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Transcript
Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
Speaker 1 (00:02):
so let's talk about um, the glp-1s and the science
of it.
So how does it kind of actuallywork?
You went over just a generaloverview.
But how is it working in thebody and um?
So I had stated that glucagon,like peptide and glp-1, it's a
hormone in the gut.
(00:23):
It plays a crucial role inregulating the appetite, the
metabolism, and it is part ofthe incretin hormone family,
meaning that it is insulinreleasing from eating, endocrine
, meaning the body is excreting,and scientists have discovered
(00:46):
that this GLP-1 level either isdone naturally through the body
or has now produced medicationsfor better blood sugar control,
weight loss and improvingmetabolic health in many areas
and many other areas that it hasshown that has had improvement.
(01:07):
As I talk and we'll discussfurther, increased
hyperinsulinia has caused manychronic illnesses.
In this situation we're tryingto talk about why it's important
to have proper balance of GLP-1, whether it is through
medication or naturally, how toget to there and it's an amazing
(01:30):
thing what the body can do.
It's about how it's functioning.
You know what's the link.
You know when you think about aGLP-1, it's secreted, actually
through the intestines.
It intestines by the L cellsand in that response it helps
regulate our metabolism and ithelps stimulate pancreatic beta
(01:55):
cells to release insulin whenglucose levels are high.
So, yes, this was initiallygiven for diabetic patients so
that it can prevent blood sugarspikes and to prevent and help
move glucose within thebloodstream into the cells for
energy.
The main issue is when we haveexcess and too much.
(02:17):
This is so important, obviously, for type 1 diabetes
individuals that have an insulinsecretion or excess, so they
call it insulin resistance, butreally it's maybe an excess
amount of insulin within thebloodstream not able to get out,
or there's an impairment.
In type 1 diabetes, there's anactual impairment in the beta
(02:40):
cells in producing the insulin.
So it's a little bit different.
One can be managed.
The other one actually is agenetic component that needs the
insulin to prove, but in turnyou still can benefit in a GLP-1
component that if you can getrid of the excess of insulin
that is not needed, that will behelpful for both patients, for
(03:02):
weight loss and metabolic health.
So when you boost it, it willhelp your insulin function, your
metabolic health, your overallmetabolic and weight.
Now, things that it does doinitially, not just by insulin
secretion.
It slows gastric emptying.
So you're going to see and hearbig conversation constipation,
(03:24):
nausea.
Why does it do that?
It does that because it staysin, makes food and digestion a
little slower.
One, making you feel full soyou're not eating and eating.
Two, it regulates the leptinwhere your food intake.
So there's hormones calledleptin and ghrelin.
Ghrelin is for when you'rehungry.
(03:47):
Leptin is that food, thatfullness.
The GLP-1 will slow that feelingof fullness satay and it keeps
the blood sugar level stable,reduces your post-meal energy
crashing and prolongs feelingsof fullness, which is why you
are able to sustain thismedication.
What does it matter?
(04:07):
The slower it reduces thehunger.
Now I will say a caveat to thatis that if you drink more water
kind of help with the digestionyou won't get as many as much
of the constipation that maycome with a GLP-1.
The benefits of slowing yourdigestion is eating less.
But if you're not having highquality, nutrient dense foods,
(04:31):
then that is a problem.
You know, having zero calories,a bunch of French fries and
then saying I or I, and then Ihad a protein shake, I'm good,
that's not going to cut it Ifyou're still not eating and
taking like medications, ifyou're taking GLP medications
and you're not using this as atool and you're still not
(04:52):
nutritively, giving yourself theright amount of foods for the
body, then there is problems.
Yes, it reduces your appetiteand your satay, like I had been
initially saying.
This is because, um, the GLPone acts on the hypothalamus,
which is the brain's hungercenter.
So it signals and says, hey,I'm full.
(05:14):
So that leptin number, if itwas really high, usually the GLP
would signal it and say, hey,you're, you're.
It'll start lowering it.
So, in saying you're full,you're good, don't overeat, now
You're okay.
And that's helpful, becausewhat it is is it's, um, wanting
you not to just overeat and itshould be eating for fuel, not
(05:37):
eating just to be eating andeating and eating, and it helps
naturally decrease the body'sneed for food intake.
It's more of okay, we need this, not I have to have, I have to
have.
