205: How to Stay Young For the Rest of Your Life - with Dr. Jeffrey Gladden - ReversABLE

Episode Transcript
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Dr. Jeffrey Gladden (01:52.802)good to be here. Thanks for having me.

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Josh Dech - CHN (01:55.512)Good to have you back so soon. I know we had just seen each other, was it 48 hours ago, I believe, for your show.
Dr. Jeffrey Gladden (01:59.484)Yeah, 48 hours ago. Sir Josh, exactly. What are you doing this weekend? There you go.
Josh Dech - CHN (02:04.717)You'll get sick of me real fast. Don't go down that one. I'm not that much fun. Now, Jeff, we're here. You're a longevity specialist. You're the guy that people want to go to to learn how to live longer, but not just lifespan. It's one thing to live longer, but health span is the most important aspect where you can actually live and feel good and enjoy your final years rather than just spend those in a nursing home. Right out of the gate, what are the biggest mistakes?
that we are doing on a day-to-day basis is a general population that are just impacting our health span and lifespan so dramatically.
Dr. Jeffrey Gladden (02:41.936)Yeah, it's a great question, right? So I think one of the biggest problems that we have when it comes to longevity is it's kind of multifaceted. But the biggest problem is I don't think we actually understand what the target is. And I don't think we actually understand the process that we're in. So let me explain what I mean by that. I think that the
One of the big issues that we have is we, when we're younger, chronologically younger, we tend to take our health for granted. so we end up, unless we're, unless we're struggling with an issue like, like you had Josh, then, you know, your health is front and center, but for a lot of people it's not. and they end up leveraging their health for the sake of, you know, building a business, building a family, building a community, whatever else. Right. And then.
Josh Dech - CHN (03:33.771)I get that,
Dr. Jeffrey Gladden (03:34.852)Right. Burning the oil at school and, you know, internships, whatever profession, whatever they're doing. Right. And so I think health is taken for granted. And I think one of the key things is to understand that it's it's really your most precious asset. So for younger people to actually understand that, you know, health is really the most precious resource I have. Well, it's almost the most precious resource you have, because I'll get to that in a second. But it's certainly number two.
Um, so I think that's one problem. I think the other problem is that we don't really relate to the aging process in the sense that we perceive aging to be linear, right? It's like every year it's another birthday. I don't feel that much different. And even though we know that aging is exponential, we know people age a lot more between say 60 and 70, 70, 80, 80 and 90 than they do between 20 and 30, 30 and 40. If we ask ourselves, what am I going to be like 20 years from now?
Right. What am I going to be like 20 years from now? 25 years from now? What am I going to be like? It's virtually impossible for us to imagine we're going to be anything different than what we are. Right. So we're kind of clipping along in this bubble of, uh, you know, aging feels like a linear process. I see it all around me, but it's not, you know, it's kind of this denial. It's like, well, it's not affecting me. I don't, don't know. I don't think it's really going to affect me. And, and so.
I think that's another big misconception. think the third big misconception apart from leveraging health and not really understanding the exponential or relating to the exponential nature of it is related to the fact that we allow our chronological age to start to dictate to us what age we actually are. What I mean by that is there are so many social cues around us. Well, you're now 30.
You should be getting married, should be having children, you should be doing this, you're now 45, you're 50, you should be slowing down, you're 65, you time to retire. Really gonna go skiing? That's really not smart. So you get all these social cues about what you should be or shouldn't be doing. It's all reinforced by the environment we live in, your peers, your parents, your friends. It's reinforced by your company.
Dr. Jeffrey Gladden (06:02.876)excuse me, by the company that you work for, by the government. So you have all these environmental cues that, I'm aging, right? So on the one hand, we don't relate to aging. On the other hand, we're being swept along in an aging process. one of the big problems we have is we then start to identify with the chronological age. It's like, well, I guess I'm 45 or I'm 52 or I'm 65 or whatever it is. And it's like, I shouldn't be doing that. And I probably should be doing this or, you know, this is no longer in my wheelhouse. So
When I think about longevity, I tend to think about it that it's really important to know what the target is. You can't hit a target that you're not aiming for, right? And I think that in order to know what the target is, what I've defined for myself is that in the book I wrote, 100 is a new 30, that when I'm 100 years old, I want to be 30 years old physically, right? I want to have a body of a 30-year-old person.
Josh Dech - CHN (06:59.479)Mm-hmm.
Dr. Jeffrey Gladden (07:01.884)So I've been around the planet, or around the sun rather, on this planet, been riding this planet 71 times around the sun. But I wake up 27 every day. And I would encourage anybody listening to this to actually pick an age that you want to be for the rest of your life and claim that age. It is such an incredibly powerful tool to reference.
the age that you want to be as opposed to in any way identifying with your chronological age. Because when you identify with that younger age, it's if I wake up and I don't feel 27, it's like, well, I could say, you know, but you're so much better than most people your age. You can do all these things, blah, blah, blah, blah, blah. But that's acquiescing to the aging process. If you're going to win in an exponential game, you've got to have an exponential strategy. And for me, it starts with actually claiming a more youthful age and always referencing that because
Our mind, there's nothing more powerful than our mind, right? And exactly. Nothing more powerful than our minds and there's our minds and our spirit and our souls. Those are really the most powerful. So when we claim to be 20, when I claim to be 27 and you know, something is like, I don't feel 27. It's like, I'm like, well, what do I need to do to get back to 27? And in life, you only ever get the answers to the questions that you're asking.
Josh Dech - CHN (07:58.104)That was my next question. I'm glad you're going down this rabbit hole.
Dr. Jeffrey Gladden (08:23.996)So if you're simply asking, how do I manage at this age? How do I plan for retirement? How do I think about visiting the grandkids? Where's my retirement home going to be? Where's my golfing buddy going to be? That becomes your ethos for longevity. But if you reframe it and say, no, I want to be 30 when I'm 100, then you start asking completely different questions.
How do I stay 27 at this point in time? How do I continue to smoke, to snowboard, to mountain back, to do all the things I love to do, to go for a run, right? And when you ask those questions, you start to get those answers. So that's one part of the target 30 year old body at an age of a hundred. The other thing that's super important and is actually the number one thing is to develop a 300 year old mind. Right. So the 300 year old mind.

