August 29, 2025 • 33 mins
In this episode of The Lindsay Elmore Show, Lindsay sits down with David Roberts, co-founder of Mara Labs and a pioneer in sulforaphane supplementation.
Sulforaphane, derived from broccoli sprouts, has been called the "master molecule for health" thanks to its ability to support detoxification, reduce inflammation, enhance brain health, and improve metabolic function. David shares the science behind stabilizing sulforaphane, explains why most supplements fall short, and discusses its synergistic effects with molecules like curcumin.
From detoxing microplastics to balancing hormones and boosting mitochondrial energy, sulforaphane has far-reaching benefits for overall resilience.
Key Takeaways
Become a supporter of this podcast: https://www.spreaker.com/podcast/the-lindsey-elmore-show--5952903/support.
Sulforaphane, derived from broccoli sprouts, has been called the "master molecule for health" thanks to its ability to support detoxification, reduce inflammation, enhance brain health, and improve metabolic function. David shares the science behind stabilizing sulforaphane, explains why most supplements fall short, and discusses its synergistic effects with molecules like curcumin.
From detoxing microplastics to balancing hormones and boosting mitochondrial energy, sulforaphane has far-reaching benefits for overall resilience.
Key Takeaways
- Sulforaphane Basics: A compound found in broccoli sprouts with over 37 documented pro-health mechanisms.
- Brain Health: Increases BDNF, supporting neuroprotection, neurogenesis, and even enhanced dreaming.
- Detoxification: Activates NRF2 pathways, turning on over 200 antioxidant and detox genes for up to 72 hours.
- Inflammation: Synergizes with curcumin to reduce NF-kB and IL-6, two key pro-inflammatory markers.
- Practical Use: Each capsule of Mara Labs’ stabilized sulforaphane equals the benefit of 2.5 pounds of broccoli.
- Metabolic Impact: Helps balance estrogen, supports mitochondrial energy, and assists in reducing belly fat and insulin resistance.
- Environmental Defense: Aids the body in processing toxins like glyphosate and mobilizing microplastics.
- 01:00 – What is sulforaphane and why it’s the “master molecule”
- 03:00 – How sulforaphane supports brain health through BDNF
- 05:00 – Stabilizing sulforaphane and the challenges of supplementation
- 06:45 – David’s personal story: breast cancer diagnosis and discovery of sulforaphane
- 08:00 – How sulforaphane is delivered and stabilized in capsules
- 10:00 – The NRF2 pathway and turning on antioxidant defense
- 13:00 – Detox done right: why many “detox programs” fail
- 15:00 – Curcumin and sulforaphane synergy for inflammation reduction
- 18:00 – Internal studies on inflammation markers (IL-6, NF-kB)
- 20:00 – The real role of detoxification vs. buzzwords
- 24:00 – Toxins in modern life: microplastics, glyphosate, and more
- 28:00 – Genetic modification, glyphosate, and long-term toxicity
- 29:30 – Sulforaphane for metabolism, mitochondrial energy, and belly fat
- 32:00 – Additional Mara Labs products supporting metabolism (GLP-1 alternatives)
- 33:00 – How to learn more: Mara Labs discount link
Become a supporter of this podcast: https://www.spreaker.com/podcast/the-lindsey-elmore-show--5952903/support.
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Transcript
Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
Speaker 1 (00:00):
Welcome everybody to this week's episode of The Lindsay Elmore Show.
We are going to be talking about some inflammation topics
as well as some detops topics and metabolism topics. We're
going to be talking about some molecules that you may have.
Speaker 2 (00:13):
Never heard about before.
Speaker 1 (00:16):
We're going to be talking about NFCAPA B and how
bad it is for us. And we're going to be
talking about sulforaphane and how amazing it can be for
us as a supplement.
Speaker 2 (00:28):
My guest today is David Roberts.
Speaker 1 (00:30):
He is the co founder of Mara Labs and is
a pioneer in sulfurafane supplementation and cellular health. And today
we are going to be talking all about sulfurafane and
how it can unlock brain, metabolic and immune resilience. This
is going to be a great interview because we are
(00:51):
going to learn about optimizing brain, metabolic and immune.
Speaker 2 (00:56):
Function with a supplement that you may have never heard of.
This is the Lindsay Olmar Ship. David Roberts, Welcome to
the Lindsay Olmar Show.
Speaker 3 (01:08):
Lindsay, thanks for having me. It's great to be here.
Speaker 1 (01:11):
I'm so excited to get to talk to you today
about your your investigations with sulforaphane and the master molecule
for health and why you have spent so much of
your career digging into it. So for listeners who are
new to all the science, what exactly is sulforaphane and
why do you call it the master molecule for helps?
Speaker 3 (01:33):
Yeah, so sulfurofane is the basically the good molecule that's
derived from broccoli for broccoli sprouts. It's why people grow
broccoli sprouts or buying them at the store, and so
in ahead of broccoli, basically there are there's the precursor
molecule called glucra wrappinin and you start shooting the broccoli,
(01:56):
you break the cell wall down, it releases an enzyme
converts that glucoraphin into the sulfurofane, and then you basically
swallow it. You get the benefit, but the issue comes
when like you try to harness that is, store it.
The sulforaphane is not a stable so it degrades. So
(02:19):
what we've done is we basically made a way to
stabilize it. That's natural, and so that's important because of
all the good benefits that come with the molecule, and
so things like it turns on over two hundred different
(02:39):
antioxidants and something called the antioxidant or spots element. It
is great for it's the best natural molecule for phase
two detoxification, but it works in all three phases. And
then we also talk about basically how it turns on
bdn F brain drive no tripet factor, which is at
(03:01):
the center of brain health, and because it protects existing neurons,
but it also helps grow new neurons, and so there's
there's a lot there. There's over over thirty seven pro
health mechanisms for sulfor fane. But but yeah, it's a
great molecule.
Speaker 1 (03:19):
Yes, Okay, So BD and F is a molecule that
we really haven't talked about on the show that much.
So how does sulfurifane affect B, D and S And
you know what is the what is the benefits to
somebody who's using this broccoli derived molecule.