Now, granted, there'senjoyments, but when you have
those enjoyments and enjoyments,enjoyments, you know that food
intake and your metabolic healthwill change and your metabolism
(05:58):
will change and you may not beable to get back to where you
used to.
But the reason it's soeffective is it does help with
the weight loss.
Now, if you still eat your waythrough these medications and
you're not able to get throughthe behavior changes.
The science of it may not workNow.
It lowers the glucagonsecretion.
(06:18):
Glucagon is a hormone thatincreases the blood sugar,
breaking down stored glycogen inthe liver.
Glp-1 reduces the glucagonlevels and preventing
unnecessary glucose release.
So there's a lot of studiesthat have shown that GLP-1 use
will help with fatty liver, willhelp long-term because the
(06:41):
liver metabolizes and has manyfunctions and in turn, because
it will break down the glycogen.
It can also break down manyother parts, like metabolizing
cholesterol, and will helpprevent more issues or break
(07:02):
down the liver byproducts, whichI will get into in a further
lecture.
But why does it matter?
When you lower that glucagonlevel, you then can contribute
to better blood glucose balanceand reducing your diabetes risk
or management.
So it's not that you'renecessarily stopping yourself
(07:23):
from diabetes.
You're managing it if you haveit or you may be pre-diabetic,
and trying to reduce that riskof it progressing in your body,
the liver or the pancreas fromgetting, or the insulin from
becoming insulin resistant.
So it's super important, youknow, and it can be, if it's
used in the right manner.
This is an excellent way ofchange.
(07:46):
Now GLP-1, and how is iteffective with the weight loss?
So we talked about the diabetespart and the sugar.
Why is it affecting weight loss?
So initially I stated that ithas to do with you know, you'll
see the medications that are out.
Big ones are semiglutide,terzapatide, which are Wagovi
(08:07):
and Manjura, or the other one iscalled Zepan, which is
terzapatide.
These are appetite suppressionmedications.
They reduce the hunger withinyour body because it signals and
says, hey, I don't need thatmuch food.
This, in turn, is a good andbad thing.
That doesn't mean you don'tneed anything, because your body
(08:29):
does need nutrients to live.
So you still need a good amountof protein, carbs and fats to
sustain a good quality body.
And I think what happens ispeople get that triggered off
and then they stop eating andthen they wonder why they're
nutrient deficient and they'rehaving hair problems and side
effects.
You need to eat, but you needto choose the right foods the
(08:53):
highest amount of protein andquality carbs and nutrition with
hydration.
It delays digestion, which youhave talked about, to make you a
little bit more fuller.
It discusses in the sense ofwhen you're trying to fat burn,
you're trying to build up yourmetabolism and insulin
sensitivity insulin sensitivityso that your body can use that
(09:16):
fat for energy rather than juststoring it and not getting rid
of that insulin within thebloodstream.
It lowers the blood sugar andit helps with less fat storage.
So it kind of gets rid of thatinsulin within the bloodstream
and lowers the blood sugar andit helps with less fat storage.
So kind of gets it, gets rid ofit and when you stabilize that
you'll notice you'll see moreweight loss.
Now the clinical evidence onhere I'll show you and leave
(09:40):
some research articles available.
But basically the main thing isyou can reach anywhere between
15 to 24% of body fat weightloss with these medications, in
addition to, obviously, behaviormanagement, dietary and
long-term goals.
You can do very well andmaintain.
(10:00):
Trust me, I have been on thesemedications and I maintain for
the past year and a half at mygoal weight and have micro-dosed
these medications four to sixweeks within as needed for
weight and inflammatory reasons.
So yes, these medications dowork and are very effective at
done and used properly and usedproperly.
(10:29):
Other research has shown higheramounts of GLP-1 tends to have
that person eat less and theyalso have a lot less of that
body fat percentage, especiallyif you know how to maintain the
amount of protein in your bodyand I talk about this in other
lectures and online about what'sthe right amount of protein for
you.
So key takeaways for you isGLP-1s can be in the body
naturally throughout theintestines, and it can also be
(10:52):
used with this medication toenhance weight loss but as, in
turn, help with many othermetabolic issues within the body
.
So it is a very effectiveanti-inflammatory, metabolic
health and for weight loss, soit can be used very well.
