December 16, 2024 • 49 mins
Transform your understanding of amino acids with insights from Dr. Joel Bryn, a leading expert in biochemistry, physiology, and immunology. Discover the surprising impact that dietary choices on amino acids like methionine and glycine can have on longevity. Dr. Bryn shares groundbreaking research from the Orentreich Foundation, suggesting that a reduction in methionine intake and an increase in glycine might hold the key to a longer life. Prepare to challenge your preconceptions about what makes an amino acid "essential" as we uncover the significant health benefits of glycine.
The episode takes a closer look at the often misunderstood term "non-essential" in the context of amino acids. Learn how glycine, despite being classified as non-essential, plays a vital role in managing inflammation and preventing chronic diseases like cancer, autism, and cardiovascular issues. Through Dr. Bryn's analysis, we explore how glycine deficiency impacts our health, particularly in younger generations, shedding light on modern health challenges. With analogies that simplify complex processes, this discussion reveals why rethinking our protein sources could be crucial for our well-being.
The conversation with Dr. Bryn also navigates the historical and modern dietary landscape, emphasizing the importance of collagen-rich animal products to boost glycine intake. These age-old dietary habits might just be the key to combating the chronic inflammation pervasive in today's society. As we close out the episode, we reflect on how a balanced approach, centering on evidence-based nutrition, can lead to improved health outcomes. Tune in for a compelling narrative that intertwines scientific rigor with practical dietary advice, promising to reshape your view on nutrition and longevity.
Learn More at: www.Redefine-Fitness.com
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Transcript
Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
Speaker 1 (00:11):
Hello and welcome to the Hedonist Ministry Defined.
I'm your host, anthony Amen,and we got another great episode
for all of you.
Happy, happy, happy December.
Christmas is right around thecorner, I hope are already got
all the gifts purchased done.
We, luckily enough, did itprior my I say we.
I take that back.
(00:31):
My wife did it prior to givingbirth.
It took care of all the kidsand stuff getting getting ready
for him to be here.
So make our lives a littleeasier.
But enough about that.
Let's stop with today's show.
That further do is welcome DrJoel Bryant.
Dr Joel, it's a pleasure tohave you on today.
Oh, it's stop in today's showthat further ado.
Let's welcome dr joel bryant.
Dr joel, it's a pleasure tohave you on today oh, it's fine.
Oh, it's bryn, by the way, yeahwell, you know the spelling
(00:52):
doesn't tell you it could beeither way, so I have to tell
you right, it's like starbuckswhen you come on this show, you
never know how I'm going tospell or say your name.
Speaker 2 (00:59):
So well, it's like if you see the word wind, you
don't know if it's wind or wind.
You have to tell by the context.
Speaker 1 (01:06):
And for a name you have.
You know, the guy with the namehas to tell you.
Speaker 2 (01:09):
And I neglected to do that, so I apologize.
It's all good.
Speaker 1 (01:14):
Before we get into today's topic, tell us a little
bit about your background andhow you got into the health
fitness realm.
Speaker 2 (01:21):
Oh well, I've been a scientist all my life.
Really, I decided I wanted tocure cancer and stuff.
You know, be a medicalscientist when I was about 10
years old and uh, just, uh.
So one of those life magazinearticles about you know
scientists working on cancercures and using electron
(01:43):
microscopes uh, while I waswaiting for a haircut in Tom's
Barbershop on 227th Street andMerrick Road in Long Island, in.
Queens, and that was 1961.
That's what I decided I wantedto do and you know.
So 10 years later I had mybachelor's degree and 10 years
after that I had my PhD in basicmedical science from NYU, and
(02:09):
that's in biochemistry,physiology and immunology.
And then I was a benchscientist for a number of years
exclusively, and then, 1986, Igot a faculty position at Baruch
College, city University of NewYork, and I taught
endocrinology there for over 30years that's the science of
hormones and continued doingresearch.
(02:31):
And on about it was about 2007,I was working with a foundation
in the Hudson Valley foundationin the Hudson Valley, which is
actually where I had moved to bythen, and the the group that I
was working with.
It's called the OrantrikeFoundation and they had they had
(02:52):
discovered that if you take mythey were working on aging
mainly and they discovered thatif you take rats that had been
that were fed a diet almostdeficient in methionine, which
is an essential amino acid,that's what you need for all
your methylation.
Lots of people thinking canceris responsible for not having
(03:14):
enough methionine and so forth,but actually they found that if
animals were almost starved ofmethionine like 80 less of it
than is in the normal diet theyactually lived about 30 or 40%
longer, even though they didn'tgrow to normal size.
And that was repeated a numberof times and other groups had
repeated it in rats and in miceand nobody knew why.
(03:37):
So as a consultant then forthis foundation, where I had
worked full time years before,they wanted me to try and figure
out why that was.
When I found it they didn'treally believe it.
That's their problem.
But what I discovered was thatglycine is really the key, and
(04:03):
I'll tell you what glycine is an?
amino acid which is generallyconsidered non-essential, and
the reason I came upon glycinewas that we were looking at why
does having a normal amount, arelatively high amount, of
methionine in your diet make youlive less long than if you have
less methionine.
You live less long than if youhave less methionine.
(04:28):
So others had discovered bythis time and published the fact
that glycine is the amino acidthat actually is used by the
body to get rid of excessmethionine when we have too much
, and so in fact, we do have toomuch.
Your body's really designed forfamine, not feast, so you know
like we get too much sugar andso forth.
You know it's difficult to getrid of and that's why we have
(04:49):
you know, so much problem withthat and so much extra sugar,
but also extra protein.
Right, we eat, you know, lotsand lots of meat, fish and
poultry.
A lot more than our ancestorsdid or than the rest of the
world does, even today.
You know, in a lot of parts ofthe world, you know, you eat
meat once every couple of monthswhen the neighbor's goat dies,
(05:09):
right, and everybody has a feastand that's about it.
Till you know, it's beans andrice and all in the interim.
But uh glycine is a way to.
Uh is used by the liver as away to get rid of excess
methionine.
Now what's interesting is thatwe tried, and so I proposed an
experiment to feed glycine as asupplement to try and accelerate
(05:34):
the disposal of methionine.
Speaker 1 (05:36):
And it turns out it doesn't accelerate the disposal
of methionine.
Speaker 2 (05:39):
It doesn't have any effect on the levels of
methionine in the body, but theanimals did live significantly
longer anyway.
So something else was going on.
And it turns out what else wasgoing on and the reason that
methionine is important in thisregard is that because
methionine uses glycine to get,because the liver uses glycine
(06:02):
to get rid of excess methionine,because the liver uses glycine
to get rid of excess methionine,it uses up glycine and glycine
is in fact, not non-essential,it's really essential.
It's non-essential, they callit, because your body can make
it from simpler compounds, whichit can, and you also have as
much as you need to makeproteins with glycine as you can
(06:25):
with a normal diet, or yourbody can make enough glycine to
make all the protein.
Thing is, glycine has anotherrole in the body and it's the
main regulator of inflammation.
As the free amino acid, kind oflike a salt, like the cells of
the body need to be bathed in ahigh concentration of glycine,
(06:46):
otherwise they arehypersensitive to being
activated and in particular,it's the cells of the immune
system called macrophages, whichare the cells that actually do
inflammation.
So everybody knows you can lookit up in Wikipedia or anywhere
else, that inflammation is theimmune system's first response
to infection or injury.
That is what I discovered to bea half-truth.
(07:08):
It is not a natural response toinjury, it only hurts.
It only injures normal tissue.
So if you get a sports injury,what's the first thing you do?
Right, you put ice on it.
What's the purpose of puttingice on it?
To suppress inflammation.
Well, that leads to anotherinteresting question, which is
why is the body doinginflammation if it's only going
(07:30):
to do more harm?
The answer is it has anutritional deficiency, there's
not enough glycine, and noweverybody realizes that almost
everything that makes peoplesick and die these days
arthritis, cardiovasculardisease, cancer, even autism and
other diseases are reallyrooted in chronic inflammation
(07:52):
and science doesn't know why.
And that's what I reallydiscovered, is I discovered why,
is that most people are glycinedeficient.
We think inflammation ishappening normally in response
to injury, because it almostalways happens.
It does almost happen toeverybody almost, and it used to
happen to me.
So the thing is, I was doing anexperiment in by 2008, 2007,
(08:18):
2008, 2009,.
I was experimenting withglycine and, starting in 2008, I
started taking 10 grams a dayof glycine Because it's you know
, it has a sweet taste.
You can easily formulate itwith other things to make it
taste more like sugar, get ridof the aftertaste.
Pretty easy to take 10 grams aday of glycine.
And so I started doing that andI did it for a month after
(08:40):
month, even for a couple ofyears, and then in 2010, you'll
like this story mybrother-in-law had scored us
tickets to a Yankee game at thenew Yankee stadium.
It was only built in 2009,right, so I had not been there
yet.
So he got us tickets you know afew rows behind the Yankee
dugout and I was all excited.
I never wear a hat, but I had aYankee t-shirt and a pair of
(09:01):
shorts and was great.
And it was also around the 10thof June and it was also a
cloudless day, sunny day, andthe brand new stadium had no
obstruction, so there was noshade and because I wasn't going
to the beach, it didn't occurto me to put on sunscreen.
I used to get very bad sunburnswhen I was in my teens, and
(09:22):
maybe when my early 20s, youknow and learned enough to go
with sunscreen and sunblock andlimit my time in the sun and
wear a shirt most of the time,all of that sort of thing.
But what happened was I was sointerested in the game that
around the fifth inning Istarted to feel a little warm on
my thighs.
I looked down and from mythighs right at the hemline of
(09:42):
my shorts, to my socks and my,my arms, you know, uh and my
neck and my face, everywherethat was exposed to the sun, it
was boiled lobster time and Ihad not done this to myself
since I was at least in my early20s and I was sure I was
certain that I was going to be,uh, in excruciating pain really,
(10:05):
for the next day or two atleast dressing, undressing,
bathing, doing all of thosethings.
Well, the first thing I did is I, you know, I got out of the sun
, I went into some seats thatwere in the shade.
By the time it was lateafternoon and then I just sort
of forgot about it, keptwatching the game.
But the funny thing is, by thetime I left the game it didn't
really bother me.
(10:25):
It had actually started to fadeand the next day I felt fine I
mean fine, it had faded most ofthe way.
Maybe I got a little bit ofcolor, a little tan out of it.
