Episode Transcript
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Speaker 1 (00:05):
Welcome, friends, to
episode 313.
And today we're talking aboutthe science of how edibles work
in your body.
Welcome to Bite Me, the showabout edibles, where I help you
take control of your high life.
I'm your host and certifiedgonger, margaret, and I love
helping cooks make safe andeffective edibles at home.
I'm so glad you're here.
(00:32):
Welcome back, friends, I'm soglad that you're here.
I want to say to the Bite Me,the Show About Edibles that I
always forget.
Of course there's a wholeintroduction that I pre-recorded
that I always add in.
You probably don't need to hearit another time, but I am
thankful that you're here and ifyou're just turning in for the
first time, this might be a goodepisode.
To start with, because we'regetting a little sciencey today
about how edibles workbiologically in your body,
because knowledge is power andthe more we know, the better we
(00:54):
can take control of our highlife.
Essentially, that's how I seeit anyway.
But welcome to the podcast thatexplores the intersection of
food culture and cannabis,helping cooks make great edibles
at home.
What are you making today?
What are you excited about?
Let me know Before we get intotoday's episode.
(01:20):
We did cover a question lastweek that I wanted to remind you
of.
I did get some responses.
What was something on yourchildhood wishlist that you're
still kind of mad that you nevergot?
And I mentioned Cabbage PatchKids because a lot of my friends
had those and they were superpopular at the time.
I also really wantedTransformers, I think.
(01:40):
As I mentioned in last week'sepisode, though I did have three
boys that lived two doors downthat had all the toys I could
ever hope for, but sometimes youjust want one of your own, am I
right?
But you know what I did playwith a lot were little plastic
figurines, and I do remembergetting a lot.
I had tons of them and I lovedthem.
(02:00):
We'd move around the house,plants and make jungles.
I loved them.
We'd move around the house,plants and make jungles, and I
remember that we would visit theRoyal Ontario Museum in Toronto
as kids because they have thecoolest dinosaur exhibit and we
would often get to pick out aplastic dinosaur figurine from
the gift shop on the way out.
I had those things forever foryears and years and years
(02:23):
Finally had to get rid of them.
I grew out of them, I guess.
Kind of wish.
I still had one or two kickingaround, but I would love to
share a couple of the responsesthat I got over in the Bite Me
Cannabis Club, because I postedit there as well, and
fortunately there were a coupleof folks that were like you know
what I didn't really want foranything when I was growing up.
That was sort of a sentimentthat I got from Wayne, based out
of New York, and Elbow, basedout of Australia.
(02:46):
They spent a lot of timeplaying outside, as I did as
well.
I had a wonderful climbing treein the yard and was playing.
The floor is lava long beforeit became a thing.
There was also Woody who saidthat as a kid he really wanted
to get a minib bike and go-kart.
Never did get one.
(03:07):
And the funny thing is, nowthat you get older you think you
know I have the money.
Now I could probably go get oneof those things.
I could probably, reminiscently, go get some kind of vintage
Cabbage Patch doll, but alas,priorities change.
So I'm going to ask you anotherquestion today and I'll try and
change it in the fan mail textmessaging feature in the app
that you're listening from.
You can make use of that.
(03:27):
I'll post it in the Bite MeCannabis Club as well.
What popular TV series do youthink is extremely overrated?
And, as you may have guessed,as I mentioned last week when I
first did this question, theseare not necessarily cannabis
related.
I'll go first, friends.
Yep, I said it, the showFriends.
I admittedly didn't really everget that into it.
(03:48):
The laugh track I can't do TVshows with a laugh track.
I never found it that funny.
It was kind of unrealistic.
It was just I don't know.
I know so many people that lovethe show Friends.
I'm like I don't get it.
So let me know what TV show doyou think is extremely overrated
?
And I'll read out your answerson the show.
And because we're also here toexpand our cannabis knowledge,
(04:17):
I'm also going to Read aquestion, a culture question,
from the Stoner Trivia Race 420Trivia Pack.
Shirak is a word used todescribe high quality hashish.
In what country?
Afghanistan, new Zealand orEgypt?
I've not heard of this termbefore.
Shirak S-H-I-R-A-K.
(04:38):
And your options areAfghanistan, new Zealand and
Egypt.
If you guessed Afghanistan, youare correct and you know a lot
about hash.