Speaker 3 (03:37):
Yeah, and so you know the BD and F again
is upregulated by sulforaphane, and another way you can upregulate
BD and F is through exercise. And so so basically
the if you look at you know the different impacts
you list saying PubMed use type in b n F,
(04:00):
you'll you'll in brain you'll get a lot of studies
on how it is impactful and helps in different disease
states like Alzheimer's, Parkinson's, just different types of dementia. And
so it's it's very important for for brain health. It's
(04:23):
really at the center of brain health. And it's interesting
we have with our product broccoli, we have an unconditional
money back guarantee. So early on, you know, we're startup,
everybody does everything. I'm doing customer service, and so this
guy's like, I don't want I want my money back.
It doesn't work. And I'm like, okay, no, that's fine,
(04:46):
but let me ask you, like, did you have any
vivid dreams? And he's like, no, way, that's this He's like, yes,
I've been having incredibly vivid dreams. So that's the the
kind of the neuroplasticity effect of the b D and
F and the sul fore feane turning on that system.
Speaker 2 (05:05):
So interesting, why does it affect our dreams? Like, what
does it? How does this relate to each other?
Speaker 3 (05:12):
Yeah, I mean I think you know, I'm not a
dream expert, though I guess I should be at this stage.
But the you know, when when you're trying to process information,
you know, there's, there's and and kind of come to
grips with it. That's what the dream maybe aspect does.
I think it has to do with the different stages
(05:33):
of sleep too. I know that Broccoli, it helps both
with deep the deeper sleep and getting more of that
which is more the restorative physically restorative sleep, but also
the dreaming side is the r r M and so
you know, similar like no tripics have sort of that
(05:54):
brain enhancing effect, you know, I know, like another one
would be an alliance made but yeah, basically, you know,
I don't know all the specifics of that, but but
I think it has to do with with you know,
the processing and helping build neurons, the the processing information
(06:17):
and the enhancement of the RAM side of sleep.
Speaker 2 (06:22):
Interesting.
Speaker 1 (06:22):
Interesting, So you talked about a moment ago how the
delivery of sulforaphane is so difficult and so stabilization of
a product is going to be important, it would sound like,
so talk to us about the stabilization process and why
that is so important.
Speaker 3 (06:42):
So yeah, I mean, you know, so just to back
up a bit of my story was we got interested
in sulforfane after my wife was diagnosed with breast cancer
and and she ended up we ended up growing, you know,
(07:02):
growing her cancer cells in our lab and we put
sixty different types of supplements on them to see what
specifically killed her type of cancer, and sulfor fane was
number three in directly killing or type of cancer. So
when I went out to buy it, what I found
was something called sulfur fane glucosylate, which it's technically the
(07:24):
precursor of sulforaphane, and so it's not self forthing, which
is a little bit deceptive. It's a little bit confusing,
and I think they different supplent companies do that purposefully
because they want people to think it's soul forthning. But
it glucraphinin is the precursor, and so that's stable. And
so it's also why you know, the stabilization aspect is
(07:48):
why so many people, you know, we ended up growing
broccoli sprouts. We had I had like a broccoli sprout farm,
enough for like ten families because we would use it
every day and she drink the juice and it just
you know, is a production. But you can do it
that way because it's stable in the sprouts and then
(08:12):
when you masticate it, when you juice it, and there's
the end zomatic reaction and so.
Speaker 1 (08:20):
And so tell tell us about the process of actually
using the product.
Speaker 3 (08:25):
Sure, so, yeah, basically we we recommend so two capsules
has the or actually in each capsule there's the equivalent
of two and a half pounds of mature broccoli, and
so the amount of you know, lucrapmly. What we do
is we do the end soomatic reaction and we it's
(08:46):
already done. And so the sulforfane is in the capsule.
Each capsule has five milligrams of sallo sulforfane. But what's
more is it has all of the other cousin molecules
that come from this and then we add one that
uh into from from watercress. It's called finethyl isopy was
(09:08):
saying the name is not important, but what is important
is adding, well the name.
Speaker 1 (09:12):
Nobody can say it's an except for you. So I hope,
I'm glad it's not important to us.
Speaker 3 (09:17):
You know, just just think, I think the cousin molecule
from watercress, we add that because of what it does
to that it works synergistically. So one plus one does
an equal to that's added of one plus one equals
five and so there and that that synergis effect. It
has to do with the inter F two system, which
(09:39):
is why it's the where the magic lies with this
master molecule soul far fame, and it turns it on
that much more and so you get a really really
really strong effect. That's the plus and and we call
it broccoli plus.
Speaker 1 (09:58):
So we haven't talked about an r F two on
the podcast, I don't think ever, So talk to us
about what this pathway is and how it impacts detoxification
and cellular protection.
Speaker 3 (10:11):
Sure, so it's a transcription factor and so basically what
it happens is it's outside of the it's in the cell,
outside of the nucleus of the cell. And when you
ingest sulforfane and it gets into the cell, it actually
releases it has this reaction that releases the n F
(10:31):
two to go into the cell. And when it once
it goes into the cell, it interacts the inter F
two and interacts with it interacts in the in the nucleus.
Like I was talking about before it turns on over
(10:52):
two hundred different genes to begin cranking out these antiox
that sits. Then that's called the antox ont settlement, and
that's important, just to drill down on that a little bit.
It's like with with one antioxidant like vitamint C, it
combines with a pro occident and it cancels out, and
(11:14):
that that antioxidant's gone right with soul for a fane
itself is not an antoxidant, but it turns on over
to undred different antixidants that stay on for over seventy
two hours, and so it just keeps cranking them. It creeps,
keeps cranking them out. I was camping backpack camping with
(11:37):
my youngest son and we ended up going Uh. It
was in Colorado. Was supposed to be dry, and I didn't.
Actually I took him out of the bottle, the broccoli
out of the bottle, put them in a baggie. Didn't
have a desiccant, and I woke up and they had
gotten moist somehow. And so that moisture actually can and
(12:00):
you can tell that it oxidizes it It basically reacts
and and it's no good. And so it was a
four day trip, and so the first three days I
was fine, you know, because the systems still turned on
from my last dose. But that fourth day I was like, oh,
I can I can start feeling you know that it's
it's running up. So it is it's great that it
(12:22):
turns on and stays on. Now with phase two detoxification,
there you know three phases of detox. So first is
making the toxin less toxic, the second is making order
soil also goes into the set of the plasma, and
then the third is kind of binding an excretion and
(12:43):
and and so it is actually so forfeane is the
best natural mole if you'll at phase two detox in front.
