Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
Speaker 1 (00:01):
Welcome to Harmony
Hub Health, where my mission is
to provide comprehensive,affordable, integrative care
that addresses the root cause ofhealth issues.
At the Hub, the focus is onindividual patient journeys.
I strive to optimize health,vitality and longevity,
fostering a community where eachperson can thrive in body, mind
and spirit.
(00:21):
In this episode, I want to talkabout a genetic mutation that
can really mess with your lifeand what to do about it.
(00:41):
It's the MTHFR.
It's the gene mutation with theworst branding ever.
If you stumbled upon this termand thought WTF is MTHFR, you
are not alone.
It stands for methylenetetrahydrofolate reductase,
which sounds like a bad sciencefiction monster, but in reality
(01:02):
it's an enzyme that plays amassive role in your health, and
if your MTHFR gene isn'tworking properly, your body is
essentially running like aglitchy iPhone that won't update
, it's slow, it's inefficientand pretty dramatic.
So the craziest thing happenedtoday True story, you can't even
(01:22):
make this up.
I was seeing virtual patientson a platform that I work with
and typically I open Sundaymornings up for ADHD so people
can get their medications thatare busy working during the week
, but anybody can book in myopen time slots and I had a very
nice gentleman.
I can't say too much because ofHIPAA, but he was actually a
(01:43):
medical professional and hescheduled an appointment for it
just said blood draw.
And I was like, well, I can'tdo that virtually, but talking
with him, he didn't have adoctor, that was a primary care.
Some issues had happened.
So he was looking for somebodythat can order blood work so
that this provider in BeverlyHills could give him
(02:07):
cyclosporine for skin issues.
And I was like, well, since youdon't have a primary care, I
would love to be your provider.
Why don't we change yourappointment from me ordering
blood work to why don't we gothrough your medical history and
find out what is going on?
And why do you have to go toBeverly Hills for your eczema,
(02:31):
especially someone that's amedical professional?
And he said I've been battlingthis since I was a child and
this is the only thing that kindof has worked.
I see this doctor virtually inBeverly Hills.
He gives me cyclosporine, Ijust need to give him my blood
work.
I was like, okay, and when hisdoctor no longer would give him
(02:52):
his blood work, he actually wentinto like a steroid withdrawal
syndrome.
That was horrible for him.
So I decided I'm going to takecare of this guy.
Who else is better than me,right?
So I was shocked.
He had never seen functionalmedicine before for his skin,
since he's been battling itsince he was a child and we're
getting into family history.
(03:13):
And he's itching and scratchingthe whole time during this
appointment, to the point that Itold him I'm going to order him
a pair of mitts.
And he just laughed it off andsaid my skin is so broken from
scratching.
And I said well, you know, havethey ever looked into histamine?
Have they ever looked into rootcause?
And he looked at me like no,but I have seen every
(03:35):
dermatologist I can and nobody'sbeen able to help me.
And I said well, you know,there are like some genetic
mutations, there are differentthings that can cause elevated
histamine or homocysteine.
I mean, I'm reaching, I toldhim.
But you know, there's such athing called MTHFR.
He looked through me at thiscomputer screen and said what?
(04:01):
And I was like no, it's a thinghe goes.
No, no, no.
My son has autism and MTHFRmutation.
And I said, well, where do youthink he got it from?
And he looked at me like itnever dawned on him.
They just told them thatthrough the genetic testing for
autism, that his son had thisMTHFR mutation, but they didn't
tell him what it was, where hecould have got it from and the
(04:25):
fact that it's genetic.
And you know, the apple neverfalls far from the tree.
So as I was talking to him, youwould have thought this man won
the lottery today.
Because I came up with a plan.
I ordered blood work for himand I hate to say this because I
(04:46):
had to explain to him howcyclosporine is actually very
dangerous, because cyclosporinecan increase your homocysteine
levels and he said that makessense.
That makes total sense.
He had high blood pressure.
This puts him at risk for heartdisease and I don't want to get
emotional about it, because theonly reason why I brought this
(05:08):
up was because I've had MTHFR inthe brain.
Because Harmony Hub Health, evenat Monarch Beauty and Spa, I
have done blood work on severalpeople within the last two
months and I think I'm up tofour people that I have been
like this is all MTHFR and I'venever seen this much at one time
(05:31):
.
