November 9, 2025 • 44 mins
In this episode of The Root of the Matter, Dr. Rachaele Carver sits down with regenerative medicine pioneer Dr. Jeff Gross, founder of Re-CELLebrate, to explore how stem cells, exosomes, and regenerative therapies are reshaping the future of healing. You’ll learn how these tiny cellular messengers help the body repair itself naturally, what they mean for oral health, joint pain, TMJ dysfunction, inflammation, and aging, plus everyday ways to stimulate your own stem cells through fasting, sauna, and mindful living.
If you’re curious about the science of cellular regeneration, longevity, and whole-body repair, this episode offers both grounded science and real-world hope.
Key Topics
- What stem cells and exosomes are, and how they accelerate healing
- How regenerative medicine supports joint, spine, and TMJ health
- Why oral health and blood flow are key to faster recovery
- How to naturally boost stem cell activity with fasting, sauna, and cold therapy
- The connection between inflammation, hormones, and aging
- Why bone health is often the real root cause behind “arthritis” pain
- The future of exosome therapy for longevity and anti-aging support
Stem cell therapy, exosome therapy, regenerative medicine, natural healing, joint regeneration, oral health, PRF dentistry, TMJ therapy, anti-aging, inflammation reduction, stem cell activation, longevity medicine, holistic dentistry, cellular repair, Dr. Jeff Gross, Dr. Rachaele Carver, Re-CELLebrate, exosome benefits, regenerative dentistry, holistic health podcast.
Takeaways
- Healing happens when the body remembers how to communicate. Exosomes are those messengers.
- Blood flow equals life. Support it, don’t suppress it.
- You can activate your own stem cells through rhythm, heat, cold, and rest.
- Regenerative medicine and holistic dentistry share one truth — the body knows how to heal when you clear the interference.
Resources
- Guest: Dr. Jeff Gross, Founder of Re-CELLlebrate — re-cellebrate.co
- Instagram @recellabrate
Connect with Dr. Carver
Join the 6-Week Gum Disease Course: https://reversegumdiseaseinsixweeks.info/optinpage
Book Your Personalized Consultation: https://calendly.com/drcarver-1/health-coaching-consult?month=2025-10
Disclaimer: This podcast is for educational purposes only. Information discussed is not intended for diagnosis, curing, or prevention of any disease and is not intended to replace advice given by a licensed healthcare practitioner. Before using any products mentioned or attempting methods discussed, please speak with a licensed healthcare provider. This podcast disclaims responsibility from any possible adverse reactions associated with products or methods discussed. Opinions from guests are their own, and this podcast does not condone or endorse opinions made by guests. We do not provide guarantees about the guests' qualifications or credibility. This podcast and its guests may have direct or indirect financial interests associated with products mentioned.
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Transcript
Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
SPEAKER_01 (00:00):
Hello, everybody.
Welcome back to another episodeof The Root of the Matter.
I am your host, Dr.
Rachel Carver, and today this isa very exciting, really
interesting new topic that I'mI'm really excited to dig into.
We are fortunate to have Dr.
Jeff Gross with us today, who isthe founder of Re-Celebrate and
pioneer in regenerative stemcell and exosome medicine.
(00:22):
So I'm sure everyone's kind ofheard of the idea of stem cells,
maybe exosomes, not so much.
So we'll kind of talk about thedifference there.
And, you know, what is this goodfor?
Who can use it?
How do we use it?
How does it relate to oralhealth?
So, Dr.
Gross, thank you for uh joiningus.
Maybe just talk to us a littlebit about your background, how
you got into this, and uh whyyou founded the company.
SPEAKER_00 (00:44):
Great.
Yeah, thank you for having me.
Uh it's great to be here.
Please just call me Jeff.
So I I'm a recoveringneurosurgeon.
I'm a spine surgeon by training.
I had a fellowship in that.
And for decades I treatedpatients with neck and back
problems, nerve problems, discissues, things like that.
And I had always been sort ofbutting my head up against the
(01:04):
sick care system, theinsurance-driven cookbook,
Kool-Aid drinking nonsense, andhad always tried to find new and
better ways for patients.
As a surgeon, I was, you know,you learn to do surgery in your
residency.
And then the first thing youlearn when you get out of your
residency is how not to do it.
So always tried making that thelast thing, right?
(01:26):
So I had so many patients Itreated over the years that they
were in between the non-surgicaltreatments and the surgical
treatments.
So they they tried therapies,they tried maybe some
medications, someanti-inflammatories, they tried
some injections, and they cometo me and say, Yeah, those
things helped a little ortemporarily, but um I'm still
(01:46):
having these issues.
I say, Well, gosh, the nextthing on the menu is to talk
about surgery.
And they go, Oh, wait a minute,I'm not ready for that.
I'd say, great, because I reallydidn't want to have to offer it
to you.
But in the modern era with MRIsand things, we catch these
things earlier.
So we catch people in this limbobetween non-surgical and
surgical, and uh they're stuckthere.