And and so that's actually important because if you and
maybe you have maybe some of the listeners have, maybe
you haven't, but you may have heard of people doing
a detox program and getting sick, kind of getting what
(13:07):
I call the detox glue. And that's because all of
a sudden, you're having all these toxins mobilized in your
body and you can't get rid of them. And so
what actually soulfarteam does is that down regulates the amount
of the toxins that actually get into the plasma and
(13:29):
so so that you can actually it's a balanced at vacation,
so you don't get that same the same sickness and
and so that's you know, I kind of choke, but
I actually do this. Uh you know, at at holiday parties,
I'll go and you know, people know what you do,
and a lot of people take broccoli, uh, and but
(13:51):
I'll always bring a couple of bottles so people who
end up, you know, drinking alcohol can take some and
they will have that same sickness feeling, yuckie feeling the
next day because the the detox system is really affected
and turned on. So that yeah, the inner of two.
(14:12):
There's a couple of things that that it does. You know,
we've all heard probably heard of glutathion, which is sort
of the mass. It is an actual anti accident, the
master anti accident. And so again similarly, sulforfane does not.
It actually turns the glueithion production on and so it's
(14:33):
sort of a partners in that way. And so what
we often do is there's one of our favorite studies
is on and actually it's two studies now they repeated it,
but they looked this in this study they looked at
i think people in their seventies, and what they did
(14:55):
was basically they combined glycine and in a and gave
them these megadoses. It was like twenty grams or something
like that, and they did it over a period of
a month and showed that these these people in their seventies,
all they did sort of age markers before, age markers after,
and a lot of the age markers had reversed. And
(15:20):
the reason for that is that the glyceine and nac
are the building blocks of glue athion. And so you know,
I'll take I'll take some of those not twenty grams,
but I'll take a couple of grams of that combination
along with sulfur fane. And so basically you're turning on
the glid fine production and you have the basic building
(15:43):
blocks to create the glut fine. So it works rather well.
Speaker 1 (15:48):
And you've also combined kirk human in your products. And
why do you think sulfura fane and kirk human works
so well together?
Speaker 3 (15:57):
So it goes back. It's actually the same study where
we uh where we read as saw the the because
of molecule from watercress works and synergy that then that
same study, they looked at curcumen working in synergy with
sulfur or fine as well, and again it has a
(16:22):
three to five times impact on just everything, and so
they work really well together. We have we sell them
in a bundle because of that, we call it the
anti inflammation bundle. So kurcumen is the best national molecule
turning off the prone inflammatory pathway. N F kapa B
NF kapab is the holy grail that the pharmaceutical companies
(16:46):
are going after when they were creating an anti inflammatory drug.
And so what we've shown, we've also looked at, you know,
synergistic effects internally through our own study. We have our
full lap here in our in our building, and so
we can we can look at center centertistic effects of
(17:08):
different molecules. But yeah, basically we combine them because you know,
curcumen actually most kurkumen, less than one percent of the
curcumin gets through the gut barrier. And so you can
take regular curcumen or turmeric or whatever, and it really
(17:29):
it really helps your maybe your gut the cells in
your gut lining, which is important since about sixty percent
or seventy percent of our immune system is in our gut,
right you want don't want to unflamed gut, but it's
really not going to impact the pain in your knee.
And so with ours, we actually came up with a
novel carrier molecule where we combine a plant based protein
(17:52):
with a c based carbohydrate and it's its own molecule,
and then we add the curcumin to that and it's
basically like I like to think of it as like smuggling,
you know, it smuggles the CURCUMU pass they got bearer
and it gets into your plasma, into your cells in
a way that makes a biological difference. So even we've
(18:13):
tested a lot of different curriculum products and the vast
majority do not make a ball up. Then they don't
move the needle on the and the NF kappa B
or aisle six, which is another pro inflammatory marker, whereas
ours does.
Speaker 1 (18:35):
So so for our super science nerds out there, what
are the give us us.
Speaker 2 (18:42):
We've got NF KAAB, we've got bd n F.
Speaker 1 (18:44):
We've got all these different you know, buzzwords and all
these different names going around. Give us a list, because
one of the things that I'm picking up is that
the sulfurifane has some wide ranging effects because it acts
on many different molecules. And so what are like kind
of the top five, top three molecules that are going
(19:07):
to get impacted. For our listeners who really want to
dig in and do some more research into the basic science,
what can they look at?
Speaker 3 (19:15):
Yeah, I mean, you know, while I said Kirkuman is
the best national molecule turning on or turning off, the
NF cup of V sulfur feane does too. And it
does it really really well. And it does it so
well that we actually did our own internal study because
you know, early on, you know, I mean we started
(19:36):
taking it and we were noticing our aches and pains
to going away pretty much like within the first dose.
I actually enjoy playing the guitar. I'm not very good
at it, but I when my wife was sick, I couldn't,
like I could only play a couple of minutes because
my hands were like in a lot of pain. There's
(19:57):
a lot of inflammation there. And we once we created
you know, the capsules and or started taking that pain
went away really quickly. And most you know, our friends
and family are like, this was working really quickly, and
so we ended up were like, how quick is it working?
And so we did an internal study of some employees,
(20:19):
friends and family where we looked at aisle six, which
is interluking six. It was kind of you may have
heard about that during COVID times, but it's a pro
inflammatory marker, and so we showed that it decreases aisle
six just one one dose, so ten milligrams decreases aisle
(20:40):
six twenty eight percent in twenty four hours. So that's
enough so that you could actually feel the difference. So
nf kapab is downstream from aisle six. They're interrelated, they're
both pro inflammatory markers. So I'd say nf kapa is
a big one. NRF two, which we've explained, the transcription
(21:03):
factor is probably in terms of sulfurfane is the biggest
one bed and a f brain derive, no tripet factor
is it's so important for brain that that has to
be on the list. And then I would say that's four.
Speaker 1 (21:22):
I asked for three to five, So you're perfect, did
it great?
Speaker 2 (21:26):
You hit it right on the nail. So what the things? Yes,
exactly exactly. So a lot of people we've talked about.
Speaker 1 (21:36):
Detox and I do want to talk about metabolism and
inflammation before we before we end. But detox is such
a kind of buzzword, but a lot of people just
talk about it, you know what I mean? And you
mentioned earlier that some people do detoxifications and they get
sick because they don't do it well. So as far
(21:59):
as where is the people that are thinking about this
as just detox is just a buzzword for me to use.