But I was starting to thinkthat these things were coming to
me for a purpose, like I have apurpose and my purpose could be
helping people with their MTHFR.
If you go to the Harmony HubFacebook page, you can even go
back to a post I made when Ifirst started Harmony Hub Health
about my experience with MTHFRand I don't even want to talk
(05:56):
about it now because I'm notgoing to be able to focus and it
makes me very teary eyed totalk about folate and
methylation because of my ownpersonal experiences.
But I do feel like there's areason.
He came to me when he had noreason to come to me.
He's in a different state I'mhere, but I'm licensed in a
state.
He chose me to do his bloodwork and we had this
(06:18):
conversation and this wasbrought about.
There's a reason why peoplehave come to me at Monarch
Beauty and Spa where I'veidentified OMG, wtf, mthfr and
just Harmony Hub Health, sayingwow, okay, have you ever thought
of this?
And the answer is always no.
(06:38):
I knew before I saw this guytoday that I was going to record
this episode on MTHFR.
It just puts chills down myspine that this happened.
Like is it divine interventionor is my calling helping people
like this?
Because I am passionate aboutthis.
(07:01):
I actually got a message fromone of my Harmony Hub Health
patients that I saw.
I'm going to read this to youbecause it touched me so much
that I even showed my husband.
Here's what she sent me.
Thank you so much.
I really appreciate howinvested you are in helping
others and the time you take toeducate and explain that.
(07:23):
She sent this to me while I wasworking on my taxes for last
year, getting so overwhelmed andso grateful for what I have to
offer and the people that I'vehelped.
It's just amazing to me.
So okay, let's get back ontrack then.
I'm helped.
It's just amazing to me.
So okay, let's get back ontrack then.
I'm sorry I got off topicbecause I just can't believe
(07:44):
that this gentleman came and sawme today.
But what is MTHFR?
So the MTHFR gene?
It provides instructions formaking the MTHFR enzyme, which
is responsible for processingfolate that's your B9.
And it puts it into the activeform, methylfolate.
(08:04):
This process is calledmethylation and it's a big deal
because it impacts your liver'sability to get rid of junk, so
your detoxification.
It impacts your hormone balance, so you know period problems,
mood swings.
It can impact energy production, like chronic fatigue.
It impacts your skin, just likeit was for him and some other
(08:27):
patients that I'm treating.
You know, acne is not alwaysfrom dairy.
There's other things that cancause skin eruptions.
Mental health you know anxietyand depression can be linked to
MTHFR.
Cardiovascular health thinkblood clots and heart disease.
Anytime someone tells me theyhave a family member or somebody
(08:48):
has had blood clots that wereunprovoked, or maybe they even
were provoked, we need to lookat this and it really impacts
your neurotransmitter production, so dopamine, serotonin.
These are known as your happybrain chemicals.
If you have an MTHFR mutation,your methylation cycle is either
(09:08):
slowed or it's impaired, andthis means that your body
struggles to detox.
You can't really absorbnutrients, you can't regulate
your hormones.
It makes you feel exhausted,inflamed and a moody mess.
So since this little mutationimpacts so many systems in the
body, the symptoms can be allover the place.
(09:28):
But here are some of the big redflags that I see for signs and
symptoms of an MTHFR mutation.
The first one is chronicfatigue.
You wake up tired no matter howmuch you sleep.
The first one is chronicfatigue.
You wake up tired no matter howmuch you sleep.
Second would be brain fog.
You can walk into a room andforget why you went in there.
That's happened to me more thanI can even say, poor
(09:50):
detoxification.
If you can't handle alcohol, ifyou're sensitive to perfumes or
chemicals, that is a sign.
If you have mental healthstruggles like anxiety,
depression, ocd, even ADHD, thatwon't go away.
Or if you find that you havehigh homocysteine levels, this
means your blood is too thick.
(10:10):
It increases your heart diseaseand your risk of clots.
A sign can be heavy periods,pcos, fertility struggles you
could blame your methylationbecause it does cause hormone
imbalances.
Sleep issues you can feel wakeup like 3 am and feel wired or
(10:33):
you can't fall asleep.
