April 21, 2025 • 36 mins
Do you ever wonder why health advice that works wonders for others falls flat for you? The answer lies in your unique genetic makeup—a blueprint that determines how your body processes everything from nutrients to stress.
Dive deep into the revolutionary world of personalized healthcare through the lens of 3x4 Genetics testing. This groundbreaking approach analyzes 157 individual SNPs (single nucleotide polymorphisms) across 36 metabolic pathways, revealing crucial insights about your body that generic health advice simply cannot provide.
Through a candid exploration of her own genetic blueprint, Michelle shares how discovering her top three genetic pathways—methylation, detoxification, and collagen/joints—transformed her approach to health. Her most surprising revelation? Learning that her celiac disease wasn't something she was born with, but developed over time due to interactions between her genetic predispositions and environmental factors.
The colorful, comprehensive 3x4 Genetics report doesn't just identify issues—it provides clear, actionable recommendations tailored specifically to your genetic profile. With personalized diet suggestions, lifestyle modifications, and supplement recommendations for each pathway, you'll finally have a roadmap that works with your biology instead of against it.
Statistics show that 75% of people are more likely to follow health advice when it's based on their genetic profile. By understanding the pathways most affected by your genetic variations—from hormone balance to inflammation response—you can prioritize interventions that will have the greatest impact on your overall wellbeing.
Ready to stop comparing your health journey to others and discover what your unique genetic makeup is trying to tell you? Book a functional medicine consultation today and learn how 3x4 Genetics testing can help you optimize your health in ways you never thought possible.
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Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
Speaker 1 (00:01):
Welcome to Harmony Hub Health, where my mission is
to provide comprehensive,affordable, integrative care
that addresses the root cause ofhealth issues.
At the Hub, the focus is onindividual patient journeys.
I strive to optimize health,vitality and longevity,
fostering a community where eachperson can thrive in body, mind
and spirit.
(00:21):
In the world of functionalmedicine, one-size-fits-all
solutions just don't work.
The idea that everyone is thesame when it comes to health,
(00:42):
wellness and even our geneticmakeup is just false.
This is where the power ofindividualized care shines, and
one of the most revolutionarytools to help create truly
personalized treatment plans isthe 3x4 genetics.
It is often said thatcomparison is the root of all
evil.
(01:02):
I actually said this out loud afew times to different people
this week, and this couldn't bemore true when it comes to
health.
Too often people look atothers' wellness journeys and
try to mirror them, believingthat what works for one person
should work for them too.
But what we often fail toconsider is that every person is
(01:23):
unique.
The reality is your body, yourbiology and your genetic makeup
are not the same as anyoneelse's.
This is where a personalizedapproach to healthcare becomes
vital.
Tailored treatment plans basedon your specific genetic
information allows for a muchmore effective and efficient
(01:43):
strategy for improving healthoutcomes.
Simply put, it is not aone-size-fits-all scenario, and
this is where 3x4 Genetics comesin.
3x4 Genetics is a genetictesting company that offers
insight into an individual's DNAto help guide personalized
healthcare strategies.
It helps to identify geneticvariants called single
(02:07):
nucleotide polymorphisms, whichwe also know as SNPs, and can
influence a lot of differentaspects of your health, from
nutrient metabolism todetoxification and even your
predisposition to certain healthconditions.
With this test, we can lookinto a variety of key health
areas, including yournutritional needs.
(02:29):
You know how your bodyprocesses vitamins, minerals and
antioxidants, yourdetoxification pathways.
You know how your liverdetoxifies and if it's well or
not.
How your body's propensity forinflammation is, so your
inflammation responses, yourmethylation this is how
efficiently you process certainnutrients and your cognitive
(02:52):
function.
So this is how your genesinfluence your brain health.
These insights allowpractitioners to provide care
that is specific to your geneticprofile, helping you avoid the
pitfalls of generic wellnessadvice and may not be suited for
your body.
The name 3x4 Genetics reflectsthe company's focus on analyzing
(03:15):
how genes work together inbiological pathways to influence
health.
So the 3 represents the threemain areas of health they focus
on, which is nutrition, fitnessand wellness.
The four signifies the four keysystems that examine cellular
health systems biology,cardiovascular health and energy
(03:36):
and activity.
So, by understanding theseinterconnected pathways, three
by four, genetics providespersonalized insights into how
your genetic makeup affectsvarious aspects of your health.
So genetic SNPs are variationsin our DNA that are common, but
they can have significantimpacts on how our bodies
(03:58):
function.
While these variations arewidespread, understanding their
specific effects on eachindividual can be incredibly
complicated.
A SNP might indicate a higherlikelihood for a particular
condition or disease, but thisdoesn't mean you're destined to
get it.
Instead, it provides a valuableopportunity for intervention,
(04:23):
whether that's through lifestylechanges, different supplements
or medications.
They're tailored specificallyto your genetic makeup.
For example, some people have aSNP that makes it harder for
them to metabolize certainvitamins or minerals, without
knowing that they might betaking supplements that aren't
optimal for their body.
(04:44):
With 3x4 testing, we canidentify these gaps and address
them proactively, adjustingnutrient intake or supplement
strategies accordingly.
And while SNPs in your geneticscan be helpful, they don't
always paint a clear picture ontheir own.
This is where the realexpertise comes in.
Interpreting these geneticresults requires an in-depth
(05:07):
understanding of functionalmedicine principles and how to
connect genetic information withactionable care plans.
With Harmony Hub Health, I knowthat these results are just the
beginning.
The 3x4 test provides afoundation, but we then work
closely with you to ensure youunderstand what the findings
(05:29):
mean in practical terms.
Another example might be youknow the test might reveal a
genetic variant that couldaffect your ability to detoxify
heavy metals, but how does thataffect your daily life and how
do we address the potentialissue?
This is where functionalmedicine really shines.
(05:49):
By pairing genetic data withenvironmental, lifestyle and
clinical factors, we can createa full picture of your health.
So I don't just treat a geneticmutation.
I help you understand how itaffects you and what could be
done to mitigate any risks.
Understanding your uniquegenetics allows us to
(06:11):
individualize your care in waysthat are impossible with generic
advice or treatments.
It's not just aboutunderstanding what's in your
genes, but knowing how tooptimize your health in line
with that knowledge.
So, three by four, geneticsisn't just a tool for looking at
(06:32):
disease risks.
It's a roadmap for betterhealth, one that is personalized
, right for you.
The results can help withthings like tailoring your
nutrition plans based on how youprocess different nutrients,
personalized supplementstrategies that align with your
body's needs, precision medicinethat addresses your unique
(06:53):
genetic risks, and optimizeddetox and inflammation
management to reduce chronicconditions.
In a world where health is oftenoversimplified, it's very
important to understand thateach person has their own set of
genes that affects how theirbody reacts to food, stress,
exercise and even sleep.
(07:14):
3x4 genetics helps you takecontrol of your health in a way
that aligns with your biologyand that is very powerful, right
?
Some of the reasons why I love3x4 genetics and have spent the
last several weeks learning asmuch as I can and becoming
certified is because we alreadyknow that about 80% of chronic
(07:36):
diseases are caused by lifestylefactors.