What are some of the misconceptions that you think that
people have when they try to detox and supplement.
Speaker 3 (22:15):
I feel like there's you know what I call the
different health and willess gurus, and I feel like everybody
and their brother if you if they have like a
supplement offering, they will have something in terms of detox.
So I before I started more labs and broccoli, you know,
(22:37):
I we waited up getting a few different detox programs
and they come in a big box and it seems nice,
and there's te's and there's capsules. But most of them
focus on phase one because that's the really the easiest way,
that's the easiest one to focus. And that's the phase
(23:00):
one when you're when you are kind of beginning to
you know, mobilize these toxins into your system. You know,
you'll we want to limit that, and so it's important.
And that's why you know people get sick is if
they overdo that step, they don't feel well. I think,
(23:20):
you know, as far as misconceptions, I would just be
very skeptical about a detox program. You know, I think
there there are good ones. We write about detos on
our blog, people at Maura desh labs dot com can
go there. But really you just want to be careful
and you want to make sure you're covering all three
(23:42):
faces of detox. Yeah, I will say, you know, we
live in a toxic world. We just actually learned a
couple of weeks ago this guy did a study from
he's from Sanford, not Stanford, but Sanford University and.
Speaker 2 (24:04):
He used to work there.
Speaker 3 (24:06):
Yeah. He he looked at mobilizing microplastics and so we're
you know, we if you eat an apple, you're getting
a million microplastics because of the the covering that's on
the apple. Bottle of water, hundreds of thousands of microplastics
plastic bottles. I just learned on the drive over to
(24:27):
do the podcast that actually glass bottled water has like
ten times more microplastics than plastic bottle water because of
the mica. Yeah, because of the lid. Yeah.
Speaker 2 (24:41):
Wow, okay, all right, and so.
Speaker 3 (24:44):
I don't have a reference for that, but I will
I will. But all to say is, you know, we
get we ingest the the amount is kind of staggering,
the amount of microplastics create uh A basically a credit
card the amount of microplastics we ingest every in one
(25:05):
year period. And so mobilizing those getting out as important.
This guy showed that by taking brock Elite you actually
mobilize the microplastics into your system to begin the excretion.
And so that's the first study of it. If it's
kind microplastics toxin, you know, it messes with you know,
(25:27):
hormones and all sorts of things. But that's just one toxin.
There are chemically, there's tens of thousands of toxins. You know,
if you just look at your sunscreen or it might
be your sunscreen because you probably ever good subscription. But toothpaste,
are cleaners, are soaps, everything is just if you can't
you know, if you don't know what, if you have
(25:49):
trouble pronouncing it, the rule of thumb is like it
may not be good for you, you know, and so
so those are chemicals we are bodies have to we
have to process. And as another aside, do you know
if you're glyphosate, oh, glyphysate And for those listening, basically
(26:14):
the active ingredient round up and we showed that just
by the amount of life state and that kind of
a regular it's a basically the highest level you can get,
but in a but it's in a regular meal, and
it can reduce your ability your inner of to and
(26:36):
which is your ability to detox, by thirty percent. And
so that's basically that's that sounds like, okay, well you
still have seventy percent, but that's like any it's major.
It's if you can get really really sick, if you
if that is continuously insulted. And so what we showed
is broccolite actually reverses that life state's ability to turn off.
(27:00):
That's that innerve to And so that's huge in detox
because you know, we think think about detox with liver, yes,
but every cell in our bodies has the ability to
detox and so you know, whereas sulfurfane it is sort
of a master module life to say I call it
the master toxin because it makes every other toxin that
(27:23):
much more toxic because it reduces the body's ability to
detox well.
Speaker 1 (27:29):
And that is also has so many environmental effects that
have to be noted as well.
Speaker 3 (27:34):
Yes, it's just on and on and on, right, it
goes on and on.
Speaker 1 (27:39):
Absolutely, it's so pervasive, this chemical, and we kind of
put it everywhere before we knew we were doing it,
and now we look back on it and go, what
were we doing. It's the same thing with all of
the PFCs and pfbs that we put into water, that
(28:00):
we just kind of put them there and then now
we realize it had major effects.
Speaker 3 (28:05):
Sure, yeah, and you know, and that's where you know,
I'm big on not eating genetically modified foods. It's because
the genetic modification is to receive the round up and
not kill it. And so corn soy are the two biggies,
and so you know, but those are basically hypergers. Scorn
(28:28):
syrup and vegetableil or soyde and oil are if it's like,
it's almost in every processed food and so just read
your label and avoid that because there's not a lot.
It's actually not a lot in any any processed food.
But the issue is there's a bioaccumulation because it's in everything,
you're just kind of continually getting it and getting it
(28:50):
and getting it in over months and years. Really it
makes a big impact.
Speaker 1 (28:57):
So let's transition in our last few minutes that we
have here and talk about metabolism. We've talked a lot
about detoxification. But when I talk about metabolism, I'm actually,
you know, in this situation, I'm talking about what belly
fat inflammation, in insulin resistance. How does sulfur fane play
(29:18):
a role in metabolic help There.
Speaker 3 (29:21):
Are probably a decent amount of listeners or women over
forty and so with with if you think about estrogen,
they're good estrogens, bad estrogens, and metabolically balancing them. There's
an interplay between metabolism and the detox So basically, because
(29:42):
sulfur fane is so good at detoxication, it can remove
the bad estrogens and help they basically balance the good.
And so you actually, and that's important you know, for
a lot of reasons in women's self and so so
in terms of metabolism, Like we have a decent number
(30:06):
of people who take sulforaphane for performance. So our bodies
the sort of the mitochondria is part of the cell
that is sort of the energy production part. And and
there's it's the center of where kind of glucose, which
is like money in the bank, turns into ATP, which
(30:27):
is the usable form of energy. It's like cash money.
And so and that's important because the sulforaphane actually can
can stimulate that that system. It's called the creb cycle.
That's why we breathe in oxygen breathe out carbon dioxide.
