PANS/PANDAS 101: What Every Parent Should Know About Sudden Psychiatric Shifts

Dr. Paula Kruppstadt explains PANS and PANDAS, how infections and inflammation trigger sudden psychiatric symptoms, and what families can do next.

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In this episode, Dr. Paula Kruppstadt unpacks the complex world of PANS and PANDAS—conditions that often begin with sudden, dramatic changes in a child’s behavior, emotions, or health. Dr. K shares both her expertise as a physician and her experience as a parent of children affected by these disorders. She explores what PANS and PANDAS are, how they differ, why these conditions are so frequently misdiagnosed, and the key symptoms parents should watch for.

This episode provides clarity on brain inflammation, the role of infections and environmental factors, and why early recognition is critical. While the conversation doesn’t shy away from the challenges, it also leaves listeners with encouragement and a foundation of understanding to build on in the episodes to come.

An abrupt overnight change in a child’s behavior can be frightening, but it may not be “just a phase.” In this first episode of the three-part PANS/PANDAS series, Dr. Paula Kruppstadt explains these often misunderstood conditions that can trigger sudden anxiety, OCD, food restriction, and mood swings. She clarifies the difference between PANS and PANDAS, why brain inflammation is at the root, and how these conditions are frequently misdiagnosed. Families will find validation, understanding, and hope as they begin to navigate this complex journey.

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Dr. Paula Kruppstadt, MD, IFMCP, is a board-certified pediatrician and Certified Practitioner of Functional Medicine through The Institute for Functional Medicine. As the founder of Hope for Healing, she has dedicated her career to helping children and adults uncover the root causes of complex health challenges. One of the few pediatricians worldwide to hold IFMCP certification, Dr. Kruppstadt is also an expert in PANS/PANDAS and was appointed by Texas Governor Greg Abbott to the state’s Pediatric Acute-onset Neuropsychiatric Syndrome Advisory Council, where she advises on research, diagnosis, treatment, and education for these conditions.

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