But nothing like I had alwaysexperienced, in which I was sure
was going to happen again.
But that wasn't enough for me,even though I knew I was
(10:46):
experimenting with glycine andeven though I had worked at NYU
in the dermatology departmentwhere I did my PhD thesis.
So I knew something aboutsunburn really being
inflammation in response to sundamage rather than directly sun
damage.
So we were actually at the timemy wife and I were preparing
the house for an influx ofrelatives because our daughter
(11:08):
was getting married, so we werehaving relatives stay over and I
had to finish a project I wasdoing in the basement I was
putting in a bathroom, and so Ineeded a few pieces of sheetrock
which don't fit in the car.
So I would go and cut them inthe store.
You know I'd go up and get onthe top of sheetrock which is
about four feet high, sitting ona concrete floor in the store.
(11:31):
Go up, measure it, cut it, handthe pieces down to my wife,
jump down, you know, get them onthe on the cart and you know,
jump up and do the the othercuts and for some reason I
must've been distracted and Istepped the wrong way and I went
right down to the floor, fourfeet onto a concrete floor,
directly on my tailbone, and ithurt like hell for about 30
(11:53):
seconds I suppose, and you knowit was still hurting, but I
managed to hobble around, finishwhat I was doing.
That night we had tickets to adinner dance.
We figured well, we'll goanyway.
And then, while we were there,we figured well, I'll try a
dance or two anyway.
And guess what, it didn'tbother me and the next day I
felt absolutely normal and theonly evidence was a huge bruise
on my lower back.
(12:16):
So this was an experiment I wasconducting and when the results
are that clear, you can't denyit here.
I was expecting inflammation,sunburn, blunt injury.
Yes, of course you getinflammation.
Nope, not a hint of it.
So this is what led me on thepath of doing some more research
(12:36):
, not just in the aging field,did more research and published
it on glycine, extending thelife of rats.
And then, uh, worked with thenational institute of aging, one
of the nih institutes, and weshowed that glycine also
significantly extended thelifespan of mice.
And uh, this is uh, you knowthat's so.
(13:00):
That's part of the aging partof it.
As far as the inflammation partof it is concerned, most it's
basically going to theliterature and seeing what other
people have discovered aboutglycine, and it's just not tends
not to be put together becauseof these certain ideas.
You know, when you say that anamino acid part of the diet is
(13:21):
non-essential, who's going tostudy it?
Right?
Who's going to give you grantmoney to study?
It's non-essential, you don'tneed it, and we all found that
out during covid, didn't we?
It's the word non-essential istoxic.
Your job's non-essential.
Too bad, you're gone right.
So, um, that's so that's theproblem with it's it's the word
(13:42):
non-essential, and it's also theidea of inflammation and the
fact that it usually, or almostuniversally, is experienced as a
response to blunt injury.
But it's also understanding thecell biology of it, and that is
that the cells that doinflammation are yes, indeed,
(14:03):
they are the immune system'sfirst responders.
Well, so what's a firstresponder?
It's like a cop, right?
So if you go out on the highwayand there's an accident on the
highway, so what happens?
So the cops come, right, statetroopers come, state troopers
come, and they'll come, andthey'll have their lights
(14:25):
flashing in there, you know, andthey'll be rerouting traffic,
blocking up a lane so that thetow trucks could come.
And they call the tow trucks,they call the ambulances, they
take the accident reports andthen, when they're done, they go
back to their base and, youknow, then normal function is
restored on the highway.
Well, they're first responders,right.
(14:45):
So they got loaded weapons intheir holsters too.
They don't use them.
If there's an accident on thehighway, they wouldn't think of
drawing their guns and shootingthe place up, but they can, and
they, because if there's a badactor present that needs to be
eliminated, a threat that needsto be eliminated, they can do it
.
Well, so the first respondercells, these macrophages, have
(15:05):
the same dual functionality.
They can be activated to bejust in clean up the mess mode,
which is called M2.
Now it's understood.
It's given a name M2, versus M1, which is where they are
activated to produceinflammation, to start secreting
poisons that can destroy tissue, because it's there to destroy
(15:26):
microbes that might have gottenin during an infection of some
kind and kill them before itkills you.
Kill the infection before theinfection kills you, and that's
a whole different thing.
But because we're deficient inglycine, most of us, this is
what happens in the body all thetime You're inside your
(15:49):
arteries, inside your brain,inside all your other organs.
When there is normal injury,even if you don't experience it
as injury, it's tissue or cellsdying.
This happens normally.
So, for example, when yourblood is circulating, especially
at high pressure branch points,your coronary arteries, your
(16:09):
carotid arteries, right whenthere's excess pressure, you get
turbulence.
If there is inflammation inresponse, you eventually get
damage which can lead to a heartattack or a stroke or kidney
failure at these high pressurebranch points, because the micro
(16:29):
injuries are responded to withan inflammatory response rather
than a just clean up the messand repair it response.
And so we have now in oursociety when.
So why is it worse now?
Why even are the?
Are the people in yourgeneration more prone to getting
(16:49):
cancer.
Colon cancer is now more commonin your generation.
Autism is off the charts.
Uh, what's going on?
Why are all these seeminglyunrelated diseases?
Why do they seem to have to dowith inflammation?
What, what's going on?
And that's because there isnormally cellular injury and
cellular death involved in theseconditions, or involved in
(17:12):
normal conditions which willlead to inflammation if glycine
is deficient.
So, for example, I said autism.
I published a letter about thisin the British Medical Journal
about five years ago.
I published a letter about thisin the British Medical Journal
about five years ago.
Autism has to do with braindevelopment and the way brain
develops, just like the wayother organs develop, is the
(17:32):
brain grows.
You get a solid mass of cellsand then it is sculpted, All of
the cells in between, thoselittle creases and convolutions
that had cells in them.
Those cells die off and it'sperfectly normal for the cells
to die off.
But if you're glycine, deficientyou get inflammation in the
brain, starting even in uteroand by the time the child is
(17:55):
born they have autism spectrumdisorder.
And you keep gettinginflammation in the brain all
through brain development, whichgoes in through your mid-20s,
all through brain development,which goes in through your
mid-20s.
If you talk about cancer ofvarious kinds, it's been known
for decades that the incidence,for example, of ovarian cancer,
(18:18):
cancer of the ovary, is directlyproportional to how many times
in her life a woman ovulates.
Why should that be?
Because ovulation is a violentprocess.
Why should that be?
Because ovulation is a violentprocess?
The egg is actually shot out ofa cannon almost, or like out of
a volcano, when, uh when,ovulation takes place, and it
does damage to the ovary.
Well, once every other month toeach ovary, no big deal, it just
heals, unless you're glycinedeficient, and then you end up
(18:41):
with chronic inflammation,breast cancer.
The breasts grow every month ofa normal menstrual cycle.
In the third week, the breastsnaturally grow because of
estrogen and progesterone, thehormones that are there to start
preparing the breasts for thebig growth that they're going to
need to be able to feed a babywhen the baby's born.
(19:01):
A baby when the baby's born.
But suppose there is no baby,suppose it's a non-conceptive
cycle, which these days is mostof the time, for most women are
non-conceptive cycles.
So that means all those extracells that are built up during
the cycle they end up having todie off.
No problem, perfectly normal,unless you're glycine deficient
(19:23):
and then you get a chroniclow-grade inflammation what do
you know?
year after month after month,year after year, even decade
after decade of this and you endup with uh, with breast cancer,
and it's, it's it, and youcould see the difference.
For example, in ovarian cancer,that's lower if you uh ov less.
(19:44):
So if you have kids and youbreastfeed them, you're going to
ovulate less.
But also birth control pills,right, they suppress ovulation.
So guess what?
Women who take birth controls,they have a lower risk of
ovarian cancer.
But because they have estrogenand progesterone in them, like
the normal hormones, and youtake those more days a month
than they would normally beoperating in a normal
(20:07):
non-pregnant cycle, you end upwith more growth stimulation,
more cells have to die off, andtaking birth control pills
increases the risk of breastcancer, even as it decreases the
risk of ovarian cancer.
These are all tied to events ofmassive cell death.
To events of massive cell death, which are perfectly normal,
(20:29):
but in the context of a glycinedeficiency, they produce chronic
inflammation.
Why is it worse now, though,than it was for our forebears?
You know, I didn't reallyanswer that question, and the
reason is that our dietaryhabits have changed, so our four
.
Speaker 1 (20:44):
I want to I want to hop in here, dr joel, because
there's a lot to unpack ofeverything you were going
through and I think it'simportant to really first
clarify some things and then,okay, go into a little further.
So, first being said, there arejust basics for people that
don't know.
You mentioned non-essentialamino acids.
Basically, that means it'samino acids that our bodies
(21:06):
naturally produce, as opposed tothose we have to get from food.
Scientific, what we have to getis essential right.
Correct.
So, going into your argumentabout glycine and how people
deem it non-essential, meaningyou don't need to supplement it,
let's do an easier one, which Ithink is arginine and, coming
(21:28):
from the fitness community,arginine has been shown to be
beneficial to help havevasodilation and increase your
workout capacity in an anaerobicstate.
So, while weightlifting orsupplementing with arginine has
been shown to be beneficial,deemed non-essential but taking
higher quantities of E has beenshown to help.
(21:49):
Yes, because that's nitricoxide.
Speaker 2 (21:52):
That's the nitric oxide story, which causes
vasodilation.
Speaker 1 (21:56):
Your body makes nitric oxide from arginine, so
that's what that's going to beAlso to my favorite one, which
isn't an amino acid, but youtalk about something your body
naturally produces, that'screatine.
And, as I mentioned time andtime before, we do not produce
enough creatine naturally in ourbodies to have the benefits of
(22:19):
it, as we're now showing.
Decreasing the risk ofdepression, decreasing the risk
of anxiety have the benefits ofit, as we're now showing.
Decreasing the risk ofdepression, decreasing the risk
of anxiety, uh, decreasing therisk of dementia.
They're not putting a lot ofresearch into on it, uh, it also
increases your anaerobiccapacity in the gym, helps
increase, uh, promote muscletissue repair, something else we
should be supplementing withthat we're not, because we
(22:41):
produce it naturally right, I'mgoing to take this together for
you well, because you produce itnaturally.
Speaker 2 (22:48):
You do produce it naturally from glycine so
sleeping also increases yourproduction of creatine.
So that's?