So my boys are swimmers, and so I'll give them
(30:52):
sulforaphane and a few other things before if they're competitions
and it's it's natural, it's all natural. But you're revving
up that system. And in terms of and and that
can impact that can as you're that system is impact
repped up, that can impact belly fat it and it
(31:14):
just turns out it turns on a lot of good things,
including like we talked about before, the anti accident response
C element. But we have another product as well that
is excellent at something called turning on amp kinase, which
is the master metabolic molecule. And so it's we call
(31:36):
it it's a GLP one alternative called geo perfect, and
basically that what that does is it has e G
c G from green tea and it has berberine and
then it has alpha blow alfala pok acid. Well, alpha
bok acid and berberine are two molecules that really turn
(31:59):
on this amp kind So if you think about metabolic disorder,
people who have belly fat, they're puffy in the face,
they have insulin a low insulin, high glucose, they probably
have cardiovascular issues and high triglys rides that am kindase.
Really it's almost like a fasting. It just bravs up
(32:23):
the metabolism and so it helps decrease trichless rides. It
helps improve the insulin, you know, to get the glucose
into the cells, helps decrease actually decrease blood glucose and
so goes opposite way of metabolic disorder. So those two
(32:45):
moleculars are exceptionally good at metabolism as well.
Speaker 2 (32:51):
I love all of the different things that this molecule
can do. Listeners.
Speaker 1 (32:55):
If you want to learn more about broccoli and how
you can get this soulfar or fan product, head to www.
Dot Maura dash Labs. That's m A r a dash
labs dot com slash Lindsey that will save you up
to twenty eight percent off of broccole and other Mara
(33:16):
Lab products as a special gift for all of our
listeners today.
Speaker 2 (33:21):
David, it has been a fabulous interview with you. Thank
you so much for coming in and being a guest
on Lindsayilmore Show.
Speaker 3 (33:28):
Lindsay, thanks so much for having me. It's been wonderful
to talk to you. Thank you.
Welcome everybody to this week's episode of The Lindsay Elmore Show.
We are going to be talking about some inflammation topics
as well as some detops topics and metabolism topics. We're
going to be talking about some molecules that you may have.
Speaker 2 (00:13):
Never heard about before.
Speaker 1 (00:16):
We're going to be talking about NFCAPA B and how
bad it is for us. And we're going to be
talking about sulforaphane and how amazing it can be for
us as a supplement.
Speaker 2 (00:28):
My guest today is David Roberts.
Speaker 1 (00:30):
He is the co founder of Mara Labs and is
a pioneer in sulfurafane supplementation and cellular health. And today
we are going to be talking all about sulfurafane and
how it can unlock brain, metabolic and immune resilience. This
is going to be a great interview because we are
(00:51):
going to learn about optimizing brain, metabolic and immune.
Speaker 2 (00:56):
Function with a supplement that you may have never heard of.
This is the Lindsay Olmar Ship. David Roberts, Welcome to
the Lindsay Olmar Show.
Speaker 3 (01:08):
Lindsay, thanks for having me. It's great to be here.
Speaker 1 (01:11):
I'm so excited to get to talk to you today
about your your investigations with sulforaphane and the master molecule
for health and why you have spent so much of
your career digging into it. So for listeners who are
new to all the science, what exactly is sulforaphane and
why do you call it the master molecule for helps?
Speaker 3 (01:33):
Yeah, so sulfurofane is the basically the good molecule that's
derived from broccoli for broccoli sprouts. It's why people grow
broccoli sprouts or buying them at the store, and so
in ahead of broccoli, basically there are there's the precursor
molecule called glucra wrappinin and you start shooting the broccoli,
(01:56):
you break the cell wall down, it releases an enzyme
converts that glucoraphin into the sulfurofane, and then you basically
swallow it. You get the benefit, but the issue comes
when like you try to harness that is, store it.
The sulforaphane is not a stable so it degrades. So
(02:19):
what we've done is we basically made a way to
stabilize it. That's natural, and so that's important because of
all the good benefits that come with the molecule, and
so things like it turns on over two hundred different
(02:39):
antioxidants and something called the antioxidant or spots element. It
is great for it's the best natural molecule for phase
two detoxification, but it works in all three phases. And
then we also talk about basically how it turns on
bdn F brain drive no tripet factor, which is at
(03:01):
the center of brain health, and because it protects existing neurons,
but it also helps grow new neurons, and so there's
there's a lot there. There's over over thirty seven pro
health mechanisms for sulfor fane. But but yeah, it's a
great molecule.
Speaker 1 (03:19):
Yes, Okay, So BD and F is a molecule that
we really haven't talked about on the show that much.
So how does sulfurifane affect B, D and S And
you know what is the what is the benefits to
somebody who's using this broccoli derived molecule.
Speaker 3 (03:37):
Yeah, and so you know the BD and F again
is upregulated by sulforaphane, and another way you can upregulate
BD and F is through exercise. And so so basically
the if you look at you know the different impacts
you list saying PubMed use type in b n F,
(04:00):
you'll you'll in brain you'll get a lot of studies
on how it is impactful and helps in different disease
states like Alzheimer's, Parkinson's, just different types of dementia. And
so it's it's very important for for brain health. It's
(04:23):
really at the center of brain health. And it's interesting
we have with our product broccoli, we have an unconditional
money back guarantee. So early on, you know, we're startup,
everybody does everything. I'm doing customer service, and so this
guy's like, I don't want I want my money back.
It doesn't work. And I'm like, okay, no, that's fine,
(04:46):
but let me ask you, like, did you have any
vivid dreams? And he's like, no, way, that's this He's like, yes,
I've been having incredibly vivid dreams. So that's the the
kind of the neuroplasticity effect of the b D and
F and the sul fore feane turning on that system.
Speaker 2 (05:05):
So interesting, why does it affect our dreams? Like, what
does it? How does this relate to each other?
Speaker 3 (05:12):
Yeah, I mean I think you know, I'm not a
dream expert, though I guess I should be at this stage.
But the you know, when when you're trying to process information,
you know, there's, there's and and kind of come to
grips with it. That's what the dream maybe aspect does.
I think it has to do with the different stages
(05:33):
of sleep too. I know that Broccoli, it helps both
with deep the deeper sleep and getting more of that
which is more the restorative physically restorative sleep, but also
the dreaming side is the r r M and so
you know, similar like no tripics have sort of that
(05:54):
brain enhancing effect, you know, I know, like another one
would be an alliance made but yeah, basically, you know,
I don't know all the specifics of that, but but
I think it has to do with with you know,
the processing and helping build neurons, the the processing information
(06:17):
and the enhancement of the RAM side of sleep.