The 3x4 test can tell you howto prevent, delay or even
reverse those diseases to ensurelongevity.
Right, this is your health span.
We already know that 95% ofpeople that try a diet fail, and
2.2 billion people in the worldare currently obese.
(08:00):
What if a test could take theguesswork out of dieting and
optimize a unique weight lossplan Right?
Three out of five people aroundthe world die from a disease
linked to inflammation.
Knowing how your genes worktogether in cellular pathways
and functional systems can bevery helpful to prevent being in
(08:21):
that number.
Most individuals and healthcareproviders all agree that genetic
testing offers promise for morepersonalized healthcare and
better outcomes.
3x4 Genetics did a survey andit was completed by 1,000 United
States primary care physicianson the Medscape platform in
(08:42):
October of 22, and a consumerhealth survey conducted by
Global Insights from Material inOctober of 2022.
They surveyed about 1,500Americans that were 18 years or
older.
Is that 75% of individuals inthe US said that they'd be more
(09:08):
likely to follow their healthprovider's advice if they knew
their genetic profile was usedto personalize their care.
92% of the physicians surveyedsaid genetics is, yes, an
important part of anindividual's complete health
picture, but only 17%, which is2 out of 10 United States
(09:29):
individuals, have ever even hada genetic test done, and of
those two, the genetic test thatwas done was found to be
clinically irrelevant.
So starting patients with genesfirst provides the missing link
to a personalized approach toincrease healthspan and prevent,
(09:50):
reverse, delay and manage painor chronic disease.
But in order to havepersonalized health care, we
need to have genetics plus thathealth care right.
When you do a three by fourgenetics test, it's one single
test that's really easy to do.
You take the swab and you swabthe inside of your cheek.
It tests 157 individual SNPsand it looks at 36 metabolic and
(10:16):
biochemical pathways and sixkey health areas.
These are weight balance, yourheart health, blood sugar
regulation, brain health,fitness and tissue health and
hormone health.
The 3x4 genetics uses advancedtechnology.
It's known as the Darwinmethodology and it determines
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the impact of individual genevariants on multiple pathways.
The pathway-based polygenicscores determines the impact of
genes on 36 metabolic areas orpathways.
Weighted genetic scoresdetermines the impact threshold
for each metabolic pathway.
So I have offered many genetictests to patients.
(10:58):
Some of them could be as highas $600.
And all I get back are someletters of the SNPs, and it can
be really hard to interpret.
What I like about 3x4 Geneticsis I give a user-friendly report
with language of color andpictures and personalized
visuals.
That also improves the patientengagement.
The clinical guide providesdiet, lifestyle supplement and
(11:22):
functional test recommendationsto help me better explain how we
can use genetics to optimizeyour health.
The training and report that Iget is so extensive that I can
even search by SNPs.
I can search by metabolicpathways all of the things to
bring you the most personalized,tailored care.
Talk about precision.
(11:44):
Now, of course I wanted to be myown patient.
Zero.
I did swab my son Ezra, and I'mwaiting for his results.
But I became interested inepigenetics a long time ago and
around Christmas time I cameacross an ad on social media for
a, a company that uses your DNAto tell you the best exercise
(12:05):
to do to be successful ondifferent journeys, and I was so
intrigued so I got the test.
It sat there for a little bitbecause I wasn't sure if I
wanted to send my DNA throughthe mail, but I did the test and
when it came back I got a verygeneric report and I was not
very impressed.
(12:25):
Then, you know, a couple monthslater I messaged the company
and I asked for the raw data ofthose gene tests and they were
very nice.
They gave it to me right away,but the report looked like
hieroglyphics and all I couldthink was this is what my
patients see when I ordergenetic tests on them.
They're looking at it, probablysaying what the heck is this?
(12:46):
But I wanted to know what theyall meant and I have tested many
patients for the MTHFR and theCOMT and the DAO and when I get
those results back I can see theSNPs, but it's hard to look at
a SNP and just know the best wayto personalize care without it
still feeling like there's moreto look at.
(13:13):
Then, when I confirmed I hadSNPs in the MTHFR and COMT, I
didn't want to create protocolsthat were generic and not
everybody to follow, becausethere's so much more to consider
.
I did a lot of research andeven considered going back to
school to study genetics, butthat was not going to happen.
I love to learn but Idefinitely don't need another
degree.
So I stumbled upon 3x4 geneticsin order to test for Ezra and
(13:35):
for myself, and when the resultscame back I was blown away.
I knew I wanted to offer thisto my patients and sure I could
always order it and just usetheir reports.
But I wanted to really deepdive and learn everything I
could and in that process Ibecame certified and now I'm a
certified licensed provider with3x4 Genetics and I'm helping so
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many people on their ownjourney.
So just to be vulnerable, I'mgoing to go ahead and walk
through my own blueprint, justso you guys can know the
information that's in here.
And again, this is a 32 pagereport that you get.
That's very colorful, it's verypretty.
The first page actually saysthe personal genetic story of
(14:21):
Michelle Postal.
So this is just attractivewithin itself.
And when you look at the firstpages of it, there's a great
introduction that talks abouthow our genes determine who we
are and how we respond to theworld around us, from the food
that we eat to the exercise wedo, to the exposure to the
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environment, and even how werespond to stress.
Okay, so it talks about all ofyour genes and then it shows you
, color coded, how thesedifferent genes are impacting
your health.
You know, you know it does coverthose 36 metabolic pathways
across the six health categories.
So you get categories of low,medium, high and very high.
(15:07):
And the first thing that itkind of goes to is it breaks
down, looking at your SNPs, yourtop three pathways.
So everybody's top threepathways are going to be
different based on their SNPs.
So all of the ones that arepurple are going to be very high
.
But then they look at thedifferent genes and how each
(15:27):
thing affects each other andthey give it your top three
pathways.
This is amazing, because if Iwould have looked at this
genetic testing and I would havereally flipped out when I saw,
what did I have.
I think I have 10 very highaffected pathways and I would
never know where to startbecause change is the hardest
thing to do.
(15:48):
So not only does it have yourtop pathways.
For example, my top threepathways identified are
methylation, which I alreadyknew that I had MTHFR, but it's
so generic to say I need to helpmy methylation, what else?
Number two was detoxification.
Number three was collagen andjoints, which I would have never
(16:11):
thought of would be my topthree priority.
So under methylation, itdescribes what that is.
It tells you for every singlepathway, you for every single
pathway.
It then breaks it down to threediet recommendations, three
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lifestyle recommendations andthen three supplement
recommendations.
Easy peasy, and it's so brightand colorful.
So it goes on to say whatmethylation is and I will just
read to you for this one.
We'll go down to collagen andjoints because that is very
exciting because I've alreadydone podcasts on methylation is.
And I will just read to you forthis one.
We'll go down to collagen andjoints because that is very
exciting because I've alreadydone podcasts on methylation.
But number two wasdetoxification.
(16:51):
So it tells me all about whatdetoxification is and it gives
me three diet recommendations,three lifestyle recommendations
and then three supplementrecommendations.
So let's go down to my thirdpathway, which was collagen and
joints, because this wassurprising to me.