Speaker 1 (22:57):
yeah, I think it's.
I think it's related, and youmentioned, uh, about our dietary
habits a little bit ago and Iwant to talk about that because
I think this is probably themost talked about topic and most
comfort.
Like people just don't agreeabout dietary habits and I've
talked about my viewpoint a lotand I want to approach it
(23:20):
directly to you.
You mentioned back when we werehunting gathering.
I disagree in the sense that weonly had, like your goat
example, once in a while and wemainly had rice and beans.
Oh, because if you go backprior to even us having towns or
all coming together ascommunity, that's all we did was
(23:42):
animal products and I think alot of our issues stemmed in
with, like we're talking about abody's information spots, even
into your argument with glycineand not getting enough of it
right.
We actually should be eatingmore animal products than we
consume and less of everythingelse.
For example, all of these thingswe mentioned come from red meat
(24:04):
all of it right, and we justtend to go strictly straight for
cow, which is a lot fattier,especially the way we raise the
cows and purposely, like wagyu,make them extremely fatty and
which can produce a lot morefree radicals in the meat and
cause health issues, as opposedto eating what we call gamier
(24:28):
meat, which is way leaner and itcontains a lot of these EAAs
and non-essential amino acids.
It contains the extra creatineswe need.
It contains the proteins weneed, which, in turn, would help
us recover faster, put moreoutput into what we needed to go
get food for our families.
Speaker 2 (24:53):
And I think that's really the disconnect that we
may not disagree where you think.
So I was getting to the pointwhere the problem is not that
we're eating more meat thesedays.
The problem is that we'reeating more muscle meat these
days and, as you said, themuscle meat is compromised and
(25:15):
we throw the bones into thetrash instead of the soup.
See, when they talk about itnot being as healthy, they say
oh, vegans, they live longerthan meat eaters.
They have, you know, they haveless chronic disease like cancer
and so on, than meat eaters do.
So you should all be vegans,and I say not so fast.
There was actually a veryinteresting study that proved my
(25:37):
hypothesis on this, and thatwas.
That was back in 2015, not toolong ago, and I had been saying
listen, the trouble is that meateaters, or omnivores, end up
with less glycine in their bloodthan than vegans have, even
though the meat eaters eat moreof all the amino acids, and that
(26:00):
was actually approved by agroup at Oxford in 2015, where
they took 100 meat eaters eatmore of all the amino acids, and
that was actually approved by agroup at Oxford in 2015, where
they took 100 meat eaters and100 fish eaters and 100 lacto
vegetarians and 100 vegans andthey looked at all the amino
acids in their blood and theylooked at all the amino acids in
their diet to see how itcorrelated.
They really didn't have ahypothesis, they just wanted to
see the correlations, one ofthese so-called database studies
(26:23):
, which is not really goodscience, but it's really a lot
of what passes for science thesedays.
so then they they found that thevegans had the most uh glycine
in their blood and the meateaters, who ate the most glycine
, had the least glycine in theirblood and they couldn't figure
it out, and it goes back tohaving more of that muscle meat,
(26:48):
which actually helps to get ridof glycine, which you don't
want to do.
But, that's because most of theglycine is in the collagen, and
the collagen is in the bones andin the connective tissue and
also in the wild game in themuscles.
The muscles are more sinewy,the meat is tougher.
There's more collagen in it, sothe muscle meat is not only
(27:11):
glycine deficient, but it'sparticularly glycine deficient,
or glycine poor that's the wordyou use for the food stuff.
That muscle meat is moreglycine poor than it used to be.
We're also eating more of thatglycine poor meat.
We're throwing most of theglycine in the trash instead of
the soup.
Right, we're doing that, and youput all those things together
(27:35):
and you end up with less glycinein the blood of people in this
generation than in previousgenerations, with less glycine
in the blood of people in thisgeneration than in previous
generations.
So there is a balance there andI do not disagree with you that
animal products, the problemwith research that has been done
and anybody that can listen toAnthony Amen and say, oh well,
he says, eat a lot of meat.
(27:56):
But I've read all this researchhas shown for 50 years the meat
eaters, they don't live as long, they get more cancer.
That you know, and all of thatis true.
But it's because of theincomplete protein.
It's the fact that glycinereally is efficient and you're
throwing so much of the glycineaway and you really need to.
(28:21):
So the idea that it's meatprotein is bad for you and
vegetable protein is good foryou is based on bad science,
which, when it says the animalprotein is causing chronic
disease, it's not completeprotein.
You're not eating the wholeanimal.
Speaker 1 (28:47):
So there aren't any bone broth enthusiasts who are
really glycine deficient.
You know, if you talk about thephenomenal.
Speaker 2 (28:51):
What's that?
Yes, you gotta eat, not justthe muscle, you know that.
So that's that's what I wouldsay, especially as you say now
the meats that are available areworse than a generation or two
ago, when, when, or you knowwild meats, if you, if you hunt
you and you, you know you havevenison, you know stuff that
you've gotten from wild game orbirds, or fish or that, all of
(29:13):
that If you actually eat themeat that has more glycine in it
, it's not as bad.
But you still need to have moreglycine from the you know bones
in the connective tissue.
And if you don't do that,that's what that's what my
product is about.
That's what sweetamine does.
It gives you, it gives you theglycine.
(29:34):
You can just take it straightas a, as a simple amino acid,
because it it, you know it'sformulated as a sweetener, it's
very easy to take and whatscience tells us really is that
it's the glycine that's theimportant component.
There are other people who sayoh yes there's so many collagen
peptides and you kind of take atype two or a type three and not
(29:56):
a this type or that type and nocollagen peptides or gelatin.
You know, any formulation ofthose things is fine as a source
of glycine.
It's got about 25 percentglycine by weight and uh, it's,
it's a very good source ofglycine.
It doesn't really matter whatit is.
Some people say, oh it's, yougot to take glycine with
(30:18):
n-acetylcysteine and it's thecombination no it's not the
combination, and science tellsus that, because when that one
component is enough to accountfor all of the benefits, you
know, that's what it's doing.
That's the principle of Occam'srazor, which is one of the
scientific principles that tendsto be forgotten these days,
(30:39):
unfortunately, by scientists.
Speaker 1 (30:40):
Crazy.
I talk about that all the timeand you're absolutely right, I
mean, this is, you know the.
I don't even think people knowwhat that expression means.
Speaker 2 (30:51):
Yes, well, it was coined by John of Ockham in, I
don't know, the 12th century orsomething like that, which is
basically, if you have, when youhave a scientific question, you
ask a question.
That which is basically, if youhave, when you you have a
scientific question, you ask aquestion, the answer, what
appears as a hypothetical answer, is your hypothesis.
That's what you want to testexperimentally.
(31:12):
And so the the Occam's razorsays that the simplest
hypothesis is is is probably theright one.
You know, you, you don't, youhave, you have to eliminate, you
don't.
So some people have said to me,for example oh, glycine for all
these conditions.
Nah, it can't be that simple.
You even read scientific papers.
Oh, no, it's very complex, it'ssuch a complex symptomatology,
(31:35):
we need customized medicine, andyou need.
You know.
You need one medicine forpsoriatic arthritis and another
one for Crohn's disease andanother one for, you know,
irritable bowel syndrome andanother one for arthritis.
No, it's a common denominator,you know it's all chronic
inflammation.
So why shouldn't it be a simplething?
You don't when you have ahypothesis that you're testing
(31:56):
scientifically.
You don't reject a hypothesisbecause it's too simple.
You reject a hypothesis becauseit's too simple.
You reject a hypothesis becauseit's too complicated.
When Ptolemy, back in the oldEgyptian and Greek times,
hypothesized and this was viewedas dogma for some centuries
that the planets and the sun allrevolved around the earth in
complex epicycles and the Sunall revolved around the Earth in
(32:19):
complex epicycles.
And then along came Copernicus,you know, who said it makes
more sense for all the planets,and the Earth as one of them, to
revolve in simple ellipticalorbits around the Sun.
So we threw away thecomplicated epicycles of Ptolemy
Because it was too complicated.
Now we all know the planets,you know orbit around the sun.
Speaker 1 (32:42):
Well, after he was told he was wrong, Well, yeah, I
mean, but Locked up.
Speaker 2 (32:50):
Yeah Well, this happens all the time, though
with you know, I mean Copernicus, and then, of course, galileo
was locked up for echoing andusing a telescope and
calculations there to confirmCopernican theory.
You know the church locked himup and all that kind of thing,
so but I don't really.
(33:11):
I mean you and I both rely onevidence.
You know scientificallyverifiable evidence and when we
actually hash it out here youknow there's really not any
disagreement.
It's just a matter of gettinggetting to the fine points.
You know a lot of peoplethey'll just look at oh say oh
17 studies say this and only twostudies say that.
(33:34):
So this must be correct, andthey don't.
They have no way of evaluatingwhether science is good or not,
and a lot of it isn't.
Speaker 1 (33:41):
Well, I said it all the time p values.
Uh, oh sorry, n values twopeople in it.
Speaker 2 (33:47):
You can't take a study with two people, well you
know you can take a study withone actually, and that is you
know, you before and after, youknow and you can.
You can repeat it x number oftimes.
I mean, that's what I did.
Self-experimentation, if youlook back, is what people like
Pasteur did and other scientistsdid.
They would test it onthemselves, because then you
(34:09):
have a before and an after andso on.
Two people, if they'reidentical twins is a great end
for a study like that, becausethey're identical in every other
aspect.
But you're right when you wantto confirm it.
You know we do hundreds of mice, hundreds of rats, hundreds of
people, and there have been some.
(34:32):
That's what a clinical trialright, a placebo controlled
clinical trial is always lookingfor, you know, looking to
emulate a controlled experiment.
It's as close as you can get toa controlled experiment using
people, so it's ethical.
And there was actually done, atleast one or more, I think, on
(34:54):
diabetes.
It was one that was publishedas early as 2008, where they
took a bunch of diabetic peoplein Mexico, mexico City.
There's a lot of research ondiabetes in Mexico because that
population is particularly,particularly strongly prone to
get diabetes, especially PimaIndians, you know, people of
Mexican Native American origin.
(35:14):
So a lot of research ondiabetes.
So they had these, they haddiabetics, they took I think it
was only 37 people, half men andhalf women, roughly um, who uh
were given 15 grams of glycineevery day.
You know, uh, that's about two,two packets of sweet amines
worth and you know they werelike most people with diabetes.
