychologicalstress, like, you know, the loss of a loved one or, you know, a tsunami hits a village or,
you know, something that's, you know, heartbreaking, if you will.
And all of the release of catecholamines into the system, the epinephrine, the dopamine,norepinephrine, all that dumps in and it overwhelms the heart in terms of
(10:40):
what it's asking the heart to do, right?
Speeding it up, forcing it to contract more vigorously, things like that in response toall those stress hormones and the nervous system as well.
And the heart just kind of shuts down, right?
And so what happens is it kind of balloons out and instead of going from pumping out about60 % of the blood with each beat that it's been filled up with, it doesn't pump out every
(11:03):
last drop, but pumps out about 55, 60, 65 % of the blood.
It may drop down to pumping out 15%.
Right.
Yeah.
What does that cause?
heart failure causes heart failure where you're not pumping enough blood and the bloodbacks up into your lungs and people get pulmonary edema and they can die from that.
(11:26):
it's like acute heart failure.
It's also associated, depending times, with chest pain.
So there's kind of a pain response to it as well, kind of like a heart attack.
it many times is diagnosed, somebody comes in with acute heart attack symptoms, but theydon't show
some of the classic findings of heart attack on the EKG.
(11:46):
It's different kind of EKG and I'm not going to the EKG details because we don't havepictures to show people, but it can be determined that it's not an acute heart attack.
And when you take them to the cath lab, you see that the arteries are typically clear.
There's no clot, there's no plaque, but the heart muscle itself is very weak and itballoons out.
(12:06):
If you can imagine the body of an octopus, how it's kind of that big body now it has allthe eight
legs coming off, tentacles coming off.
The heart kind of looks like that.
It just looks like it's ballooned out and hardly contracts.
So that's how it got to name Takasubo.
It can also happen with physical stress and it can also happen with, let's say you're aninpatient and you just had your gallbladder out or you just had a major surgery and you're
(12:36):
under a lot of physical stress as well as emotional stress.
can occur in that setting as well.
So yeah, Takasubo, it's an interesting thing.
really only accounts for probably two, three, four, five percent of people that are seenin an emergency room, probably more around two percent.
Again, women more than men.
yeah.
(12:57):
Interesting.
What's the treatment?
the treatment, it tends to get better.
Reduced.
Yeah.
In our world, reducing stress.
When a heart is strong enough doing low dose beta blockade to block the beta receptorsthat this is where the epinephrine, norepinephrine things are reacting, alpha and beta
(13:23):
blockers like Corag, Corvetilol, kind of rest the heart, kind of remove that.
stimulus from the heart, it allows it to regain strength.
And then you can do regenerative things here too, right?
This is a place where some of the regenerative factors, whether it's stem cells orplacental derived trophic factors and cord blood factors and things like that can all be
(13:49):
beneficial.
And then improving hormone levels can be helpful.
You know, where you do get testosterone and estrogen back.
which makes all the tissues more sturdy, you will, enables them to manage that stress.
So there's two things here.
One to try to prevent it.
One, I would do hormone replacement therapy so that you're, you know, you don't lose themuscle mass, both not only in your arms and your legs, but in your heart.
(14:15):
the second is monitoring how your body manages stress.
And we're really big, have become big fans of brain tap, which is a device that's a visorand headphones that
you know, uses binaural beats and photobiomodulation through the eyes and the ears toactually entrain your brain into a particular waveform like alpha for meditation or theta
(14:38):
for deep meditation or delta for sleep.
And you can actually train your nervous system to receive a stressful quote unquotestressful input and yet have more equanimity around it, not be as impacted by it.
There's also some interesting cognitive insights about that too.
(14:59):
in terms of how to manage stress.
So one of them is, many times the reason we feel stress is because we are identified orassociated or attached to a particular outcome.
Right.
And if we, if we don't, if we unattach ourselves from the outcome, right.
(15:24):
This is kind of a perspective shift.
Yes.
You see, then all of a sudden, stress can be decreased dramatically, particularly when ouridentity is caught up in it.
