February 25, 2025 • 33 mins
There's a new weight loss fad drug on the market. While it may help speed the rate of weight loss, what caused its quick rise to popularity... and what horrrors does it hold for our time in the bathroom?
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-- Sources:
https://www.goodrx.com/ozempic/diarrhea
https://gradstudies.musc.edu/about/blog/2024/08/the-ozempic-era
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Transcript
Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
>> Hunter Hoover (00:00):
If I'm sumaggluting myself on the daily,
but I'm still eating like two to seven pieces of
pizza for lunch
and I'm just goblin down sugar drinks
and I refuse to exercise in any
way, I have a feeling it's not going to have
the accomplished effect.
(00:24):
Welcome back to Privy.
Privy is a podcast about
bathrooms recorded from
my home bathroom. I'm your host,
Hunter Hoover, and I love bathrooms.
Welcome back everyone. Thank you so much for being here.
Um, thank you for joining us as we're closing out
February. February is a short month and it's a challenging
(00:46):
month. There's a lot of frustration. There's a lot of,
I think unexpected surprises
in February. You know, I think there's a lot
of folks that, that come towards the end of the year,
they'renn have, they're gonna have a lot of, a lot of extra stuff
going on. And in February is one of those
months where sometimes that type stuff happens.
(01:07):
Uh, I want to note here at the top
of the show, I have a co worker, uh, at the high school I
work at who has told me, he's told me on
a number of occasions, he's like, hey, I got
some pretty sweet bathroom store. Like
I used to work as this. You
worker, like worked with kids. I've got some
(01:27):
stories to tell. The incredible
bummer is he is unwilling to come
on the show. I've been working on it. There's actually a handful of
people that I know who are like, yeah, I've
got some sweet stories, but they're unwilling to come on the
show. It's a real bummer. It's real
unfortunate because the world needs
their bathroom wisdom, but they are unwilling to share
(01:49):
it. It's an ongoing problem. It's an
apprehension that I find that a lot of people have when they
begin interfacing with this show. You know, maybe they're met with
some embarrassment, like, oh, I'm listening to this
guy talk about bathrooms. He says he likes
bathrooms. I sure like bathrooms. I would much
rather do this than diaper dumpy
(02:09):
myself. But, um, these bathroom stories,
they need shared. So I'm going to put a little call out here
at the top of the show. If you have what
you believe is a bathroom story that you'd love to share, hit me
up. Those who've heard, ah,
an episode where I've had someone on before know that
you do not have to carry the bulk of the episode. You
(02:30):
do not have to carry the episode with your story. Now,
your story will probably be the
highlight of the show. It usually is. But I
always have some things that I need to be asking people about
bathrooms. So if you're interested, hit me up
privycastmail.com. it's
February. The other thing that happens in February, besides
leading to post your regret,
(02:52):
uh, is a lot of people have
abandoned a lot of those, uh,
diets and things that they,
you know, they started out the beginning of the year
and maybe January is a little bumpy. In February is the month we're going to
lock it down. But by the time
Valentine's Day rolls around and everybody's
(03:13):
gobbled up their, their dang,
you know, they've gotten there,
Valentine's candy,
they've blown the New Year's
resolution. It's done, it's failed.
And so while these New Year's resolutions and
health fads are all
(03:33):
but totally cast by the wayside
by this point in the year, there's another
fad that seems to be a little
more prominent than I think it needs to be.
And before we jump into this fad and specifically
how this fad affects our
bathrooming, we need to do a little history
(03:53):
lesson in privy, cast style.
In 1902, British
physiologist William Bayless and
Ernest Starling. Those are some very British
names, by the way, I might add. They discovered
a chemical, uh, a compound
(04:15):
in our bodies called secretin.
It's the first hormone which they
discovered helps regulate
pancreatic secretions.
This discovery marked the
beginning of research into
gastrointestinal hormones and
their role in the metabolic process. In other
(04:36):
words, they started to learn about how the
very yummy drippy juices that our internal organs
produce help break down the food and metabolize
the food that we eat. Just an
FYI, in today's episode, we're going to
say the word secretion a lot.
So if the word secretion is a word that
bothers you, um, I'm sorry, but
(04:58):
we're going to say secretion a lot this episode.
It's an unfortunate byproduct of us talking
about these things, but what's a guy to
do?
Secretion. The idea of
incretins were more of a concept.
(05:20):
The term in cretin
or in incretin was introduced to
describe gut derived
factors that enhance insulin
secretion in response to oral
glucose. So you eat the yummy sugar glucose, yum, yum, yum,
yum, yum, yum, yum, yum, yum, yum, yum, and then your gut
(05:40):
it. This in incretin
is this thing that helps
enhance insulin
secretion in order to respond to that intake glucose.
Like, you eat a big fat brownie,
big sloppy, wet brownie, a big old sloppy
guy, and they're like, he's gonna have more
in incretins due to the brownie. However,
(06:03):
the specific hormones
responsible weren't, uh,
immediately identified. It wasn't like, hey, this is
the one to one of what's going on here.
It seems incretin, or
incretin is tied specifically to the glucose you
eat and as a result is
related to the digestive systems in our
(06:25):
bodies. Here on Privy, we're a
big fan of digestion. I had a big
old fancy meatball sub with
fancy ham on it this afternoon, this evening, so very
delicious. And I'm going to learn a little bit about
digestion here in the coming hours, I'll tell you what.
But the incretin phenomenon was used
(06:46):
to describe this observation.
Researchers labeled this in
the 1960s and 70s,
and they came to believe
that oral glucose intake
stimulates a stronger
insulin response compared
(07:06):
to intravenous glucose.
So, um, in other words, like, if you
eat something that is high in sugar, it
causes a greater response than if you just straight
up inject the sugar straight into the good
old SS bloodstream right there and get it right on
in. This M phenomenon that when
you eat it, it produces a greater insulin
(07:29):
response became known as the Crein
effect. But the hormones
responsible for this phenomenon were not really
perceived or that well known
or could not be identified. It
took them a bit, but by
1971, they pinned
down what was causing this thing.