So what it says is all our cellsare continuously being renewed
(17:15):
by being broken down andreplaced by new ones.
Collagen is the majorstructural protein and the
foundation of all our softtissue, which is skin, hair,
nails, joints and organs.
Variations in collagen genesmight affect the structure and
function of these areas, causingexcessive breakdown of cells
without a comparable formationof new cells will result in
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degeneration.
Genes play a large part in theprocess of collagen formation
and breakdown, as does lifestylefactors such as diet and
exercise.
So how did this end up in mytop three?
Thank goodness I have theorthomolecular collagen, but
let's see what this says.
So for diet, it says, my threetips are number one ensure two
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to three servings of collagendaily, of foods that boost
collagen production, which arequality animal protein, wild
caught seafood, cashews, which Ilove oats, quinoa, legumes,
griefy, griefy green leafyvegetables, bone broth, hemp and
pumpkin seeds.
I actually can't have pumpkinseeds because of my IgG, so make
(18:21):
sure that if you've had yourIgG food testing, you're
following that as well.
Number two for food is consumeat least one cup each day of
foods that reduce jointinflammation, slows cartilage
breakdown and containssulforaphane, like raw broccoli,
cabbage, mustard, bok choy,watercress, horseradish and
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cauliflower.
Number three ensure dailyintake of at least two to three
foods that support collagen andjoints and contain vitamins C, d
and biotin Mushrooms left inthe sun to increase vitamin D
content that's something I hadnever heard Almonds, eggs, sweet
potatoes, berries, citrusfruits, mangoes and bell peppers
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.
So those are my top three dietrecommendations for this pathway
, which I did not even knowcollagen and joints was a
pathway in your body, but itmakes a lot of sense if you know
me and my history with my body.
And then it gives threelifestyle recommendations.
Number one is improve jointhealth with a variety of
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exercise aerobic strengthtraining, flexibility.
Increase the frequency andintensity of exercise slowly.
Number two is participate inlow impact activities such as
bicycling, walking and swimming.
Limit extensive high impacttraining, jump, rope, step
aerobics and road running.
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Oh my gosh, if any of you guysknew me when I was running that
half marathon, this mightexplain some of that.
Number three focus onmaintaining good posture and
form when standing, sitting,bending, reaching and lifting.
Attain a healthy strength toweight ratio to prevent joint
injuries, and those of you whohave seen me sitting at a desk
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can probably see that, yes, thisis an issue.
And then it comes down to thethree recommendations for
supplements.
And number one it says zinc,magnesium, glycinate, hydrolyzed
collagen, vitamin A and biotin,which they give dosages as well
.
But this is great because I hadalready identified this with my
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body and have all of thesethings now and a lot of that is
in my Vicon.
And then it tells me number twoimportant for me is vitamin D3,
which, if you've ever heard metalk about it, I had a really
difficult time beforeorthomolecular supplements
getting my vitamin D over 20.
And right now it's good.
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And then number three it saysBoswellia, serrata, curcumin and
MSM or methyl silvanomethane.
So those are my three toprecommendations for supplements.
For that collagen and jointpathway, for that collagen and
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joint pathway.
So methylation, detoxificationand collagen and joints.
And this was just amazing.
The next part of that blueprintshows all of the gene results
and they're color coded so youcan see your protective genes.
It will have a shield there.
You can also see which ones arevery high and those are going
to be in purple.
And oh my gosh, if I look atmine that are very high impact
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on my, on my life.
Let me tell you one, two, three, four, five, six, seven, eight,
nine, ten, eleven, twelve,thirteen, fourteen, fifteen,
sixteen, seventeen, eighteen,nineteen, twenty twenty one,
twenty two, three.
I have 25 in the in the purple7, 12, 13, 14, 15, 16, 17, 18,
19, 20, 21, 22, 23.
I have 25 in the purplecategory, so that's 25 genes
that are impacting my day-to-day.
They do place a star these arecalled your rock stars of the
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ones that are significantlyimpact and I have four there and
the interesting thing, one ofthose are not MTHFR.
Yes, the MTHFR is on the list,but actually the top four that
are impacting me the worst arethe COMT, the GSTM1, the PEMT
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and the TCN2.
So, even though I have MTHFRand I've kind of made
adjustments to my day based onknowing I have MTHFR, I was
close, I was doing things, but Iwas still not on the mark
because I had not done full DNAtesting.
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The next page talks aboutpathway-based results and this
is where you see all 36 pathwaysand the ones that are in purple
are very high impact.
I have a lot.
So my high impact between thesix different systems are
methylation, detoxification,collagen and joints, hormone
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balance.
Imagine that, because how doyou think I led to offering
hormone therapy?
I went through my own strugglesand figured it out.
Had I known this, I would haveknown that, yes, I was going to
have an issue Mood and behavior,which my husband can attest to
Exercise response, adipogenesis,vitamin B12, which I have been
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preaching for a long time nowbut, yes, it's because I'm
genetically impacted um, cholineand folate, which goes along
with that, mthfr.
So you get a very colorfulgraph that shows you which are
high, um, and which ones aremedium and which ones are are
low, which some of these aregoing to surprise you as I keep
going on, if you're still herelistening to me.
(23:48):
So the next part which I love isit gives you kind of it's
almost like a storybook, and thestorybook gives you a very
clear cellular overview and ittalks about how we are a sum of
our cells and we are only ashealthy as they are.
So every cell in our bodyfunctions independently, but it
is connected to the whole.
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So, like a small apartmentinside a high-rise building,
each unit takes care of its ownday-to-day maintenance but
ultimately it contributes to theoverall function of the whole
building right.
So it kind of goes through andbreaks things down in
non-medical, very colorful waysso you can see what's going on.
(24:30):
So it starts with themethylation process and mine
actually says you are not likelymethylating adequately, you
know.
It says prioritize intake of Bvitamins, choline and folate
foods such as dark leafy greens,eggs, nuts, seeds and whole
grains to support optimalmethylation.
Methylation is a biochemicalprocess involved in the
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production, repair and behaviorof genes and metabolic processes
.
So it goes there.
It talks about inflammation.
It tells me that I'm prone tochronic inflammation, which
that's how Harmony Hub cameabout anyway, and it will even
list, when you get to a purpleone like detoxification, which
genes you have the superstars tolike.
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This is where my com t and mygstm1 come in.
It says that my ability toneutralize and remove toxins is
likely poor, and what I love isit does tell you how to help it
under each category and alsoyour food choices.
It also tells me that myability to manage oxidative
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stress might be less thanoptimal because of my genes, and
it tells me how to do that.
And then I love how it givesyou a picture of the human body
and it kind of goes through andshows you how your systems are
affected.
Like it says, I'm highly likelyto mood imbalances.
(25:56):
Thank you very much.
But then it tells me why andwhat I can do for it, which I've
done.
So this is why I'm always in agood mood now.
If you knew me years ago, I wasnot.
If you knew me years ago, I wasnot.
It says without the rightchoices, there's potential for
cognitive decline as I age andthat's very important because we
want to stay sharp.
So that is one of my purplepathways is memory and brain
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health.
Histamine overload for me is apurple as well.
It says I'm prone to histamineoverload.