Speaker 2 (06:22):
Interesting.
Speaker 1 (06:22):
Interesting, So you talked about a moment ago how the
delivery of sulforaphane is so difficult and so stabilization of
a product is going to be important, it would sound like,
so talk to us about the stabilization process and why
that is so important.
Speaker 3 (06:42):
So yeah, I mean, you know, so just to back
up a bit of my story was we got interested
in sulforfane after my wife was diagnosed with breast cancer
and and she ended up we ended up growing, you know,
(07:02):
growing her cancer cells in our lab and we put
sixty different types of supplements on them to see what
specifically killed her type of cancer, and sulfor fane was
number three in directly killing or type of cancer. So
when I went out to buy it, what I found
was something called sulfur fane glucosylate, which it's technically the
(07:24):
precursor of sulforaphane, and so it's not self forthing, which
is a little bit deceptive. It's a little bit confusing,
and I think they different supplent companies do that purposefully
because they want people to think it's soul forthning. But
it glucraphinin is the precursor, and so that's stable. And
so it's also why you know, the stabilization aspect is
(07:48):
why so many people, you know, we ended up growing
broccoli sprouts. We had I had like a broccoli sprout farm,
enough for like ten families because we would use it
every day and she drink the juice and it just
you know, is a production. But you can do it
that way because it's stable in the sprouts and then
(08:12):
when you masticate it, when you juice it, and there's
the end zomatic reaction and so.
Speaker 1 (08:20):
And so tell tell us about the process of actually
using the product.
Speaker 3 (08:25):
Sure, so, yeah, basically we we recommend so two capsules
has the or actually in each capsule there's the equivalent
of two and a half pounds of mature broccoli, and
so the amount of you know, lucrapmly. What we do
is we do the end soomatic reaction and we it's
(08:46):
already done. And so the sulforfane is in the capsule.
Each capsule has five milligrams of sallo sulforfane. But what's
more is it has all of the other cousin molecules
that come from this and then we add one that
uh into from from watercress. It's called finethyl isopy was
(09:08):
saying the name is not important, but what is important
is adding, well the name.
Speaker 1 (09:12):
Nobody can say it's an except for you. So I hope,
I'm glad it's not important to us.
Speaker 3 (09:17):
You know, just just think, I think the cousin molecule
from watercress, we add that because of what it does
to that it works synergistically. So one plus one does
an equal to that's added of one plus one equals
five and so there and that that synergis effect. It
has to do with the inter F two system, which
(09:39):
is why it's the where the magic lies with this
master molecule soul far fame, and it turns it on
that much more and so you get a really really
really strong effect. That's the plus and and we call
it broccoli plus.
Speaker 1 (09:58):
So we haven't talked about an r F two on
the podcast, I don't think ever, So talk to us
about what this pathway is and how it impacts detoxification
and cellular protection.
Speaker 3 (10:11):
Sure, so it's a transcription factor and so basically what
it happens is it's outside of the it's in the cell,
outside of the nucleus of the cell. And when you
ingest sulforfane and it gets into the cell, it actually
releases it has this reaction that releases the n F
(10:31):
two to go into the cell. And when it once
it goes into the cell, it interacts the inter F
two and interacts with it interacts in the in the nucleus.
Like I was talking about before it turns on over
(10:52):
two hundred different genes to begin cranking out these antiox
that sits. Then that's called the antox ont settlement, and
that's important, just to drill down on that a little bit.
It's like with with one antioxidant like vitamint C, it
combines with a pro occident and it cancels out, and
(11:14):
that that antioxidant's gone right with soul for a fane
itself is not an antoxidant, but it turns on over
to undred different antixidants that stay on for over seventy
two hours, and so it just keeps cranking them. It creeps,
keeps cranking them out. I was camping backpack camping with
(11:37):
my youngest son and we ended up going Uh. It
was in Colorado. Was supposed to be dry, and I didn't.
Actually I took him out of the bottle, the broccoli
out of the bottle, put them in a baggie. Didn't
have a desiccant, and I woke up and they had
gotten moist somehow. And so that moisture actually can and
(12:00):
you can tell that it oxidizes it It basically reacts
and and it's no good. And so it was a
four day trip, and so the first three days I
was fine, you know, because the systems still turned on
from my last dose. But that fourth day I was like, oh,
I can I can start feeling you know that it's
it's running up. So it is it's great that it
(12:22):
turns on and stays on. Now with phase two detoxification,
there you know three phases of detox. So first is
making the toxin less toxic, the second is making order
soil also goes into the set of the plasma, and
then the third is kind of binding an excretion and
(12:43):
and and so it is actually so forfeane is the
best natural mole if you'll at phase two detox in front.
And and so that's actually important because if you and
maybe you have maybe some of the listeners have, maybe
you haven't, but you may have heard of people doing
a detox program and getting sick, kind of getting what
(13:07):
I call the detox glue. And that's because all of
a sudden, you're having all these toxins mobilized in your
body and you can't get rid of them. And so
what actually soulfarteam does is that down regulates the amount
of the toxins that actually get into the plasma and
(13:29):
so so that you can actually it's a balanced at vacation,
so you don't get that same the same sickness and
and so that's you know, I kind of choke, but
I actually do this. Uh you know, at at holiday parties,
I'll go and you know, people know what you do,
and a lot of people take broccoli, uh, and but
(13:51):
I'll always bring a couple of bottles so people who
end up, you know, drinking alcohol can take some and
they will have that same sickness feeling, yuckie feeling the
next day because the the detox system is really affected
and turned on. So that yeah, the inner of two.
(14:12):
There's a couple of things that that it does. You know,
we've all heard probably heard of glutathion, which is sort
of the mass. It is an actual anti accident, the
master anti accident. And so again similarly, sulforfane does not.
It actually turns the glueithion production on and so it's
(14:33):
sort of a partners in that way. And so what
we often do is there's one of our favorite studies
is on and actually it's two studies now they repeated it,
but they looked this in this study they looked at
i think people in their seventies, and what they did
(14:55):
was basically they combined glycine and in a and gave
them these megadoses. It was like twenty grams or something
like that, and they did it over a period of
a month and showed that these these people in their seventies,
all they did sort of age markers before, age markers after,
and a lot of the age markers had reversed. And
(15:20):
the reason for that is that the glyceine and nac
are the building blocks of glue athion. And so you know,
I'll take I'll take some of those not twenty grams,
but I'll take a couple of grams of that combination
along with sulfur fane. And so basically you're turning on
the glid fine production and you have the basic building
(15:43):
blocks to create the glut fine. So it works rather well.