(07:52):
An incretin hormone was
discovered, known as
GIP, I.e. gastric
inhibitory polypeptide.
This gastric inhibitory
polypeptide was identified
as an incretin hormone.
However, GIP's effectiveness was limited
(08:13):
to individual type, limited
in individuals with type 2 diabetes. So
people with type 2 diabetes, that GIP, they had
the GIP, you know what I'm saying? The GIP was really gipping on.
And so that caused these scientists to
wonder, why do people with this
specific type of diabetes, type 2
(08:33):
diabetes, have this
gastric inhibitory polypeptide?
And. Or, uh, rather, why are they so
limited in it? Like, why does their body
not seem to produce or not seem to have
the same reaction in the face of glucose
as others? In the 1980s,
(08:53):
advances in molecular biology
revealed that there was
actually a gene that had
some things to do
with these matters. The
proglucagon gene
in the pancreas produces
multiple peptides, including
(09:15):
glucagon. Researchers found
that in the intestines the same gene
produces different peptides,
GLP1 and
GLP2. Now I will notice this is different
than GIP. We've been talking about GIP.
This is GLP. And
these two, GLP1 and GLP 2
(09:37):
are responsible for helping break down
sugars in the body.
In 1985 they isolated
GLP2 when a
team, uh, uh, led by Dr.
Joel Haernner.
Haernner, Haernner
and other colleagues from Harvard Medical School
(09:59):
identified GLP1 as one of
the products of
proglucagone. They
determined that it exists in these two
active forms, both of which are port
to insulantropic
agents. I think that's agents that respond
to or need to respond to insulin. But like
(10:22):
that's a lot of science mumbo jumbo, right?
And I acknowledge I just went on a science mumbo
jumbo jumbo. Mumbo jumbo.
But so what, what does this bad boy
do exactly? Like what is this thing? I
mean we got like medical history
lesson and a chemistry lesson all wrapped up
(10:42):
in the first 10 minutes of this episode and you've barely even
talked about the bathroom.
Weren't trying to be doctors here.
What's this even, what's this got to do with anything? So
the scientists found that GLP1 could
stimulate glucose dependent
insulin release from pancreatic beta
(11:03):
cells, a key function in
maintaining blood glucose levels.
GLP1
delays gastric empty,
which usually results
in you taking a poo and acts on the
brain to promote satiaiety and reduce
(11:24):
appetite. So this
peptide, GLP1
is found to be able to reduce
your appetite and slow
the rate by which you have to drop. A Chaz
Royale could be helpful.
Seems unhelpful to me. If I don't drop,
(11:45):
if I'm ir, regul it. Like I'm pretty regular guy,
I stay pretty regular. I'm not going to lie about it.
If I get off on my shazz schedule,
I know it like I know
it. And so it's
important to me to make sure that my shazz schedule
stays pretty regular. But
(12:06):
GLP1 delays gastric empty,
empty. And somehow
they've also found that this peptide,
this hormone peptide, I don't even
know, I'm not a scientist. I don't understand what freaking
peptide is. Like I have a game or there is
a game, I don't know if I have it. I have to go check my very good board
(12:26):
game wall. But there's a game called Peptide. I
assume it has something to do with that.
But somehow they found that this thing can
also be good for your heart. It improves
cardiovascular function and may
have other protective effects. Problem
is this peptide,
(12:46):
GLP1, it's like a two minute half
life, meaning if you are to
introduce it to the system,
if you do it orally, like if you snack it down,
if you GLP1 straight down the
topside mouth hole in
two minutes it's going to be rendered completely
(13:06):
ineffective. You can't do it orally.
And so they went looking for something a little
more stable.
Just like them teenagers that are dating, you know what I'm saying? They're looking
for something a little more stable. Early studies
using synthetic GLP1
(13:28):
showed promising results
however in improving blood
glucose control in individuals with type 2
diabetes. So they needed this
thing to resist
degrading that happens within the body. So if
you put this peptide in, it
is going to naturally degrade and it
(13:51):
degrades quick like two minutes. And so
they're trying to figure out a way and they began to work
on synthetic versions of
GLP1 that would have a greater half
life and maybe be able to be introduced in different
ways.
The GLP1 receptor
agonists, I don't know what that means, um, such
(14:14):
as xenotide, are introduced in the
2000s. Novo Nordisk,
a Danish pharmaceutical company, began
to work on semagglutide in the
2000s. If you're looking for a
good name for your baby, if you find
yourself suddenly or otherwise in the
(14:34):
market for a good name for your baby
or maybe your enemy, look no farther
than sumaagglutide. Sumagglutide
was designed as a modified
GLP1 analog with an
extended half life, meaning it lasts longer once
it's introduced to this system of
about one week. This was
(14:56):
achieved by substituting specific. It's all
chemistry, you chemistry, wemistry,
just friggin Bill Nye the science guy thing. Out of this
medication they added a
fatty acid side chain to enhance
binding. I don't even know,
it's a bunch of pharmaceutical mumbo jumbo.
But Novo Nordisck
(15:19):
conducted extensive preclinical
studies followed by clinical trials
to establish semaglutides
safety and uh, efficacy.
In 2017 this
drugmaglutide gained
approval by the FDA to treat
(15:39):
type 2 diabetes.
It was introduced as a once
weekly injectable treatment, a uh,
convenient option compared to the daily
injections. Nowadays similar
drugs are not only used to treat type
2 diabetes.
(16:05):
Somaglutide and other similar drugs
began to be explored for their benefits in
treating obesity. Observations
from diabetes Trials showed that
semaglutide also led to significant weight
loss. Novo Nordisk initiated
trials to study higher doses of
somaglutrid in treating
(16:27):
obesity. So
you know, you just give them the shot,
make them skinnier. Clinical trials for
obesity began in 2021 where they
showed they can lower body weight when
paired with lifestyle changes. That uh,
lifestyle changes seems to be pretty important.