So let's talk about how itaffects the gut and brain.
(11:14):
Now.
I discuss the gut and brainconnection quite often and how
the microbiome influences it.
I think the microbiomeinfluences almost everything in
some manner, being that the gutis a second immune system.
So because of that, you canimagine the importance of the
(11:37):
bacteria within your entire GIsystem and how it's a role it
aids in your hunger regulationand how much GLP-1 secretion is
actually happening.
So if you have poor gut health,meaning there's an irregularity
of the right good bacteriawithin it, you actually will
(12:00):
decrease your amount of GLP-1use within your body, which then
is why you need medication.
And you'll know this when youstart to see visceral fat,
meaning that donut surroundingyour waistline, when you see the
waistline and you get thatbelly anything from small belly
(12:21):
to big belly and your hip towaist ratio is greater than one,
you'll know this is a very bigsign of what, um, the gut is
telling you.
Yes, there is a fat issue,there's an inflammatory issue
and something is not right.
So things that stimulate GLP-1to boost it more naturally and
(12:46):
if you weren't taking anymedication, the probiotics would
be first would be fiber.
You know, think fibrous foods,and fibrous foods are short
chain fatty acid foods.
This helps enhance that L cellactivity.
As I was saying, that L cellactivity is in the intestines
and it's boosted.
(13:06):
And how do you do that?
You're going to have morefibrous foods.
Think broccoli.
You know veggies things, moreveggies in the diet.
You're going to bring that upNow when you're talking about
the gut bacteria, probioticswithin the actual intestines and
colon that will build up thatGLP-1, it's called acromansia.
It's one that improves the gutlining and increases GLP-1
(13:29):
production.
Bactrotirocytes is linked tolean body mass and metabolism
increase, and lactobacillusbifidobacterium probiotic
strains that support GLP-1function.
Now you'll see many streams ofthat and I talk about that in a
podcast about different types ofprobiotics, but these are three
(13:51):
main ones that will help reduceand increase the GLP-1
production naturally, so you cantake these in conjunction with
medication or without.
It also is very big on, notonly for insulin resistance,
which is the decreasing insulinsecretion within the bloodstream
(14:13):
, but also for inflammation.
So I've had many clients takeGLP-1s due to inflammatory
reasons and myself included.
I have a history ofendometriosis and I've had to
use this in conjunction, notjust for weight loss but for
inflammatory reasons.
So it is so important.
But there's a huge connectionagain with an unhealthy gut,
(14:37):
bacteria dysbiosis, which isdysregulation, and that can lead
to inflammation, insulinresistance and reduced GLP-1s.
Factors that damage the gutinclude high sugar intake,
processed foods and artificialsweeteners, antibiotic overuse
and chronic stress.
Now, that is just one part, butwhen you put all of them
(15:01):
together, they will affect yourgut.
Let me tell you personally ifyou don't take care, at least
modify sugar intake, processedfoods, antibiotic overuse and
your overall stress, you'regoing to have inflammation and
you will get more insulinresistance.
Until you start looking within,these things will not change.
(15:25):
That's why these medicationshighly effective, but parts of
this is learning the differentareas to get better.
Now, how do you optimize it?
Let's chat.
We're just in lesson three.
Right, a lot to talk about.
So there's many more things wewill go into, but we optimize
(15:47):
our gut by eating fibrous foods,incorporating fermented foods
if that's in your diet.
But you can always just useyogurt that has probiotics or a
sauerkraut low sauerkraut.
You can take pre and probioticsin your diet or take foods that
are digestible for you.
Avoid the processed things asmuch as possible, you know.
(16:09):
Modify it in your diet as muchas you can, or at least really
look for more nutrient densethings and manage your stress.
So when you just do this, thispart, you'll be so surprised how
much you've improved.
So I'll see you on the nextlesson.
so let's talk about um, the glp-1s and the science
of it.
So how does it kind of actuallywork?
You went over just a generaloverview.
But how is it working in thebody and um?
So I had stated that glucagon,like peptide and glp-1, it's a
hormone in the gut.
(00:23):
It plays a crucial role inregulating the appetite, the
metabolism, and it is part ofthe incretin hormone family,
meaning that it is insulinreleasing from eating, endocrine
, meaning the body is excreting,and scientists have discovered
(00:46):
that this GLP-1 level either isdone naturally through the body
or has now produced medicationsfor better blood sugar control,
weight loss and improvingmetabolic health in many areas
and many other areas that it hasshown that has had improvement.