So this is where you want toidentify foods and environmental
triggers and prioritizehistamine degrading foods and
make sure you know that I am allgood there.
My hormone balance it says yourhormone balance is likely
impaired and it gives me somehints on how to work on that.
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Glucose and insulin it says I'mprone to blood sugar
dysregulation.
Nobody would have thought thatI had this many issues right,
but again, that's why I'm here.
It also tells me that there's amoderate likelihood that I may
be prone to blood clots.
That's important to know.
I do have a dad that's hadmultiple blood clots.
He's on a blood thinner.
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I always thought it was justbetween surgery or his already
bad poor health, but I'mactually genetically predisposed
to that.
Also, it says I'm prone toraise cholesterol levels.
Luckily I don't have highcholesterol.
It says I have a moderatelikelihood of blood vessel
damage.
I may experience blood pressuredysregulation and if you guys
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knew me, after I had Ezra I wason three prescription medicines
to control my blood pressure.
It says my bone turnover islikely to be imbalanced.
So it tells me ways to helpthat.
And it says I am highlysusceptible to tissue damage,
which is that collagen andjoints.
And if you guys saw my pictureslast year when I broke my ankle
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on both sides, you'll see that,yes, my soft tissue was
destroyed, okay, and some peoplecan fall and hurt themselves
and not have that much damageright.
Then it goes on to your energyoverview and here's some
interesting things.
One of my purples is appetite,satiety intake and it says you
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likely feel hungry more oftenand or take longer to feel full.
People that have known mebefore my weight loss journey
will agree with you how quicklyI get hangry.
My husband can attest to that.
It does say that my fat cellsmay be prone to inflammation,
which luckily some of these arejust medium, which is the
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pro-inflammatory fat, the energyexpenditure and the weight gain
and weight loss.
They are all just medium, butthe adipogenesis is a purple.
It says that my potential toreadily store fat is highly
elevated because I need tosupport my detox and
inflammation.
So it kind of goes all aroundso you can see what's going on
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and this says that you know yourfat cells likely release fuel
inefficiently when exercising.
So this is why it can kind ofbreak it down to tell you so
you're doing the right exercises, so you're not hurting your
body when you're trying to dosomething like exercise.
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So that is really nice to seeas well.
Next, the activity overview.
It talks about trainingresponse.
Again, the injury for me comesup with a little picture and it
says I'm likely prone to softtissue injuries and then tells
me how to prevent it.
Endurance is also purple for me, which surprised me.
It says I have above averageendurance potential and will
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likely respond well to endurancetraining.
Um, not so much when I wasoverweight trying to run that
half marathon, but even forpower it was good.
It said my power capacity willlikely respond moderately to
training.
So it talks about all thedifferent.
It talks about how I recoverfrom exercise.
(30:06):
So it almost looks like astorybook as you go through and
you see all of the tips, all ofthe pictures, all of the
information on here.
It goes to nutrient overflow,which you know.
It does list my PMT SNP undercholine, because it says I do
have a significant requirementfor dietary choline, which is
(30:27):
very interesting, because when Idid add choline because it says
I do have a significantrequirement for dietary choline,
which is very interesting,because when I did add choline
to my supplements a lot ofthings changed in my body for
the better, from mood to healthand hormones.
So that is interesting.
And then it says folate.
My ability to optimize or toutilize dietary folate is highly
(30:50):
reduced and that has to do withthe MTHFR, but it gives me tips
on how to treat that.
One of the most interestingthings in my book is that it
says you have a rare chance ofdeveloping celiac disease, a gut
condition associated withexposure to gluten.
So then I almost threw this outand said well, you are wrong.
(31:11):
Three by four I have celiac.
And then I had to really sitdown and reflect and think about
like, why, why did this happen?
And then it came to me veryclear I was not born with celiac
.
I mean, it wasn't until 2012that I was diagnosed with celiac
(31:32):
and I was born in 1977.
So what it breaks down to is thedirty genes it breaks down to.
I had poor detox.
I had MTHFR.
I could not break down folicacid, which is in everything
that has gluten, and I continuedto damage myself and hurt
(31:54):
myself by eating gluten that Ihad a reaction in my small
intestine on biopsy that showedceliac, but I wasn't born with
celiac.
I had pizza, bread, baked goodsall the way until 2012, until
Ezra put that animal cracker inmy mouth and we had to call an
ambulance.
So this makes complete sensehow my DNA.
(32:16):
I wasn't meant to have celiac.
I did it to myself with astandard American diet.
And then you know B12 wasanother one with my gene TCN2,
because my ability to absorb andtransport B12 was really
reduced.
So my B12 was always in the200s and it made no sense
because I was taking a form ofB12.
(32:37):
It just happened not to be theright form for my genes.
So it also goes into vitamin D,even though it's not a purple,
it is a turquoise.
And it says that I may have ahigher requirement for vitamin D
, which, though it's not apurple, it is a turquoise.
And it says that I may have ahigher requirement for vitamin D
, which is so true.
Um, not everybody has the samerequirement, which is why not
everybody should take the samesupplementation.
(32:59):
Okay, um, let me see.
It does say for vitamin C, I donot have an increased demand,
which is good.
It does say for vitamin C, I donot have an increased demand,
which is good.
What else, then, what I like?
After it goes through all ofthose, it gives you a glossary.
So if there's anything in thesystems that you're not sure,
(33:19):
you can read more informationabout it, and it goes really
in-depth, it doesn't leave anystone unturned.
And then, after that, it givesyou a list of your genes by each
pathway.
So mine is the methylation, thedetoxification, inflammation,
oxidative stress, collagen andjoints, hormone balance, mood
(33:43):
and behavior, glucose andinsulin, bone health, memory,
brain health, histamine,overload, blood pressure,
cholesterol, vascular health,blood clotting, exercise
response, adipogenesis andappetite, satiety and intake,
pro-inflammatory fat, energyexpenditure and weight gain and
(34:05):
weight loss resistance.
So those are all the 36pathways and it shows you all of
your genes, all of the impactsand your superstars.
Okay, what else Isn't thatexciting?
So the next time you look atsomeone else's health journey,
remember comparison is the rootof all evil.
(34:25):
Your body deserves its ownunique, tailored path to
wellness.
By understanding your geneticmakeup through 3x4 genetics
testing, we can help craft apersonalized approach that is
much more effective thanfollowing a generic plan that
everybody's doing the same thing.
So genetic testing through 3x4genetics can provide you insight
(34:46):
that you need to finally takecontrol of your health.
You can understand your DNAresults and use them to optimize
your well-being in the mostindividualized way possible.
If you're ready to take thenext step in personalized health
care, you're going to want tobook your functional medicine
consultation today and learnmore about the 3x4 genetics and
(35:06):
how it can transform your healthjourney.
If you do book a functionalmedicine consultation, we can
talk about the 3x4 genetics testor anything that you would like
to optimize your health, andyou can find me at
wwwharmonyhubhealthcom.
(35:29):
You can email me at michellewith one L M-I-C-H-E-L-E at
harmonyhubhealthcom.
If you don't want to be seenvirtually, you can come see me
in person at Monarch Beauty andSpa in Manchester, maryland, and
I would love to have thispersonalized blueprint done for
you.