Like if I'm
(16:49):
sumaggluting myself on the daily but
I'm still eating like two to seven pieces of
pizza for lunch
and I'm just goblin down sugar drinks
and I refuse to exercise in any
way, I have a feeling it's not going to have
the accomplished effect. I think that lifestyle change
(17:10):
is pretty important to this situation.
Those lifestyle changes like
they're important. That's what I'm saying. But the
drug gained approval, Semaglutide and others, uh,
it gained approval for weight loss in
2021 under the brand name Wegoi
for chronic weight management in adults with
(17:31):
obesity or overweight and at least
one weight related condition such as hypertension
or uh, dyslipidemia. I don't know.
In other words if they deemed that a
person is big enough to where
they're going to have health complications either now or down the
line they would, we would prescribe them
(17:51):
Wagoi. It is a fat loss
drug. A weight loss drug. Sorry I can't weight loss.
But another similar drug,
Ozempic took on the
role of the diabetes management while
Wagoi was more the weight loss
drug. These are still
injections and researchers are
(18:13):
exploring oral formulations already approved
as Ribosis and investigating
Semaglutide for other potential indications such as non
alcoholics. They can't say that word, don't know
it. But
Ozempicmalutide gained
a significant popularity
in the last few years as a weight
(18:34):
loss drug due to its
remarkable effectiveness, its mechanism
of action and the growing demand for safe
and effective treatments for obesity.
Apparently exercise,
dieting and self control
just won't cut it. Here uh, are the
primary reasons for Ozempics
(18:56):
popularity. First of
all Ozempic had exceptional
weight loss results and it could
also treat diabetes which is this type 2
diabetes is often a condition that
they see that runs like side by side with
obesity. This was
also related to a new view of obesity
(19:18):
as being a quote medical
condition. Now I'm
going to say something. I'm not a skinny
person, I'm full
bodied as the kids say. I'm a
size 2x. I understand the
level of fat kid. I have achieved. But here's the
deal. I am not
(19:40):
fat because I have a medical problem called
obesity. I'm fat
because I ate, again, a very
sloppy meatball sub
sandwich, and within the hour
purchased a large shamrock
shake, which I shared with my family. But
I did do it. Do you know what I'm saying?
(20:03):
Like, I'm not blaming a medical
condition for the fact that I like Oreos.
I'm not blaming a medical condition for the fact
that video games are more fun
than exercising. It's just true.
And so it has nothing to do with me
thoroughly enjoying pizza and ice cream. It's a medical problem. That's
(20:24):
pretty much what these people are trying to say. But
Ozempic also got a lot of press. Even though
there were alternatives out there,
social media and other celebrity
endorsements really drove
Ozempic'popularity way, way up.
Another reason that people point to
Ozempic'popularity was the global pandemic.
(20:46):
This thing called the novel coronavirus,
uh, uh, echo chamber, in which
men and women, but like, kind of like man,
decided to really hunker down and start podcasts. You
know, it's just weird. It's a weird
phenomenon. It's weird. I've seen a lot of people wearing
masks again recently. And I'm not here to make a comment about
the masks, but it is kind of
(21:09):
traumatizing when I see that. And people are going to hear that and
like, shut up. Yes, as you should.
But my thing is like, the whole mask
thing was kind of hellish to me. It was
very awful. I.
The minute that, oh, I remember
the day that they lifted the MAS mandate, and
(21:29):
I was like, you'll never be able to put it back on.
You got me. Fool me once, shame on. Shame on
me or fame on you or whatever. And
you're not gonna fool me twice on this. Like,
uh, it's just an unbearably awful experience.
But here we are. We must soldier forth.
But the global pandemic, the novel coronavirus,
(21:52):
caused a huge spike in profit from the pharmaceutical
company. It's weird how that worked. It's weird
how as we directly, you
know, were pushing
this idea of a need for a vaccine, we were also
making wooy bucks off of that
vaccine. It's fascinating to me, you know, I don't know if
there could possibly any collusion or like,
(22:15):
anybody that was like, pushing an agenda in order to make a
trainload of money. Fat shot.
Uh, also it's considered like.
So in this, they, they
began to, as, as the coronavirus
pandemic ended they needed, they had
these new profit margins that were kind of unheard of.
(22:36):
Like, how do we meet these profit mar. Like how do we, how do
we meet these, these profit expectations
again? And so they began to push
Ozempic as a fat loss, weight loss drug,
uh, in order to drive up some sales, uh,
some profit margins on, on these companies, pharmaceutical
companies. Also, because the
(22:57):
procedure and the use of this medication can be considered
medical, a lot of it is covered by
insurance. As we discussed,
Ozempic and other similar drugs take a
significant role in your bathroom.
They come up a lot there. They're going to affect you
when you get in the zone. It should be
(23:17):
noted if you're looking to Ozempic for weight
loss or blood sugar regulation and you're concerned
about the bathroom, should be aware of a number of things.
Before I continue, another thing you should be aware of
is that I'm not a doctor. I've never been to medical
school. I don't even,
like, I barely go to the
(23:37):
doctor to be checked up.
And so don't take anything that I tell you for medical
advice. This is explicitly not medical advice and
nothing in this episode has been.
But you should be aware if
you're looking toward Ozempic or other similar
drugs for weight loss control,
about a number of ways that it is reported to affect you
(24:00):
in the bathroom. Now,
depending on where you look, there are
reports that say Ozempic can cause both
diarrhea
and somehow
constipation. And, uh, it's a baffling phenomenon.
Truly, these drugs that have
(24:21):
both diarrhea and constipation as a side
effect always throw me for a loop because like
in my brain
diarrhea and
constipation are like the opposites.
And in my brain it's difficult to have the opposites at
the same time. Like you're either plugged up or it's rocketing through
you. I'IT'S usually rocketing
(24:44):
through me. You know what I'm saying? It's flying right through
me. It is noted that you can also
experience nausea and vomiting from Ozempic.
Those two are a no fly for me. If
a medication is non necessary, like
if it is to treat something that I don't need
to be treated and it causes nausea and
vomiting. I don't know about that. Like
(25:06):
I might be a hard skip on it. That's just me.