(01:07):
As I talk and we'll discussfurther, increased
hyperinsulinia has caused manychronic illnesses.
In this situation we're tryingto talk about why it's important
to have proper balance of GLP-1, whether it is through
medication or naturally, how toget to there and it's an amazing
(01:30):
thing what the body can do.
It's about how it's functioning.
You know what's the link.
You know when you think about aGLP-1, it's secreted, actually
through the intestines.
It intestines by the L cellsand in that response it helps
regulate our metabolism and ithelps stimulate pancreatic beta
(01:55):
cells to release insulin whenglucose levels are high.
So, yes, this was initiallygiven for diabetic patients so
that it can prevent blood sugarspikes and to prevent and help
move glucose within thebloodstream into the cells for
energy.
The main issue is when we haveexcess and too much.
(02:17):
This is so important, obviously, for type 1 diabetes
individuals that have an insulinsecretion or excess, so they
call it insulin resistance, butreally it's maybe an excess
amount of insulin within thebloodstream not able to get out,
or there's an impairment.
In type 1 diabetes, there's anactual impairment in the beta
(02:40):
cells in producing the insulin.
So it's a little bit different.
One can be managed.
The other one actually is agenetic component that needs the
insulin to prove, but in turnyou still can benefit in a GLP-1
component that if you can getrid of the excess of insulin
that is not needed, that will behelpful for both patients, for
(03:02):
weight loss and metabolic health.
So when you boost it, it willhelp your insulin function, your
metabolic health, your overallmetabolic and weight.
Now, things that it does doinitially, not just by insulin
secretion.
It slows gastric emptying.
So you're going to see and hearbig conversation constipation,
(03:24):
nausea.
Why does it do that?
It does that because it staysin, makes food and digestion a
little slower.
One, making you feel full soyou're not eating and eating.
Two, it regulates the leptinwhere your food intake.
So there's hormones calledleptin and ghrelin.
Ghrelin is for when you'rehungry.
(03:47):
Leptin is that food, thatfullness.
The GLP-1 will slow that feelingof fullness satay and it keeps
the blood sugar level stable,reduces your post-meal energy
crashing and prolongs feelingsof fullness, which is why you
are able to sustain thismedication.
What does it matter?
(04:07):
The slower it reduces thehunger.
Now I will say a caveat to thatis that if you drink more water
kind of help with the digestionyou won't get as many as much
of the constipation that maycome with a GLP-1.
The benefits of slowing yourdigestion is eating less.
But if you're not having highquality, nutrient dense foods,
(04:31):
then that is a problem.
You know, having zero calories,a bunch of French fries and
then saying I or I, and then Ihad a protein shake, I'm good,
that's not going to cut it Ifyou're still not eating and
taking like medications, ifyou're taking GLP medications
and you're not using this as atool and you're still not
(04:52):
nutritively, giving yourself theright amount of foods for the
body, then there is problems.
Yes, it reduces your appetiteand your satay, like I had been
initially saying.
This is because, um, the GLPone acts on the hypothalamus,
which is the brain's hungercenter.
So it signals and says, hey,I'm full.
(05:14):
So that leptin number, if itwas really high, usually the GLP
would signal it and say, hey,you're, you're.
It'll start lowering it.
So, in saying you're full,you're good, don't overeat, now
You're okay.
And that's helpful, becausewhat it is is it's, um, wanting
you not to just overeat and itshould be eating for fuel, not
(05:37):
eating just to be eating andeating and eating, and it helps
naturally decrease the body'sneed for food intake.
It's more of okay, we need this, not I have to have, I have to
have.
Now, granted, there'senjoyments, but when you have
those enjoyments and enjoyments,enjoyments, you know that food
intake and your metabolic healthwill change and your metabolism
(05:58):
will change and you may not beable to get back to where you
used to.
But the reason it's soeffective is it does help with
the weight loss.
Now, if you still eat your waythrough these medications and
you're not able to get throughthe behavior changes.
The science of it may not workNow.
It lowers the glucagonsecretion.
(06:18):
Glucagon is a hormone thatincreases the blood sugar,
breaking down stored glycogen inthe liver.