Like, I, know, I'm here to do this job and you know, I didn't get something done on timeor whatever.
now it's like, there's a threat to me, my own identity.
I'm attached to that outcome.
(15:44):
Right.
Yeah.
And so.
A lot of stress comes from that and the inside of realizing that, I will actually be afree individual if I, it's, it's not a question of not caring.
It's not a question of not connecting.
It's not even a question of not loving or participating or really trying hard.
It's just not identifying with the outcome and attaching our identity and our self-worthand everything else to that outcome.
(16:09):
Right.
That's really important to learn to separate that.
Right.
And then that will really help.
manage stress dramatically,
It's massive.
It's massive.
Once I started to do that, I noticed my overall stress levels significantly decrease.
Hey, whatever happens, happens.
Yeah.
And it's not even, yeah, I mean, it can be that, and it doesn't mean you don't even careabout the outcome.
(16:33):
Like you want a good thing to happen, but if it doesn't happen, it's like, but it's not,it's not me.
It's like, well, what can I do to be helpful here?
Right.
And so you get away from that being caught up with your identity tied to it.
I once heard this speaker in the Christian communities give this thought, and it's neverask the why question because it'll never be answered.
(16:57):
Instead, ask, what does this mean and what must I do?
And changing that kind of perspective can be massive.
Yeah.
Yeah, that's right.
What I find is that when you are not attached to an outcome, right, like in this podcast,for example, I'm not attached to an outcome as much as I love this podcast and I love
(17:19):
having these conversations and I care about the audience, right.
But I'm not attached to the outcome.
My identity is not attached to the outcome.
Yeah.
And what that does is it frees me up psychically to do the podcast and not be fatigued ortired at the end of it.
Right.
Or it also frees me up to be more, either both thoughtful or creative in my responses, mythoughts.
(17:42):
So it actually it's, you know, we talk about freedom all the time, right?
We talk about freedom and yet everybody signs up for indentured servitude, right?
They tie themselves to a job and a salary and a, and, and for me to be a good person, I'vegot to do this and perform at that.
You see what I'm saying?
We all sign ourselves up for indentured servitude.
(18:04):
And yet we can free ourselves from all that.
And this is how you do it, is by unattaching.
And that decreases stress and that will protect you from Takasubo.
So that's my take on Takasubo.
Dr.
Gladden dropping truth bombs.
Next article we've got, if you can do this many pushups, your heart is healthier than youthink.
(18:27):
Dr.
Gladden, truth or myth?
What do you do to improve your heart health?
Well, there are many, many, many, many metrics like this, right?
You could say the longer you can hold a plank, the longer you can hang from a bar, themore pull-ups you can do, the higher your VO2 max, really the stronger your hand grip
(18:49):
strength is, right?
So all of these things are really similar measures, if you will, of just total overallbody fitness.
And I think
What we're saying here is something obvious.
If you're fit, you do better, right?
You have more physiologic reserve.
(19:10):
So you have the ability to be more anti-fragile, which is a really important concept,right?
So fragility, of course, is when something unexpected happens, we're damaged by it.
Strength is, resilience is the ability to actually absorb that and recover from it.
(19:30):
And then basically being
really sturdy, so to speak, or strong means that you're not even impacted in the firstplace, right?
anyway, I think when we think about the body and being in shape, you just want to be inthe best shape that you can.
(19:52):
And I will tell you that some insights I've had are that you never can get in shape in agym.
And you can never get in shape without a What I mean by that is that when you train,you're not training your muscles.
Everybody goes to the gym because they're going to train today.
(20:12):
It's upper body today.
It's legs today.
It's this actually being fit.
or whatever.
Being fit is actually having a nervous system that is fast and responsive and agile andquick and balanced and all those kinds of things and powerful and strong, right?
And to generate all that force.
And so you're really, if you focus on the fact that you're training your nervous system,you'll realize that you can't sit on a machine or do a limited range of motion something
(20:41):
and really train the nervous system to be fast, agile, strong, quick and balanced, right?