So about 8% it says of people
who have taken Ozempic experience
diarrhea. And there's
a number of sources that say that if you avoid
fat Rich foods and sugary drinks, it can help
keep the diarrhea down. And that's because
(25:28):
it's just passing that stuff through. It's not trying
to break it down. It's just moving along the way.
In some cases, it can be severe enough diarrhea
that you elect to stop taking the medication that
is reported to be a thing to happen. Some people,
the squirts get so bad that they're like, I'm
done. I'm done ozempicking
(25:49):
myself. But in most cases, the
runs would go away on their own. In
fact, if 8% of people
who use Ozempic experience d, which is not
nothing. I mean, imagine if you went to
McDonald's and they gave you a bag of food and they said,
hi, 8% of our food is going to give
you flaming, raging diarrhea, Would you
(26:11):
do it? Would you still eat it?
I know I would. I would eat it
and then I would get the pupils
who have decided they're not going to eat it, and I would eat
theirs. But if
8% of this population
experience diarrhea, GoodRx
(26:32):
reports that 4% of those
quit taking the medication due to
rigorous diarrhea. And I want to
know, like,
that's actually a lot. Like
4% of people are like, the
diarrhea has overcome me so much. The
wild spray is more than I can handle.
(26:55):
Usually the diarrhea will last
for three days to a week. As your body adjusts,
you'll likely be experiencing diarrhea.
Ozempic does this because it changes
the way your body absorbs nutrients
and impacts how quickly things move
down the digestive tract.
(27:16):
What's even more wild is on Ozempic, many
people experience again both diarrhea
and constipation at the same time.
When this happens, it can result in
something fun. A phrase which is
haunting to me. And we all
hoped to never have to face
a phrase called overflow
(27:38):
diarrhea. Help us, Father, for we have
strayed far from you. Overflow
diarrhea. Dear Lord,
just, just help us.
And if the idea of overflow diarrhea isn't
scary enough, in these cases, the overflow
diarrhea is happening in what could possibly
(27:58):
be the worst place for
overflow diarrhea to happen Inside of
your body, in your colon and digestive
tract. What happens is
you get constipated and the poo
sets up and it's like it just
hardens right there inside you just
smashed, just doink,
(28:20):
just really clogged up the pen
down in there. Then as the
Ozempic makes the diarrhea run wild.
It runs into the poop plug
mid tr mid system and it
begins, because it cannot pass through, it begins
to eek out the edges of the turd log
(28:40):
that is still in the system. It's so fun.
Just a seepy turd log.
Other reports state that it affects urination,
but the correlation is not as strong to
speak to whether this is directly related to the
use of Ozempic or not.
And all of these things beg the question,
(29:02):
the rapid fat loss, the way it affects your
bathroomoming, the trouble with constipation and
diarrhea, uh, all these
things asked is
is it safe? And
the answer is sort of.
Ozempic and other similar drugs are
(29:23):
FDA approved for type 2 diabetes.
So as of the point of this record, it's
not technically approved as a
weight loss drug. Now
often it will still be used as a weight loss drug and
they'll say well you know, we're
treating pre type 2 diabetes by doing
(29:44):
this. Weight loss is
a side effect of Ozempic
and cocaine, so there's that.
It's not recommended for weight loss. But I'm not a doctor and this
isn't medical advice so talk to your doctor
if you want to shed some pounds quick. I guess you could
stab yourself in the tummy with thosezempic. I mean
(30:06):
it seems like it would work. It's worked for lots of people.
Talk to your doctor in treating type 2
diabetes which can develop into life altering or
problematic changes. It has side effects
which include the possibilities of developing
thyroid tumors and causing
pancreatitis. My mom had pancreatitis
(30:27):
when I was in school and I remember that
experience being pretty awful for her.
Like pretty awful.
It's not a miracle shot that's going to make you
skinny, but it will, except
for it comes with some side effects.
Impossible ongoing problems for the person who
uses it.
(30:49):
I'm fat. Hello, it's
me. The diary of a chunky kid.
And as a bigger guy I'm convinced
that the path forward is found
not in Ozempic and taking
these tummy injections and
trying to lose weight via a uh,
(31:12):
medication, but that the path
forward comes through, for lack of a better
way of saying it, trying to eat better,
eat smarter and working harder.
It's the best path forward for
losing weight. But if you
want to tummy jab yourself with some Ozempic and
(31:32):
get strange leaky gut,
constipation, diarrhea, you just go right
ahead and tell me your experience.
Privycastmail, dot com.
This will bring us to the end of another episode of Privy.
Thank you so much for being here. Thank you for joining us. Uh,
(31:54):
thank you for listening. I know I say this Share
the show on social media. Take you don't have to be this
episode. Go find maybe the most interesting looking
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episode. I know I have some of my favorites. But go
find one that you think and share it out to your social
media. Share with a friend, tag the show, do what you need to do. Get the
word out there about this thing. Do you know what I'm saying?
(32:17):
Um, you can follow the show at Privycast, you can follow me
and I'm @allet7. Leave the show a
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some money to Living Water International as a reminder that
(32:37):
we need to pursue cleaner water for all. Not everyone has
it and everyone should have it. Uh,
as always, send us an email
privycastmail.com. uh,
thanks to Kevin and Poddtington for the use of your music
this week. You can check out the links to their stuff in the ding
dong below. This brings us to the end of another
episode of Privy. Oh, by the way, if you're looking to
(32:59):
start a podcast, there'sn toa be a link down below.
It is an affiliate link to the my
podcast distributor of choice,
Podbean. I've been using Podbeans since this
show came out and I like it. And I like it so
much that I signed up to tell you guys that if you want to make a
podcast, you should join Podbean. It's pretty great.
(33:19):
Um, if you're thinking about joining doing a podcast, use the link
down below. It just helps them know that we're doing
this and that we like Podbean.
Uh, it's a good program, so check that out.
Thanks for being here on another episode of Privy.