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is really all the equanimity, all the insight, all the transcendence, all the peace, all the perspective that comes from a 300 year old mind. Right. And when you combine a 30 year old body with a 300 year old mind, that now becomes the bullseye for longevity. It's like, how do I develop a 300 year old mind? How do I go back and solve the traumas that I've been living in reaction to, you know, all the different things that go into this. And so I think
And I can go into this in great detail. I was just explaining to you before we started, I just gave a talk on this to a group, it was recorded to a group in the Bahamas that'll be airing down there later this month. But the point is that if you understand what the target is, and you actually understand that you need an exponential strategy, and you have to resist this cultural sweep towards getting older, you've actually now...
started on the journey of longevity. That's how I would frame it up.
Josh Dech - CHN (10:18.861)Now, it's really interesting this rabbit hole we sort of found ourselves in because I would have expected the first thing we're doing, the first question is what are the top things we're doing to harm ourselves and really decrease our own health and lifespan? I would have expected seed oils or high stress or cell phones or something along that line. But instead you went, we take
age for granted or we take our health for granted we sacrifice it for business we sacrifice it for the now we sacrifice it for a good time then we're in denial it's kind of like a savings account i'll save when i'm older we don't start saving now for our future and then this chronological age in the social cues
Dr. Jeffrey Gladden (10:55.228)That's right.
Josh Dech - CHN (11:02.093)I had heard something years back, you know, there was always this idea of how do you prevent Alzheimer's? How do you stay sharp when you're aging? The idea was, well, do Sudoku puzzles, keep yourself, keep your mind sharp. What they actually found was it was socialization. It wasn't about using your brain. It was about being social, being lively, being active. And that plays into exactly what you're saying. Yes, there's a biological clock. Telomeres are starting to get shorter. Cells are dividing to their max. We age, we wrinkle and that's it. But there's also a very real
Social physiological or even psychological Q we give ourselves that can speed that up or slow that down And in your opinion then minus the general health is that really the defining factor between someone like Betty White who's 90 and actually she's 27 But before she died versus somebody who's 60 and acts like they're 90
Dr. Jeffrey Gladden (11:50.18)A thousand percent. Like there are people that are 25 years old going on 65 and there are 65 years old that are going on 25, right? And it's completely related to mindset.
Josh Dech - CHN (11:51.915)Wow.
Josh Dech - CHN (11:55.782)man, there are.
Dr. Jeffrey Gladden (12:01.532)It's completely related. And interestingly enough, genetics will play into that. Some people have a much higher incidence of depression or anxiety or whatever else. And so this is another key factor in the longevity equation. If you're really going to be 31 when you're 100 and you're going to develop a 300-year-old mind, then you have to know two things. You have to know what card you're holding in this exponential game. You have to know what your genetics are. If you don't know what your genetics are, how are you going to play the hand? The other thing you have to know is where you are in
Josh Dech - CHN (12:02.189)Hmm.
Dr. Jeffrey Gladden (12:31.526)game, right? And I think one of the greatest disservices in longevity is the fact that people relate to a quote unquote biological age. It's like, well, I my biological age tested and I'm five years younger, I'm 10 years younger than my chronological age, so I'm good, right? There is nothing further from the truth because we are a mosaic of many, many, many, biological ages, right? You know, the whole idea of the Longevity Olympics, right?
Josh Dech - CHN (12:43.917)Mm.
Dr. Jeffrey Gladden (13:00.408)was basically based on one metric, what's your doon it and pace rate of aging, right? The Brian Johnson scenario, right? Well, we have many people in our practice that have a very good rate of aging, and yet they have an omic age, a DNA methylation age that's much higher than their chronological age. They have a vascular age that's not good at all. They have a brain age that's not that good at all, right? So the point is that if you don't know your mosaic of ages, you have no idea where you are in the game, right?
win a game if you don't know the cards you're holding you don't know where you are right so this becomes another major thing
Josh Dech - CHN (13:33.773)Sure. Let's talk about that mosaic. What happens when we age? Psychologically, physiologically, what is happening in our bodies as we age and both look at and feel it?
Dr. Jeffrey Gladden (13:47.876)So this is another sort of misconception. It might be even helpful if I shared a screen with you, if I can do that. I know the audience won't be able to see this. I don't believe, is that correct?
Josh Dech - CHN (14:01.503)Yeah, we are primarily just audio based. So if you want to just walk us through it in audio format, that'd be helpful.
Dr. Jeffrey Gladden (14:07.79)Yeah, okay, I can do that. imagine if you were that

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The way to think about it is that a truly exponential longevity strategy consists of five different circles, right? Five areas that need to be addressed.
At the center of those circles, they're interlacing circles, right? So they're like Venn diagrams that overlap. And yet there's one circle that encircles all of them. That's the fifth circle. So the four circles that are in the middle that are overlapping with each other are health, right? Everything you know about health, know, seed oil, sleep, exercise, everything you know about that. Then the environments we reside in, right? The environments we control. If we don't architect those environments to support the mission, then it's very easy for the wheels to come off and nobody has enough psychics.
energy or enough time to actually reconstruct what they're supposed to be doing in every new environment. So they have to be pre-architected and we all live in four for the most part, right? Homework, business travel, vacation travel. So making sure you architect the environments to support the mission once you know what to do. And then performance is super important, right? Like when I'm 100, I want to be fast, agile, strong, quick, balanced, great cardiovascular capacity, reserve, flexibility, right? That's what I want. So if I'm going to be that at 100, then I need to be that today, right?
And when you're 18, you go for a run and lift some weights and you're fine. But at this point in life, you've got to be training things differently, right? And you've got to really understand that when you come to any kind of training, it's really training your nervous system. It's not about your muscles. It's really about your nervous system. The other thing is there's actually a longevity circle.
Dr. Jeffrey Gladden (15:52.59)And the longevity circle is looking at, to answer your question, the real drivers of aging. What are the physiologic processes that are creating the current in the river that's carrying us down over the falls, right? And those are referenced as the hallmarks of aging, right? So the hallmarks of aging, we're up to about 16 of them now. And these are biological processes that sit below what your, you know, symptom-driven doctor would be addressing. They're sitting below what your functional medicine doctor would be addressing.
honestly, it becomes the root cause of the root cause, right? And so these are processes like stem cell exhaustion, cellular senescence and mitochondrial dysfunction and genomic instability and loss of proteostasis and, you know, epigenetic alterations in terms of how DNA is being expressed and telomere attrition, right? Where telomeres are getting shorter and cells can no longer divide properly. Disregulated nutrient sensing, right? Balancing being in an anabolic state and being in a catabolic state, right?