It's not gonna happen.
Even if you're doing
you curls on one leg.
You have to put yourself in an environment that's unpredictable.
And the only way you get that is to get outside.
You've got the wind, you've got the rain, you've got the boulder in front of you.
You've got the tree that fell down in front of you, whatever it is, you've got to haveyour skiing, your walking, your hiking, your running, whatever, biking, whatever it is,
(21:08):
you got to have unpredictability to train your nervous system to be adaptable to thesethings.
And I think that's why you can never really get in shape in a gym.
And I think you also need a gym because you do need to sit there and do some, some squatsand you do some leg presses and some other stuff to actually build up just pure strength,
if you will, which is also a nervous system situation.
(21:30):
But when you carry that strength into the unexpected environment of the outdoors, now youhave the fun of like, yeah, I'm strong.
I can pedal up this hill.
Right.
But now I've got to dodge that and hop this and whatever else.
So anyway, that's how I think about it.
What's your normal ratio of strength training outside all of that and how has it evolvedover the last number of years?
(21:53):
Yeah, well, it's a function of the weather to some extent, and it's a function of thestatus of my body.
So if I'm injured, it's a little harder for me to do certain things outside.
So I'm a little bit more confined to a gym, but even in a gym, I'll try to make itunpredictable and I'll get outside as soon as I can.
(22:18):
If I have access to the outside,
I will be outside probably five days a week and I'll be in a gym two days a week would beabout the right ratio.
When the weather's bad or it's cold or this or, know, and it's, I can't get out and runfor either a scheduling reason or something, you know, in reality, it probably works out
(22:39):
to where I get outside three days a week and I'm inside four days a week, but I'm stilloutside as much as I can be.
Yeah.
GLP-1s are being used to treat heart disease.
I can assume you have some thoughts about this.
(23:00):
Yeah.
Well, I JLP ones were basically, mimic, you know, the hormones that are secreted when weeat that, you know, basically indicate that we're full.
And so they decrease appetite.
They, and so they've been used for controlling blood sugars in the sense of decreasingappetite.
Also, they do seem to improve insulin sensitivity and improve beta cell function andthings like that.
(23:28):
And so.
You know, they really were developed for diabetes.
but then it was found that, people are actually losing weight on these drugs.
So then it became weight loss.
At the same time, people were realizing that when diabetics would take JLP once they had alower incidence of heart attacks, right.
(23:48):
And strokes.
And so there was been a cardiovascular benefit, right?
There's an impact on lipid levels and, and, the way the heart responds to certainstresses.
So.
It's really important to know that you're kind of enhancing a normal function in the body.
The problem is that it's like anything.
(24:10):
If you push it too hard, you start to get the negative effects.
And so we see people that are, have become reliant on GLP-1s and GL1s to basically, youknow, lose weight.
And what we find many times, because we measure everybody's
body composition is that they're losing muscle instead of fat and they can be losing bonedensity.
(24:34):
Now there are papers published on this as well.
So while it's useful, particularly for diabetics and for decreasing cardiovascular eventsin diabetics and even in non-diabetics, and it's also good for preserving kidney function,
they have to be used cautiously at the same time.
(24:55):
And so
We're fans of, of going about it a little bit differently.
We'll use GLP once to kind of jumpstart a situation if somebody wants to lose weight, butwe actually think that a five day fast mimicking diet is really a great jumpstart.
it resets the gut, bio resets or taste buds resets or appetite.
(25:19):
and then from there you can use Mimeo.
We've had a podcast on Mimeo, right?
Which basically.
has PEA and OEA and spermidine in it, a little bit of niacin.
And the PEA and OEA, the OEA in particular, decreases appetite.
So if you take three or four of those, now you're getting the benefits of appetitesuppression without loss of bone density or muscle mass.
(25:45):
And you're getting spermidine, which is increasing basically autophagy in your cells andyou're increasing reverse cholesterol transport.
So that's like a magical formula for keeping your arteries healthy.