The information shared intoday's episode about three by
(35:52):
four genetics and DNA testing isintended for educational
purposes only.
While genetic testing canprovide valuable insights into
your health, it is not asubstitute for medical advice,
diagnosis or treatment.
Always consult with a qualifiedhealthcare provider before
making any changes to yourhealth regimen based on genetic
test results.
The recommendations providedthrough genetic testing are
(36:15):
individualized but should beviewed as part of a
comprehensive health plan.
Thank you for listening andhere's to your best health Music
.
Welcome to Harmony Hub Health, where my mission is
to provide comprehensive,affordable, integrative care
that addresses the root cause ofhealth issues.
At the Hub, the focus is onindividual patient journeys.
I strive to optimize health,vitality and longevity,
fostering a community where eachperson can thrive in body, mind
and spirit.
(00:21):
In the world of functionalmedicine, one-size-fits-all
solutions just don't work.
The idea that everyone is thesame when it comes to health,
(00:42):
wellness and even our geneticmakeup is just false.
This is where the power ofindividualized care shines, and
one of the most revolutionarytools to help create truly
personalized treatment plans isthe 3x4 genetics.
It is often said thatcomparison is the root of all
evil.
(01:02):
I actually said this out loud afew times to different people
this week, and this couldn't bemore true when it comes to
health.
Too often people look atothers' wellness journeys and
try to mirror them, believingthat what works for one person
should work for them too.
But what we often fail toconsider is that every person is
(01:23):
unique.
The reality is your body, yourbiology and your genetic makeup
are not the same as anyoneelse's.
This is where a personalizedapproach to healthcare becomes
vital.
Tailored treatment plans basedon your specific genetic
information allows for a muchmore effective and efficient
(01:43):
strategy for improving healthoutcomes.
Simply put, it is not aone-size-fits-all scenario, and
this is where 3x4 Genetics comesin.
3x4 Genetics is a genetictesting company that offers
insight into an individual's DNAto help guide personalized
healthcare strategies.
It helps to identify geneticvariants called single
(02:07):
nucleotide polymorphisms, whichwe also know as SNPs, and can
influence a lot of differentaspects of your health, from
nutrient metabolism todetoxification and even your
predisposition to certain healthconditions.
With this test, we can lookinto a variety of key health
areas, including yournutritional needs.
(02:29):
You know how your bodyprocesses vitamins, minerals and
antioxidants, yourdetoxification pathways.
You know how your liverdetoxifies and if it's well or
not.
How your body's propensity forinflammation is, so your
inflammation responses, yourmethylation this is how
efficiently you process certainnutrients and your cognitive
(02:52):
function.
So this is how your genesinfluence your brain health.
These insights allowpractitioners to provide care
that is specific to your geneticprofile, helping you avoid the
pitfalls of generic wellnessadvice and may not be suited for
your body.
The name 3x4 Genetics reflectsthe company's focus on analyzing
(03:15):
how genes work together inbiological pathways to influence
health.
So the 3 represents the threemain areas of health they focus
on, which is nutrition, fitnessand wellness.
The four signifies the four keysystems that examine cellular
health systems biology,cardiovascular health and energy
(03:36):
and activity.
So, by understanding theseinterconnected pathways, three
by four, genetics providespersonalized insights into how
your genetic makeup affectsvarious aspects of your health.
So genetic SNPs are variationsin our DNA that are common, but
they can have significantimpacts on how our bodies
(03:58):
function.
While these variations arewidespread, understanding their
specific effects on eachindividual can be incredibly
complicated.
A SNP might indicate a higherlikelihood for a particular
condition or disease, but thisdoesn't mean you're destined to
get it.
Instead, it provides a valuableopportunity for intervention,
(04:23):
whether that's through lifestylechanges, different supplements
or medications.
They're tailored specificallyto your genetic makeup.
For example, some people have aSNP that makes it harder for
them to metabolize certainvitamins or minerals, without
knowing that they might betaking supplements that aren't
optimal for their body.
(04:44):
With 3x4 testing, we canidentify these gaps and address
them proactively, adjustingnutrient intake or supplement
strategies accordingly.
And while SNPs in your geneticscan be helpful, they don't
always paint a clear picture ontheir own.
This is where the realexpertise comes in.
Interpreting these geneticresults requires an in-depth
(05:07):
understanding of functionalmedicine principles and how to
connect genetic information withactionable care plans.
With Harmony Hub Health, I knowthat these results are just the
beginning.
The 3x4 test provides afoundation, but we then work
closely with you to ensure youunderstand what the findings
(05:29):
mean in practical terms.
Another example might be youknow the test might reveal a
genetic variant that couldaffect your ability to detoxify
heavy metals, but how does thataffect your daily life and how
do we address the potentialissue?
This is where functionalmedicine really shines.
(05:49):
By pairing genetic data withenvironmental, lifestyle and
clinical factors, we can createa full picture of your health.
So I don't just treat a geneticmutation.
I help you understand how itaffects you and what could be
done to mitigate any risks.
Understanding your uniquegenetics allows us to
(06:11):
individualize your care in waysthat are impossible with generic
advice or treatments.
It's not just aboutunderstanding what's in your
genes, but knowing how tooptimize your health in line
with that knowledge.
So, three by four, geneticsisn't just a tool for looking at
(06:32):
disease risks.
It's a roadmap for betterhealth, one that is personalized
, right for you.
The results can help withthings like tailoring your
nutrition plans based on how youprocess different nutrients,
personalized supplementstrategies that align with your
body's needs, precision medicinethat addresses your unique
(06:53):
genetic risks, and optimizeddetox and inflammation
management to reduce chronicconditions.
In a world where health is oftenoversimplified, it's very
important to understand thateach person has their own set of
genes that affects how theirbody reacts to food, stress,
exercise and even sleep.
(07:14):
3x4 genetics helps you takecontrol of your health in a way
that aligns with your biologyand that is very powerful, right
?
Some of the reasons why I love3x4 genetics and have spent the
last several weeks learning asmuch as I can and becoming
certified is because we alreadyknow that about 80% of chronic
(07:36):
diseases are caused by lifestylefactors.
The 3x4 test can tell you howto prevent, delay or even
reverse those diseases to ensurelongevity.
Right, this is your health span.
We already know that 95% ofpeople that try a diet fail, and
2.2 billion people in the worldare currently obese.
(08:00):
What if a test could take theguesswork out of dieting and
optimize a unique weight lossplan Right?
Three out of five people aroundthe world die from a disease
linked to inflammation.
Knowing how your genes worktogether in cellular pathways
and functional systems can bevery helpful to prevent being in
(08:21):
that number.
Most individuals and healthcareproviders all agree that genetic
testing offers promise for morepersonalized healthcare and
better outcomes.
3x4 Genetics did a survey andit was completed by 1,000 United
States primary care physicianson the Medscape platform in
(08:42):
October of 22, and a consumerhealth survey conducted by
Global Insights from Material inOctober of 2022.
They surveyed about 1,500Americans that were 18 years or
older.