(35:37):
They were moder, were mild tomoderately overweight, and they
were to make it an ethical trial.
You can't say, okay, stop yourdiabetes medication while we do
this trial for three months,that's not ethical either
because they need the medicationto keep their sugar in control.
So, even though they were stilltaking the medication, the A1C,
(36:01):
for example, was reduced from anaverage of 8.3 to an average of
6.9, right down to the bottomof the diabetic range even
though they were still takingthe medication and even though
they didn't lose any weight.
Because if you're 20 or 30pounds overweight and you have
diabetes, if you lose that 20,30 pounds, the diabetes will go
(36:22):
away.
But so they they here.
The diabetes went away evenwithout losing the weight.
So you could see it was not.
It's because it's not the fattissue itself, it's the
macrophages, the inflammatorycells that are embedded in the
fat, that caused the trouble.
So if you lose, all that weightyeah it'll go away because those
macrophages are not thereeither.
(36:44):
So the thing that's reallyamazing about the science is
once you it's like doing ajigsaw puzzle you find this sort
of central piece to the picture.
All of a sudden you seesomething like it's a
recognizable object in thepicture, all of a sudden, all
the other pieces in the puzzle.
You couldn't figure out wherethey went.
(37:05):
They all make sense.
So it was kind of like that.
And I've been a scientist all mylife really, I mean, as I told
you earlier, and so I've neverhad such clear, dramatic results
from my ownself-experimentation, from the
experimentation we were doingwith rodents in the laboratory,
(37:26):
such clear, dramatic resultsfrom my own self-experimentation
, from the experimentation wewere doing with rodents in the
laboratory, from all theresearch that's been published
in all kinds of disciplines.
And unfortunately, in scienceit's not so much the end, as you
say, which is a problem in alot of research, but it's also
the way the experiment is set up, but also the hypothesis
Everybody says show me the data.
(37:46):
Right, that's science, show methe data.
The data is the last thing youdo.
The good part about science, orthe important parts about
science are, in the beginning,mainly asking the right
questions and then setting up anexperiment that can actually
test the hypothesis andrejecting a hypothesis that's
either too complicated orunnecessary.
(38:08):
So this happens all the time isthat now everybody thinks it's
the data.
The reason for that is now youcan gather immense amounts of
data.
You can take a drop of blood,stick it in a machine and
analyze 300 or 400 differentmetabolites, 300 or 400
different gene products, mrna,all of that stuff.
(38:30):
So there's an explosion ofpapers being published.
Oh, yes, we did diabeticsversus non-diabetics or we did
prostate cancer versusnon-cancer or we did whatever.
We're studying the experimentalgroup and the control group.
And yes, there was asignificant difference in
methionine or a significantdifference in some marker,
(38:52):
creatine, or a significantdifference in something.
And then, now that the computerhas identified a difference
between the experimental groupand the controls, then they try
to speculate as to why thatmight be based on what else is
known.
So they're basically shootingin the dark.
Instead of starting with ahypothesis, they're just
collecting data.
(39:12):
Now, in the old days and I'm anold guy, an old scientist, so
the old days for me, I'm talking1970s and 80s- Okay so 40, 50
years ago you couldn't do that.
If you wanted to do that and say, wow, you know, there probably
is a difference in the aminoacid combination.
So wait a minute, we're notgoing to do amino acid analysis
on all that.
Speaker 1 (39:32):
We don't have the money.
Speaker 2 (39:34):
Nobody's going to give us the money to check
everything that's called.
That would be a study in whatthey call now today's
metabolomics or genomics orlipomics.
All these omics disciplines aredisciplines or really
methodologies that can measuresimultaneously hundreds of
different substances.
And they wouldn't do it inthose days.
(39:55):
Nobody would ever give you anymoney to do research like that,
because they called it a fishingexpedition.
That's what it is.
So now probably most sciencethat's done is fishing
expeditions, because becausethey got these trawling nets,
they can haul up so many fishand and then they look at them
and figure, oh, how come we havemore mackerels than we have, uh
(40:17):
, tuna fish, you know, andfigure it out that way.
But that's, that's not reallygood science.
Good science is what they havecalled now hypothesis based
science.
In the old days that was calledscience and now they're.
Now it's all.
As you see, show me the dataand you know the data may
(40:38):
corroborate what your hypothesisis, but it might not be valid.
You know, yes, it's not as goodto be a meat eater as it is to
be a vegan if you want to livelonger and not get cancer
because the animal protein.
Wait a minute you didn't look atall the animal protein because
you threw the bones in the trashand not in the soup.
So it's, all of these thingsare important to consider and
(41:01):
that's you know.
If you're an old schoolscientist, you look at these
things instead of just acceptingthe fact that, oh, such and
such a study from such and suchan institute found ABC and they
must be right because they havea high impact journal and a
famous institution and thescientist is well known and you
know and all and that's you know.
(41:23):
Unfortunately, most people, ifyou're not a science, a
scientist, you're not, you'renot really trained to look at
all this stuff.
You know to look at ascientific study, you know and
just.
But you can, if you are.
You know it's like anythingelse.
If you are trained to look atit, like when you're trained to
(41:44):
look at anything else, you cansee the flaws, like a, you know,
like a jeweler who you knowknows diamonds.
He can look at a diamond andsee the flaws in it and tell at
a glance if it's a real one or alaboratory created one, or if
it's got a lot of flaws ordefects in it.
Everybody else, oh, it's adiamond, you know.
Or if it's got a lot of flawsor defects in it.
Everybody, oh, it's a diamond,you know, looks the same to me.
$10 diamond, $10,000 diamond,right?
(42:07):
So it's like that with science.
Unfortunately, these days thereare not too many real experts,
real scientists around who arenot somehow compromised.
And when I say that that'susually because of granting
agencies.
You know it gets into.
You know, gets into globalwarming and all that other stuff
.
If you don't kowtow to theprevailing dogma that is driving
(42:29):
the funding machinery, thenthey're not going to give you a
grant, then you're going to getcanceled.
Scientists get canceled all thetime when they can't get grants
.
So I was fortunate in my career, able to basically do what I
wanted, working for a smallresearch foundation, and you
(42:52):
know, that's just.
You know God's grace, I guess,put me in a position where I
could actually just function asa scientist and not have to
worry about functioning as afundraiser or a political
operative or a you know what'sthe word I'm looking for or a
(43:12):
political doctrine massager orpromoter, and you know, and
there's politics in everything,and so that's how I published
the book you know this.
You know the there's politics ineverything, and so that's how I
published the book.
You know this.
You know the glycine miracleRight, I showed this before.
That's that's the sciencebehind this product, behind
Sweden, and in the book I talkabout all these things that we
(43:34):
touched on here about the statusof science and research and how
you have to evaluate it andwhat's wrong with a lot of it.
There's a lot of science whichis good science, at least in
part, and how you can takewhat's good in it and understand
(43:55):
what's good about it and what'sreally meaningful, and throw
out the part that may bethrowing us off the scent, but
it's amazing, it's there.
I hope now that everybody knowsthat that chronic illness is
largely due to inflammation.
Uh, so we're not talking about,you know, building more muscle
and health, you know, and havinghealth like that, but not
(44:16):
talking about building up thehealth, but avoiding building up
the, you know, the, theinflammation and and you even
find this in muscle recovery too, because when you, when you
work out, what do you do?
You tear muscle fibers, youcause injury and then the next
day, you know, you know, it getssore because of inflammation.
Most of that pain is because ofinflammation.
I remember when I was living inthe Hudson Valley and shoveling
(44:39):
snow every year, you know Iused to.
When I was in my 30s my backused to bother me the next day,
but by the time I was in my 60sit didn't bother me anymore
because I was taking glycinesupplements, I was taking
sweetamine, and so I didn't getthat inflammation the following
day, you know, so that you knowthe muscle might be sore.
(45:01):
If I tried to shovel snow, itmight be a little sore, but if I
, if, but the muscle wasn't sore, it didn't hurt If I wasn't
straining it.
You know, because, becausethere isn't that inflammation
and that's really the killer andit really is because of
glycineine deficiency.
So it's that's not the wholestory to health.
(45:23):
I mean, if you really want thewhole story to health and
fitness.
Well then, you got to watchanthony amen every day, you know
, every week appreciate it?
Okay, people do and continue tokeep up with the whole five
years in yeah, you got to keepup with the whole story.
But for this part of the story,the inflammation, which
inflammation?
Which is really the big kahunain chronic disease.
(45:44):
Right, rfk Jr says thecountry's having a chronic
disease epidemic, especially inchildren, and I'm trying to.
I'd love to be able to get tohim to say you know, it's not
really what you eat, it's whatyou don't eat that's killing you
, not just the creatine or thearginine, but also, in terms of
the inflammation and the chronicdisease, it's really the
(46:05):
glycine.
That's my story.
Speaker 1 (46:09):
I'm sticking to it.
Speaker 2 (46:11):
I hope you appreciate it.
Speaker 1 (46:14):
Thank you for coming on and doing this.
I'm just going to ask you twofinal questions.
The first one, which I thinkyou know the answer to, is if
you were to summarize thisepisode in one sentence, what
would be your take-home message?
Speaker 2 (46:26):
the take-home message in one sentence is uh, most
people are glycine deficient.
That's why they haveinflammation and therefore you
need a glycine supplement, likesweetamine, to avoid chronic
inflammation, which is most ofwhat makes us sick and die these
days.
Speaker 1 (46:41):
So that's it.
And the second question how canpeople find you and get a hold
of you to learn more?
Speaker 2 (46:44):
Ah, very good, so that's just sweetaminecom
S-W-E-E-T-A-M-I-N-E,sweetaminecom, and that's you
can get.
If you want to just try it, wehave a 12-day challenge for
$19.95, free shipping, and it'sso totally risk-free.
If you don't like it for anyreason, it just let us know.
(47:06):
Email text, whatever it is, letus know and you get your money
back.
You will find the difference.
If inflammation is bothering you, you should feel the difference
within two or three days and itgives you time to experiment
with it.
Try it for a week.
Oh, it seems to be working.
Go off it for a few days, seewhat happens.
Try it for and then, if you, ifyou like it, especially if you
(47:28):
order it soon you know, by untilthe end of the year, we have a
special going on on six packs.
So if you have six monthssupply or a full case of a
15-month supply, if you reallylike it, you'll still be able to
take advantage by January 1st.