So we're big fans of that.
And then there are also probiotics out there now that have GLP, that increased GLP-1activity.
(26:10):
And acromansia is one that is good for improving blood sugar control.
So my point is if you're on a GLP-1 and you're listening to this, there are ways to getyou off of it.
not lose ground and actually gain ground in terms of muscle mass, bone density and whereyou really want to be.
I think it's super important for people not to focus on the number on a scale.
(26:32):
It's really body composition you want.
And if you're serious about your health, get a scale that has a body composition componentto it.
I think withings has one of those, I in body makes a scale.
I think there's different ones out there.
You can resource.
but if you
How accurate are those?
Obviously it's not as...
How accurate are those?
Obviously it's not as...
really matter.
It doesn't really matter in a sense.
(26:55):
It matters.
Well, my point is it matters.
They're not as accurate as the DEXA scan, right?
But they're accurate enough that you can see changes in a positive direction.
if muscle mass is going up, muscle mass is going up.
If fat, percent body fat's going down, percent body fat's going down.
It doesn't matter if it's 18 % or 22 % even.
(27:16):
It's the fact that it's moving in the right direction.
So yes, you want to try to get one that's been
know, verified and accurate.
But the point is it's really the change that you're looking for.
So, yeah.
(29:20):
Well, you mentioned artery health and our last article is dietary salt substitutes toprevent heart attack, stroke and death.
Basically it's talking about using potassium rich salt as a salt alternative.
Dr.
Gladden, what are your thoughts?
I'd never heard of this.
(29:41):
Yeah, well, it turns out that, yeah, there's some really interesting things around salt,right?
So we all grew up with, you know, Morton salt, iodide salt, right?
And then we got away from that because everybody got infatuated with sea salt and Celticsalt and things like that, which is great because it is many salts.
It's not just sodium chloride.
It's actually many different minerals.
(30:02):
And having all those minerals is actually really good because a lot of the time in ourpasteurized world, we don't get all those minerals.
So using those kinds of salts are helpful.
What's also known though, is that potassium rich foods help lower blood pressure and raisepotassium.
And likewise, if you put some potassium chloride into your sodium chloride, or even somepotassium chloride into your Celtic sea salt, to where you're getting some potassium, some
(30:28):
extra potassium, that's been shown to actually relax tension in the arteries and lowerblood pressure, improve heart function and...
improve arterial function.
So you can get potassium from, you know, things like potatoes, or they're higher inpotassium than bananas, for example, sweet potatoes and white potatoes.
(30:48):
And if you want to refrigerate a baked potato overnight and turn it into a resistantstarch, you don't get all the carbs from it.
You get resistant starch that feeds your gut biome and you're still getting the potassium.
So there are many ways to boost potassium.
You don't have that necessarily get a salt substitute to boost potassium.
You do it with food.
But the idea of having more potassium is a smart idea for hard function.
(31:12):
We know that too much sodium pushes us into higher blood pressure and things like that.
So it's not that salt is bad, especially if you're getting all the minerals from like aCeltic sea salt or something, but too much pure sodium chloride is not what you're after.
Dr.
Gladden, February, what's the latest?
(31:34):
What's new?
What are you excited for in the next month?
Um, well, we're, we're basically, um, starting a new brain optimization program here.
So we're super excited about that.
We're, coupling many of the technologies that we have here, both diagnostically andtherapeutically.
(31:55):
And we've always used a Dale Bredesen's protocol here in terms of, you know, fixing the 36holes in the roof that are associated with dementia.
Yeah.
And so.
We've been all over that, but now we have a number of things that actually are veryadditive to that in terms of regenerative therapies, trans-cranial magnetic stimulation
and peptides and no tropics and regenerative technologies like placental derived exosomesand stem cells and things like that.
(32:25):
So you put all that together.
It's pretty magical plasma freezes to kind of clear out the trash and the inflammation.
And then we have.
genetic testing to actually understand who's at risk for what kind of dementia, thingslike that.