Keep hoping in the free world, own your stank.
And now, as always,
(33:39):
don't forget to flush.
If I'm sumaggluting myself on the daily,
but I'm still eating like two to seven pieces of
pizza for lunch
and I'm just goblin down sugar drinks
and I refuse to exercise in any
way, I have a feeling it's not going to have
the accomplished effect.
(00:24):
Welcome back to Privy.
Privy is a podcast about
bathrooms recorded from
my home bathroom. I'm your host,
Hunter Hoover, and I love bathrooms.
Welcome back everyone. Thank you so much for being here.
Um, thank you for joining us as we're closing out
February. February is a short month and it's a challenging
(00:46):
month. There's a lot of frustration. There's a lot of,
I think unexpected surprises
in February. You know, I think there's a lot
of folks that, that come towards the end of the year,
they'renn have, they're gonna have a lot of, a lot of extra stuff
going on. And in February is one of those
months where sometimes that type stuff happens.
(01:07):
Uh, I want to note here at the top
of the show, I have a co worker, uh, at the high school I
work at who has told me, he's told me on
a number of occasions, he's like, hey, I got
some pretty sweet bathroom store. Like
I used to work as this. You
worker, like worked with kids. I've got some
(01:27):
stories to tell. The incredible
bummer is he is unwilling to come
on the show. I've been working on it. There's actually a handful of
people that I know who are like, yeah, I've
got some sweet stories, but they're unwilling to come on the
show. It's a real bummer. It's real
unfortunate because the world needs
their bathroom wisdom, but they are unwilling to share
(01:49):
it. It's an ongoing problem. It's an
apprehension that I find that a lot of people have when they
begin interfacing with this show. You know, maybe they're met with
some embarrassment, like, oh, I'm listening to this
guy talk about bathrooms. He says he likes
bathrooms. I sure like bathrooms. I would much
rather do this than diaper dumpy
(02:09):
myself. But, um, these bathroom stories,
they need shared. So I'm going to put a little call out here
at the top of the show. If you have what
you believe is a bathroom story that you'd love to share, hit me
up. Those who've heard, ah,
an episode where I've had someone on before know that
you do not have to carry the bulk of the episode. You
(02:30):
do not have to carry the episode with your story. Now,
your story will probably be the
highlight of the show. It usually is. But I
always have some things that I need to be asking people about
bathrooms. So if you're interested, hit me up
privycastmail.com. it's
February. The other thing that happens in February, besides
leading to post your regret,
(02:52):
uh, is a lot of people have
abandoned a lot of those, uh,
diets and things that they,
you know, they started out the beginning of the year
and maybe January is a little bumpy. In February is the month we're going to
lock it down. But by the time
Valentine's Day rolls around and everybody's
(03:13):
gobbled up their, their dang,
you know, they've gotten there,
Valentine's candy,
they've blown the New Year's
resolution. It's done, it's failed.
And so while these New Year's resolutions and
health fads are all
(03:33):
but totally cast by the wayside
by this point in the year, there's another
fad that seems to be a little
more prominent than I think it needs to be.
And before we jump into this fad and specifically
how this fad affects our
bathrooming, we need to do a little history
(03:53):
lesson in privy, cast style.
In 1902, British
physiologist William Bayless and
Ernest Starling. Those are some very British
names, by the way, I might add. They discovered
a chemical, uh, a compound
(04:15):
in our bodies called secretin.
It's the first hormone which they
discovered helps regulate
pancreatic secretions.
This discovery marked the
beginning of research into
gastrointestinal hormones and
their role in the metabolic process. In other
(04:36):
words, they started to learn about how the
very yummy drippy juices that our internal organs
produce help break down the food and metabolize
the food that we eat. Just an
FYI, in today's episode, we're going to
say the word secretion a lot.
So if the word secretion is a word that
bothers you, um, I'm sorry, but
(04:58):
we're going to say secretion a lot this episode.
It's an unfortunate byproduct of us talking
about these things, but what's a guy to
do?
Secretion. The idea of
incretins were more of a concept.
(05:20):
The term in cretin
or in incretin was introduced to
describe gut derived
factors that enhance insulin
secretion in response to oral
glucose. So you eat the yummy sugar glucose, yum, yum, yum,
yum, yum, yum, yum, yum, yum, yum, yum, and then your gut
(05:40):
it. This in incretin
is this thing that helps
enhance insulin
secretion in order to respond to that intake glucose.
Like, you eat a big fat brownie,
big sloppy, wet brownie, a big old sloppy
guy, and they're like, he's gonna have more
in incretins due to the brownie. However,
(06:03):
the specific hormones
responsible weren't, uh,
immediately identified. It wasn't like, hey, this is
the one to one of what's going on here.
It seems incretin, or
incretin is tied specifically to the glucose you
eat and as a result is
related to the digestive systems in our
(06:25):
bodies. Here on Privy, we're a
big fan of digestion. I had a big
old fancy meatball sub with
fancy ham on it this afternoon, this evening, so very
delicious. And I'm going to learn a little bit about
digestion here in the coming hours, I'll tell you what.
But the incretin phenomenon was used
(06:46):
to describe this observation.
Researchers labeled this in
the 1960s and 70s,
and they came to believe
that oral glucose intake
stimulates a stronger
insulin response compared
(07:06):
to intravenous glucose.
So, um, in other words, like, if you
eat something that is high in sugar, it
causes a greater response than if you just straight
up inject the sugar straight into the good
old SS bloodstream right there and get it right on
in. This M phenomenon that when
you eat it, it produces a greater insulin
(07:29):
response became known as the Crein
effect. But the hormones
responsible for this phenomenon were not really
perceived or that well known
or could not be identified. It
took them a bit, but by
1971, they pinned
down what was causing this thing.
(07:52):
An incretin hormone was
discovered, known as
GIP, I.e. gastric
inhibitory polypeptide.
This gastric inhibitory
polypeptide was identified
as an incretin hormone.