The skin problems, like theacne, the eczema, psoriasis, are
just dull inflamed skin If youhave migraines, chronic
headachesczema psoriasis, orjust dull inflamed skin If you
have migraines, chronicheadaches that don't respond to
normal treatments, or recurrentmiscarriages.
You know MTHFR mutations havebeen linked to pregnancy
complications.
So basically, if you feel likeyou're falling apart for no
(10:56):
clear reason, mthfr could be amissing piece of the puzzle and
I see a lot of people with thesesigns and symptoms.
And you know, when I do mycomprehensive lab panel I'm not
looking for MTHFR, but I canspot inconsistencies and things
in the blood work that doespoint in that direction.
(11:18):
So but who should get testedfor MTHFR?
Probably more people than youwould think, especially if you
have any of the symptoms I justsaid, if you've had multiple
miscarriages or struggle withfertility.
If you don't know my story,ezra, my wonderful, beautiful
son was my fifth pregnancy.
(11:38):
I was not able to keep amiscarriage and one of my
pregnancies see, I'm going totalk about it anyway, and I
didn't want to was a late missum, where the amniotic fluid
went in and dissolved the brainand I had to deliver this that
(12:01):
way because of methylationissues.
Folate you know.
Folate is what forms neuraltubes in developing babies.
But if you've had multiplemiscarriages or struggle with
fertility, if you have familymembers with cardiovascular
disease, blood clots, strokes,if you have anxiety, depression
or other mental health struggles, if you feel worse when you
(12:23):
take synthetic B vitamins likefolic acid or eat processed
foods with that synthetic folicacid, or if you have chronic
inflammation, autoimmune issuesor like weird food sensitivities
, then you should get tested andtesting is very simple and you
can do that with Harmony HubHealth.
Mthfr is an enzyme critical forprocessing amino acids and
(12:49):
converting the vitamin folateinto its active form, which is
essential for DNA synthesis andrepair as well as for the
methylation process in your body, so variants in the MTHFR gene
can affect the enzyme's function.
There has been a lot ofcontroversy with conventional
medicine surrounding MTHFR.
(13:09):
The two most studied mutationsare the C677T and the A129AC.
That one, that variant, theC67T, can lead to reduced enzyme
activity, which can result inelevated homocysteine levels.
It's a risk factor for varioushealth issues, including
(13:31):
cardiovascular disease,neurological disorders and
complications in pregnancy.
Some proponents of MTHFR arguethat these mutations are linked
to numerous health conditions,including depression, anxiety
and chronic illnesses.
But some of those critics pointout that while homocysteine
(13:52):
might be elevated, it's just arisk factor and it's not always
indicative of causation.
And many people with MTHFRmutations may not experience any
health issues.
That's true, but what aboutthose that are?
Why would you discount all ofthose that have it and are
having issues because somepeople have it and don't have
(14:13):
issues?
That is insane to me.
So there is a divide in themedical community about the
significance of the mutations.
Some practitioners emphasize theimportance in health management
, while many conventionalmedical professionals just view
it as a very minor factor thatdoes not warrant special
treatment or any type ofintervention.
But functional medicine andalternative medicine
(14:36):
practitioners advocate forhigh-dose folate or other B
vitamins for those with MTHFRmutations to mitigate these
potential issues.
Conventional medicine tends tobe more cautious about
recommending treatments justsolely based on genetic testing,
without that robust evidenceand big pharma.
So the C677T variant, when Ilooked it up, is estimated to
(15:01):
affect about 10 to 20% ofvarious populations.
Higher prevalence are incertain ethnic groups.
I saw one that was as high as30 to 50% in Hispanic population
.
The A1298C variant is much morecommon, with prevalence of 20
to 30% across all populations.
20 to 30%, that means out of 10people you know, 2 to 3 really
(15:30):
can have these mutations andthey don't feel like they should
be offered any type of help andjust let them go on or get
cyclosporine from another area.
That is negligent.
I that is negligent.
I think that is absolutelyhorrible.
And 20% to 30% even if I canhelp one of those percents of
the 20% to 30%, then that makesit all worthwhile to raise
(15:55):
awareness and get people helpedwith this.
And there are a lot moremutations.
These are just the ones thatare most popular and let me be
clear with this Like, if youhave the mutation, just the
presence of it does not dictatehealth outcomes.