So they ask, what about this?
(02:06):
What about that?
What about stem cells?
So you hear that enough, you'refrustrated enough, and chance
favors the prepared mind.
So luckily I have someundergraduate background in
molecular biology, biochemistry.
And I said, you know what?
I know that these athletes havebeen going to Europe to get stem
cells, you know, Tiger Woods,Peyton Manning, these other
(02:26):
guys, you know, for years youhear about this.
Something's going on.
Something must be happeningthere.
A lot must have happened since Iwent to college.
So I decided one year, insteadof going to these stuffy
neurosurgery conferences, Idon't know if you go to the
dental ones, but it's it's thesame academic bowtie wearing
knuckleheads, patting themselveson the back for doing the same
old thing year after year,publishing the same thing that
(02:49):
they published 50 years ago.
Nothing's changing.
It's stagnation.
We don't do anything differentlysurgically than we were doing in
the 1940s and 50s.
Yeah, there's a new widget orgadget, but it's the same thing.
So I said, screw that, I'm goingto learn something new and
better.
So I started going to stem cellconferences and re-educated
myself and took courses and readand read and read and did the
(03:12):
homework and did the research.
Luckily, the internet affords usaccess to a lot of the journal
articles now, you know.
So you don't have to go sit inthe library and pull a bound
journal.
Uh, it became clear to me that Iwanted to offer this as a tool
for my spine patients, but ithas blossomed into so much more.
And uh it's all I do now.
(03:33):
And if I never do another spinesurgery, you know, I enjoy it,
I'm good at it, but uh it'sprobably a service to most
people.
So that's kind of where we are.
SPEAKER_01 (03:41):
Well it's funny because I say that too.
I'm looking forward to the daywhere I never pick up a drill
ever again because I will haveprevented all disease.
And so that's why the whole ideaof stem cells, right, it's very
exciting.
So maybe for those of us whoaren't really familiar, what is
a stem cell?
Why is it important?
Why as we get older we havefewer and fewer?
(04:01):
So why is it a good repairmechanism?
SPEAKER_00 (04:03):
So let's talk about that.
Stem cells created us.
When you're when you're afertilized egg in your mother's
womb, you are a single stemcell.
You are the master stem cellfrom which all other cells will
stem, hence its name.
And from there you develop intoa uh you know, a fe uh an embryo
and a fetus, and you have thesedifferent types of stem cells.
So stem cells just not onething, but we have different
(04:26):
types of stem cells, andeventually become almost ready
to be born.
You're this full-grown fetalbaby, and you still have lots of
stem cells, and they're floatingaround the amniotic fluid, and
they're doing all kinds of magicto create you.
Then you're born, and you'reyou're born and you maintain
many stem cells throughout yourbody, mostly in your bone marrow
and your fat and other places,but uh, you know, those are the
(04:49):
main stores.
And during your growth, you'reusing those stem cells to grow
and make new cells and developand become an adult.
And even as an adult to renewand repair and restore and heal,
you're tapping into stem cellsto do that.
Well, aging is this accumulationof cellular, chronic,
inflammatory changes, and allour cells get affected by what's
(05:10):
in our diet, what's in ourwater, what's not in our diet,
what's, you know, theelectromagnetic forces around
us, maybe mental stress, allkinds of bad stuff that we can't
always control.
So our cells get, you know, theyget rusty internally, they get
oxidized, they don't function aswell.
And that's aging.
It's called inflammation, if youwant to be cute about it.
(05:32):
And our stem cells are alsoaffected by those same things.
They become less functional.
You mentioned earlier, theybecome fewer of them.
That's true.
You do exhaust the numbers, butyou also exhaust the function.
And that's why you can't healand repair like a
three-year-old.
You're you're made of the samegenes you were when you were
three.
And if you fell down and scrapedyour knee when you were three,
(05:53):
and your mother would clean itup, you know, put some back teen
on it, maybe a band-aid, kissit, and send you on your way.
Three days later in the bathtub,that band-aid comes off and your
scab's almost almost healed,done.
And if, you know, if and now ifyou bang your arm on something,
you got to bruise for like aweek and a half, two weeks.
Well, wait a minute, how comeyou can't heal as fast?
Because your stem cellrestorative functions just
(06:14):
aren't there.
So that's where we tap into thestrategy of stem cell medicine
or what we call regenerativemedicine to help regenerate you,
to leverage that youthfulhealing ability in someone who
needs it.
That's that's the magic.
SPEAKER_01 (06:29):
Yeah.
And that's again what's excitingfor those of us who are hoping
to, you know, not just livelonger, but live better.
You know, that's what we need todo, right?
How do we maintain a robustimmune system?
How do we heal?
You know, I used to always weara badge of honor, like, I never
get sick.
And then I kind of learned,well, hmm, that's not
necessarily the goal.
The goal is if you and when youget sick, you heal quickly,
(06:51):
right?
I remember my kids when theywere little, you know, they had
great diet, great exercise, allthe things, and they'd get sick
24 hours.
