Latest Advances in Alzheimer's Research and Treatment

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Dr. Michael Koren joins Kevin Geddings to share insights from his recent meeting with Alzheimer's expert Dr. Reza Bolouri. The doctor highlights advances in understanding the disease's progression, mechanisms, and treatment options. This progress offers new hope for patients through early screening, diagnosis, and medications that have been brought to market because of the pioneering work of clinical trials. Dr. Koren also reveals how participation in clinical trials can offer complementary screening and tests for memory loss that are very expensive when accessed through traditional healthcare avenues.

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Have a question for Dr. Koren? Email him at [e-mail]

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Episode Transcript

Announcer (00:00):
Welcome to the MedEvidence Monday Minute Radio
Show hosted by Kevin Geddings ofWSOS St Augustine Radio and
powered by ENCORE Research Group.
Each Monday morning, Dr MichaelKoren calls in to bring you the
latest medical updates withinsightful discussions.
Medevidence is where we helpyou navigate the real truth
behind medical research, withboth a clinical and research

(00:20):
perspective.
So sit back, relax and getready to learn about the truth
behind the data in medicine andhealthcare.
This is MedEvidence!

Kevin Geddings (00:30):
Dr.
Michael Koren is with me liveon the air and of course he
joins us on Monday mornings.
He's a medical doctor,cardiologist, research scientist
.
He's also, of course, withENCORE Research Group, where
they're doing leading-edgeclinical research right here in
St.
John's County and St.
Augustine that you canparticipate in, including in the
area of Alzheimer's right, Dr.
Koren.

Dr. Michael Koren (00:51):
Yeah, thanks for bringing that up.
So I had an interestingexperience this past week where
we brought in a speaker who isan expert in Alzheimer's disease
from North Carolina a fellownamed Reza Bolouri and it got me
realizing that I'm so fortunateto be able to bring these

(01:12):
national experts in and actuallylearn incredible amounts from
them.
So we have always done memoryresearch and neurological
research.
We have a team that does thatwork here in Northeast Florida
research we have a team thatdoes that work here in Northeast
Florida.
But to learn the latest andgreatest about a disease such as
Alzheimer's is just truly agift for me, and I had a great

(01:33):
opportunity this past weeklearning more about the amyloid
hypothesis of Alzheimer's, whichis this type of protein that
folds improperly in the brainthat causes the pathology of
Alzheimer's dementia.
And then also learn about someof the genetic risk factors,
such as high levels of tauprotein, and with this greater

(01:53):
understanding of how Alzheimer'sdisease affects people, we can
help people in the community.
We can help people by gettingthem screened earlier.
We have that ability to do thisand it's all performed free of
charge at the research centers,and then if we do diagnose
something that's treatable, thenwe can get people involved in a
clinical research trial.
So it's really gratifying totake something that was

(02:15):
literally considered a deathsentence and something that we
didn't have really anything tooffer for many, many years, and
now actually offer things thatwill change the progression of
the disease.
So that was exciting and it wasfun for me to be part of this
discussion.

Kevin Geddings (02:31):
And Dr.
Koren, if folks are listeningand either they have received
maybe an early diagnosis ofAlzheimer's or forms of dementia
or they have a loved one who isdealing with an Alzheimer's
diagnosis, are thereopportunities here locally for
them to be involved in the kindof clinical trials you were just
talking about?

Dr. Michael Koren (02:49):
Absolutely.
Yeah, just give us a call andif you're just worried about
your memory, we'll come and do amemory screen.
And unfortunately this is oneof the gaps in our healthcare
system, because a doctor'soffice doesn't really get
reimbursed adequately for memoryscreens.
A lot of doctors just won't doit or they'd be reluctant to do

(03:11):
it.
It's just time-consuming andunfortunately just doesn't get
reimbursed well, whereas in theresearch office we have a grant
to cover all those expenses.
So you will get a memory screenand then we'll dig into your
family history.
Alzheimer's is a disease thatdefinitely has a genetic
component and we'll look intothat for you and then, if you
look like you may be somebodythat would be helped by research

(03:34):
, we'll actually do a lot ofvery expensive scans on your
brain to determine whether infact you have the diagnosis and
whether or not you would be agood person for possible
treatment options.

Kevin Geddings (03:45):
Absolutely and I guess overall, just as a layman
out here.
I mean are we making anyprogress in the area of
Alzheimer's?
Obviously, you've beenpracticing medicine for a long
time.
I mean, do you sense that weare making progress?

Dr. Michael Koren (03:57):
Oh, totally, totally.
You know we have some approveddrugs in the market that are
really the fruits of theresearch that we and other
people have done around thecountry, so they're already
products in the market.
They tend to be expensive andunfortunately they're mostly
used for people that are at thelater stages of Alzheimer's
dementia.
So now the research is reallyturning to making a more quick

(04:19):
and early diagnosis so that wecan block the disease
progression much earlier.
So we're very, very hopefulthat there'll be more
breakthroughs in treatingAlzheimer's dementia and also
continuing our understanding ofwhy this happens to some people.

Kevin Geddings (04:35):
Yeah, absolutely .
Well, if you have a loved one oryou have received an
Alzheimer's diagnosis, weencourage you to reach out to
ENCORE Research group, you know.
Learn about what options areavailable to participate in
leading edge, you know, clinicalresearch.
Learn more by going toEncoreDocs.
com EncoreDocs.
com, that's spelled E-N-C-O-R-E,and of course their offices are

(04:57):
right here in St.
John's County in the WhetstoneBuilding near UF Flagler
Hospital, so it's convenient foranyone within the sound of my
voice.
Also, punch this number intoyour cell phone [phone].
That's 904-730-0166.
That's 904-730-0166.
And we should mention too, theconversation that you had with

(05:17):
the expert in Alzheimer's fromNorth Carolina will soon, in the
next few days or so, beavailable on medevidence.
com, right.

Dr. Michael Koren (05:24):
That's right.
The Truth Behind the Data.
Oh my God, Kevin.
There's so much information outthere that is just not
supported by any kind ofscientific research.
So the latest rumor you and Ibriefly talked about it last
week that Tylenol causes autismis an example of these crazy

(05:44):
things that are just notsupported by any scientific
information.
So we try to help people reallyunderstand what we truly know
about something, that we don'tknow about things, and how we
learn about the stuff we don'tknow.
So please look at MedEvidence!as a credible source for
information, rather than a lotof rumor mills, which is what
the Internet has become.

Kevin Geddings (06:03):
Yeah, absolutely .
Now you can trust MedEvidence!such a better resource than
TikTok or Snapchat or Instagramor all these other places where
there's nothing filtered andthere's no medical experts that
are reviewing the data that'sput out there.
Medevidence.
com, that's MedEvidence.
com the truth behind the data.
And, of course, to learn moreabout clinical trials you can
participate in, not only in thearea of Alzheimer's, but across

(06:24):
all health statuses, we wouldencourage you to look at
EncoreDocs.
com.
Encoredocs.
com, Dr.
Koren.
Be safe out there and we'lltalk with you again next week.

Dr. Michael Koren (06:34):
Sounds great, Kevin, have a great week.

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