One is anabolic, we're building, growing, but if you do that all the time, you end up with cancer and you die sooner. If you're catabolic all the time, you know, you're a waif, but you need to be cycling back and forth between these two states effectively, right? So, and then compromised autophagy, the ability to recycle proteins and microbiome disturbances, right? The gut plays a big role in longevity and decreasing inflammation, improving digestion, getting rid of bacteria and yeast overgrowth in the gut, improving the gut lining, increasing butyrate to basically keep the
the enteric cells healthy, all these things become super important. Then there's some ones like altered mechanical properties in the cells and displacing dysregulation for messenger RNA and inflammation. Yeah, it's complicated. That's my point. It's complicated. And so most physicians are not looking at this layer that's really driving the current in the river, right? And so that's what we do at Gliden Longevity. That's what we do. We look there, we start.
Josh Dech - CHN (17:34.401)That sounds complicated.
Dr. Jeffrey Gladden (17:52.078)looking at longevity, we look at health, we look at performance, and we look at the environments. But the circle that binds them all is really the life energy circle, right? And the life energy circle is really the one that focuses on the psycho-spiritual health of the individual. And I think that's the real piece, because you know,
For example, I'll just walk you through that circle for a second. So the first point on the life energy circle is having a growth mindset.
So my definition of a growth mindset is, is really, are you married to your questions? Are you married to your answers? Right. Because when you're married to your answers, you've already put yourself in a box, right? You're now you're defending your position. Right. And what I've learned is that all, all answers have a shelf life, right? They change over time. We get new information, new, new insights, new, whatever. And so, and yet many clinicians and physicians and lay people, they learn about a particular answer and they get married to it. And now everybody needs
Josh Dech - CHN (18:44.29)true.
Dr. Jeffrey Gladden (18:54.558)to doing this, right? You hear this over and over again, everybody needs to be doing this. And what we found is that nothing could be further from the truth. We each are holding a different set of cards. And if you know the cards you're holding, then you can decide what actions you need to take. If you know where you are in the game, then you can start taking the right actions. So it's really a custom fit for each one of us. And in a way, that's kind of a blessing because each of us is our own person. We intuitively know that it's not a one size fits all. So having this growth mindset of being married to the questions, right? So in our case,
Dr. Jeffrey Gladden (19:24.498)the questions we have are, wonder how good I can be, right?
How good can I be? How do I make 100 to new 30? How do I live well beyond 120? How do we crack the Hayflick limit and live well beyond 120? How do we live young for a lifetime? How do we maintain that youthfulness? And how do we develop a 300-year-old mind? So those questions drive us all day long. We're not married to any answers here. We're only married to the questions, because those drive all the innovation. And it's a very exciting. Your life is so much more exciting when you give up on your answers and you get married to your questions.
that it transforms your life and you'll be finding better answers all the time. It's super fun, right? So having that growth mindset I think is super important. That's the first point.
Josh Dech - CHN (20:04.055)Yeah.

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Josh Dech - CHN (20:09.473)Jeffrey, how did you get involved in this anyway? mean, 71 years old, anti-aging. Why? I mean, when did you start this? When you were 17 years old, you started at 60 years old with their health issues. What led you to this where you thought I would like to live longer and live better?
Dr. Jeffrey Gladden (20:25.872)Well, it happened for me in my 50s, right? I was always athletic. I played some soccer, basketball. I wasn't a star athlete or anything, but I just always enjoyed being athletic and being very kinetic.
I got into snowboarding, mountain biking, skiing prior to snowboarding, stuff like that. In my 50s, I got sick is what happened. I was exhausted all the time. So I have my own trauma here. I was exhausted all the time. I was putting on weight. I was losing strength. I was losing muscle mass. And when I would become stressed, and I had a lot of things going on. My background is interventional cardiology. I had a group that I started. I had 10 offices, 12 docs. We flew around in a little plane servicing.
I co-founded a large heart hospital here in Dallas. I'm involved with medical device companies sitting on boards doing all these things, right, raising a family. So I got a lot going on. And when I would come under stress, I would get depressed, like really depressed, right? And I start developing brain fog.
Josh Dech - CHN (21:18.369)Busy guy, yeah.
Dr. Jeffrey Gladden (21:28.356)My father ultimately died with with dementia, and so I'm really concerned about all of this, right? I just feel like I can't keep up anymore. And so I go in and I get tested. And what I'm told is everything is normal for your age. You're just getting older. Why don't you take an antidepressant? Right.
Josh Dech - CHN (21:45.621)Hmm, classic answer from a Western medical doctor.
Dr. Jeffrey Gladden (21:48.764)Exactly. so I'm like, no, no, no, no, no, no. It was an existential moment. It's like, really? It's going to be downhill from here? Like, really? This is, I've hit the zenith right here at 53. That's it. It's over. I'm like, no, no, no, no, no, I'm not going to do that. So that's when I threw myself into the functional integrative age management medicine space. And it took me two and a half years. I could do it in 10 minutes now if I had the labs in front of us, but two and a half years. And I figured out everything that was going on. Of course I had help from other people, but I had some
clinical hypothyroidism, right? Completely misdiagnosed by looking at the blood work. Blood work was all normal. My reflexes were slow. My arrestive metabolic rate was low. And genetically, knowing my genetics, I don't convert inactive to active thyroid in my brain efficiently. I'm homozygous for a SNP that decreases my ability to do that. So when I got on the right combination of active thyroid T3 and inactive T4, my gosh, was like the lights came back on. I'm like, my gosh, I'm not exhausted all the time anymore. My brain started to work again.
Dr. Jeffrey Gladden (22:48.638)I was hormonally depleted. There's menopause for women, andropause for men, cetosterone, DHEA, of a sudden, you know, I lost 20 pounds of fat, put on 10 pounds of muscle, weigh what I do in college, I can do anything I want again. And when it comes to the anxiety and the brain fog and the depression, I don't make certain neurotransmitters very efficiently. My genetics showed me that again, right? If I didn't know what my genetics were, I'd have no idea. But from that, I could actually understand what supplements I needed to make.
Dr. Jeffrey Gladden (23:18.598)my genetics actually work for me instead of against me. And once I got that sorted out, it's like, I could come under all kinds of stress and not get depressed. So.