Is that 75% of individuals inthe US said that they'd be more
(09:08):
likely to follow their healthprovider's advice if they knew
their genetic profile was usedto personalize their care.
92% of the physicians surveyedsaid genetics is, yes, an
important part of anindividual's complete health
picture, but only 17%, which is2 out of 10 United States
(09:29):
individuals, have ever even hada genetic test done, and of
those two, the genetic test thatwas done was found to be
clinically irrelevant.
So starting patients with genesfirst provides the missing link
to a personalized approach toincrease healthspan and prevent,
(09:50):
reverse, delay and manage painor chronic disease.
But in order to havepersonalized health care, we
need to have genetics plus thathealth care right.
When you do a three by fourgenetics test, it's one single
test that's really easy to do.
You take the swab and you swabthe inside of your cheek.
It tests 157 individual SNPsand it looks at 36 metabolic and
(10:16):
biochemical pathways and sixkey health areas.
These are weight balance, yourheart health, blood sugar
regulation, brain health,fitness and tissue health and
hormone health.
The 3x4 genetics uses advancedtechnology.
It's known as the Darwinmethodology and it determines
(10:37):
the impact of individual genevariants on multiple pathways.
The pathway-based polygenicscores determines the impact of
genes on 36 metabolic areas orpathways.
Weighted genetic scoresdetermines the impact threshold
for each metabolic pathway.
So I have offered many genetictests to patients.
(10:58):
Some of them could be as highas $600.
And all I get back are someletters of the SNPs, and it can
be really hard to interpret.
What I like about 3x4 Geneticsis I give a user-friendly report
with language of color andpictures and personalized
visuals.
That also improves the patientengagement.
The clinical guide providesdiet, lifestyle supplement and
(11:22):
functional test recommendationsto help me better explain how we
can use genetics to optimizeyour health.
The training and report that Iget is so extensive that I can
even search by SNPs.
I can search by metabolicpathways all of the things to
bring you the most personalized,tailored care.
Talk about precision.
(11:44):
Now, of course I wanted to be myown patient.
Zero.
I did swab my son Ezra, and I'mwaiting for his results.
But I became interested inepigenetics a long time ago and
around Christmas time I cameacross an ad on social media for
a, a company that uses your DNAto tell you the best exercise
(12:05):
to do to be successful ondifferent journeys, and I was so
intrigued so I got the test.
It sat there for a little bitbecause I wasn't sure if I
wanted to send my DNA throughthe mail, but I did the test and
when it came back I got a verygeneric report and I was not
very impressed.
(12:25):
Then, you know, a couple monthslater I messaged the company
and I asked for the raw data ofthose gene tests and they were
very nice.
They gave it to me right away,but the report looked like
hieroglyphics and all I couldthink was this is what my
patients see when I ordergenetic tests on them.
They're looking at it, probablysaying what the heck is this?
(12:46):
But I wanted to know what theyall meant and I have tested many
patients for the MTHFR and theCOMT and the DAO and when I get
those results back I can see theSNPs, but it's hard to look at
a SNP and just know the best wayto personalize care without it
still feeling like there's moreto look at.
(13:13):
Then, when I confirmed I hadSNPs in the MTHFR and COMT, I
didn't want to create protocolsthat were generic and not
everybody to follow, becausethere's so much more to consider
.
I did a lot of research andeven considered going back to
school to study genetics, butthat was not going to happen.
I love to learn but Idefinitely don't need another
degree.
So I stumbled upon 3x4 geneticsin order to test for Ezra and
(13:35):
for myself, and when the resultscame back I was blown away.
I knew I wanted to offer thisto my patients and sure I could
always order it and just usetheir reports.
But I wanted to really deepdive and learn everything I
could and in that process Ibecame certified and now I'm a
certified licensed provider with3x4 Genetics and I'm helping so
(13:57):
many people on their ownjourney.
So just to be vulnerable, I'mgoing to go ahead and walk
through my own blueprint, justso you guys can know the
information that's in here.
And again, this is a 32 pagereport that you get.
That's very colorful, it's verypretty.
The first page actually saysthe personal genetic story of
(14:21):
Michelle Postal.
So this is just attractivewithin itself.
And when you look at the firstpages of it, there's a great
introduction that talks abouthow our genes determine who we
are and how we respond to theworld around us, from the food
that we eat to the exercise wedo, to the exposure to the
(14:42):
environment, and even how werespond to stress.
Okay, so it talks about all ofyour genes and then it shows you
, color coded, how thesedifferent genes are impacting
your health.
You know, you know it does coverthose 36 metabolic pathways
across the six health categories.
So you get categories of low,medium, high and very high.
(15:07):
And the first thing that itkind of goes to is it breaks
down, looking at your SNPs, yourtop three pathways.
So everybody's top threepathways are going to be
different based on their SNPs.
So all of the ones that arepurple are going to be very high
.
But then they look at thedifferent genes and how each
(15:27):
thing affects each other andthey give it your top three
pathways.
This is amazing, because if Iwould have looked at this
genetic testing and I would havereally flipped out when I saw,
what did I have.
I think I have 10 very highaffected pathways and I would
never know where to startbecause change is the hardest
thing to do.
(15:48):
So not only does it have yourtop pathways.
For example, my top threepathways identified are
methylation, which I alreadyknew that I had MTHFR, but it's
so generic to say I need to helpmy methylation, what else?
Number two was detoxification.
Number three was collagen andjoints, which I would have never
(16:11):
thought of would be my topthree priority.
So under methylation, itdescribes what that is.
It tells you for every singlepathway, you for every single
pathway.
It then breaks it down to threediet recommendations, three
(16:31):
lifestyle recommendations andthen three supplement
recommendations.
Easy peasy, and it's so brightand colorful.
So it goes on to say whatmethylation is and I will just
read to you for this one.
We'll go down to collagen andjoints because that is very
exciting because I've alreadydone podcasts on methylation is.
And I will just read to you forthis one.
We'll go down to collagen andjoints because that is very
exciting because I've alreadydone podcasts on methylation.
But number two wasdetoxification.
(16:51):
So it tells me all about whatdetoxification is and it gives
me three diet recommendations,three lifestyle recommendations
and then three supplementrecommendations.
So let's go down to my thirdpathway, which was collagen and
joints, because this wassurprising to me.
So what it says is all our cellsare continuously being renewed
(17:15):
by being broken down andreplaced by new ones.
Collagen is the majorstructural protein and the
foundation of all our softtissue, which is skin, hair,
nails, joints and organs.
Variations in collagen genesmight affect the structure and
function of these areas, causingexcessive breakdown of cells
without a comparable formationof new cells will result in
(17:39):
degeneration.
Genes play a large part in theprocess of collagen formation
and breakdown, as does lifestylefactors such as diet and
exercise.
So how did this end up in mytop three?
Thank goodness I have theorthomolecular collagen, but
let's see what this says.
So for diet, it says, my threetips are number one ensure two
(18:00):
to three servings of collagendaily, of foods that boost
collagen production, which arequality animal protein, wild
caught seafood, cashews, which Ilove oats, quinoa, legumes,
griefy, griefy green leafyvegetables, bone broth, hemp and
pumpkin seeds.