Many individuals with thesevariants lead very healthy lives
(16:16):
without any notable issues.
What I'm talking about arethose that have all of these
symptoms and they have thesemutations.
You know, most clinicalguidelines do not recommend
routine screening for MTHFRunless there are specific
indications.
Like I said, I found thesepeople not looking for it.
(16:38):
It just popped up when I wasdoing a comprehensive workup.
But if you have a history ofthrombosis or you've had
pregnancy complications, youshould always have this checked.
Okay?
So if we talk about how MTHFRaffects everything else, let's
talk about hormones, becausethat is how I find this, because
(16:59):
I do optimize hormones usingbioidentical hormones.
So MTHFR really messes withestrogen detoxification.
That means if your body can'tclear excess estrogen, you're in
for a hormonal roller coaster.
So think PMS from hell, heavypainful periods or low
progesterone, which leads toanxiety and fertility issues.
(17:21):
So MTHFR can cause this.
So if you have estrogendominance, if you are trying to
find ways to balance that,luckily you might come to me for
your hormone optimization and Imight find reasons to go and
check this or if yourmethylation cycle is slow and
(17:42):
your body can't make ATP, whichis our cellular energy,
efficiently, this is when we getadrenal burnout, chronic
fatigue, an over-reliance oncaffeine, like people are
telling me they're drinkingthree, four cups of coffee a day
but they still just feel tired.
And then skin, just like thispoor gentleman I met today.
(18:04):
Methylation affects collagenproduction.
It also affects your detoxpathways.
Inflammation, which means youcan have acne, you can have
breakouts, you may have likedull, solid skin, you can have
very slow wound healing, or theeczema, the rosacea, psoriasis.
It all can come from thatmethylation process.
(18:26):
And MTHFR mutations cansignificantly influence the
metabolism of homocysteine andhistamine, both of which play
critical roles in various bodilyfunctions and, if you
understand, their relationship,is essential for managing health
, especially for individualswith these MTHFR variants.
(18:47):
Homocysteine is an amino acidthat's produced during the
metabolism of methionine.
That's an essential amino acidfound in protein.
Under normal circumstances,homocysteine is converted into
other substances like cysteineand methionine through various
pathways cysteine and methioninethrough various pathways.
(19:13):
The MTHFR enzyme is reallyimportant for converting
5,10-methyltetrahydrofolate to5-methyltetrahydrofolate.
That's the active form offolate.
So this active form isessential for the remethylation
of homocysteine back tomethionine.
Did you catch all that?
So variants like the C677T andthe A1298C can lead to reduced
(19:35):
enzyme activity, which mayresult in elevated homocysteine
levels, also known ashyperhomocystenemia.
High levels of homocysteine areassociated with various health
issues that can includecardiovascular disease.
Elevated homocysteine areassociated with various health
issues that can includecardiovascular disease.
Elevated homocysteine levelscan damage blood vessels and
promote clot formation,increasing the risk of heart
(19:55):
disease and strokes.
There's also evidence linkinghigh homocysteine levels to
cognitive decline, even dementia, and other neurological
disorders, and that elevatedhomocysteine does pose risks
like preeclampsia andmiscarriage.
So most conventional providersthey don't check homocysteine
(20:15):
and if they do, they'll tell youthat it's completely normal by
following that reference rangeon the labs.
So the ideal homocysteine tofunctional medicine is about
seven, but you could be muchhigher than that.
I've seen a lot that the labsthey say if you're 10, that's
normal and they just stoplooking.
My goal is to get people sevenand under.
(20:37):
That is a great spot forhomocysteine.
If I see that you're at a 10,then I know we need to look
further for these mutations.
Histamine is a biogenic amineinvolved in local immune
responses and regulation ofstomach acid and
neurotransmission.
So it is produced in the bodyfrom the amino acid histidine
(21:00):
through the action of the enzymehistidine decarboxylase.
You know I have to add thisstuff into my podcast, but MTHFR
mutation influences themetabolism of histamine,
primarily through the effect onfolate and methylation process.
People with MTHFR mutations mayhave a reduced ability to break
(21:21):
down histamine due to impairedmethylation.
This impairment can lead to anaccumulation of histamine in the
body, resulting in histamineintolerance, and symptoms of
histamine intolerance can beheadaches or migraines, skin
rashes or hives, digestiveissues like bloating and
diarrhea, respiratory problems.