Glp-1 reduces the glucagonlevels and preventing
unnecessary glucose release.
So there's a lot of studiesthat have shown that GLP-1 use
will help with fatty liver, willhelp long-term because the
(06:41):
liver metabolizes and has manyfunctions and in turn, because
it will break down the glycogen.
It can also break down manyother parts, like metabolizing
cholesterol, and will helpprevent more issues or break
(07:02):
down the liver byproducts, whichI will get into in a further
lecture.
But why does it matter?
When you lower that glucagonlevel, you then can contribute
to better blood glucose balanceand reducing your diabetes risk
or management.
So it's not that you'renecessarily stopping yourself
(07:23):
from diabetes.
You're managing it if you haveit or you may be pre-diabetic,
and trying to reduce that riskof it progressing in your body,
the liver or the pancreas fromgetting, or the insulin from
becoming insulin resistant.
So it's super important, youknow, and it can be, if it's
used in the right manner.
This is an excellent way ofchange.
(07:46):
Now GLP-1, and how is iteffective with the weight loss?
So we talked about the diabetespart and the sugar.
Why is it affecting weight loss?
So initially I stated that ithas to do with you know, you'll
see the medications that are out.
Big ones are semiglutide,terzapatide, which are Wagovi
(08:07):
and Manjura, or the other one iscalled Zepan, which is
terzapatide.
These are appetite suppressionmedications.
They reduce the hunger withinyour body because it signals and
says, hey, I don't need thatmuch food.
This, in turn, is a good andbad thing.
That doesn't mean you don'tneed anything, because your body
(08:29):
does need nutrients to live.
So you still need a good amountof protein, carbs and fats to
sustain a good quality body.
And I think what happens ispeople get that triggered off
and then they stop eating andthen they wonder why they're
nutrient deficient and they'rehaving hair problems and side
effects.
You need to eat, but you needto choose the right foods the
(08:53):
highest amount of protein andquality carbs and nutrition with
hydration.
It delays digestion, which youhave talked about, to make you a
little bit more fuller.
It discusses in the sense ofwhen you're trying to fat burn,
you're trying to build up yourmetabolism and insulin
sensitivity insulin sensitivityso that your body can use that
(09:16):
fat for energy rather than juststoring it and not getting rid
of that insulin within thebloodstream.
It lowers the blood sugar andit helps with less fat storage.
So it kind of gets rid of thatinsulin within the bloodstream
and lowers the blood sugar andit helps with less fat storage.
So kind of gets it, gets rid ofit and when you stabilize that
you'll notice you'll see moreweight loss.
Now the clinical evidence onhere I'll show you and leave
(09:40):
some research articles available.
But basically the main thing isyou can reach anywhere between
15 to 24% of body fat weightloss with these medications, in
addition to, obviously, behaviormanagement, dietary and
long-term goals.
You can do very well andmaintain.
(10:00):
Trust me, I have been on thesemedications and I maintain for
the past year and a half at mygoal weight and have micro-dosed
these medications four to sixweeks within as needed for
weight and inflammatory reasons.
So yes, these medications dowork and are very effective at
done and used properly and usedproperly.
(10:29):
Other research has shown higheramounts of GLP-1 tends to have
that person eat less and theyalso have a lot less of that
body fat percentage, especiallyif you know how to maintain the
amount of protein in your bodyand I talk about this in other
lectures and online about what'sthe right amount of protein for
you.
So key takeaways for you isGLP-1s can be in the body
naturally throughout theintestines, and it can also be
(10:52):
used with this medication toenhance weight loss but as, in
turn, help with many othermetabolic issues within the body
.
So it is a very effectiveanti-inflammatory, metabolic
health and for weight loss, soit can be used very well.
So let's talk about how itaffects the gut and brain.
(11:14):
Now.
I discuss the gut and brainconnection quite often and how
the microbiome influences it.
I think the microbiomeinfluences almost everything in
some manner, being that the gutis a second immune system.
So because of that, you canimagine the importance of the
(11:37):
bacteria within your entire GIsystem and how it's a role it
aids in your hunger regulationand how much GLP-1 secretion is
actually happening.
So if you have poor gut health,meaning there's an irregularity
of the right good bacteriawithin it, you actually will
(12:00):
decrease your amount of GLP-1use within your body, which then
is why you need medication.