I actually can't have pumpkinseeds because of my IgG, so make
(18:21):
sure that if you've had yourIgG food testing, you're
following that as well.
Number two for food is consumeat least one cup each day of
foods that reduce jointinflammation, slows cartilage
breakdown and containssulforaphane, like raw broccoli,
cabbage, mustard, bok choy,watercress, horseradish and
(18:42):
cauliflower.
Number three ensure dailyintake of at least two to three
foods that support collagen andjoints and contain vitamins C, d
and biotin Mushrooms left inthe sun to increase vitamin D
content that's something I hadnever heard Almonds, eggs, sweet
potatoes, berries, citrusfruits, mangoes and bell peppers
(19:04):
.
So those are my top three dietrecommendations for this pathway
, which I did not even knowcollagen and joints was a
pathway in your body, but itmakes a lot of sense if you know
me and my history with my body.
And then it gives threelifestyle recommendations.
Number one is improve jointhealth with a variety of
(19:24):
exercise aerobic strengthtraining, flexibility.
Increase the frequency andintensity of exercise slowly.
Number two is participate inlow impact activities such as
bicycling, walking and swimming.
Limit extensive high impacttraining, jump, rope, step
aerobics and road running.
(19:44):
Oh my gosh, if any of you guysknew me when I was running that
half marathon, this mightexplain some of that.
Number three focus onmaintaining good posture and
form when standing, sitting,bending, reaching and lifting.
Attain a healthy strength toweight ratio to prevent joint
injuries, and those of you whohave seen me sitting at a desk
(20:07):
can probably see that, yes, thisis an issue.
And then it comes down to thethree recommendations for
supplements.
And number one it says zinc,magnesium, glycinate, hydrolyzed
collagen, vitamin A and biotin,which they give dosages as well
.
But this is great because I hadalready identified this with my
(20:28):
body and have all of thesethings now and a lot of that is
in my Vicon.
And then it tells me number twoimportant for me is vitamin D3,
which, if you've ever heard metalk about it, I had a really
difficult time beforeorthomolecular supplements
getting my vitamin D over 20.
And right now it's good.
(20:48):
And then number three it saysBoswellia, serrata, curcumin and
MSM or methyl silvanomethane.
So those are my three toprecommendations for supplements.
For that collagen and jointpathway, for that collagen and
(21:10):
joint pathway.
So methylation, detoxificationand collagen and joints.
And this was just amazing.
The next part of that blueprintshows all of the gene results
and they're color coded so youcan see your protective genes.
It will have a shield there.
You can also see which ones arevery high and those are going
to be in purple.
And oh my gosh, if I look atmine that are very high impact
(21:37):
on my, on my life.
Let me tell you one, two, three, four, five, six, seven, eight,
nine, ten, eleven, twelve,thirteen, fourteen, fifteen,
sixteen, seventeen, eighteen,nineteen, twenty twenty one,
twenty two, three.
I have 25 in the in the purple7, 12, 13, 14, 15, 16, 17, 18,
19, 20, 21, 22, 23.
I have 25 in the purplecategory, so that's 25 genes
that are impacting my day-to-day.
They do place a star these arecalled your rock stars of the
(21:59):
ones that are significantlyimpact and I have four there and
the interesting thing, one ofthose are not MTHFR.
Yes, the MTHFR is on the list,but actually the top four that
are impacting me the worst arethe COMT, the GSTM1, the PEMT
(22:21):
and the TCN2.
So, even though I have MTHFRand I've kind of made
adjustments to my day based onknowing I have MTHFR, I was
close, I was doing things, but Iwas still not on the mark
because I had not done full DNAtesting.
(22:43):
The next page talks aboutpathway-based results and this
is where you see all 36 pathwaysand the ones that are in purple
are very high impact.
I have a lot.
So my high impact between thesix different systems are
methylation, detoxification,collagen and joints, hormone
(23:04):
balance.
Imagine that, because how doyou think I led to offering
hormone therapy?
I went through my own strugglesand figured it out.
Had I known this, I would haveknown that, yes, I was going to
have an issue Mood and behavior,which my husband can attest to
Exercise response, adipogenesis,vitamin B12, which I have been
(23:26):
preaching for a long time nowbut, yes, it's because I'm
genetically impacted um, cholineand folate, which goes along
with that, mthfr.
So you get a very colorfulgraph that shows you which are
high, um, and which ones aremedium and which ones are are
low, which some of these aregoing to surprise you as I keep
going on, if you're still herelistening to me.
(23:48):
So the next part which I love isit gives you kind of it's
almost like a storybook, and thestorybook gives you a very
clear cellular overview and ittalks about how we are a sum of
our cells and we are only ashealthy as they are.
So every cell in our bodyfunctions independently, but it
is connected to the whole.
(24:09):
So, like a small apartmentinside a high-rise building,
each unit takes care of its ownday-to-day maintenance but
ultimately it contributes to theoverall function of the whole
building right.
So it kind of goes through andbreaks things down in
non-medical, very colorful waysso you can see what's going on.
(24:30):
So it starts with themethylation process and mine
actually says you are not likelymethylating adequately, you
know.
It says prioritize intake of Bvitamins, choline and folate
foods such as dark leafy greens,eggs, nuts, seeds and whole
grains to support optimalmethylation.
Methylation is a biochemicalprocess involved in the
(24:50):
production, repair and behaviorof genes and metabolic processes
.
So it goes there.
It talks about inflammation.
It tells me that I'm prone tochronic inflammation, which
that's how Harmony Hub cameabout anyway, and it will even
list, when you get to a purpleone like detoxification, which
genes you have the superstars tolike.
(25:12):
This is where my com t and mygstm1 come in.
It says that my ability toneutralize and remove toxins is
likely poor, and what I love isit does tell you how to help it
under each category and alsoyour food choices.
It also tells me that myability to manage oxidative
(25:33):
stress might be less thanoptimal because of my genes, and
it tells me how to do that.
And then I love how it givesyou a picture of the human body
and it kind of goes through andshows you how your systems are
affected.
Like it says, I'm highly likelyto mood imbalances.
(25:56):
Thank you very much.
But then it tells me why andwhat I can do for it, which I've
done.
So this is why I'm always in agood mood now.
If you knew me years ago, I wasnot.
If you knew me years ago, I wasnot.
It says without the rightchoices, there's potential for
cognitive decline as I age andthat's very important because we
want to stay sharp.
So that is one of my purplepathways is memory and brain
(26:25):
health.
Histamine overload for me is apurple as well.
It says I'm prone to histamineoverload.
So this is where you want toidentify foods and environmental
triggers and prioritizehistamine degrading foods and
make sure you know that I am allgood there.
My hormone balance it says yourhormone balance is likely
impaired and it gives me somehints on how to work on that.
(26:46):
Glucose and insulin it says I'mprone to blood sugar
dysregulation.
Nobody would have thought thatI had this many issues right,
but again, that's why I'm here.
It also tells me that there's amoderate likelihood that I may
be prone to blood clots.
That's important to know.
I do have a dad that's hadmultiple blood clots.
He's on a blood thinner.
(27:06):
I always thought it was justbetween surgery or his already
bad poor health, but I'mactually genetically predisposed
to that.