However, GIP's effectiveness was limited
(08:13):
to individual type, limited
in individuals with type 2 diabetes. So
people with type 2 diabetes, that GIP, they had
the GIP, you know what I'm saying? The GIP was really gipping on.
And so that caused these scientists to
wonder, why do people with this
specific type of diabetes, type 2
(08:33):
diabetes, have this
gastric inhibitory polypeptide?
And. Or, uh, rather, why are they so
limited in it? Like, why does their body
not seem to produce or not seem to have
the same reaction in the face of glucose
as others? In the 1980s,
(08:53):
advances in molecular biology
revealed that there was
actually a gene that had
some things to do
with these matters. The
proglucagon gene
in the pancreas produces
multiple peptides, including
(09:15):
glucagon. Researchers found
that in the intestines the same gene
produces different peptides,
GLP1 and
GLP2. Now I will notice this is different
than GIP. We've been talking about GIP.
This is GLP. And
these two, GLP1 and GLP 2
(09:37):
are responsible for helping break down
sugars in the body.
In 1985 they isolated
GLP2 when a
team, uh, uh, led by Dr.
Joel Haernner.
Haernner, Haernner
and other colleagues from Harvard Medical School
(09:59):
identified GLP1 as one of
the products of
proglucagone. They
determined that it exists in these two
active forms, both of which are port
to insulantropic
agents. I think that's agents that respond
to or need to respond to insulin. But like
(10:22):
that's a lot of science mumbo jumbo, right?
And I acknowledge I just went on a science mumbo
jumbo jumbo. Mumbo jumbo.
But so what, what does this bad boy
do exactly? Like what is this thing? I
mean we got like medical history
lesson and a chemistry lesson all wrapped up
(10:42):
in the first 10 minutes of this episode and you've barely even
talked about the bathroom.
Weren't trying to be doctors here.
What's this even, what's this got to do with anything? So
the scientists found that GLP1 could
stimulate glucose dependent
insulin release from pancreatic beta
(11:03):
cells, a key function in
maintaining blood glucose levels.
GLP1
delays gastric empty,
which usually results
in you taking a poo and acts on the
brain to promote satiaiety and reduce
(11:24):
appetite. So this
peptide, GLP1
is found to be able to reduce
your appetite and slow
the rate by which you have to drop. A Chaz
Royale could be helpful.
Seems unhelpful to me. If I don't drop,
(11:45):
if I'm ir, regul it. Like I'm pretty regular guy,
I stay pretty regular. I'm not going to lie about it.
If I get off on my shazz schedule,
I know it like I know
it. And so it's
important to me to make sure that my shazz schedule
stays pretty regular. But
(12:06):
GLP1 delays gastric empty,
empty. And somehow
they've also found that this peptide,
this hormone peptide, I don't even
know, I'm not a scientist. I don't understand what freaking
peptide is. Like I have a game or there is
a game, I don't know if I have it. I have to go check my very good board
(12:26):
game wall. But there's a game called Peptide. I
assume it has something to do with that.
But somehow they found that this thing can
also be good for your heart. It improves
cardiovascular function and may
have other protective effects. Problem
is this peptide,
(12:46):
GLP1, it's like a two minute half
life, meaning if you are to
introduce it to the system,
if you do it orally, like if you snack it down,
if you GLP1 straight down the
topside mouth hole in
two minutes it's going to be rendered completely
(13:06):
ineffective. You can't do it orally.
And so they went looking for something a little
more stable.
Just like them teenagers that are dating, you know what I'm saying? They're looking
for something a little more stable. Early studies
using synthetic GLP1
(13:28):
showed promising results
however in improving blood
glucose control in individuals with type 2
diabetes. So they needed this
thing to resist
degrading that happens within the body. So if
you put this peptide in, it
is going to naturally degrade and it
(13:51):
degrades quick like two minutes. And so
they're trying to figure out a way and they began to work
on synthetic versions of
GLP1 that would have a greater half
life and maybe be able to be introduced in different
ways.
The GLP1 receptor
agonists, I don't know what that means, um, such
(14:14):
as xenotide, are introduced in the
2000s. Novo Nordisk,
a Danish pharmaceutical company, began
to work on semagglutide in the
2000s. If you're looking for a
good name for your baby, if you find
yourself suddenly or otherwise in the
(14:34):
market for a good name for your baby
or maybe your enemy, look no farther
than sumaagglutide. Sumagglutide
was designed as a modified
GLP1 analog with an
extended half life, meaning it lasts longer once
it's introduced to this system of
about one week. This was
(14:56):
achieved by substituting specific. It's all
chemistry, you chemistry, wemistry,
just friggin Bill Nye the science guy thing. Out of this
medication they added a
fatty acid side chain to enhance
binding. I don't even know,
it's a bunch of pharmaceutical mumbo jumbo.
But Novo Nordisck
(15:19):
conducted extensive preclinical
studies followed by clinical trials
to establish semaglutides
safety and uh, efficacy.
In 2017 this
drugmaglutide gained
approval by the FDA to treat
(15:39):
type 2 diabetes.
It was introduced as a once
weekly injectable treatment, a uh,
convenient option compared to the daily
injections. Nowadays similar
drugs are not only used to treat type
2 diabetes.
(16:05):
Somaglutide and other similar drugs
began to be explored for their benefits in
treating obesity. Observations
from diabetes Trials showed that
semaglutide also led to significant weight
loss. Novo Nordisk initiated
trials to study higher doses of
somaglutrid in treating
(16:27):
obesity. So
you know, you just give them the shot,
make them skinnier. Clinical trials for
obesity began in 2021 where they
showed they can lower body weight when
paired with lifestyle changes. That uh,
lifestyle changes seems to be pretty important.
Like if I'm
(16:49):
sumaggluting myself on the daily but
I'm still eating like two to seven pieces of
pizza for lunch
and I'm just goblin down sugar drinks
and I refuse to exercise in any
way, I have a feeling it's not going to have
the accomplished effect. I think that lifestyle change
(17:10):
is pretty important to this situation.
