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September 9, 2025 8 mins

Darshan Kulkarni and Edye Edens launch an exciting new episode, focusing on the unique challenges academic medical centers (AMCs) face in securing funding in an ever-changing political and regulatory environment. Unlike independent or commercial sites, AMCs operate at a different scale, often managing millions of dollars in government-funded research while navigating complex administrative structures, compliance layers, and internal politics. Edye, drawing from her 10 years inside a major AMC, shares firsthand insights into the heightened sensitivity surrounding controversial research topics, the impact of presidential and state-level funding shifts, and the pressures of maintaining compliance and operational efficiency under intense scrutiny.

The episode explores the top five factors that can determine funding success for AMCs:

  1. Research topics – Certain areas may be restricted or politically sensitive.

  2. DEI stances and organizational culture – Internal positions can influence perceptions and funding opportunities.

  3. Key opinion leaders – Their political positions and reputations can affect institutional funding.

  4. State government relationships – AMCs’ alignment with state priorities can be critical for state-funded research.

  5. Regulatory efficiency – Streamlining IRB, HRPP, and other compliance processes can create operational advantages.

Darshan and Edye emphasize that understanding these factors directly from AMC administrators is invaluable. By listening to those navigating funding, compliance, and research operations in real time, AMCs and sponsors alike can better position themselves to maximize resources, maintain compliance, and continue driving innovation and patient impact.

Future episodes will expand on additional considerations, featuring industry experts and administrators sharing their perspectives and practical strategies. The series aims to provide actionable insights for AMCs, sponsors, and CROs who want to understand the realities of high-volume, high-stakes academic research.


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