Zepbound Wegovy Not Working Anymore? Understanding Weight loss Stalls & Plateaus Part 1

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If you’ve ever hit a weight loss stall and thought, “What am I doing wrong?”—this one’s for you.

In this episode, we sit down with Dr. Lindsay Ogle, a board-certified obesity medicine specialist, to unpack what’s really happening when the scale stops moving, even on a GLP-1. We explore the body’s built-in defenses against weight loss, the role of metabolic disease, and how hormones—especially during perimenopause and menopause—complicate the picture. Dr. Ogle breaks down the science with compassion, helping us understand why stalls happen, how to respond to them, and why it’s not about failure. It’s about biology.

Joining us as well is a powerful voice from the community: Mrs. Clark, who began sharing her journey through a nervous breakdown in 2022 on social media and unexpectedly found herself with millions of followers. After years of struggling with her weight, she decided to try tirzepatide—and it changed everything. She opens up about the emotional toll of obesity, what it felt like to stall, and why the journey is about so much more than a number on the scale.

We also dig into obesity phenotypes and why GLP-1 medications don’t work the same way for everyone. For those not seeing the results they expected, Dr. Ogle walks us through combination therapies, mindset shifts, and what sustainable care really looks like.

This episode is a reality check wrapped in compassion. Whether you’re stalled, stuck, or just trying to make sense of what your body is doing, this conversation is your reminder: you’re not alone—and it’s not your fault.

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Mrs Clark

Tik Tok: @mrskariclark

Doctor Guests
Dr. Lindsay Ogle

Dr. Lindsay Ogle, MD is a board certified family & obesity medicine physician
who is passionate about preventative health. Her goal is to help patients stay healthy so they may live longer and fuller lives. She recently started a telehealth clinic called Missouri Metabolic Health where she helps adults all throughout the state of Mis

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