Josh Dech - CHN (23:26.417)That's highly individualized though to you and your situation. mean someone listening to this right now go, wow, Jeffrey, I'm so glad you had all these labs and all this information to help you pinpoint exactly what you need. What on earth can I do though? Like, do I just pretend that I'm 27?
Dr. Jeffrey Gladden (23:37.596)That's right. You can get tested. can start. You can. You can start by getting tested. That's if you're serious about this, if you're really serious about it. Well, there's two approaches, three approaches. One is you can say, well, that's nice. It's just not for me. That's one approach. Two is you can say.
Josh Dech - CHN (23:53.271)Sure.
Dr. Jeffrey Gladden (23:54.544)Well, that's nice, but it's probably going to cost some money to get some testing done. So I'm not going to do that. And what I am going to do is I'm going to try everything I can try and see what actually works for me. Right. That's for approach number two. Approach number three is to say, you know, I don't have time for that. I actually need to know what's going on. Right. I need to do the diagnostics on my car and not just have a mechanic keep throwing parts at it to see if it works properly. Right. And so when you do the deconstruction of the situation, and this is the piece that's missing.
Josh Dech - CHN (24:05.453)It usually doesn't work, I'll preface that right now.
Dr. Jeffrey Gladden (24:23.586)I think all over the place in longevity is that people do not deconstruct the situation before they start making recommendations. What we find over and over again is when you deconstruct the situation, when you understand the genetics, when you understand where somebody is in the process and you really start to deeply understand them psychologically and spiritually, my gosh, all of a sudden here's the path.
And it's like the clarity people are so energized. It's like, finally somebody's figured it out. Here's the path. And now I'm going down the path and I feel so much better. So it's really a shortcut, but yes, it does take some resources to do that. Of course.
Josh Dech - CHN (24:57.261)I think one of the things that we make is a mistake often is we wait till we're in a crisis. You if you want your car to last a lifetime, you park it inside, you drive it gently, you change the oil, you wash it often, you get it buffed and waxed and you take care of the coat on it and it'll last a long time. I've had cars go 20, 30 years that I've seen them, but you get people who get a brand new one and trash it in five. And the amount of times, Jeff, I've had people come to me.

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Josh Dech - CHN (25:23.661)who have gone, again, my specialty is Crohams, colitis, severe IBS. Like, well, I was gonna join a program and get some help, but I feel like I'm actually pretty good right now, so I'll come back if things flare up again. I said, I'm not a rescue organization. I'm not here to save you once things screw up. Like, we're gonna be preventative. We're gonna fix this and stop it from happening in the first place. So you listening right now, wow, I'm not worried about aging yet. You will be, and by then it's too late. My wife is 39, and let me tell you, she looks like she's 32.
too. And she's taking care of herself. She does the face creams, the eye creams, you know, once a year she'll go in for like a preventative something or she uses her red light mask and she eats really well and exercises and she's taking care of herself now so she can age gracefully when the wrinkles hit. She's 39, hardly a wrinkle on her. And because she's proactive, but you get people who hit 30, 40, 50 and still be waiting and by then man, it's too late, way too late.
Dr. Jeffrey Gladden (26:20.486)Well, I understand your sentiment there. think there's definitely an element of truth there. think that there's a couple of things going on there. One, if you're listening to this and you're in your 50s and your 60s and you haven't paid attention, it's never too late to start. there's a lot that can be reclaimed. There is, yeah. There's a lot that can be reclaimed. So don't give up on yourself would be my admonition there. The other thing I would say is when you're 39 or
Josh Dech - CHN (26:37.013)Yes, I want to correct myself on that. It's not too late to start. Yes.
Dr. Jeffrey Gladden (26:49.852)32 or look 32 and you're 39 is that people age a lot in their 30s. It's one of the biggest accelerants of aging is actually happens in the 30s. And so there's no better time to actually understand the cards that you're holding, right? Because you can look in the mirror and that can be deceptive, right? The body has a lot of physiologic reserve.
Right? In other words, lot of redundancy is capabilities. Like you've got lung capacity. If you lose a lung, you still can breathe. If you lose a kidney, you can still filter urine. If you lose part of your liver, you can still, you know, detox and do the things the liver does. Right? If you have a heart attack and lose part of your heart, you can still pump blood. So there's a lot of redundancy there. But what you want to your point about the analogy with the car is you want to maintain that redundancy going through life because that redundancy is eroded.
just through the natural process of aging. And so if you really want to take care of that car, you understand the DNA of that car, how it's built, how it runs, how the different parts work, which parts are most prone to wear out the soonest, and you start doing the preventative maintenance to your point. So it's not too early to start that in your 30s. If you're really serious about this, just because you look good in the mirror and you can run four miles, it's not good enough.
Right. If you really want to make 100 to new 30, that's what I would say. And I'm not trying to scare people and I'm trying to do anything. I'm just I'm just speaking from this place of passion that what is possible is so far beyond what most people realize. Like I literally believe that we can crack the code on aging, that we can be 30 when we're 100. But I just want people to take it seriously and say, hey, OK, well, let me start now. Let me let me let me figure out some stuff so I can point myself in a truly right direction.
Josh Dech - CHN (28:33.983)Let's talk about what this looks like. In my mind, not being a longevity expert. Anti-aging, it means fresh air, safe sunlight, or even better, sunlight exposure, shaded, covered in green things, because that reflects infrared. It means getting adequate sleep, managing your stress, eating healthy, exercising often to tolerance. This is anti-aging in my eyes. But as a longevity specialist who comes in and says, well, you're doing all the right things.
You're identifying as 27. You're acting your age as your identifiable age, not sitting into the social cues. We say, okay, well, there's more to the picture. You need to do testing. You need to do lab work. need to whatever. What does it actually look like?
Dr. Jeffrey Gladden (29:14.512)That's right. Yeah, the point you're making is a good one, right? So people equate taking action in the longevity space by doing all the things that you pointed out. And those are all vital. None of those are unimportant. They're all very important. The problem is that they're not enough. If you're playing an exponential game, right, that becomes a linear response to an exponential problem.
And a linear response will work for a certain period of time, but then it no longer works, right? Because the exponential elements of aging sweep right past it. So if you're really going to win at aging, you have to have an exponential strategy. And it's not just enough to get sunlight, need healthy and get exercise and sleep well and that kind of stuff. It's vital. You can't get there without it, but it's not enough. So then you have to ask yourself, okay, well, if it's not enough, then what else do I need to be doing? Right.
