Dihydrotestosterone - history, chemistry, biosynthesis, molecular mechanisms, sexual development, male & female physiology, pathological conditions, pharmacology, controversies

Today's episode answers the following questions, among others:

• What is Dihydrotestosterone (DHT)?

• How is DHT different from testosterone?

• How is DHT produced in the body?

• What enzyme is primarily responsible for converting testosterone to DHT?

• Why is DHT considered more potent than testosterone?

• What are the main roles of DHT in male fetal development (e.g., formation of external genitalia)?

• What changes during male puberty are driven by DHT?

• How is DHT involved in conditions like male pattern baldness and benign prostatic hyperplasia (BPH)?

• What are the known roles or effects of DHT in females?

• How is DHT inactivated or removed from the body?

• What are 5-alpha-reductase inhibitors (like finasteride and dutasteride) and how do they work?

• What are common side effects associated with 5-alpha-reductase inhibitors?

• What is Post-Finasteride Syndrome (PFS)?

• Can DHT be synthesized through a "backdoor pathway" that doesn't directly involve testosterone?

• How does DHT exert its effects at a cellular level (e.g., interaction with the androgen receptor)?

 

About Deep Research Review:

In this ad-free educational podcast, Deep Research reports from Gemini, ChatGPT, Grok, and Perplexity are synthesized to find the objective truth about any topic. Join researcher and entrepreneur Landon Kelson as he pushes the boundaries of research and access to information. Topics include family, technology, pharmacology, astronomy, geography, philosophy, psychology, medicine, history, sports, music, religion, politics, and more. New episodes every morning.

 

Disclaimer: 

This show includes experimental AI-generated content and may contain offensive, false, or misleading claims. As with anything, always do your own research. Nothing in this show is meant as medical, financial, or legal advice.