You'll still be able to takeadvantage of much lower prices
on quantity discount.
But most people who use itregularly spend a dollar a day
(47:50):
or less on larger quantities andthat's pretty reasonable.
And it's not just a sweetener.
That's a lot to pay for asweetener, but this is really a
very important glycinesupplement and you should feel
the difference, especially ifyou work out.
Now.
I'm going on and on.
(48:10):
I guess we're supposed to bedone by now, right?
Speaker 1 (48:13):
Yeah, thank you.
Thank you, dr Joe, appreciateyou coming on.
Thank you, guys, for joining usin this week's episode of
(48:33):
health and fitness redefined.
Don't forget, hit thatsubscribe button and join us
next week as you dive deeperinto this ever-changing field,
and remember thanks for havingme on.
So bye.
Hello and welcome to the Hedonist Ministry Defined.
I'm your host, anthony Amen,and we got another great episode
for all of you.
Happy, happy, happy December.
Christmas is right around thecorner, I hope are already got
all the gifts purchased done.
We, luckily enough, did itprior my I say we.
I take that back.
(00:31):
My wife did it prior to givingbirth.
It took care of all the kidsand stuff getting getting ready
for him to be here.
So make our lives a littleeasier.
But enough about that.
Let's stop with today's show.
That further do is welcome DrJoel Bryant.
Dr Joel, it's a pleasure tohave you on today.
Oh, it's stop in today's showthat further ado.
Let's welcome dr joel bryant.
Dr joel, it's a pleasure tohave you on today oh, it's fine.
Oh, it's bryn, by the way, yeahwell, you know the spelling
(00:52):
doesn't tell you it could beeither way, so I have to tell
you right, it's like starbuckswhen you come on this show, you
never know how I'm going tospell or say your name.
Speaker 2 (00:59):
So well, it's like if you see the word wind, you
don't know if it's wind or wind.
You have to tell by the context.
Speaker 1 (01:06):
And for a name you have.
You know, the guy with the namehas to tell you.
Speaker 2 (01:09):
And I neglected to do that, so I apologize.
It's all good.
Speaker 1 (01:14):
Before we get into today's topic, tell us a little
bit about your background andhow you got into the health
fitness realm.
Speaker 2 (01:21):
Oh well, I've been a scientist all my life.
Really, I decided I wanted tocure cancer and stuff.
You know, be a medicalscientist when I was about 10
years old and uh, just, uh.
So one of those life magazinearticles about you know
scientists working on cancercures and using electron
(01:43):
microscopes uh, while I waswaiting for a haircut in Tom's
Barbershop on 227th Street andMerrick Road in Long Island, in.
Queens, and that was 1961.
That's what I decided I wantedto do and you know.
So 10 years later I had mybachelor's degree and 10 years
after that I had my PhD in basicmedical science from NYU, and
(02:09):
that's in biochemistry,physiology and immunology.
And then I was a benchscientist for a number of years
exclusively, and then, 1986, Igot a faculty position at Baruch
College, city University of NewYork, and I taught
endocrinology there for over 30years that's the science of
hormones and continued doingresearch.
(02:31):
And on about it was about 2007,I was working with a foundation
in the Hudson Valley foundationin the Hudson Valley, which is
actually where I had moved to bythen, and the the group that I
was working with.
It's called the OrantrikeFoundation and they had they had
(02:52):
discovered that if you take mythey were working on aging
mainly and they discovered thatif you take rats that had been
that were fed a diet almostdeficient in methionine, which
is an essential amino acid,that's what you need for all
your methylation.
Lots of people thinking canceris responsible for not having
(03:14):
enough methionine and so forth,but actually they found that if
animals were almost starved ofmethionine like 80 less of it
than is in the normal diet theyactually lived about 30 or 40%
longer, even though they didn'tgrow to normal size.
And that was repeated a numberof times and other groups had
repeated it in rats and in miceand nobody knew why.
(03:37):
So as a consultant then forthis foundation, where I had
worked full time years before,they wanted me to try and figure
out why that was.
When I found it they didn'treally believe it.
That's their problem.
But what I discovered was thatglycine is really the key, and
(04:03):
I'll tell you what glycine is an?
amino acid which is generallyconsidered non-essential, and
the reason I came upon glycinewas that we were looking at why
does having a normal amount, arelatively high amount, of
methionine in your diet make youlive less long than if you have
less methionine.
You live less long than if youhave less methionine.
(04:28):
So others had discovered bythis time and published the fact
that glycine is the amino acidthat actually is used by the
body to get rid of excessmethionine when we have too much
, and so in fact, we do have toomuch.
Your body's really designed forfamine, not feast, so you know
like we get too much sugar andso forth.
You know it's difficult to getrid of and that's why we have
(04:49):
you know, so much problem withthat and so much extra sugar,
but also extra protein.
Right, we eat, you know, lotsand lots of meat, fish and
poultry.
A lot more than our ancestorsdid or than the rest of the
world does, even today.
You know, in a lot of parts ofthe world, you know, you eat
meat once every couple of monthswhen the neighbor's goat dies,
(05:09):
right, and everybody has a feastand that's about it.
Till you know, it's beans andrice and all in the interim.
But uh glycine is a way to.
Uh is used by the liver as away to get rid of excess
methionine.
Now what's interesting is thatwe tried, and so I proposed an
experiment to feed glycine as asupplement to try and accelerate
(05:34):
the disposal of methionine.
Speaker 1 (05:36):
And it turns out it doesn't accelerate the disposal
of methionine.
Speaker 2 (05:39):
It doesn't have any effect on the levels of
methionine in the body, but theanimals did live significantly
longer anyway.
So something else was going on.
And it turns out what else wasgoing on and the reason that
methionine is important in thisregard is that because
methionine uses glycine to get,because the liver uses glycine
(06:02):
to get rid of excess methionine,because the liver uses glycine
to get rid of excess methionine,it uses up glycine and glycine
is in fact, not non-essential,it's really essential.
It's non-essential, they callit, because your body can make
it from simpler compounds, whichit can, and you also have as
much as you need to makeproteins with glycine as you can
(06:25):
with a normal diet, or yourbody can make enough glycine to
make all the protein.
Thing is, glycine has anotherrole in the body and it's the
main regulator of inflammation.
As the free amino acid, kind oflike a salt, like the cells of
the body need to be bathed in ahigh concentration of glycine,
(06:46):
otherwise they arehypersensitive to being
activated and in particular,it's the cells of the immune
system called macrophages, whichare the cells that actually do
inflammation.
So everybody knows you can lookit up in Wikipedia or anywhere
else, that inflammation is theimmune system's first response
to infection or injury.
That is what I discovered to bea half-truth.
(07:08):
It is not a natural response toinjury, it only hurts.
It only injures normal tissue.
So if you get a sports injury,what's the first thing you do?
Right, you put ice on it.
What's the purpose of puttingice on it?
To suppress inflammation.
Well, that leads to anotherinteresting question, which is
why is the body doinginflammation if it's only going
(07:30):
to do more harm?
The answer is it has anutritional deficiency, there's
not enough glycine, and noweverybody realizes that almost
everything that makes peoplesick and die these days
arthritis, cardiovasculardisease, cancer, even autism and
other diseases are reallyrooted in chronic inflammation
(07:52):
and science doesn't know why.
And that's what I reallydiscovered, is I discovered why,
is that most people are glycinedeficient.
We think inflammation ishappening normally in response
to injury, because it almostalways happens.
It does almost happen toeverybody almost, and it used to
happen to me.
So the thing is, I was doing anexperiment in by 2008, 2007,
(08:18):
2008, 2009,.
I was experimenting withglycine and, starting in 2008, I
started taking 10 grams a dayof glycine Because it's you know
, it has a sweet taste.
You can easily formulate itwith other things to make it
taste more like sugar, get ridof the aftertaste.
Pretty easy to take 10 grams aday of glycine.
And so I started doing that andI did it for a month after
(08:40):
month, even for a couple ofyears, and then in 2010, you'll
like this story mybrother-in-law had scored us
tickets to a Yankee game at thenew Yankee stadium.
It was only built in 2009,right, so I had not been there
yet.
So he got us tickets you know afew rows behind the Yankee
dugout and I was all excited.
I never wear a hat, but I had aYankee t-shirt and a pair of
(09:01):
shorts and was great.
And it was also around the 10thof June and it was also a
cloudless day, sunny day, andthe brand new stadium had no
obstruction, so there was noshade and because I wasn't going
to the beach, it didn't occurto me to put on sunscreen.
I used to get very bad sunburnswhen I was in my teens, and
(09:22):
maybe when my early 20s, youknow and learned enough to go
with sunscreen and sunblock andlimit my time in the sun and
wear a shirt most of the time,all of that sort of thing.
But what happened was I was sointerested in the game that
around the fifth inning Istarted to feel a little warm on
my thighs.
I looked down and from mythighs right at the hemline of
(09:42):
my shorts, to my socks and my,my arms, you know, uh and my
neck and my face, everywherethat was exposed to the sun, it
was boiled lobster time and Ihad not done this to myself
since I was at least in my early20s and I was sure I was
certain that I was going to be,uh, in excruciating pain really,
(10:05):
for the next day or two atleast dressing, undressing,
bathing, doing all of thosethings.
Well, the first thing I did is I, you know, I got out of the sun
, I went into some seats thatwere in the shade.
By the time it was lateafternoon and then I just sort
of forgot about it, keptwatching the game.
But the funny thing is, by thetime I left the game it didn't
really bother me.
(10:25):
It had actually started to fadeand the next day I felt fine I
mean fine, it had faded most ofthe way.
Maybe I got a little bit ofcolor, a little tan out of it.
But nothing like I had alwaysexperienced, in which I was sure
was going to happen again.
But that wasn't enough for me,even though I knew I was
(10:46):
experimenting with glycine andeven though I had worked at NYU
in the dermatology departmentwhere I did my PhD thesis.
So I knew something aboutsunburn really being
inflammation in response to sundamage rather than directly sun
damage.
So we were actually at the timemy wife and I were preparing
the house for an influx ofrelatives because our daughter
(11:08):
was getting married, so we werehaving relatives stay over and I
had to finish a project I wasdoing in the basement I was
putting in a bathroom, and so Ineeded a few pieces of sheetrock
which don't fit in the car.
So I would go and cut them inthe store.
You know I'd go up and get onthe top of sheetrock which is
about four feet high, sitting ona concrete floor in the store.
