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April 25, 2025 24 mins

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Episode description

How Raising Your VO₂ Max Helps Fight Cancer
The Molecular and Physiological Truth Behind Oxygen Efficiency and Cancer Risk

In this breakthrough episode of The New Science of Physical Health, host Shane Stubbs reveals how oxygen efficiency—measured by your VO₂ Max—can be one of the most powerful tools in the fight against cancer.

Forget the idea that VO₂ Max is just for athletes. Shane breaks down the molecular, hormonal, and immune system upgrades that occur when you increase your cardiorespiratory fitness—and how these changes can reduce your cancer risk by up to 70%.

This episode will completely reframe how you think about exercise, fitness, and long-term disease protection.

  • The Oxygen Efficiency Score that predicts disease risk

  • How low VO₂ Max signals inflammation, poor immunity, and metabolic dysfunction

  • Why improving VO₂ Max triggers systemic resilience

  • How myokines fight chronic inflammation

  • Reprogramming insulin and IGF-1 to reduce cancer fuel

  • Antioxidant enzymes and DNA repair via improved oxygen efficiency

  • Activation of p53: your body’s anti-cancer gene

  • Enhanced immune surveillance: NK cells, T-cells, and macrophages

  • Oxygen-rich internal environment = less cancer growth

  • Fat loss and hormone balance that detoxifies your biology

  • 45% lower cancer risk with high VO₂ Max

  • 55% lower cancer mortality in fit individuals

  • Up to 70% reduction in recurrence risk after treatment

  • From a VO₂ Max of 33 to 50—and aiming for 60 by age 60

  • How targeted high-intensity training reshaped his internal biology

  • Why VO₂ Max training is his personal cancer prevention plan

  • How to track VO₂ Max and earn AQ Points

  • Ideal training zones (Zone 3–5)

  • Weekly targets for adaptation

  • Why consistency beats intensity

VO₂ Max isn’t just a fitness number—it’s a biological shield against cancer.
Every point you increase makes your internal environment less friendly to disease—and more resilient to illness, aging, and cellular damage.

  1. Estimate or track your VO₂ Max (smartwatch, software, or test)

  2. Earn 100–150 AQ Points weekly

  3. Train 2–3x per week in Zones 3–5

  4. Focus on oxygen delivery, not calorie burn

  5. Stay consistent—adaptati

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