El pan es el mayor contribuyente a la ingesta de aditivos alimentarios comunes en los países que consumen dietas occidentales, con ramificaciones en la salud y las enfermedades a través de la microbiota intestinal. Los estudios preclínicos y clínicos a pequeña escala sugieren que el uso de cereales alternativos, la suplementación del pan para inducir propiedades funcionales y la fermentación de masa madre tienen un gran potencial para reducir los factores de riesgo asociados con enfermedades no transmisibles relacionadas con la dieta al modular la microbiota intestinal. Sin embargo, es posible que sea necesario aplicar ingredientes funcionales formulados en el pan de manera específica y específica para cada individuo para brindar los beneficios esperados y evitar consecuencias potencialmente perjudiciales. En general, existen importantes lagunas de conocimiento y oportunidades de investigación para desarrollar panes respetuosos con el intestino con beneficios para la salud científicamente validados.
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