(11:31):
Go up, measure it, cut it, handthe pieces down to my wife,
jump down, you know, get them onthe on the cart and you know,
jump up and do the the othercuts and for some reason I
must've been distracted and Istepped the wrong way and I went
right down to the floor, fourfeet onto a concrete floor,
directly on my tailbone, and ithurt like hell for about 30
(11:53):
seconds I suppose, and you knowit was still hurting, but I
managed to hobble around, finishwhat I was doing.
That night we had tickets to adinner dance.
We figured well, we'll goanyway.
And then, while we were there,we figured well, I'll try a
dance or two anyway.
And guess what, it didn'tbother me and the next day I
felt absolutely normal and theonly evidence was a huge bruise
on my lower back.
(12:16):
So this was an experiment I wasconducting and when the results
are that clear, you can't denyit here.
I was expecting inflammation,sunburn, blunt injury.
Yes, of course you getinflammation.
Nope, not a hint of it.
So this is what led me on thepath of doing some more research
(12:36):
, not just in the aging field,did more research and published
it on glycine, extending thelife of rats.
And then, uh, worked with thenational institute of aging, one
of the nih institutes, and weshowed that glycine also
significantly extended thelifespan of mice.
And uh, this is uh, you knowthat's so.
(13:00):
That's part of the aging partof it.
As far as the inflammation partof it is concerned, most it's
basically going to theliterature and seeing what other
people have discovered aboutglycine, and it's just not tends
not to be put together becauseof these certain ideas.
You know, when you say that anamino acid part of the diet is
(13:21):
non-essential, who's going tostudy it?
Right?
Who's going to give you grantmoney to study?
It's non-essential, you don'tneed it, and we all found that
out during covid, didn't we?
It's the word non-essential istoxic.
Your job's non-essential.
Too bad, you're gone right.
So, um, that's so that's theproblem with it's it's the word
(13:42):
non-essential, and it's also theidea of inflammation and the
fact that it usually, or almostuniversally, is experienced as a
response to blunt injury.
But it's also understanding thecell biology of it, and that is
that the cells that doinflammation are yes, indeed,
(14:03):
they are the immune system'sfirst responders.
Well, so what's a firstresponder?
It's like a cop, right?
So if you go out on the highwayand there's an accident on the
highway, so what happens?
So the cops come, right, statetroopers come, state troopers
come, and they'll come, andthey'll have their lights
(14:25):
flashing in there, you know, andthey'll be rerouting traffic,
blocking up a lane so that thetow trucks could come.
And they call the tow trucks,they call the ambulances, they
take the accident reports andthen, when they're done, they go
back to their base and, youknow, then normal function is
restored on the highway.
Well, they're first responders,right.
(14:45):
So they got loaded weapons intheir holsters too.
They don't use them.
If there's an accident on thehighway, they wouldn't think of
drawing their guns and shootingthe place up, but they can, and
they, because if there's a badactor present that needs to be
eliminated, a threat that needsto be eliminated, they can do it
.
Well, so the first respondercells, these macrophages, have
(15:05):
the same dual functionality.
They can be activated to bejust in clean up the mess mode,
which is called M2.
Now it's understood.
It's given a name M2, versus M1, which is where they are
activated to produceinflammation, to start secreting
poisons that can destroy tissue, because it's there to destroy
(15:26):
microbes that might have gottenin during an infection of some
kind and kill them before itkills you.
Kill the infection before theinfection kills you, and that's
a whole different thing.
But because we're deficient inglycine, most of us, this is
what happens in the body all thetime You're inside your
(15:49):
arteries, inside your brain,inside all your other organs.
When there is normal injury,even if you don't experience it
as injury, it's tissue or cellsdying.
This happens normally.
So, for example, when yourblood is circulating, especially
at high pressure branch points,your coronary arteries, your
(16:09):
carotid arteries, right whenthere's excess pressure, you get
turbulence.
If there is inflammation inresponse, you eventually get
damage which can lead to a heartattack or a stroke or kidney
failure at these high pressurebranch points, because the micro
(16:29):
injuries are responded to withan inflammatory response rather
than a just clean up the messand repair it response.
And so we have now in oursociety when.
So why is it worse now?
Why even are the?
Are the people in yourgeneration more prone to getting
(16:49):
cancer.
Colon cancer is now more commonin your generation.
Autism is off the charts.
Uh, what's going on?
Why are all these seeminglyunrelated diseases?
Why do they seem to have to dowith inflammation?
What, what's going on?
And that's because there isnormally cellular injury and
cellular death involved in theseconditions, or involved in
(17:12):
normal conditions which willlead to inflammation if glycine
is deficient.
So, for example, I said autism.
I published a letter about thisin the British Medical Journal
about five years ago.
I published a letter about thisin the British Medical Journal
about five years ago.
Autism has to do with braindevelopment and the way brain
develops, just like the wayother organs develop, is the
(17:32):
brain grows.
You get a solid mass of cellsand then it is sculpted, All of
the cells in between, thoselittle creases and convolutions
that had cells in them.
Those cells die off and it'sperfectly normal for the cells
to die off.
But if you're glycine, deficientyou get inflammation in the
brain, starting even in uteroand by the time the child is
(17:55):
born they have autism spectrumdisorder.
And you keep gettinginflammation in the brain all
through brain development, whichgoes in through your mid-20s,
all through brain development,which goes in through your
mid-20s.
If you talk about cancer ofvarious kinds, it's been known
for decades that the incidence,for example, of ovarian cancer,
(18:18):
cancer of the ovary, is directlyproportional to how many times
in her life a woman ovulates.
Why should that be?
Because ovulation is a violentprocess.
Why should that be?
Because ovulation is a violentprocess?
The egg is actually shot out ofa cannon almost, or like out of
a volcano, when, uh when,ovulation takes place, and it
does damage to the ovary.
Well, once every other month toeach ovary, no big deal, it just
heals, unless you're glycinedeficient, and then you end up
(18:41):
with chronic inflammation,breast cancer.
The breasts grow every month ofa normal menstrual cycle.
In the third week, the breastsnaturally grow because of
estrogen and progesterone, thehormones that are there to start
preparing the breasts for thebig growth that they're going to
need to be able to feed a babywhen the baby's born.
(19:01):
A baby when the baby's born.
But suppose there is no baby,suppose it's a non-conceptive
cycle, which these days is mostof the time, for most women are
non-conceptive cycles.
So that means all those extracells that are built up during
the cycle they end up having todie off.
No problem, perfectly normal,unless you're glycine deficient
(19:23):
and then you get a chroniclow-grade inflammation what do
you know?
year after month after month,year after year, even decade
after decade of this and you endup with uh, with breast cancer,
and it's, it's it, and youcould see the difference.
For example, in ovarian cancer,that's lower if you uh ov less.
(19:44):
So if you have kids and youbreastfeed them, you're going to
ovulate less.
But also birth control pills,right, they suppress ovulation.
So guess what?
Women who take birth controls,they have a lower risk of
ovarian cancer.
But because they have estrogenand progesterone in them, like
the normal hormones, and youtake those more days a month
than they would normally beoperating in a normal
(20:07):
non-pregnant cycle, you end upwith more growth stimulation,
more cells have to die off, andtaking birth control pills
increases the risk of breastcancer, even as it decreases the
risk of ovarian cancer.
These are all tied to events ofmassive cell death.
To events of massive cell death, which are perfectly normal,
(20:29):
but in the context of a glycinedeficiency, they produce chronic
inflammation.
Why is it worse now, though,than it was for our forebears?
You know, I didn't reallyanswer that question, and the
reason is that our dietaryhabits have changed, so our four
.
Speaker 1 (20:44):
I want to I want to hop in here, dr joel, because
there's a lot to unpack ofeverything you were going
through and I think it'simportant to really first
clarify some things and then,okay, go into a little further.
So, first being said, there arejust basics for people that
don't know.
You mentioned non-essentialamino acids.
Basically, that means it'samino acids that our bodies
(21:06):
naturally produce, as opposed tothose we have to get from food.
Scientific, what we have to getis essential right.
Correct.
So, going into your argumentabout glycine and how people
deem it non-essential, meaningyou don't need to supplement it,
let's do an easier one, which Ithink is arginine and, coming
(21:28):
from the fitness community,arginine has been shown to be
beneficial to help havevasodilation and increase your
workout capacity in an anaerobicstate.
So, while weightlifting orsupplementing with arginine has
been shown to be beneficial,deemed non-essential but taking
higher quantities of E has beenshown to help.
(21:49):
Yes, because that's nitricoxide.
Speaker 2 (21:52):
That's the nitric oxide story, which causes
vasodilation.
Speaker 1 (21:56):
Your body makes nitric oxide from arginine, so
that's what that's going to beAlso to my favorite one, which
isn't an amino acid, but youtalk about something your body
naturally produces, that'screatine.
And, as I mentioned time andtime before, we do not produce
enough creatine naturally in ourbodies to have the benefits of
(22:19):
it, as we're now showing.
Decreasing the risk ofdepression, decreasing the risk
of anxiety have the benefits ofit, as we're now showing.
Decreasing the risk ofdepression, decreasing the risk
of anxiety, uh, decreasing therisk of dementia.
They're not putting a lot ofresearch into on it, uh, it also
increases your anaerobiccapacity in the gym, helps
increase, uh, promote muscletissue repair, something else we
should be supplementing withthat we're not, because we
(22:41):
produce it naturally right, I'mgoing to take this together for
you well, because you produce itnaturally.
Speaker 2 (22:48):
You do produce it naturally from glycine so
sleeping also increases yourproduction of creatine.
So that's?
Speaker 1 (22:57):
yeah, I think it's.
I think it's related, and youmentioned, uh, about our dietary
habits a little bit ago and Iwant to talk about that because
I think this is probably themost talked about topic and most
comfort.
Like people just don't agreeabout dietary habits and I've
talked about my viewpoint a lotand I want to approach it
(23:20):
directly to you.
You mentioned back when we werehunting gathering.
I disagree in the sense that weonly had, like your goat
example, once in a while and wemainly had rice and beans.
Oh, because if you go backprior to even us having towns or
all coming together ascommunity, that's all we did was
(23:42):
animal products and I think alot of our issues stemmed in
with, like we're talking about abody's information spots, even
into your argument with glycineand not getting enough of it
right.
We actually should be eatingmore animal products than we
consume and less of everythingelse.