Speaker 1 (15:48):
And you've also combined kirk human in your products. And
why do you think sulfura fane and kirk human works
so well together?
Speaker 3 (15:57):
So it goes back. It's actually the same study where
we uh where we read as saw the the because
of molecule from watercress works and synergy that then that
same study, they looked at curcumen working in synergy with
sulfur or fine as well, and again it has a
(16:22):
three to five times impact on just everything, and so
they work really well together. We have we sell them
in a bundle because of that, we call it the
anti inflammation bundle. So kurcumen is the best national molecule
turning off the prone inflammatory pathway. N F kapa B
NF kapab is the holy grail that the pharmaceutical companies
(16:46):
are going after when they were creating an anti inflammatory drug.
And so what we've shown, we've also looked at, you know,
synergistic effects internally through our own study. We have our
full lap here in our in our building, and so
we can we can look at center centertistic effects of
(17:08):
different molecules. But yeah, basically we combine them because you know,
curcumen actually most kurkumen, less than one percent of the
curcumin gets through the gut barrier. And so you can
take regular curcumen or turmeric or whatever, and it really
(17:29):
it really helps your maybe your gut the cells in
your gut lining, which is important since about sixty percent
or seventy percent of our immune system is in our gut,
right you want don't want to unflamed gut, but it's
really not going to impact the pain in your knee.
And so with ours, we actually came up with a
novel carrier molecule where we combine a plant based protein
(17:52):
with a c based carbohydrate and it's its own molecule,
and then we add the curcumin to that and it's
basically like I like to think of it as like smuggling,
you know, it smuggles the CURCUMU pass they got bearer
and it gets into your plasma, into your cells in
a way that makes a biological difference. So even we've
(18:13):
tested a lot of different curriculum products and the vast
majority do not make a ball up. Then they don't
move the needle on the and the NF kappa B
or aisle six, which is another pro inflammatory marker, whereas
ours does.
Speaker 1 (18:35):
So so for our super science nerds out there, what
are the give us us.
Speaker 2 (18:42):
We've got NF KAAB, we've got bd n F.
Speaker 1 (18:44):
We've got all these different you know, buzzwords and all
these different names going around. Give us a list, because
one of the things that I'm picking up is that
the sulfurifane has some wide ranging effects because it acts
on many different molecules. And so what are like kind
of the top five, top three molecules that are going
(19:07):
to get impacted. For our listeners who really want to
dig in and do some more research into the basic science,
what can they look at?
Speaker 3 (19:15):
Yeah, I mean, you know, while I said Kirkuman is
the best national molecule turning on or turning off, the
NF cup of V sulfur feane does too. And it
does it really really well. And it does it so
well that we actually did our own internal study because
you know, early on, you know, I mean we started
(19:36):
taking it and we were noticing our aches and pains
to going away pretty much like within the first dose.
I actually enjoy playing the guitar. I'm not very good
at it, but I when my wife was sick, I couldn't,
like I could only play a couple of minutes because
my hands were like in a lot of pain. There's
(19:57):
a lot of inflammation there. And we once we created
you know, the capsules and or started taking that pain
went away really quickly. And most you know, our friends
and family are like, this was working really quickly, and
so we ended up were like, how quick is it working?
And so we did an internal study of some employees,
(20:19):
friends and family where we looked at aisle six, which
is interluking six. It was kind of you may have
heard about that during COVID times, but it's a pro
inflammatory marker, and so we showed that it decreases aisle
six just one one dose, so ten milligrams decreases aisle
(20:40):
six twenty eight percent in twenty four hours. So that's
enough so that you could actually feel the difference. So
nf kapab is downstream from aisle six. They're interrelated, they're
both pro inflammatory markers. So I'd say nf kapa is
a big one. NRF two, which we've explained, the transcription
(21:03):
factor is probably in terms of sulfurfane is the biggest
one bed and a f brain derive, no tripet factor
is it's so important for brain that that has to
be on the list. And then I would say that's four.
Speaker 1 (21:22):
I asked for three to five, So you're perfect, did
it great?
Speaker 2 (21:26):
You hit it right on the nail. So what the things? Yes,
exactly exactly. So a lot of people we've talked about.
Speaker 1 (21:36):
Detox and I do want to talk about metabolism and
inflammation before we before we end. But detox is such
a kind of buzzword, but a lot of people just
talk about it, you know what I mean? And you
mentioned earlier that some people do detoxifications and they get
sick because they don't do it well. So as far
(21:59):
as where is the people that are thinking about this
as just detox is just a buzzword for me to use.
What are some of the misconceptions that you think that
people have when they try to detox and supplement.
Speaker 3 (22:15):
I feel like there's you know what I call the
different health and willess gurus, and I feel like everybody
and their brother if you if they have like a
supplement offering, they will have something in terms of detox.
So I before I started more labs and broccoli, you know,
(22:37):
I we waited up getting a few different detox programs
and they come in a big box and it seems nice,
and there's te's and there's capsules. But most of them
focus on phase one because that's the really the easiest way,
that's the easiest one to focus. And that's the phase
(23:00):
one when you're when you are kind of beginning to
you know, mobilize these toxins into your system. You know,
you'll we want to limit that, and so it's important.
And that's why you know people get sick is if
they overdo that step, they don't feel well. I think,
(23:20):
you know, as far as misconceptions, I would just be
very skeptical about a detox program. You know, I think
there there are good ones. We write about detos on
our blog, people at Maura desh labs dot com can
go there. But really you just want to be careful
and you want to make sure you're covering all three
(23:42):
faces of detox. Yeah, I will say, you know, we
live in a toxic world. We just actually learned a
couple of weeks ago this guy did a study from
he's from Sanford, not Stanford, but Sanford University and.
Speaker 2 (24:04):
He used to work there.
Speaker 3 (24:06):
Yeah. He he looked at mobilizing microplastics and so we're
you know, we if you eat an apple, you're getting
a million microplastics because of the the covering that's on
the apple. Bottle of water, hundreds of thousands of microplastics
plastic bottles. I just learned on the drive over to
(24:27):
do the podcast that actually glass bottled water has like
ten times more microplastics than plastic bottle water because of
the mica. Yeah, because of the lid. Yeah.