So then I think this is where the deconstruction process comes in. You really need to know where do I stand relative to these hallmarks of aging? Where am I in the aging process? How are my organ systems working? What are my genetic predispositions for dementia, heart disease, diabetes, ulcerative colitis, Crohn's, know, whatever else, What osteoporosis, you know, what are the things that are gonna take me out, right? And once you actually understand that, then you can actually start to augment
the good things that you mentioned with specific things that will help you navigate that. Right. So we just had a woman we were talking with today out of Colorado who is with her mother who's dying of dementia and she has genes for dementia. Right. And so she's a high functioning optometrist. And yet when we look at her brain we already see it's not working as well as it should. Right.
And yet she's in her 50s. if you talk with her, she's articulate, she's exercise, we got her exercising again, she's lost 11 pounds. She's actually genetically, she's athletically gifted, although she doesn't like to exercise. She's athletically gifted for VO2, for anaerobic threshold, for muscle mass, for strength. And so these are gifts that she has. And so she's excited to start leveraging those. But we get great insight into what are the genes that would drive
Dr. Jeffrey Gladden (31:28.74)Alzheimer's for her like her mother has and because we understand them we can manipulate the system to steer her away. She never has to hit that iceberg and we can get her brain better than it ever was and we understand what to do. Right. So there's tremendous power in this moving past the concept of I'm I look okay in the mirror. I'm feeling all right. I'm doing okay. I'm going to get outside get some exercise keep going and that'll be enough. Right. Because it just isn't it just isn't enough. It's a linear response to an exponential strategy. So

(01:46):
Josh Dech - CHN (31:58.938)I want to circle back to the question about what it is we can do to test what this looks like. But first, when you really crack it down, I mean, as a longevity specialist working with people in this space, why do they come into you? I mean, is it a fear of dying? Is it a fear of not being around for their kids? What are the drivers that people have for dealing with longevity or anti-aging?
Dr. Jeffrey Gladden (31:59.119)or problems.
Dr. Jeffrey Gladden (32:21.796)I would say that the fear of dying is probably not near the top. I think the top things are people don't want to be disabled. They don't want to lose their capabilities as a function, their ability to function. That's right. Either mentally, physically, sexually, athletically, you know, in business, whatever it might be, right? They don't want to lose their ability to function.
Josh Dech - CHN (32:36.353)loss of function.
Dr. Jeffrey Gladden (32:50.268)Even in my own case, right, if I get hit by a bus today on my way to the airport, I'm flying to Denver here in an hour or so, I'm okay with that. It's like, it's been a beautiful life. I'm off to the next adventure. So it's not death. I'm not doing this because of a fear of death. What I do fear, if you will, is decline, the kind of decline I saw my father go through, my mother go through, my sister go through, these kinds of things, right? So if there's a fear there, it's that I don't want to end up...
struggling the way that they struggled. And I think we live in a day and age where we don't have to if we're, if we take a conscientious approach. So that's, that's, think what drives most people, right?
Josh Dech - CHN (33:29.023)Yeah, so we don't have to decline the way we do. But what you're saying then is people just afraid of losing their quality of life, the way that they've always grown, the ways that they've always known, the things that they do. If they're a business owner, they're afraid of not being able to operate their business. If they're a mom or a dad, they're afraid of not being able to see their grandkids. Like it's really about the life they live and preserving that as long as possible.
Dr. Jeffrey Gladden (33:51.354)I think that's right. think the other thing that's interesting to me is that you have people that have been working and they may own their own business or they may have inherited a business or they may work for other people or with other people. Many people are focused on retirement. Like I'm working, I'm working, I'm working. I can't wait to get to retirement, right? I think when you think about longevity,
What you really want is you want to basically define an activity for yourself that you feel like you never really need a vacation from and you never need to retire from something that you love so much that gives you so much joy and so much pleasure and that you have the opportunity to bring all of your grist forward and be fully expressed within that context where you don't want to retire from it. Right. Because that's life giving. Right. We know that retirement itself is synonymous with people aging and dying.
People retire, they go downhill. So retirement's not the answer. And working hard is not the answer either. It's really about finding joy in life and being able to continue to iterate off of that. I think that's a better way to go.
Josh Dech - CHN (34:57.705)really circles back to the very first things that you talked about when we got in here is that we're living our lives and sacrificing it to do something else, sacrificing our health. We're not investing in ourselves. We're identifying with these old ages. Well, I just can't wait till I retire. Well, then once you do, you slow down and you die anyway. So the irony is on you. I gotcha. So what testing then? I mean, we talk about testing. Is it blood? Is it DNA? Is it what, what, are we testing? If I come to your longevity clinic, I'm like, Jeff, give me the workout.
That's right.
Dr. Jeffrey Gladden (35:15.29)That's right. That's right. Yeah.
Dr. Jeffrey Gladden (35:26.886)Yo.
Josh Dech - CHN (35:27.679)I want to live forever.
Dr. Jeffrey Gladden (35:29.254)Sure. Well, what we would do is we would basically probably chat with you for about an hour and a half, understanding everything we could that you understood about yourself, your parents, your grandparents, all these kinds of things, right? Understand all that. Then we build out a program that would look at cardiovascular health, which would involve looking at your cardiovascular system through about six different lenses, right? So putting you on a bike, having you do a VO2 max anaerobic threshold test, looking at lung function.
doing labs to look at cholesterol numbers, but even more importantly, inflammatory markers that drive cardiac events, your ability to do something called reverse cholesterol transport where you can actually get cholesterol out of plaque or sell membranes back to the liver. We would look at healthy fats in your blood that most people don't look at. We do a prodrome plasmalogen scan looking at plasmalogen fats which are incredibly healthy for us. When they're optimized, they decrease our risk of dementia, heart disease, cancer, and we live longer, right?
Super important and yet nobody tests for them. So super important to test for these kinds of things, right? And then we would look at your carotid arteries. We would look at your hormone levels. We would do biometric testing to look at your thyroid function. We would do cognitive assessments. We do EEGs to look at your brain, maybe a functional MRI, if that seemed to be indicated. We would do genetic tests to understand your risk for dementia, heart disease, insulin resistance, diabetes.
We screen everybody for cancer. We look at, we can do full genome sequencing if there are oddball things out there, risk for breast cancer, risk for prostate cancer, et cetera. We can look at athletic genetics to get an idea of how you're built to exercise. We would look at body composition. Exactly, exactly.