For example, all of these thingswe mentioned come from red meat
(24:04):
all of it right, and we justtend to go strictly straight for
cow, which is a lot fattier,especially the way we raise the
cows and purposely, like wagyu,make them extremely fatty and
which can produce a lot morefree radicals in the meat and
cause health issues, as opposedto eating what we call gamier
(24:28):
meat, which is way leaner and itcontains a lot of these EAAs
and non-essential amino acids.
It contains the extra creatineswe need.
It contains the proteins weneed, which, in turn, would help
us recover faster, put moreoutput into what we needed to go
get food for our families.
Speaker 2 (24:53):
And I think that's really the disconnect that we
may not disagree where you think.
So I was getting to the pointwhere the problem is not that
we're eating more meat thesedays.
The problem is that we'reeating more muscle meat these
days and, as you said, themuscle meat is compromised and
(25:15):
we throw the bones into thetrash instead of the soup.
See, when they talk about itnot being as healthy, they say
oh, vegans, they live longerthan meat eaters.
They have, you know, they haveless chronic disease like cancer
and so on, than meat eaters do.
So you should all be vegans,and I say not so fast.
There was actually a veryinteresting study that proved my
(25:37):
hypothesis on this, and thatwas.
That was back in 2015, not toolong ago, and I had been saying
listen, the trouble is that meateaters, or omnivores, end up
with less glycine in their bloodthan than vegans have, even
though the meat eaters eat moreof all the amino acids, and that
(26:00):
was actually approved by agroup at Oxford in 2015, where
they took 100 meat eaters eatmore of all the amino acids, and
that was actually approved by agroup at Oxford in 2015, where
they took 100 meat eaters and100 fish eaters and 100 lacto
vegetarians and 100 vegans andthey looked at all the amino
acids in their blood and theylooked at all the amino acids in
their diet to see how itcorrelated.
They really didn't have ahypothesis, they just wanted to
see the correlations, one ofthese so-called database studies
(26:23):
, which is not really goodscience, but it's really a lot
of what passes for science thesedays.
so then they they found that thevegans had the most uh glycine
in their blood and the meateaters, who ate the most glycine
, had the least glycine in theirblood and they couldn't figure
it out, and it goes back tohaving more of that muscle meat,
(26:48):
which actually helps to get ridof glycine, which you don't
want to do.
But, that's because most of theglycine is in the collagen, and
the collagen is in the bones andin the connective tissue and
also in the wild game in themuscles.
The muscles are more sinewy,the meat is tougher.
There's more collagen in it, sothe muscle meat is not only
(27:11):
glycine deficient, but it'sparticularly glycine deficient,
or glycine poor that's the wordyou use for the food stuff.
That muscle meat is moreglycine poor than it used to be.
We're also eating more of thatglycine poor meat.
We're throwing most of theglycine in the trash instead of
the soup.
Right, we're doing that, and youput all those things together
(27:35):
and you end up with less glycinein the blood of people in this
generation than in previousgenerations, with less glycine
in the blood of people in thisgeneration than in previous
generations.
So there is a balance there andI do not disagree with you that
animal products, the problemwith research that has been done
and anybody that can listen toAnthony Amen and say, oh well,
he says, eat a lot of meat.
(27:56):
But I've read all this researchhas shown for 50 years the meat
eaters, they don't live as long, they get more cancer.
That you know, and all of thatis true.
But it's because of theincomplete protein.
It's the fact that glycinereally is efficient and you're
throwing so much of the glycineaway and you really need to.
(28:21):
So the idea that it's meatprotein is bad for you and
vegetable protein is good foryou is based on bad science,
which, when it says the animalprotein is causing chronic
disease, it's not completeprotein.
You're not eating the wholeanimal.
Speaker 1 (28:47):
So there aren't any bone broth enthusiasts who are
really glycine deficient.
You know, if you talk about thephenomenal.
Speaker 2 (28:51):
What's that?
Yes, you gotta eat, not justthe muscle, you know that.
So that's that's what I wouldsay, especially as you say now
the meats that are available areworse than a generation or two
ago, when, when, or you knowwild meats, if you, if you hunt
you and you, you know you havevenison, you know stuff that
you've gotten from wild game orbirds, or fish or that, all of
(29:13):
that If you actually eat themeat that has more glycine in it
, it's not as bad.
But you still need to have moreglycine from the you know bones
in the connective tissue.
And if you don't do that,that's what that's what my
product is about.
That's what sweetamine does.
It gives you, it gives you theglycine.
(29:34):
You can just take it straightas a, as a simple amino acid,
because it it, you know it'sformulated as a sweetener, it's
very easy to take and whatscience tells us really is that
it's the glycine that's theimportant component.
There are other people who sayoh yes there's so many collagen
peptides and you kind of take atype two or a type three and not
(29:56):
a this type or that type and nocollagen peptides or gelatin.
You know, any formulation ofthose things is fine as a source
of glycine.
It's got about 25 percentglycine by weight and uh, it's,
it's a very good source ofglycine.
It doesn't really matter whatit is.
Some people say, oh it's, yougot to take glycine with
(30:18):
n-acetylcysteine and it's thecombination no it's not the
combination, and science tellsus that, because when that one
component is enough to accountfor all of the benefits, you
know, that's what it's doing.
That's the principle of Occam'srazor, which is one of the
scientific principles that tendsto be forgotten these days,
(30:39):
unfortunately, by scientists.
Speaker 1 (30:40):
Crazy.
I talk about that all the timeand you're absolutely right, I
mean, this is, you know the.
I don't even think people knowwhat that expression means.
Speaker 2 (30:51):
Yes, well, it was coined by John of Ockham in, I
don't know, the 12th century orsomething like that, which is
basically, if you have, when youhave a scientific question, you
ask a question.
That which is basically, if youhave, when you you have a
scientific question, you ask aquestion, the answer, what
appears as a hypothetical answer, is your hypothesis.
That's what you want to testexperimentally.
(31:12):
And so the the Occam's razorsays that the simplest
hypothesis is is is probably theright one.
You know, you, you don't, youhave, you have to eliminate, you
don't.
So some people have said to me,for example oh, glycine for all
these conditions.
Nah, it can't be that simple.
You even read scientific papers.
Oh, no, it's very complex, it'ssuch a complex symptomatology,
(31:35):
we need customized medicine, andyou need.
You know.
You need one medicine forpsoriatic arthritis and another
one for Crohn's disease andanother one for, you know,
irritable bowel syndrome andanother one for arthritis.
No, it's a common denominator,you know it's all chronic
inflammation.
So why shouldn't it be a simplething?
You don't when you have ahypothesis that you're testing
(31:56):
scientifically.
You don't reject a hypothesisbecause it's too simple.
You reject a hypothesis becauseit's too simple.
You reject a hypothesis becauseit's too complicated.
When Ptolemy, back in the oldEgyptian and Greek times,
hypothesized and this was viewedas dogma for some centuries
that the planets and the sun allrevolved around the earth in
complex epicycles and the Sunall revolved around the Earth in
(32:19):
complex epicycles.
And then along came Copernicus,you know, who said it makes
more sense for all the planets,and the Earth as one of them, to
revolve in simple ellipticalorbits around the Sun.
So we threw away thecomplicated epicycles of Ptolemy
Because it was too complicated.
Now we all know the planets,you know orbit around the sun.
Speaker 1 (32:42):
Well, after he was told he was wrong, Well, yeah, I
mean, but Locked up.
Speaker 2 (32:50):
Yeah Well, this happens all the time, though
with you know, I mean Copernicus, and then, of course, galileo
was locked up for echoing andusing a telescope and
calculations there to confirmCopernican theory.
You know the church locked himup and all that kind of thing,
so but I don't really.
(33:11):
I mean you and I both rely onevidence.
You know scientificallyverifiable evidence and when we
actually hash it out here youknow there's really not any
disagreement.
It's just a matter of gettinggetting to the fine points.
You know a lot of peoplethey'll just look at oh say oh
17 studies say this and only twostudies say that.
(33:34):
So this must be correct, andthey don't.
They have no way of evaluatingwhether science is good or not,
and a lot of it isn't.
Speaker 1 (33:41):
Well, I said it all the time p values.
Uh, oh sorry, n values twopeople in it.
Speaker 2 (33:47):
You can't take a study with two people, well you
know you can take a study withone actually, and that is you
know, you before and after, youknow and you can.
You can repeat it x number oftimes.
I mean, that's what I did.
Self-experimentation, if youlook back, is what people like
Pasteur did and other scientistsdid.
They would test it onthemselves, because then you
(34:09):
have a before and an after andso on.
Two people, if they'reidentical twins is a great end
for a study like that, becausethey're identical in every other
aspect.
But you're right when you wantto confirm it.
You know we do hundreds of mice, hundreds of rats, hundreds of
people, and there have been some.
(34:32):
That's what a clinical trialright, a placebo controlled
clinical trial is always lookingfor, you know, looking to
emulate a controlled experiment.
It's as close as you can get toa controlled experiment using
people, so it's ethical.
And there was actually done, atleast one or more, I think, on
(34:54):
diabetes.
It was one that was publishedas early as 2008, where they
took a bunch of diabetic peoplein Mexico, mexico City.
There's a lot of research ondiabetes in Mexico because that
population is particularly,particularly strongly prone to
get diabetes, especially PimaIndians, you know, people of
Mexican Native American origin.
(35:14):
So a lot of research ondiabetes.
So they had these, they haddiabetics, they took I think it
was only 37 people, half men andhalf women, roughly um, who uh
were given 15 grams of glycineevery day.
You know, uh, that's about two,two packets of sweet amines
worth and you know they werelike most people with diabetes.
(35:37):
They were moder, were mild tomoderately overweight, and they
were to make it an ethical trial.
You can't say, okay, stop yourdiabetes medication while we do
this trial for three months,that's not ethical either
because they need the medicationto keep their sugar in control.
So, even though they were stilltaking the medication, the A1C,
(36:01):
for example, was reduced from anaverage of 8.3 to an average of
6.9, right down to the bottomof the diabetic range even
though they were still takingthe medication and even though
they didn't lose any weight.
Because if you're 20 or 30pounds overweight and you have
diabetes, if you lose that 20,30 pounds, the diabetes will go
(36:22):
away.
But so they they here.
The diabetes went away evenwithout losing the weight.
So you could see it was not.