Those lifestyle changes like
they're important. That's what I'm saying. But the
drug gained approval, Semaglutide and others, uh,
it gained approval for weight loss in
2021 under the brand name Wegoi
for chronic weight management in adults with
(17:31):
obesity or overweight and at least
one weight related condition such as hypertension
or uh, dyslipidemia. I don't know.
In other words if they deemed that a
person is big enough to where
they're going to have health complications either now or down the
line they would, we would prescribe them
(17:51):
Wagoi. It is a fat loss
drug. A weight loss drug. Sorry I can't weight loss.
But another similar drug,
Ozempic took on the
role of the diabetes management while
Wagoi was more the weight loss
drug. These are still
injections and researchers are
(18:13):
exploring oral formulations already approved
as Ribosis and investigating
Semaglutide for other potential indications such as non
alcoholics. They can't say that word, don't know
it. But
Ozempicmalutide gained
a significant popularity
in the last few years as a weight
(18:34):
loss drug due to its
remarkable effectiveness, its mechanism
of action and the growing demand for safe
and effective treatments for obesity.
Apparently exercise,
dieting and self control
just won't cut it. Here uh, are the
primary reasons for Ozempics
(18:56):
popularity. First of
all Ozempic had exceptional
weight loss results and it could
also treat diabetes which is this type 2
diabetes is often a condition that
they see that runs like side by side with
obesity. This was
also related to a new view of obesity
(19:18):
as being a quote medical
condition. Now I'm
going to say something. I'm not a skinny
person, I'm full
bodied as the kids say. I'm a
size 2x. I understand the
level of fat kid. I have achieved. But here's the
deal. I am not
(19:40):
fat because I have a medical problem called
obesity. I'm fat
because I ate, again, a very
sloppy meatball sub
sandwich, and within the hour
purchased a large shamrock
shake, which I shared with my family. But
I did do it. Do you know what I'm saying?
(20:03):
Like, I'm not blaming a medical
condition for the fact that I like Oreos.
I'm not blaming a medical condition for the fact
that video games are more fun
than exercising. It's just true.
And so it has nothing to do with me
thoroughly enjoying pizza and ice cream. It's a medical problem. That's
(20:24):
pretty much what these people are trying to say. But
Ozempic also got a lot of press. Even though
there were alternatives out there,
social media and other celebrity
endorsements really drove
Ozempic'popularity way, way up.
Another reason that people point to
Ozempic'popularity was the global pandemic.
(20:46):
This thing called the novel coronavirus,
uh, uh, echo chamber, in which
men and women, but like, kind of like man,
decided to really hunker down and start podcasts. You
know, it's just weird. It's a weird
phenomenon. It's weird. I've seen a lot of people wearing
masks again recently. And I'm not here to make a comment about
the masks, but it is kind of
(21:09):
traumatizing when I see that. And people are going to hear that and
like, shut up. Yes, as you should.
But my thing is like, the whole mask
thing was kind of hellish to me. It was
very awful. I.
The minute that, oh, I remember
the day that they lifted the MAS mandate, and
(21:29):
I was like, you'll never be able to put it back on.
You got me. Fool me once, shame on. Shame on
me or fame on you or whatever. And
you're not gonna fool me twice on this. Like,
uh, it's just an unbearably awful experience.
But here we are. We must soldier forth.
But the global pandemic, the novel coronavirus,
(21:52):
caused a huge spike in profit from the pharmaceutical
company. It's weird how that worked. It's weird
how as we directly, you
know, were pushing
this idea of a need for a vaccine, we were also
making wooy bucks off of that
vaccine. It's fascinating to me, you know, I don't know if
there could possibly any collusion or like,
(22:15):
anybody that was like, pushing an agenda in order to make a
trainload of money. Fat shot.
Uh, also it's considered like.
So in this, they, they
began to, as, as the coronavirus
pandemic ended they needed, they had
these new profit margins that were kind of unheard of.
(22:36):
Like, how do we meet these profit mar. Like how do we, how do
we meet these, these profit expectations
again? And so they began to push
Ozempic as a fat loss, weight loss drug,
uh, in order to drive up some sales, uh,
some profit margins on, on these companies, pharmaceutical
companies. Also, because the
(22:57):
procedure and the use of this medication can be considered
medical, a lot of it is covered by
insurance. As we discussed,
Ozempic and other similar drugs take a
significant role in your bathroom.
They come up a lot there. They're going to affect you
when you get in the zone. It should be
(23:17):
noted if you're looking to Ozempic for weight
loss or blood sugar regulation and you're concerned
about the bathroom, should be aware of a number of things.
Before I continue, another thing you should be aware of
is that I'm not a doctor. I've never been to medical
school. I don't even,
like, I barely go to the
(23:37):
doctor to be checked up.
And so don't take anything that I tell you for medical
advice. This is explicitly not medical advice and
nothing in this episode has been.
But you should be aware if
you're looking toward Ozempic or other similar
drugs for weight loss control,
about a number of ways that it is reported to affect you
(24:00):
in the bathroom. Now,
depending on where you look, there are
reports that say Ozempic can cause both
diarrhea
and somehow
constipation. And, uh, it's a baffling phenomenon.
Truly, these drugs that have
(24:21):
both diarrhea and constipation as a side
effect always throw me for a loop because like
in my brain
diarrhea and
constipation are like the opposites.
And in my brain it's difficult to have the opposites at
the same time. Like you're either plugged up or it's rocketing through
you. I'IT'S usually rocketing
(24:44):
through me. You know what I'm saying? It's flying right through
me. It is noted that you can also
experience nausea and vomiting from Ozempic.
Those two are a no fly for me. If
a medication is non necessary, like
if it is to treat something that I don't need
to be treated and it causes nausea and
vomiting. I don't know about that. Like
(25:06):
I might be a hard skip on it. That's just me.
So about 8% it says of people
who have taken Ozempic experience
diarrhea. And there's
a number of sources that say that if you avoid
fat Rich foods and sugary drinks, it can help
keep the diarrhea down. And that's because
(25:28):
it's just passing that stuff through. It's not trying
to break it down. It's just moving along the way.