Josh Dech - CHN (37:12.511)So you can exercise optimally for your body's genes and what it wants to do. Is that accurate? mean, Eddie Hall, world's strongest man, big boy, first guy lift over a thousand pounds on his deadlift. He tested his genes and they said he's a long distance runner.

(02:07):
Dr. Jeffrey Gladden (37:27.674)Yeah. So the point is there's another famous guy that set a triple jump record who was genetically never going to be able to do that. We don't feel like your genes are your destiny. That's not what we're saying. What we're saying is we want to play to your strengths and steer you away from the liabilities, right? We all have potholes in our genes, right? I have mine. I shared some of those here on the podcast. I'm sure you have yours. I'm sure everyone listening has those potholes.
Josh Dech - CHN (37:46.967)Mm.
Dr. Jeffrey Gladden (37:55.866)What we're trying to do is to help people avoid the potholes and then leverage themselves from a joyous place into the things they love to do. If you want to be a strong man and you're built like a runner, go for it, right? There's no downside to that. We're not trying to pigeonhole anybody. We're just trying to enable people to avoid the potholes, right? So that's the main thing. Yeah.
Josh Dech - CHN (38:13.441)Gotcha. That makes a lot of sense. You are leveraging your strengths to live the best life you can live provided it meets you in whatever it is that you want to do. You know, I would love to run. Hey, turns out you're actually built to run. Go enjoy yourself. It's going to be good for you. And okay. Purpose meaning. Wow. When somebody comes in to see you.
Dr. Jeffrey Gladden (38:23.612)100%.
Dr. Jeffrey Gladden (38:28.028)Exactly. That's right.
Dr. Jeffrey Gladden (38:34.352)And that's only part of the testing, by the way. just so you know, I mean, there's a whole lot more, right? yeah, that's right. That's right.
Josh Dech - CHN (38:37.641)Right. I imagine it's just a smorgasbord of things we can go through. Yeah. Now if somebody comes in to see you, are there any major red flags where you'd say, hey, you should not be doing XYZ testing. You should not be eating or taking this thing that's going to harm you.
Dr. Jeffrey Gladden (38:55.142)Well, I think there are some obvious ones. We know processed food, know sugar, we know, you know, lack of exercise, poor sleep, high stress. You know, one of the things that we are able to measure here is how much stress somebody's carrying in their system, right? It's looking at the balance between their parasympathetic and sympathetic nervous systems, right? The autonomic or automatic nervous system.
Josh Dech - CHN (38:59.052)No sure.
Dr. Jeffrey Gladden (39:20.336)Parasympathetic is really rest, recovery, repair. It's kind of the Zen state, if you will. Sympathetic is a bear's coming through the door with stress. We're anxious, you know, and that can carry on. So that balance has a big impact on health, right? We know that people in high stress jobs age so much more quickly, right? We know blood pressures go up, heart diseases more common, heart attacks, strokes, diabetes, all of it, weight gain, everything. Stress drives so much, which is now we're back to the 300 year old mind.
How do we actually cultivate that 300 year old mind? And there's a lot to that, right? Really beautiful stuff there in terms of understanding that we've all lived in response to trauma. We've all had trauma in our lives. I'm not a meta person that has it. And we all live in reaction to that trauma, right? And then that puts us on tilt. So now we're going through life on tilt like a poker player that's lost three hands in a row and now they're on tilt, right? And everybody sees it in the room, but they don't see it because
Josh Dech - CHN (40:04.023)Yes.
Dr. Jeffrey Gladden (40:16.334)It's normal. They've normalized it, right? And so being able to go back and actually understand the traumas and dissect them and actually understand who did what to whom and what responsibility I had and what responsibility they have and forgive everybody involved, myself and everyone else. That's how you start to heal this. And then you can actually transcend it to where...
Dr. Jeffrey Gladden (40:36.452)And maybe you've gotten to this point in your own story where you become grateful for everything that ever happened because it's brought you to this conversation today. It's allowed you to have more empathy, more insight, more wisdom to share with more people and touch more people's lives than you ever would have had before. Right. And so that's when you start to transcend the trauma. And then this enables you to actually become your unencumbered self where you're no longer encumbered by the things that you're living in reaction to, which then allows you to actually bring all of your gifts forward.
right? The full expression of who you are, Josh Desch, right? And the biggest impact you will make. So it's really a beautiful thing to go in and help people actually go in and solve these things and reclaim who they really are and what they're capable of. Now you're really starting to energize people's biology and their psychology and their spirituality and really live the life of their dreams. And that's really what this is about.
Josh Dech - CHN (41:27.725)I think that's an amazing, powerful gift you can give yourself is transcending your stress and trauma. I'll tell you, Jeff, when I was probably 13, maybe 12 years old, I was out at a friend's birthday party and we're walking at nighttime because we were cool, right? It's late at night. It's dark when you go for a walk and bunch of guys, right? Of course. Anyway, so a bunch of guys.
Dr. Jeffrey Gladden (41:44.742)Sure, I used to do that. Yeah. Couldn't drive. You couldn't drive, but you wanted to go someplace, right? So you're out walking.
Josh Dech - CHN (41:51.79)You wanna go somewhere? one guy gets a bicycle and four jump on top of a clown car. And so there's a bunch of us walk in, probably four guys, four girls, if I had to picture it. Anyway.
Long time ago, we're out for a walk here at nighttime and this car drives by and somebody's yelling something at somebody for whatever reason and we're like, woo, yay, you you go. They slam on the brakes and get out of the car, start throwing stuff, they're throwing beer bottles at us. One just misses my face and they come over and start putting, and these guys are probably 17, 18, 19, right? So we're a bunch of kids and they're pushing us around. I got punched in the head and I remember there was one guy, one of my friends was on the ground. They're being kicked up against a fence.

(02:28):
Dr. Jeffrey Gladden (42:17.457)Wow.
Dr. Jeffrey Gladden (42:21.254)Right. Right.
Josh Dech - CHN (42:31.413)over and I shoved this kid out he pushes me back long and short I ended up getting hit in the head I got the scar over my eyebrow now from his watch actually sliced me open I fell back hit my head and I blacked out and I remember waking up on the ground and my friends are around me like guess the guys had taken off and allegedly while I was out I was getting my head kicked in while I was you know laying on this curb and that moment forward
Dr. Jeffrey Gladden (42:31.461)Well.
