The Role of Tau Protein and Tau Tangles in the Progression and Development of Alzheimer’s Disease

In the fifth episode of The Alzheimer’s Solutions Revolution podcast with Ralph Sanchez, I talk with my co-host Susan Brender, as we continue with our special podcast series called Think Ahead.

In this week’s episode, I'll provide an overview on the role of tau protein and neurofibrillary tangles (tau tangles) in the progression and development of late-onset Alzheimer's disease (LOAD).

The toxic accumulation of tau tangles in brain cells (neurons) are one of the two hallmark lesions associated with Alzheimer's disease (AD). The aggregation of beta-amyloid peptides (protein) into amyloid plaque is the other toxic hallmark lesion linked to the onset and progression of LOAD.

Additionally, I'll give an a summary on the importance that tau protein plays in a critical component in the conveyance network and cytoskeletal structure that is an essential element of neuronal function and structure.

The cytoskeletal conveyance structure of the neuron contributes to the shuttling of mitochondria to the neurons axonal terminal and synapse in order to provide the energy metabolism required for synaptic function.

Please listen in and be informed!

Ralph Sanchez, MTCM, CNS, D.Hom

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