We are talking about thescience of edibles and how they
work in your body.
If you know somebody who mightenjoy this episode, I know I'm
(04:58):
asking you this before you'veactually heard the episode
itself, but you know me, I'vedone 300 episodes by now.
It's going to be full ofinformation that you can use to
take control of your high life.
So please share this episodewith someone that you think
would enjoy it or learnsomething from it or help to
reduce stigma as well, and let'sget into it.
(05:18):
So I don't know about you, butthe first time I had an edible,
I probably expected it to hitlike smoking a joint, like fast,
familiar, easy, maybe with atouch of paranoia.
This was happening to me quiteoften, which is why I was
exploring edibles in the firstplace.
But I took the edible, I knewnothing, I made this butter on
the stove, didn't really knowwhat I was doing, and I waited
(05:42):
and I waited and I waited, andthen suddenly you get this
twinge.
You're like oh, maybe is thatit.
And the next thing, you know,I'm just enveloped in this warm
hug, having a heart to heart,I'd say, with my dog, but I
can't remember if I still had mydog at that time, I might've,
actually I might've.
Regardless.
It was a lovely experience.
It is by some miracle that Ididn't overdose myself, based on
(06:06):
what I knew then versus what Iknow now.
But I really liked that slowonset I discovered and the
feeling of the high as well.
But why does this happen?
Today we're going to explorethe science of how edibles
actually work in your body, fromyour stomach to your liver, to
your brain and don't worry, thisisn't going to feel like a
boring biology lecture From yourstomach to your liver, to your
brain, and don't worry, thisisn't going to feel like a
(06:26):
boring biology lecture.
Think of it more like a guidededible trip through your
digestive system.
Think what was that magicschool bus where Miss I can't
remember her name offhand MissFrazzle took the kids through
people's bodies.
Dealing with myself a littlebit, I'd use a more current
example, but I'm really not upto date on kids cartoon
(06:47):
entertainment.
But buckle up, friends.
Regardless it's going to getnerdy and delicious.
So the journey begins, and itbegins with digestion.
When you smoke or vape, thctakes a shortcut it goes
straight from your lungs intoyour bloodstream and then right
to your brain, and that's whyyou feel it almost instantly.
You know you take that puff andthen 60 seconds later the
(07:11):
process has happened and you'restarting.
You're feeling that high, butedibles, they're taking a scenic
route and we're going to walkthrough it.
So you eat your infused cookie,gummy brownie, infused pesto,
because you're a listener ofthis show and you've expanded
your horizons substantially.
So the first stop is yourstomach.
If your stomach's full, thc isgoing to hang out there longer
(07:32):
waiting for its turn, and ifit's empty, it's going to move
along faster, but the ride mightbe bumpier.
Then it heads into your smallintestine and that's where the
real action begins.
So here's the key THC is fatsoluble.
That means it loves clinging tofat, and this is why infusing
cannabis into fat butter oilcream any high fat infusion
(07:55):
works so well.
The fat molecules act likelittle taxis that carry THC
across the gut lining and intoyour bloodstream.
So while you're wondering whynothing's happening, your body's
literally breaking down theedible packaging THC into
fat-friendly little bundles andshipping it off for processing.
Think of it like a slowdelivery.
It's on the way, it's in thewarehouse, it's on the truck,
(08:17):
but it hasn't hit your doorstepyet.
Did you know?
Your stomach acid doesn'tactually break down the THC,
it's the small intestine thatabsorbs it into your bloodstream
, and without fat, much less THCgets through.
So yes, that little extrabutter in your brownie is
science approved.
Next we go to the liver, andthat's where the magic happens.
(08:38):
Once THC leaves the smallintestine, it doesn't just
cruise directly to your brain,it takes a detour through your
liver, and this is where thereal magic happens.
The liver is like the body'schemistry lab.
Its job is to filter,metabolize and break down
compounds.
And when it meets THC, itdoesn't just process it, it
(08:59):
transforms it.
And this is what makes ediblesdifferent from smoking or vaping
.
Smoking gives you mostlydelta-9-THC.
Edibles get converted by theliver into 11-hydroxy-THC.
So why does that matter?
11-hydroxy-thc is more potent.
Some studies suggest it's twoto three times stronger.
(09:20):
It also crosses the blood-brainbarrier more easily, meaning it
can flood into your brain moreeffectively.