And you'll know this when youstart to see visceral fat,
meaning that donut surroundingyour waistline, when you see the
waistline and you get thatbelly anything from small belly
(12:21):
to big belly and your hip towaist ratio is greater than one,
you'll know this is a very bigsign of what, um, the gut is
telling you.
Yes, there is a fat issue,there's an inflammatory issue
and something is not right.
So things that stimulate GLP-1to boost it more naturally and
(12:46):
if you weren't taking anymedication, the probiotics would
be first would be fiber.
You know, think fibrous foods,and fibrous foods are short
chain fatty acid foods.
This helps enhance that L cellactivity.
As I was saying, that L cellactivity is in the intestines
and it's boosted.
(13:06):
And how do you do that?
You're going to have morefibrous foods.
Think broccoli.
You know veggies things, moreveggies in the diet.
You're going to bring that upNow when you're talking about
the gut bacteria, probioticswithin the actual intestines and
colon that will build up thatGLP-1, it's called acromansia.
It's one that improves the gutlining and increases GLP-1
(13:29):
production.
Bactrotirocytes is linked tolean body mass and metabolism
increase, and lactobacillusbifidobacterium probiotic
strains that support GLP-1function.
Now you'll see many streams ofthat and I talk about that in a
podcast about different types ofprobiotics, but these are three
(13:51):
main ones that will help reduceand increase the GLP-1
production naturally, so you cantake these in conjunction with
medication or without.
It also is very big on, notonly for insulin resistance,
which is the decreasing insulinsecretion within the bloodstream
(14:13):
, but also for inflammation.
So I've had many clients takeGLP-1s due to inflammatory
reasons and myself included.
I have a history ofendometriosis and I've had to
use this in conjunction, notjust for weight loss but for
inflammatory reasons.
So it is so important.
But there's a huge connectionagain with an unhealthy gut,
(14:37):
bacteria dysbiosis, which isdysregulation, and that can lead
to inflammation, insulinresistance and reduced GLP-1s.
Factors that damage the gutinclude high sugar intake,
processed foods and artificialsweeteners, antibiotic overuse
and chronic stress.
Now, that is just one part, butwhen you put all of them
(15:01):
together, they will affect yourgut.
Let me tell you personally ifyou don't take care, at least
modify sugar intake, processedfoods, antibiotic overuse and
your overall stress, you'regoing to have inflammation and
you will get more insulinresistance.
Until you start looking within,these things will not change.
(15:25):
That's why these medicationshighly effective, but parts of
this is learning the differentareas to get better.
Now, how do you optimize it?
Let's chat.
We're just in lesson three.
Right, a lot to talk about.
So there's many more things wewill go into, but we optimize
(15:47):
our gut by eating fibrous foods,incorporating fermented foods
if that's in your diet.
But you can always just useyogurt that has probiotics or a
sauerkraut low sauerkraut.
You can take pre and probioticsin your diet or take foods that
are digestible for you.
Avoid the processed things asmuch as possible, you know.
(16:09):
Modify it in your diet as muchas you can, or at least really
look for more nutrient densethings and manage your stress.
So when you just do this, thispart, you'll be so surprised how
much you've improved.
So I'll see you on the nextlesson.
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Current and classic episodes, featuring compelling true-crime mysteries, powerful documentaries and in-depth investigations. Special Summer Offer: Exclusively on Apple Podcasts, try our Dateline Premium subscription completely free for one month! With Dateline Premium, you get every episode ad-free plus exclusive bonus content.
On Purpose with Jay Shetty
I’m Jay Shetty host of On Purpose the worlds #1 Mental Health podcast and I’m so grateful you found us. I started this podcast 5 years ago to invite you into conversations and workshops that are designed to help make you happier, healthier and more healed. I believe that when you (yes you) feel seen, heard and understood you’re able to deal with relationship struggles, work challenges and life’s ups and downs with more ease and grace. I interview experts, celebrities, thought leaders and athletes so that we can grow our mindset, build better habits and uncover a side of them we’ve never seen before. New episodes every Monday and Friday. Your support means the world to me and I don’t take it for granted — click the follow button and leave a review to help us spread the love with On Purpose. I can’t wait for you to listen to your first or 500th episode!