66. The Next Frontier of Testosterone Replacement Therapy

In this episode, I’m joined by Shalin Shah, CEO of Marius Pharmaceuticals, to talk about the past, present, and future of testosterone replacement therapy (TRT). From the systemic decline in testosterone levels among younger men to the breakthrough FDA-approved oral testosterone Kyzatrex, this conversation explores what’s next for hormone optimization—and why it matters more than ever.Take a look and listen as we dive deep into the myths around oral testosterone, why SHBG levels matter, how testosterone therapy affects inflammation, cardiovascular risk, cognition, libido, and longevity, and why optimizing free testosterone—not just total T—is the true goal. Plus, we discuss clinical pearls for transitioning from injections or pellets to oral therapy, monitoring labs effectively, and future directions for female testosterone replacement.

Whether you’re a clinician, a patient, or someone interested in living with more energy, drive, and clarity—this episode is a must-listen.🧠 About Shalin Shah:Shalin Shah is the Chief Executive Officer of Marius Pharmaceuticals, a company pioneering innovative therapies to address testosterone deficiency and cardiometabolic disease. With a background in economics, biotech leadership, and healthcare strategy, Shalin has become a leading advocate for rethinking how testosterone is tested, prescribed, and perceived. He’s also the founder of RethinkTestosterone.com, an educational platform for clinicians and patients aiming to shift the paradigm from symptom-based care to proactive, personalized hormone optimization.This episode is brought to you by Tides Health, formulating physician-grade peptide-based supplements designed for performance, recovery, and longevity.🛒 Shop now at yourtides.com — Use code DRJONES for 15% off your first order📍 Resources & Links:• Learn more about Kyzatrex: https://www.kyzatrex.com/• Rethink Testosterone: https://www.rethinktestosterone.com/• 📲 Follow Shalin Shah on Instagram: @TheMetabolicCEO⏱️ TIMESTAMPS:00:00 – Welcome & the testosterone crisis in men01:00 – Meet Shalin Shah: Why testosterone is his mission04:30 – What’s causing the testosterone collapse in younger men?08:15 – Low T symptoms and why “normal” labs can be misleading13:00 – Comparing TRT delivery options: injections, topicals, pellets, and oral16:30 – Why SHBG matters more than you think22:00 – Kyzatrex: Oral testosterone that bypasses the liver26:00 – The importance of dietary fat for oral testosterone absorption33:00 – Estrogen management and why most men don’t need AIs38:00 – TRT and fertility: What the Kyzatrex trials reveal41:00 – How to transition from other TRT forms to oral43:00 – Best practices for lab testing Kyzatrex44:30 – How testosterone affects inflammation, cardiovascular risk & longevity46:00 – Future of TRT for women48:00 – What Shalin would tell his younger self49:00 – Where to learn more about Kyzatrex, Marius, and TRT science📣 Subscribe + Follow:Don’t miss an episode! Subscribe and leave a review.📺 YouTube: https://www.youtube.com/@DrJonesNMDTV🎧 Spotify: https://open.spotify.com/show/2QrMGwCIGo1kjdezfCyYDK?si=WhH4DW3oQw2k9qkfCtHZdQDisclaimer: The information shared on The Dr. Jones Optimization Podcast and its associated YouTube channel is intended for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Listening to this podcast or viewing its content does not create a doctor–patient relationship, and nothing shared should be interpreted as individualized medical guidance. Always consult with a qualified healthcare provider before making changes to your health regimen or managing a medical condition. The opinions expressed by Dr. Jones and his guests are their own and do not reflect official medical advice or recommendations