It's because it's not the fattissue itself, it's the
macrophages, the inflammatorycells that are embedded in the
fat, that caused the trouble.
So if you lose, all that weightyeah it'll go away because those
macrophages are not thereeither.
(36:44):
So the thing that's reallyamazing about the science is
once you it's like doing ajigsaw puzzle you find this sort
of central piece to the picture.
All of a sudden you seesomething like it's a
recognizable object in thepicture, all of a sudden, all
the other pieces in the puzzle.
You couldn't figure out wherethey went.
(37:05):
They all make sense.
So it was kind of like that.
And I've been a scientist all mylife really, I mean, as I told
you earlier, and so I've neverhad such clear, dramatic results
from my ownself-experimentation, from the
experimentation we were doingwith rodents in the laboratory,
(37:26):
such clear, dramatic resultsfrom my own self-experimentation
, from the experimentation wewere doing with rodents in the
laboratory, from all theresearch that's been published
in all kinds of disciplines.
And unfortunately, in scienceit's not so much the end, as you
say, which is a problem in alot of research, but it's also
the way the experiment is set up, but also the hypothesis
Everybody says show me the data.
(37:46):
Right, that's science, show methe data.
The data is the last thing youdo.
The good part about science, orthe important parts about
science are, in the beginning,mainly asking the right
questions and then setting up anexperiment that can actually
test the hypothesis andrejecting a hypothesis that's
either too complicated orunnecessary.
(38:08):
So this happens all the time isthat now everybody thinks it's
the data.
The reason for that is now youcan gather immense amounts of
data.
You can take a drop of blood,stick it in a machine and
analyze 300 or 400 differentmetabolites, 300 or 400
different gene products, mrna,all of that stuff.
(38:30):
So there's an explosion ofpapers being published.
Oh, yes, we did diabeticsversus non-diabetics or we did
prostate cancer versusnon-cancer or we did whatever.
We're studying the experimentalgroup and the control group.
And yes, there was asignificant difference in
methionine or a significantdifference in some marker,
(38:52):
creatine, or a significantdifference in something.
And then, now that the computerhas identified a difference
between the experimental groupand the controls, then they try
to speculate as to why thatmight be based on what else is
known.
So they're basically shootingin the dark.
Instead of starting with ahypothesis, they're just
collecting data.
(39:12):
Now, in the old days and I'm anold guy, an old scientist, so
the old days for me, I'm talking1970s and 80s- Okay so 40, 50
years ago you couldn't do that.
If you wanted to do that and say, wow, you know, there probably
is a difference in the aminoacid combination.
So wait a minute, we're notgoing to do amino acid analysis
on all that.
Speaker 1 (39:32):
We don't have the money.
Speaker 2 (39:34):
Nobody's going to give us the money to check
everything that's called.
That would be a study in whatthey call now today's
metabolomics or genomics orlipomics.
All these omics disciplines aredisciplines or really
methodologies that can measuresimultaneously hundreds of
different substances.
And they wouldn't do it inthose days.
(39:55):
Nobody would ever give you anymoney to do research like that,
because they called it a fishingexpedition.
That's what it is.
So now probably most sciencethat's done is fishing
expeditions, because becausethey got these trawling nets,
they can haul up so many fishand and then they look at them
and figure, oh, how come we havemore mackerels than we have, uh
(40:17):
, tuna fish, you know, andfigure it out that way.
But that's, that's not reallygood science.
Good science is what they havecalled now hypothesis based
science.
In the old days that was calledscience and now they're.
Now it's all.
As you see, show me the dataand you know the data may
(40:38):
corroborate what your hypothesisis, but it might not be valid.
You know, yes, it's not as goodto be a meat eater as it is to
be a vegan if you want to livelonger and not get cancer
because the animal protein.
Wait a minute you didn't look atall the animal protein because
you threw the bones in the trashand not in the soup.
So it's, all of these thingsare important to consider and
(41:01):
that's you know.
If you're an old schoolscientist, you look at these
things instead of just acceptingthe fact that, oh, such and
such a study from such and suchan institute found ABC and they
must be right because they havea high impact journal and a
famous institution and thescientist is well known and you
know and all and that's you know.
(41:23):
Unfortunately, most people, ifyou're not a science, a
scientist, you're not, you'renot really trained to look at
all this stuff.
You know to look at ascientific study, you know and
just.
But you can, if you are.
You know it's like anythingelse.
If you are trained to look atit, like when you're trained to
(41:44):
look at anything else, you cansee the flaws, like a, you know,
like a jeweler who you knowknows diamonds.
He can look at a diamond andsee the flaws in it and tell at
a glance if it's a real one or alaboratory created one, or if
it's got a lot of flaws ordefects in it.
Everybody else, oh, it's adiamond, you know.
Or if it's got a lot of flawsor defects in it.
Everybody, oh, it's a diamond,you know, looks the same to me.
$10 diamond, $10,000 diamond,right?
(42:07):
So it's like that with science.
Unfortunately, these days thereare not too many real experts,
real scientists around who arenot somehow compromised.
And when I say that that'susually because of granting
agencies.
You know it gets into.
You know, gets into globalwarming and all that other stuff
.
If you don't kowtow to theprevailing dogma that is driving
(42:29):
the funding machinery, thenthey're not going to give you a
grant, then you're going to getcanceled.
Scientists get canceled all thetime when they can't get grants
.
So I was fortunate in my career, able to basically do what I
wanted, working for a smallresearch foundation, and you
(42:52):
know, that's just.
You know God's grace, I guess,put me in a position where I
could actually just function asa scientist and not have to
worry about functioning as afundraiser or a political
operative or a you know what'sthe word I'm looking for or a
(43:12):
political doctrine massager orpromoter, and you know, and
there's politics in everything,and so that's how I published
the book you know this.
You know the there's politics ineverything, and so that's how I
published the book.
You know this.
You know the glycine miracleRight, I showed this before.
That's that's the sciencebehind this product, behind
Sweden, and in the book I talkabout all these things that we
(43:34):
touched on here about the statusof science and research and how
you have to evaluate it andwhat's wrong with a lot of it.
There's a lot of science whichis good science, at least in
part, and how you can takewhat's good in it and understand
(43:55):
what's good about it and what'sreally meaningful, and throw
out the part that may bethrowing us off the scent, but
it's amazing, it's there.
I hope now that everybody knowsthat that chronic illness is
largely due to inflammation.
Uh, so we're not talking about,you know, building more muscle
and health, you know, and havinghealth like that, but not
(44:16):
talking about building up thehealth, but avoiding building up
the, you know, the, theinflammation and and you even
find this in muscle recovery too, because when you, when you
work out, what do you do?
You tear muscle fibers, youcause injury and then the next
day, you know, you know, it getssore because of inflammation.
Most of that pain is because ofinflammation.
I remember when I was living inthe Hudson Valley and shoveling
(44:39):
snow every year, you know Iused to.
When I was in my 30s my backused to bother me the next day,
but by the time I was in my 60sit didn't bother me anymore
because I was taking glycinesupplements, I was taking
sweetamine, and so I didn't getthat inflammation the following
day, you know, so that you knowthe muscle might be sore.
(45:01):
If I tried to shovel snow, itmight be a little sore, but if I
, if, but the muscle wasn't sore, it didn't hurt If I wasn't
straining it.
You know, because, becausethere isn't that inflammation
and that's really the killer andit really is because of
glycineine deficiency.
So it's that's not the wholestory to health.
(45:23):
I mean, if you really want thewhole story to health and
fitness.
Well then, you got to watchanthony amen every day, you know
, every week appreciate it?
Okay, people do and continue tokeep up with the whole five
years in yeah, you got to keepup with the whole story.
But for this part of the story,the inflammation, which
inflammation?
Which is really the big kahunain chronic disease.
(45:44):
Right, rfk Jr says thecountry's having a chronic
disease epidemic, especially inchildren, and I'm trying to.
I'd love to be able to get tohim to say you know, it's not
really what you eat, it's whatyou don't eat that's killing you
, not just the creatine or thearginine, but also, in terms of
the inflammation and the chronicdisease, it's really the
(46:05):
glycine.
That's my story.
Speaker 1 (46:09):
I'm sticking to it.
Speaker 2 (46:11):
I hope you appreciate it.
Speaker 1 (46:14):
Thank you for coming on and doing this.
I'm just going to ask you twofinal questions.
The first one, which I thinkyou know the answer to, is if
you were to summarize thisepisode in one sentence, what
would be your take-home message?
Speaker 2 (46:26):
the take-home message in one sentence is uh, most
people are glycine deficient.
That's why they haveinflammation and therefore you
need a glycine supplement, likesweetamine, to avoid chronic
inflammation, which is most ofwhat makes us sick and die these
days.
Speaker 1 (46:41):
So that's it.
And the second question how canpeople find you and get a hold
of you to learn more?
Speaker 2 (46:44):
Ah, very good, so that's just sweetaminecom
S-W-E-E-T-A-M-I-N-E,sweetaminecom, and that's you
can get.
If you want to just try it, wehave a 12-day challenge for
$19.95, free shipping, and it'sso totally risk-free.
If you don't like it for anyreason, it just let us know.
(47:06):
Email text, whatever it is, letus know and you get your money
back.
You will find the difference.
If inflammation is bothering you, you should feel the difference
within two or three days and itgives you time to experiment
with it.
Try it for a week.
Oh, it seems to be working.
Go off it for a few days, seewhat happens.
Try it for and then, if you, ifyou like it, especially if you
(47:28):
order it soon you know, by untilthe end of the year, we have a
special going on on six packs.
So if you have six monthssupply or a full case of a
15-month supply, if you reallylike it, you'll still be able to
take advantage by January 1st.
You'll still be able to takeadvantage of much lower prices
on quantity discount.
But most people who use itregularly spend a dollar a day
(47:50):
or less on larger quantities andthat's pretty reasonable.
And it's not just a sweetener.
That's a lot to pay for asweetener, but this is really a
very important glycinesupplement and you should feel
the difference, especially ifyou work out.
Now.
I'm going on and on.
(48:10):
I guess we're supposed to bedone by now, right?
Speaker 1 (48:13):
Yeah, thank you.
Thank you, dr Joe, appreciateyou coming on.
Thank you, guys, for joining usin this week's episode of
(48:33):
health and fitness redefined.
Don't forget, hit thatsubscribe button and join us
next week as you dive deeperinto this ever-changing field,
and remember thanks for havingme on.
So bye.
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