Speaker 2 (24:41):
Wow, okay, all right, and so.
Speaker 3 (24:44):
I don't have a reference for that, but I will
I will. But all to say is, you know, we
get we ingest the the amount is kind of staggering,
the amount of microplastics create uh A basically a credit
card the amount of microplastics we ingest every in one
(25:05):
year period. And so mobilizing those getting out as important.
This guy showed that by taking brock Elite you actually
mobilize the microplastics into your system to begin the excretion.
And so that's the first study of it. If it's
kind microplastics toxin, you know, it messes with you know,
(25:27):
hormones and all sorts of things. But that's just one toxin.
There are chemically, there's tens of thousands of toxins. You know,
if you just look at your sunscreen or it might
be your sunscreen because you probably ever good subscription. But toothpaste,
are cleaners, are soaps, everything is just if you can't
you know, if you don't know what, if you have
(25:49):
trouble pronouncing it, the rule of thumb is like it
may not be good for you, you know, and so
so those are chemicals we are bodies have to we
have to process. And as another aside, do you know
if you're glyphosate, oh, glyphysate And for those listening, basically
(26:14):
the active ingredient round up and we showed that just
by the amount of life state and that kind of
a regular it's a basically the highest level you can get,
but in a but it's in a regular meal, and
it can reduce your ability your inner of to and
(26:36):
which is your ability to detox, by thirty percent. And
so that's basically that's that sounds like, okay, well you
still have seventy percent, but that's like any it's major.
It's if you can get really really sick, if you
if that is continuously insulted. And so what we showed
is broccolite actually reverses that life state's ability to turn off.
(27:00):
That's that innerve to And so that's huge in detox
because you know, we think think about detox with liver, yes,
but every cell in our bodies has the ability to
detox and so you know, whereas sulfurfane it is sort
of a master module life to say I call it
the master toxin because it makes every other toxin that
(27:23):
much more toxic because it reduces the body's ability to
detox well.
Speaker 1 (27:29):
And that is also has so many environmental effects that
have to be noted as well.
Speaker 3 (27:34):
Yes, it's just on and on and on, right, it
goes on and on.
Speaker 1 (27:39):
Absolutely, it's so pervasive, this chemical, and we kind of
put it everywhere before we knew we were doing it,
and now we look back on it and go, what
were we doing. It's the same thing with all of
the PFCs and pfbs that we put into water, that
(28:00):
we just kind of put them there and then now
we realize it had major effects.
Speaker 3 (28:05):
Sure, yeah, and you know, and that's where you know,
I'm big on not eating genetically modified foods. It's because
the genetic modification is to receive the round up and
not kill it. And so corn soy are the two biggies,
and so you know, but those are basically hypergers. Scorn
(28:28):
syrup and vegetableil or soyde and oil are if it's like,
it's almost in every processed food and so just read
your label and avoid that because there's not a lot.
It's actually not a lot in any any processed food.
But the issue is there's a bioaccumulation because it's in everything,
you're just kind of continually getting it and getting it
(28:50):
and getting it in over months and years. Really it
makes a big impact.
Speaker 1 (28:57):
So let's transition in our last few minutes that we
have here and talk about metabolism. We've talked a lot
about detoxification. But when I talk about metabolism, I'm actually,
you know, in this situation, I'm talking about what belly
fat inflammation, in insulin resistance. How does sulfur fane play
(29:18):
a role in metabolic help There.
Speaker 3 (29:21):
Are probably a decent amount of listeners or women over
forty and so with with if you think about estrogen,
they're good estrogens, bad estrogens, and metabolically balancing them. There's
an interplay between metabolism and the detox So basically, because
(29:42):
sulfur fane is so good at detoxication, it can remove
the bad estrogens and help they basically balance the good.
And so you actually, and that's important you know, for
a lot of reasons in women's self and so so
in terms of metabolism, Like we have a decent number
(30:06):
of people who take sulforaphane for performance. So our bodies
the sort of the mitochondria is part of the cell
that is sort of the energy production part. And and
there's it's the center of where kind of glucose, which
is like money in the bank, turns into ATP, which
(30:27):
is the usable form of energy. It's like cash money.
And so and that's important because the sulforaphane actually can
can stimulate that that system. It's called the creb cycle.
That's why we breathe in oxygen breathe out carbon dioxide.
So my boys are swimmers, and so I'll give them
(30:52):
sulforaphane and a few other things before if they're competitions
and it's it's natural, it's all natural. But you're revving
up that system. And in terms of and and that
can impact that can as you're that system is impact
repped up, that can impact belly fat it and it
(31:14):
just turns out it turns on a lot of good things,
including like we talked about before, the anti accident response
C element. But we have another product as well that
is excellent at something called turning on amp kinase, which
is the master metabolic molecule. And so it's we call
(31:36):
it it's a GLP one alternative called geo perfect, and
basically that what that does is it has e G
c G from green tea and it has berberine and
then it has alpha blow alfala pok acid. Well, alpha
bok acid and berberine are two molecules that really turn
(31:59):
on this amp kind So if you think about metabolic disorder,
people who have belly fat, they're puffy in the face,
they have insulin a low insulin, high glucose, they probably
have cardiovascular issues and high triglys rides that am kindase.
Really it's almost like a fasting. It just bravs up
(32:23):
the metabolism and so it helps decrease trichless rides. It
helps improve the insulin, you know, to get the glucose
into the cells, helps decrease actually decrease blood glucose and
so goes opposite way of metabolic disorder. So those two
(32:45):
moleculars are exceptionally good at metabolism as well.
Speaker 2 (32:51):
I love all of the different things that this molecule
can do. Listeners.
Speaker 1 (32:55):
If you want to learn more about broccoli and how
you can get this soulfar or fan product, head to www.
Dot Maura dash Labs. That's m A r a dash
labs dot com slash Lindsey that will save you up
to twenty eight percent off of broccole and other Mara
(33:16):
Lab products as a special gift for all of our
listeners today.
Speaker 2 (33:21):
David, it has been a fabulous interview with you. Thank
you so much for coming in and being a guest
on Lindsayilmore Show.
Speaker 3 (33:28):
Lindsay, thanks so much for having me. It's been wonderful
to talk to you. Thank you.
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