And this is why edibles canfeel so much more intense than
smoking, even if the THCmilligram looks the same on
paper.
And because your body has todigest, absorb and metabolize
before you feel anything.
Edibles don't just hit stronger,but they hang around for longer
(09:43):
, sometimes six to eight hoursor more, as many of us know, if
you've had a bad time on them,because that six to eight hours
can feel like an eternity.
So the next time an ediblesneaks up on you like a surprise
boss battle in a video game.
Blame your liver it's doing itsjob a little too well.
Did you know that there areover a hundred different
(10:04):
cannabinoids in cannabis, butonly a few, like THC and CBD,
are well studied?
Some evidence suggests thatother cannabinoids, like CBG or
THCV, might change how ediblesfeel, though we're just
scratching the surface.
There is so much fascinatingscience around these new
emerging I shouldn't say they'renew, but emerging cannabinoids
(10:27):
that you're starting to see alittle more out on the market
now too.
So next is the timing, toleranceand why edibles are
unpredictable.
Let's first look at onset time.
I'm not going to get too muchinto this because I did a whole
episode on the science of onsettime which is actually really
interesting and worth a listen.
I'll link to it in the shownotes so you can find it easily.
But the onset time can beanywhere from 30 to 120 minutes
(10:48):
depending on metabolism, whatyou've eaten, body weight, gut
bacteria.
It can also depend on emptystomach versus full stomach.
An empty stomach it's going tohit you faster.
Often it will feel more intense.
If your stomach is full, theonset will be slower and a
smoother ride.
(11:09):
There's also considerations oftolerance.
Regular cannabis users maymetabolize THC differently and
bioavailability Only a fractionof the THC gets absorbed
Efficiency matters.
This is why edibles can feellike a sneaky ninja you know
nothing's happening, so you eatanother cookie and then an hour
later, bam, you're high enoughto smell colors.
(11:29):
That's where you get all thesethese edibles ain't shit memes,
which a lot of them make melaugh.
Did you know that men and womenmay metabolize edibles
differently?
Some studies suggest thatestrogen levels can actually
affect the THC sensitivity,which might explain why your
partner and you have totallydifferent experiences with the
same brownie.
(11:50):
And finally, we're going totalk about why the high feels
different.
So when you're smoking orvaping, you're going to get a
quicker, shorter high, sayaround two to three hours.
Edibles, it's that.
Slower onset, but stronger,longer high four to eight hours,
sometimes longer.
The body high is morepronounced because of digestion
(12:12):
and liver conversion.
The brain experiences a waveeffect since 11-hydroxy-THC is
stronger.
So that's why edibles are greatfor long-lasting relief, pain,
sleep or just a Saturday moviemarathon.
But it also explains why somepeople get overwhelmed if they
don't respect the timing.
Also, as I talked about atlength in last week's episode,
(12:34):
dosing matters.
You want to get your dosing in,because that is a very long
time to feel uncomfortable ifyou don't get the dosing right.
Did you know the reason ediblessometimes feel psychedelic at
higher doses is because11-hydroxy-THC is not only
stronger than delta-9, it mayalso interact differently with
serotonin receptors in yourbrain and that's why you might
(12:57):
feel almost dreamlike after abig dose.
So, to recap, edibles take thelonger road digestion first,
then metabolized by the liver,they transform THC into a
stronger version of an11-hydroxy-THC and that's why
they hit harder, last longer andfeel different than smoking.
So next time you pop an edible,you'll know the science behind
(13:20):
why your edibles convinced youthat you could in fact direct a
Broadway musical.
Knowledge is power.
It can actually help you takecontrol of your high life and
it's just wise to know thescientific mechanisms of how
these things work.
I am working to get somescientists on the show, so maybe
we can delve a little deeperinto this science, because you
(13:40):
know, my knowledge is somewhatrudimentary.
You know what I know now.
But speaking of guests, I amexcited to announce that we're
going to have a wonderful guestnext week Wesley Holloway of
Benevolent Bakery.
I'm really excited aboutreleasing that episode to you.
I think you're really going toenjoy it.
He's a fascinating character,so stay tuned for that episode
to you.
I think you're really going toenjoy it.
(14:01):
He's a fascinating character,so stay tuned for that.
My friends, I am your host,margaret, and until next time,
stay curious and stay high.