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May 23, 2019 40 min

Dr. Ken Pienta from The Johns Hopkins Hospital explains all about metastatic prostate Written Transcript at:
https://www.cancerabcs.org/transcript-dr-ken-pienta-discusses-what-is-metastatic-prostate-cancercancer and how it spreads or metastasizes.  

He Includes in his discussion how prostate cancer is staged, how cancer migrates from the prostate gland to distant sites that can then develop into tumors.  In this discussion He clarifies the  difference between local invasion and metastatic disease.  

He also talks about the current reality of our scanning technology, including the  new Axumin and PSMA scans and how large, or how many cells, need to be present in a tumor in order for it to be visualized.  

Dr. Pienta describes the current treatment issues surrounding oligometastatic prostate cancer (just a few tumors in the pelvic area) as well as the role of the tumor micro-environment in supporting the metastatic process.  

He also shared two clinical trials, the TED1 and the TED2 Trials (Total Obliteration Disease Trials) which he is conducting for newly diagnosed men with five or less metastatic lesions.     

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