Also, it says I'm prone toraise cholesterol levels.
Luckily I don't have highcholesterol.
It says I have a moderatelikelihood of blood vessel
damage.
I may experience blood pressuredysregulation and if you guys
(27:32):
knew me, after I had Ezra I wason three prescription medicines
to control my blood pressure.
It says my bone turnover islikely to be imbalanced.
So it tells me ways to helpthat.
And it says I am highlysusceptible to tissue damage,
which is that collagen andjoints.
And if you guys saw my pictureslast year when I broke my ankle
(27:52):
on both sides, you'll see that,yes, my soft tissue was
destroyed, okay, and some peoplecan fall and hurt themselves
and not have that much damageright.
Then it goes on to your energyoverview and here's some
interesting things.
One of my purples is appetite,satiety intake and it says you
(28:13):
likely feel hungry more oftenand or take longer to feel full.
People that have known mebefore my weight loss journey
will agree with you how quicklyI get hangry.
My husband can attest to that.
It does say that my fat cellsmay be prone to inflammation,
which luckily some of these arejust medium, which is the
(28:35):
pro-inflammatory fat, the energyexpenditure and the weight gain
and weight loss.
They are all just medium, butthe adipogenesis is a purple.
It says that my potential toreadily store fat is highly
elevated because I need tosupport my detox and
inflammation.
So it kind of goes all aroundso you can see what's going on
(28:59):
and this says that you know yourfat cells likely release fuel
inefficiently when exercising.
So this is why it can kind ofbreak it down to tell you so
you're doing the right exercises, so you're not hurting your
body when you're trying to dosomething like exercise.
(29:19):
So that is really nice to seeas well.
Next, the activity overview.
It talks about trainingresponse.
Again, the injury for me comesup with a little picture and it
says I'm likely prone to softtissue injuries and then tells
me how to prevent it.
Endurance is also purple for me, which surprised me.
It says I have above averageendurance potential and will
(29:42):
likely respond well to endurancetraining.
Um, not so much when I wasoverweight trying to run that
half marathon, but even forpower it was good.
It said my power capacity willlikely respond moderately to
training.
So it talks about all thedifferent.
It talks about how I recoverfrom exercise.
(30:06):
So it almost looks like astorybook as you go through and
you see all of the tips, all ofthe pictures, all of the
information on here.
It goes to nutrient overflow,which you know.
It does list my PMT SNP undercholine, because it says I do
have a significant requirementfor dietary choline, which is
(30:27):
very interesting, because when Idid add choline because it says
I do have a significantrequirement for dietary choline,
which is very interesting,because when I did add choline
to my supplements a lot ofthings changed in my body for
the better, from mood to healthand hormones.
So that is interesting.
And then it says folate.
My ability to optimize or toutilize dietary folate is highly
(30:50):
reduced and that has to do withthe MTHFR, but it gives me tips
on how to treat that.
One of the most interestingthings in my book is that it
says you have a rare chance ofdeveloping celiac disease, a gut
condition associated withexposure to gluten.
So then I almost threw this outand said well, you are wrong.
(31:11):
Three by four I have celiac.
And then I had to really sitdown and reflect and think about
like, why, why did this happen?
And then it came to me veryclear I was not born with celiac
.
I mean, it wasn't until 2012that I was diagnosed with celiac
(31:32):
and I was born in 1977.
So what it breaks down to is thedirty genes it breaks down to.
I had poor detox.
I had MTHFR.
I could not break down folicacid, which is in everything
that has gluten, and I continuedto damage myself and hurt
(31:54):
myself by eating gluten that Ihad a reaction in my small
intestine on biopsy that showedceliac, but I wasn't born with
celiac.
I had pizza, bread, baked goodsall the way until 2012, until
Ezra put that animal cracker inmy mouth and we had to call an
ambulance.
So this makes complete sensehow my DNA.
(32:16):
I wasn't meant to have celiac.
I did it to myself with astandard American diet.
And then you know B12 wasanother one with my gene TCN2,
because my ability to absorb andtransport B12 was really
reduced.
So my B12 was always in the200s and it made no sense
because I was taking a form ofB12.
(32:37):
It just happened not to be theright form for my genes.
So it also goes into vitamin D,even though it's not a purple,
it is a turquoise.
And it says that I may have ahigher requirement for vitamin D
, which, though it's not apurple, it is a turquoise.
And it says that I may have ahigher requirement for vitamin D
, which is so true.
Um, not everybody has the samerequirement, which is why not
everybody should take the samesupplementation.
(32:59):
Okay, um, let me see.
It does say for vitamin C, I donot have an increased demand,
which is good.
It does say for vitamin C, I donot have an increased demand,
which is good.
What else, then, what I like?
After it goes through all ofthose, it gives you a glossary.
So if there's anything in thesystems that you're not sure,
(33:19):
you can read more informationabout it, and it goes really
in-depth, it doesn't leave anystone unturned.
And then, after that, it givesyou a list of your genes by each
pathway.
So mine is the methylation, thedetoxification, inflammation,
oxidative stress, collagen andjoints, hormone balance, mood
(33:43):
and behavior, glucose andinsulin, bone health, memory,
brain health, histamine,overload, blood pressure,
cholesterol, vascular health,blood clotting, exercise
response, adipogenesis andappetite, satiety and intake,
pro-inflammatory fat, energyexpenditure and weight gain and
(34:05):
weight loss resistance.
So those are all the 36pathways and it shows you all of
your genes, all of the impactsand your superstars.
Okay, what else Isn't thatexciting?
So the next time you look atsomeone else's health journey,
remember comparison is the rootof all evil.
(34:25):
Your body deserves its ownunique, tailored path to
wellness.
By understanding your geneticmakeup through 3x4 genetics
testing, we can help craft apersonalized approach that is
much more effective thanfollowing a generic plan that
everybody's doing the same thing.
So genetic testing through 3x4genetics can provide you insight
(34:46):
that you need to finally takecontrol of your health.
You can understand your DNAresults and use them to optimize
your well-being in the mostindividualized way possible.
If you're ready to take thenext step in personalized health
care, you're going to want tobook your functional medicine
consultation today and learnmore about the 3x4 genetics and
(35:06):
how it can transform your healthjourney.
If you do book a functionalmedicine consultation, we can
talk about the 3x4 genetics testor anything that you would like
to optimize your health, andyou can find me at
wwwharmonyhubhealthcom.
(35:29):
You can email me at michellewith one L M-I-C-H-E-L-E at
harmonyhubhealthcom.
If you don't want to be seenvirtually, you can come see me
in person at Monarch Beauty andSpa in Manchester, maryland, and
I would love to have thispersonalized blueprint done for
you.
The information shared intoday's episode about three by
(35:52):
four genetics and DNA testing isintended for educational
purposes only.
While genetic testing canprovide valuable insights into
your health, it is not asubstitute for medical advice,
diagnosis or treatment.
Always consult with a qualifiedhealthcare provider before
making any changes to yourhealth regimen based on genetic
test results.
The recommendations providedthrough genetic testing are
(36:15):
individualized but should beviewed as part of a
comprehensive health plan.
Thank you for listening andhere's to your best health Music
.
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