This seems to be how I caughttwo of mine as well, because
(21:44):
they have nasal congestion.
They had asthma.
They're always complaining ofallergies and just sniffling all
the time, even though theyweren't sick, flushing or
sweating as well.
And both homocysteine andhistamine are linked through the
methylation cycle, which issignificantly impacted by MTHFR
(22:05):
activity.
When MTHFR function iscompromised, the body may
struggle to convert homocysteineeffectively, leading for it to
build up and accumulate, and atthe same time, reduced
methylation capacity can impairthe breakdown of histamine,
causing higher levels insusceptible individuals.
So an individual with a C677TMTHFR mutation can experience
(22:31):
elevated homocysteine levels,increasing cardiovascular risk,
while also having difficultyprocessing histamine, leading to
symptoms of intolerance.
And this dual challengeemphasizes the importance of
monitoring and managing bothhomocysteine and histamine
levels in those types ofindividuals.
(22:51):
I have a full protocol that Iuse for these, which has an
increase of folate-rich foods.
It limits high histamine foodsand I have a whole supplement
protocol for that, along withlifestyle modifications.
Which brings me to just talkabout how does functional
medicine manage MTHFR?
Not many people do.
I have done a search to seepeople around me, people in the
(23:14):
area, just different resourcesand it is few and far between.
So maybe this is why thesethings are coming to me, because
I do have a passion for this.
So the first thing that we wantto do or I guess, not do is you
have to stop overloading yourbody with synthetic folic acid.
(23:37):
This is found in processedfoods and cheap supplements.
I know a lot of people are likeoh, I take these supplements
but it does have just bad thingsin them.
So if you are MTHFR, you can'tconvert it, so it builds up and
creates more problems.
Instead, you need to go formethylfolate and methyl B12.
(23:57):
These are the activated formsthat your body can actually use.
I use orthomolecular protocolfor MTHFR that is full of
methylfolate, methylcobalamin orhydroxycobalamin, p5p
glutathione you guys know I lovemy glutathione Right now.
One of my favorites to lowerhomocysteine is the methyl CPG
(24:24):
or the TMG and definitely somearginine, and there's a lot more
than supplements that you take.
You have to avoid fortifiedbreads, cereals, cheap prenatals
.
I see a lot of people thatthey're worried they'll have
another miscarriage, so theystay and just continue taking
(24:45):
cheap prenatal vitamins that arefull of folic acid that's not
methylated.
So it's kind of like a viciouscycle.
You know processed foods,refined sugars they just inflame
everything and because MTHFR,they can't detox very well.
So they put themselves in suchdistress trying to drink alcohol
(25:09):
or a lot of caffeine andthey're making things worse.
And then, because your detoxpathways are already sluggish,
you need to look out for toxinslike BPA, heavy metals which is
one of the reasons why I love myHTMA hair mineral tissue
analysis test because you mightbe building heavy metals since
(25:30):
you don't have those good detoxpathways or the phthalates these
are your plug-in air fresheners.
Or those candles that you'reburning that are full of toxins
and endocrine disruptors.
Instead, you do want to focuson whole, nutrient-dense foods.
This would be leafy greens thathave natural folate or
grass-fed meats and organ meatsthose are B vitamins galore.
(25:52):
Or wild caught fish for theomega-3s to reduce inflammation,
eggs, which gives you cholinefor methylation, and turmeric
and cruciferous vegetables forliver support, but you also want
to make sure that you have yourfood IgG testing through my
functional medicine testing tomake sure that you are trying to
add in these foods that you arethen also giving yourself some
(26:15):
IgG antibody responses to.
Your liver is already workingovertime, so you have to support
your MTHFR with liver detox.
You should be hydrating likealmost over hydrating.
You can add lemon or applecider, vinegar, milk, thistle
and dandelion root.
These are things that I love toadd to my Vicon customs when I
(26:36):
formulate that, because thoseare very gentle liver
detoxifiers.
Cruciferous vegetables helpclear excess estrogen as well,
and just getting up and movingyou know lymphatic drainage
allows for better detox.
If you suspect that you may havean MTHFR mutation or if you're
(26:57):
experiencing health issues thatmight be related to it, you may
want to consult a functionalmedicine provider.