And now we're just getting a hold of a new product called TB006, which is a monoclonalantibody that binds a molecule called galectin 3.
(32:49):
And galectin 3 is a major player in enhancing inflammation in the brain.
It basically turns on the microglia in the brain, which are the immune cells in the brain.
And it cross-links all these proteins that are in the brain also that kind of theseneurofibrillary tangles and things like that, that actually increase inflammation in the
(33:12):
brain.
And pretty much all neurodegenerative diseases have a common denominator ofneuroinflammation or brain inflammation, right?
So hydrogen is great for decreasing the oxidative stress associated withneuroinflammation.
Using something like TB006 to bind up, collect in three and decrease
(33:32):
the inflammatory response improves cognitive ability.
So even somebody that has pretty profound dementia can improve 63%, which has never beenshown before.
And people with milder forms of cognitive impairment can improve 240%.
So it's like you start to put these things together, know, hormone optimization andthyroid and all the things we know how to do here.
(33:55):
I mean, we're at a point where, you know, I've thought for a long time that heart diseaseis optional.
And now we're thinking that dementia is optional.
And the other thing that we're doing on the cardiovascular front is we have access becausecardiovascular disease does affect brains as well, both via strokes and, and multi-infarct
dementia where there's little, little emboli that go into the brain and cause microinfarcts, if you will, or micro strokes.
(34:21):
We have access to something called Capodex, which is cyclodextrin that mines upcholesterol and pulls it out of plaque.
So, you can actually pull.
cholesterol out of plaque for the first time, not just try to decrease cholesterol, butactually pull it out.
that's the exciting part.
The less exciting part is the fact that you, you, use it as an enema, daily for, but it'sonly about five or six CCs.
(34:45):
but, we're super excited about that too, right?
mean, if you have, if you had significant blockage, it'd be like, yeah, I'll do that.
Right.
I want to get rid of that.
So we're, running trials on all these things.
we're involved.
These are all under.
IRB approved trials to sort of collect data and see what happens.
But we're very excited about the whole field around both brain and heart health.
(35:07):
Yeah.
Well, listeners, if you are interested in heart health, Dr.
Gladden has a tincture called the blood vessel formula.
Use podcast 10 to get 10 % off your order in the checkout.
And listeners, if you are interested in fighting dementia, if you're interested inunderstanding more heart health, if you're interested in getting better care of your heart
(35:35):
with Dr.
Gladden,
Go to gladdenlonggevity.com, fill out the form, reach out, someone will call you.
And Dr.
Gladden, there are ways in which to help get this paid.
You guys have creative ways to make sure that.
yeah.
Yeah.
People, people invest in themselves, free tax and things like that.
So there's lots of ways to do that.
(35:56):
And, yeah, the blood vessel formula is really, way for you to get the benefits of all themed training herbs without having to eat a bushel of basil and arugula every day.
Right.
So kind of regular per se, but, summer savory and things like that.
Sometimes that are hard to get ahold of.
and then we have a mushroom formula also that's, five different mushrooms as the tincturethat, all turn off inflammation.
(36:19):
So we use this in general for inflammatory control, if you will, but those two togetherwork really well.
yeah.
Listeners also, if you have a question for Dr.
Gladden, submit it.
Podcast at gladdenlongevity.com.
That's podcast at gladdenlongevity.com.
Dr.
Gladden.
(36:40):
Yes, sir.
I see you next month, my man.
All right, great to see you, Steve.
you
Thank you for listening to this week's episode of the Gladden Longevity Podcast.
If you would like more information on what we've discussed or other topics, pleasereference the show notes or go to gladdenlongevitypodcast.com.
You can also find us on Instagram, Facebook, and Twitter by searching Gladden Longevity.
(37:04):
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The Glide and Longevity podcast is provided for informational purposes only.
It does not constitute medical advice.
(37:24):
This content is not intended to be a substitute for professional medical advice,diagnosis, or treatment.
Always seek the advice of a physician or other qualified health provider with anyquestions you may have regarding a medical condition.
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