In some cases, it can be severe enough diarrhea
that you elect to stop taking the medication that
is reported to be a thing to happen. Some people,
the squirts get so bad that they're like, I'm
done. I'm done ozempicking
(25:49):
myself. But in most cases, the
runs would go away on their own. In
fact, if 8% of people
who use Ozempic experience d, which is not
nothing. I mean, imagine if you went to
McDonald's and they gave you a bag of food and they said,
hi, 8% of our food is going to give
you flaming, raging diarrhea, Would you
(26:11):
do it? Would you still eat it?
I know I would. I would eat it
and then I would get the pupils
who have decided they're not going to eat it, and I would eat
theirs. But if
8% of this population
experience diarrhea, GoodRx
(26:32):
reports that 4% of those
quit taking the medication due to
rigorous diarrhea. And I want to
know, like,
that's actually a lot. Like
4% of people are like, the
diarrhea has overcome me so much. The
wild spray is more than I can handle.
(26:55):
Usually the diarrhea will last
for three days to a week. As your body adjusts,
you'll likely be experiencing diarrhea.
Ozempic does this because it changes
the way your body absorbs nutrients
and impacts how quickly things move
down the digestive tract.
(27:16):
What's even more wild is on Ozempic, many
people experience again both diarrhea
and constipation at the same time.
When this happens, it can result in
something fun. A phrase which is
haunting to me. And we all
hoped to never have to face
a phrase called overflow
(27:38):
diarrhea. Help us, Father, for we have
strayed far from you. Overflow
diarrhea. Dear Lord,
just, just help us.
And if the idea of overflow diarrhea isn't
scary enough, in these cases, the overflow
diarrhea is happening in what could possibly
(27:58):
be the worst place for
overflow diarrhea to happen Inside of
your body, in your colon and digestive
tract. What happens is
you get constipated and the poo
sets up and it's like it just
hardens right there inside you just
smashed, just doink,
(28:20):
just really clogged up the pen
down in there. Then as the
Ozempic makes the diarrhea run wild.
It runs into the poop plug
mid tr mid system and it
begins, because it cannot pass through, it begins
to eek out the edges of the turd log
(28:40):
that is still in the system. It's so fun.
Just a seepy turd log.
Other reports state that it affects urination,
but the correlation is not as strong to
speak to whether this is directly related to the
use of Ozempic or not.
And all of these things beg the question,
(29:02):
the rapid fat loss, the way it affects your
bathroomoming, the trouble with constipation and
diarrhea, uh, all these
things asked is
is it safe? And
the answer is sort of.
Ozempic and other similar drugs are
(29:23):
FDA approved for type 2 diabetes.
So as of the point of this record, it's
not technically approved as a
weight loss drug. Now
often it will still be used as a weight loss drug and
they'll say well you know, we're
treating pre type 2 diabetes by doing
(29:44):
this. Weight loss is
a side effect of Ozempic
and cocaine, so there's that.
It's not recommended for weight loss. But I'm not a doctor and this
isn't medical advice so talk to your doctor
if you want to shed some pounds quick. I guess you could
stab yourself in the tummy with thosezempic. I mean
(30:06):
it seems like it would work. It's worked for lots of people.
Talk to your doctor in treating type 2
diabetes which can develop into life altering or
problematic changes. It has side effects
which include the possibilities of developing
thyroid tumors and causing
pancreatitis. My mom had pancreatitis
(30:27):
when I was in school and I remember that
experience being pretty awful for her.
Like pretty awful.
It's not a miracle shot that's going to make you
skinny, but it will, except
for it comes with some side effects.
Impossible ongoing problems for the person who
uses it.
(30:49):
I'm fat. Hello, it's
me. The diary of a chunky kid.
And as a bigger guy I'm convinced
that the path forward is found
not in Ozempic and taking
these tummy injections and
trying to lose weight via a uh,
(31:12):
medication, but that the path
forward comes through, for lack of a better
way of saying it, trying to eat better,
eat smarter and working harder.
It's the best path forward for
losing weight. But if you
want to tummy jab yourself with some Ozempic and
(31:32):
get strange leaky gut,
constipation, diarrhea, you just go right
ahead and tell me your experience.
Privycastmail, dot com.
This will bring us to the end of another episode of Privy.
Thank you so much for being here. Thank you for joining us. Uh,
(31:54):
thank you for listening. I know I say this Share
the show on social media. Take you don't have to be this
episode. Go find maybe the most interesting looking
episode. Uh, maybe your favorite
episode. I know I have some of my favorites. But go
find one that you think and share it out to your social
media. Share with a friend, tag the show, do what you need to do. Get the
word out there about this thing. Do you know what I'm saying?
(32:17):
Um, you can follow the show at Privycast, you can follow me
and I'm @allet7. Leave the show a
rating, a review and encourage others to do show. For
every rating or review you leave, we donate a dollar to the Wounded
warriors program reminding you to keep pooping in the free
world. That free world was not always free. And
some money to Living Water International as a reminder that
(32:37):
we need to pursue cleaner water for all. Not everyone has
it and everyone should have it. Uh,
as always, send us an email
privycastmail.com. uh,
thanks to Kevin and Poddtington for the use of your music
this week. You can check out the links to their stuff in the ding
dong below. This brings us to the end of another
episode of Privy. Oh, by the way, if you're looking to
(32:59):
start a podcast, there'sn toa be a link down below.
It is an affiliate link to the my
podcast distributor of choice,
Podbean. I've been using Podbeans since this
show came out and I like it. And I like it so
much that I signed up to tell you guys that if you want to make a
podcast, you should join Podbean. It's pretty great.
(33:19):
Um, if you're thinking about joining doing a podcast, use the link
down below. It just helps them know that we're doing
this and that we like Podbean.
Uh, it's a good program, so check that out.
Thanks for being here on another episode of Privy.
Keep hoping in the free world, own your stank.
And now, as always,
(33:39):
don't forget to flush.
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