Josh Dech - CHN (42:56.519)I said I will never let anybody get hurt when they're near me again. I will never get hurt again. I built up these walls, these big, thick, manly, strong walls. I was in martial arts training. I became a high level championship wrestler. was, you know, recently here pursuing my black belt in martial arts. Like never let that go. But the trauma of it through all the work that I've been able to do, I was able to say, hey, this actually got me active. It caught me into wrestling, a sport that was amazing and quite literally saved my life.
Dr. Jeffrey Gladden (43:02.556)Mm-hmm.
Dr. Jeffrey Gladden (43:15.676)Mm-hmm.
Dr. Jeffrey Gladden (43:25.414)Right.
Josh Dech - CHN (43:26.383)I mean I was definitely down the wrong path 13 14 because now here I am bitter and angry right mom and dad are divorced We're dealing with poverty. I'm dealing with all these issues and whatever and so I was in the wrong crowd I was dealing drugs by 13 14 years old and it was my wrestling and my coach is like dude You suck your life sucks your grade sucks your mom talked to me And if you don't drop your friends and fix your grades you're done. I was like I love wrestling so much Because I took this thing
where I wanted to protect myself and it taught me discipline, it taught me rigidity, it taught me all kinds of life skills. And yes, there were some threads of traumas I had to let go even into my 20s and probably into my 30s and onward, but we were able to take aspects. And that really did eat me for a long time.
Dr. Jeffrey Gladden (43:53.862)There you go. Yep. Right.
There you go.
Josh Dech - CHN (44:12.553)So my next question is for you. Someone goes through an event, physical trauma, personal trauma, sexual trauma, psychological trauma, these death in the family, whatever it is, what is this doing physiologically to our body when we do not let it go? When we ruminate, when we let it just eat us up?
Dr. Jeffrey Gladden (44:30.96)Well, have different responses to stress, Reportedly, there's five different responses to stress. Some people basically project it onto other people. Some people absorb it. Some people, it makes them stronger. Some people, they tend to shut down and hold it within. So there's different responses to stress. So there's not a one size fits all there. But in general, when we come under stress and it's unresolved stress, it actually takes a toll on our health because that sympathetic nervous system, that fight or flight,
part of the nervous system increases. Now blood pressures are going up, arteries are constricted, heart rates are higher. The brain is exposed to higher levels of cortisol. Our memories decline, our brains don't work as well. We're more inclined to insulin resistance, know, all these different things that occur. So unresolved stress is really one of the biggest drivers of many, many diseases. Now when you couple that with, you know, the wrong diet and bad food and too much blue light and everything else that we know about our modern society,
You know, it just accelerates all that, right? So, but I think, I think being able to step back from your own life and say, again, what do I need to do to develop a 300 year old mind? Right? It starts with that. How do I develop a 300 year old mind? Because when I do that, then I'm going to be connected to love and joy and peace. And the world is going to be a different place. It's going to be a special place to live in. I'm going to love being here. So how do I get to that? Right? And those questions will start to.
drive you there. And in your case, you know, the trauma drove you to wrestling. And then when you got there, it's like, I could lose this if I don't start to change my behavior and think about things differently. Right. And that was your coach coaching you along. But we start to as we go through life, then we become our own coaches. Right. It's like, and those coach, what coaches us are the questions we're asking. And then we can reach out for additional help. We can talk to other people, wiser people, more experienced people, whomever it is.
you know, people reach out to you because you have more experience and more wisdom in this area, right? That you coach people on. So you can always reach out, but the idea is that you want to be knowing what you're targeting. And if you're targeting wisdom, if you're targeting equanimity, if you're targeting peace, then you can get there. If you're just haphazardly going along, then you you just keep kind of tripping over the same part of the curve.
Josh Dech - CHN (46:49.517)What are you doing to develop a 300 year old mind? I mean, you're closer there at age 71 than maybe our listeners are in their 20s and 30s. Most of our male listeners actually are in their like 25 to 35. Most of the female listeners are 35 to 55. What are you doing that you've learned after 71 years to help cultivate a 300 year old mind that we can take being half your age or less?
Dr. Jeffrey Gladden (47:11.152)Yeah, so I think meditation is one of the biggest ones. I probably learned how to meditate about 20 years ago. And I've always been a very spiritual person. Quite honestly, I remember being three years old, actually walking down the street, debating the existence of God and deciding that when I grew up, I wanted to be wise. So very clear memory of that coming back from a pond where I was playing with polly wags and frogs.
So I've always had a bent towards this, then having, learning to meditate, right, where you can actually disconnect from what's around you and connect to a greater source, energy, if you will. I've had some really profound meditation experiences where you connect directly to loving consciousness. Let's call it that, right? People have different terms for it, God, source, whatever you want to call it. But when you connect directly to that and you can do it through meditation,

(02:49):
then my gosh, all of a sudden you realize this is a different universe than the one you thought you were in, right? And all of a sudden, you know, you realize that there's unbelievable, almost unfathomable amount of love pouring into your life all the time, and we close ourselves off to it. So when you realize that you're connected to that, then it's like, well what does love love to do? Well, love loves to create.
And what's the feedback loop for creating? Well, it's joy. So for me, the meaning of life is love creating joy. And my purpose in life is from a loving place to create joy. And these are things that I've discovered through meditation. So when you're, when you feel connected to source energy, it allows you to feel safe because most anxiety, most stress, most worry, fear, angst, even greed, I think come from not feeling safe.
When people don't feel safe, they feel stressed. And when we know that nothing external to us can ever make us feel safe, there's no amount of money, there's no family, there's no education, there's no number of followers, none of that can ever make us feel safe. All that can be taken away. History has shown us that all of that can be taken away in a nanosecond, right? Then how do you ultimately give yourself safety? How do you actually love yourself unconditionally and how do you give yourself safety? Those become psycho-spiritual questions, right?
Dr. Jeffrey Gladden (49:36.454)But once you're able to connect and you feel that, that, that pure love flowing through you now, now you are safe, right? This world or the next, we are safe. It's like, okay, cool. Now I'm good. So then it's like, well now I'm free to be me. I don't have to worry about this, right? It's going to work out. It's going to be all right. And being able to shed that, that worry and that fear.
my gosh, your biology just lights up like a plant that just had the curtain raised and got sunshine for the first time and some water, right? I mean, it just blossoms. So this is an amazing, this is an amazing piece of it, I think.