That can be a very proactivestep toward optimizing your
health.
I would love to be yourprovider.
Functional medicine does take aholistic approach.
We focus on identifying theroot cause of health issues
rather than merely treatingsymptoms.
(27:19):
So, functional medicinepractitioners, we conduct
thorough assessments, includingthe genetic testing, determine
how your specific MTHFR statusand other factors may be
affecting your health.
This personalized approachallows for tailored treatments
that address your uniquebiochemical and genetic makeup,
and a functional medicineprovider will look at your
(27:42):
entire health history, lifestyleand environmental factors.
They may also consider how yourdiet, your stress levels and
other lifestyle choices impactyour MTHFR function and overall
health.
And by understanding theimplications of your mutations,
we can help by implementingstrategies to prevent potential
health issues.
It could be dietaryrecommendations, it could be
(28:04):
lifestyle modifications andtargeted supplements.
I am on Facebook and I do followa lot of MTHFR groups.
They're not professionals, theyare just people that have the
mutations chatting to each other, and there's so many times I
(28:25):
want to post in there.
No, no, no, no, stop it,because one person will post
that they took something and 30other people are like, oh, I'm
gonna get that.
They don't understand that thisis individualized and what
works for one person may notwork for another and they could
actually be damaging themselvesmore.
Um, maybe I should actually say, hey, I can help you.
No, I'm not gonna do that, butit is very helpful to read,
because then I it helps meunderstand points of views and
(28:50):
struggles that people have, andit definitely makes me a better
practitioner when I see thestruggles that these people are
having.
I just wish I can just type inthere.
Don't do that, but I'm not, I'mjust in there for the scroll.
So, harmony Hub Health, I amcommitted to providing support
and guidance for individualslooking to navigate their health
(29:11):
concerns related to MTHFRmutations.
I can help you by giving youthat expert consultation.
You know I do understand thecomplexities of MTHFR and its
implications.
We can talk about your symptoms, your health history and
concerns in a very supportiveenvironment where personalized
attention is prioritized.
I can order your genetictesting and I can do the
(29:34):
analysis and that analysis willguide the development of a
targeted health plan.
And, based on your uniquegenetic profile and health
status, harmony Hub Health canhelp create this comprehensive
plan that might include thedietary adjustments to enhance
folate intake and reducehomocysteine levels, lifestyle
changes to improve overallhealth and well-being.
(29:57):
I have recommendations forsupplements that are medical
grade, that you can't just go tothe store and buy, that are
safe and effective, based onyour MTHFR status and you know I
like to emphasize continuouscommunication and support.
So regular follow-ups so thatwe can monitor your progress and
make necessary adjustments toyour health plan.
And just education to empoweryou in managing your health
(30:20):
actively.
This is one of I would say, abarrier sometimes because
there's nobody to give education.
I find that many people thatalready know they have MTHFR
they've already done the Googlesearches and they've done the
chat, gpt and they do think thatthey know it all and they
become very resistant to thingsthat I recommend oh, I've done
(30:44):
that, they'll say, but no, youhaven't done it my way.
That I recommend oh, I've donethat, they'll say, but no, you
haven't done it my way.
So that is something that doesmake for hard conversations
during the process For peoplethat have the known genetic
mutation.
They're already frustratedbecause the medical system has
(31:06):
failed them.
But I am here to help you.
You know, and being part ofHarmony Hub Health connects you
to a community focused onholistic health.
So I do have the Harmony HubHealth inner circle so people
can kind of get together andtalk about it also.
So seeking a functional providerto address MTHFR is a very
(31:27):
proactive approach to optimizingyour well-being and I again
would love to be your provider.
So if you've been strugglingwith weird, unexplained health
issues, mthfr could be themissing piece.
So with functional medicine,with the right provider, with
the right supplements.
With the right lifestylechanges, we can transform your
(31:48):
energy, your mood, your skin,because your body wants to
function properly.
It just needs the right tools.
So come to me and we can hackyour health, as we call it.
You can find me atwwwharmonyhubhealthcom.
You can find me on Facebook atHarmony Hub Health.
(32:09):
You can also come see me inperson at Monarch Beauty and Spa
here in Manchester, maryland.
Here's to health and happinessand I'll see you next time.
Thank you.