Josh Dech - CHN (50:12.909)I think that's incredible. Maybe it's a bit of a sidebar for this conversation, but when you sit and do meditation, do you believe it is source energy, like prayer is to God? Or do you feel like maybe, really scientifically, it's just your mind unpacking and it's finally letting go of all these subconscious knots that are working in the back end that are keeping you all bundled up?
Dr. Jeffrey Gladden (50:36.776)I think it's, well, I think first off, I think prayer, I grew up in a very sort of Protestant Christian background, right? I went to Christian schools, Christian college, I went to seminary for a while, all that sort of thing. What I find is that prayer many times can be very petitionary, right? People are asking for things. I don't think that's, yeah, and that's not really what I'm talking about. What I'm talking about is really kind of emptying out.
Josh Dech - CHN (50:54.103)Hmm. Very religious, sort of.
Dr. Jeffrey Gladden (51:05.744)thoughts and just getting in touch energetically getting in touch with consciousness that's there and it takes a while to get there right it's like learning to ride a bike if you say I'm gonna I want to learn to ride that bike that sounds cool I'm gonna learn to ride that bike okay great you'll get on that bike and you'll take a few pedals and you'll fall off right you'll pedal and you fall off and you'll fall off and then you'll get a little glide and it'll be like I felt that it's like yeah no all of a sudden everything just opened up right for a second a nanosecond it's like that's it
And you keep going back to that. And then the next thing you know, you can step into that space. And there are things that you can do to augment that, right? There are different meditation devices that can help train your brain into these alpha wave states or deep theta states, right? Where you're in deep meditation. And there are devices like Brain Tap and others out there that can help coach your brain into that. So you can start to experience that. But once you start to experience it,
You can build on it. It's like anything else, like shooting free throws, right? You know, first you're missing the rim and the backboard and everything else, then you're starting to hit a few things, then another shot goes in, and the next thing you know, oh, I'm shooting more consistently. It's like that, right? So you just have to practice, yeah.
Josh Dech - CHN (52:15.991)Hmm. That's pretty wild. This conversation can go a thousand and one different ways. Unfortunately, I hate to say it. I know we are running out of time together here. You know, Jeff, our conversation is longevity, anti-aging, so to speak, but I guess definitionally longevity. And I didn't expect it to go where it did, but I'm glad it did. There's so much more depth.
Dr. Jeffrey Gladden (52:26.064)Yeah.
Josh Dech - CHN (52:38.091)to what it is that you do than just lab testing and managing genetics, DNA and senescent cells. And I think this conversation really showed the depth that you go and your understanding and this whole process of what we have is life. And so if somebody wants to reach out to you, wants to learn more about you, glad and longevity in the clinic you're running, where can they find all this information?
Dr. Jeffrey Gladden (52:57.244)Yeah, that's a good question. People can find us at glad and longevity.com. That's the website. And then I have a podcast as well that you were on a couple of days ago, the glad and longevity podcast. People might want to listen to that show as well. And then I have a book out a hundred is the new 30 how playing the symphony of longevity will enable us to live young for a lifetime. And there's a lot in there. I also recorded as an audible book. So those are ways. And we have a glad and longevity shop. Pardon me.
Josh Dech - CHN (53:06.445)That's right.
Josh Dech - CHN (53:23.543)Did you narrate that yourself? Do you narrate that audio book yourself? I love that. it's so intensive. Wow.
Dr. Jeffrey Gladden (53:27.548)I did. It took me a week. Yeah, it's a 450 page book. read all of it myself. And I wrote every word in it. The interesting thing is that when you read a book out loud, and I read it out loud and recorded it before I published the paperback copy or the hard copy.
I made so many edits, it became such a much better book because when you're reading out loud, it's like, oh, I could say that better. I could do this a little better, right? So I don't know if you've done that, but anyway, yeah, it's a it's it's a well written book. People really seem to enjoy it. So I try to make the complex approachable. But those are ways that you can get in touch with us. And we have a shop also with supplements that we like that we've put together in bundles that we think are particularly useful for this, that and the other thing. But what I would really do if I was serious about this is you can go to all those places, but

(03:10):
Josh Dech - CHN (53:55.937)Yeah, yeah.
Dr. Jeffrey Gladden (54:19.774)Start to think about what questions you're asking, right? What questions are you asking? What are the ones that resonate with you? And then pursue those questions. That's your path forward. That's what I would say, yeah.
Josh Dech - CHN (54:30.433)That's exciting stuff. And gladden longevity. Is this a clinic? Is it online? Do they submit tests digitally? They have to come to visit you.
Dr. Jeffrey Gladden (54:38.416)Yeah, so it's a clinic. here in Dallas, Texas. We're building an app that we hope to have out later this year where we'll be able to do at-home digital testing and health coaching.
We can't practice medicine, To practice medicine, if people want prescriptions and hormones and all that sort of thing, then we need to have a physician-patient relationship, which in the state of Texas, we need to see you in the office to establish that. And when people fly in, they fly in from all over North America, Europe, Mexico to work with us. And they spend two, three, four days with us getting lots of things done. And then we have lots of regenerative technologies that we have access to that we have under our
or be approved trials so we can do a lot of things here. Many other people have to go offshore to get done. We can rebuild all kinds of things. I it's amazing what we do here, quite honestly. We focus really on the underpinnings of longevity, but the clinic itself, if you go and check it out, you'll see, and we don't advertise a lot on the website simply because we don't want to put a bullseye on our back kind of thing, but we do a lot of very cool stuff here. So, yeah.
Josh Dech - CHN (55:43.342)Sure. That's brilliant. I'm going to make sure everything there is in the show notes. I'll put your social media handles. We're going to drop in the website info, clinic information, all of that. For those of you local to Dallas who looking for some help. Dr. Jeffrey Gladden, this has been a delightful and frankly surprising conversation. Thank you so much for your time. I loved it. Looking forward to seeing you again soon.
Dr. Jeffrey Gladden (56:01.872)Well, those are the best kind. Those are the best kind. Yeah, I loved it. All right. Great to see you, Josh. All right. Likewise.

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205: How to Stay Young For the Rest of Your Life - with Dr. Jeffrey Gladden

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.css-14f5ked{margin:0;word-break:break-word;display:-webkit-box;-webkit-box-orient:vertical;box-orient:vertical;-webkit-line-clamp:2;overflow:hidden;}205: How to Stay Young For the Rest of Your Life - with Dr. Jeffrey Gladden