Now, as teenagers, and they'reeating all the junk and they're
staying up late and they got thecell phones, right?
They can be down for a week,right?
Um and so that's the thing.
Like, how do we how do we buildresilience?
And there are some things thatare, you know, it's challenging,
(07:13):
and and maybe we have to have anine to five, 40 hour job, and
we can't go in the sunshine, wecan't do all the we can't
meditate for two hours, youknow, every day.
So this is where, you know, thatthe the science and the and the
spirituality can kind ofcombine, right?
Where we can, you know, we needsometimes help, you know.
I've I've even evolved too.
It's like, hey, you know, I wasso resistant to antibiotics for
(07:35):
a while after learning all thisbiological, but at the same
time, it's like, well, sometimeswe actually need them, you know.
So I should uh, you know, eitheror but an and.
So um, and I know when I startedlearning extractions and started
learning about platelet-richfibrin, we were told, you know,
oh, this is great, you know,that's you want the stem cells
from the platelets, right?
(07:56):
And and it's gonna helpeverything grow faster.
And I have to say, the healingof the soft tissue is oh my god,
like 10 to 100 times faster.
It's just amazing how in a fewweeks it looks like what it
maybe would look like typicallyif I didn't use PRF, you know,
in 12 weeks.
So it's it's really incredible.
But then I start feeling, well,you know, after 40, maybe our
(08:17):
stem cells aren't so great, youknow.
So is it really the stem cells?
I mean, again, it's your ownbody, so it's good healing, but
am I getting what I originallythought, right?
Am I really putting stem cellsin there?
Or are there better ways?
So I'd love to tell you, haveyou tell us a little bit how to
use stem cells, whether it's inan extraction site or, you know,
(08:38):
in a degenerative um spine boneissue.
SPEAKER_00 (08:42):
Well, this this is uh this is evolved.
So I'm gonna speak at the the2025 best and latest knowledge.
Uh, a lot of doctors arepracticing stem cell medicine,
are still practicing in the inthe 1990s, where they are
harvesting stem cells from thebone in your hip and things like
that.
And that's fine.
There's nothing wrong with that.
Uh, but it's certainly not themost active and most efficient
(09:03):
way to do it these days.
We've learned something uh inthat to get the benefit of a
regenerative biologic, a stemcell or something like that,
that the benefits come from thecell signaling.
So a stem cell messages ourcells.
And at the end of the day, ourcells do the work.
The bone in the jaw, if you wantto deposit more bone, has to be
(09:26):
reinvigorated, or like you said,the gum and and the soft things
around that area have to besignaled to heal like a younger
person, right?
So the cells give off two kindsof signaling.
Signaling number one is growthfactors, little proteins that
stimulate the laying down of newvessels and capillaries and the
(09:47):
healing.
And you find these robust in theamniotic fluid.
You find them in platelet-richplasma or platelet-rich fibrin,
which you use in the dentalindustry.
And these come from the ownbody.
But you're right, if they comefrom a 70-year-old body in the
blood, they're not as robust aswhen that 70-year-old was, you
(10:08):
know, five.
So we like to tap into theyouthful sources.
Then the other signaling fromstem cells in the regenerative
capacity is called extracellularvesicles, or for short,
exosomes.
And for those of you watchingthis broadcast and not just
listening to it, at the bottomof my of my screen, it says Dr.
Jeff exosomes.
(10:28):
And that's the short word forthese vesicles.
All cells make exosomes.
All cells signal theirneighbors.
They're always talking, they'realways communicating.
Think about the movie Avatar,where all the trees and nature
were communicating with eachother through the rootlets and
things.
So, so cells are constantlytelling their neighbors what's
going on and trying to influencethem.
(10:48):
Well, what we want here in aregenerative approach is that
regenerative, useful,restorative signal.
So we can tap into that throughthe exosomes and the growth
factors.
These are, again, robust whenyou in the bloodstream, in the
bone marrow, in amniotic fluid,in umbilical cord jelly called
Wharton's jelly.
(11:09):
All these things have it.
And you have some of these inplatelet-rich plasma,
platelet-rich fibrin.
They can come in many ways.
SPEAKER_01 (11:17):
Yeah, it's it's it's really fascinating.
This is why I love ozone.
It's another one of thosesignaling molecules.
That's why I tell patients, youknow, it's when I first learned
I was like, oh, this is thegreatest thing ever, it's gonna
cure everything.
But you have to remembersomething with natural, it's not
a steroid.
It's not stopping something,it's actually signaling your
cells to heal themselves.
And that's why there's no sideeffects, no contraindications.
(11:38):
Like this is a natural process.
And that's where we get realhealing.
What you say about the growthfactor, right?
The blood supply, this isanother reason I don't use any
epinephrine in any of mypatients.
Right.
So I think that is a really bigreason why my extractions, they
heal so well.
Not only the ozone and my laserand all the things, but by not
(11:58):
shutting down the blood flow for90 minutes or whatever it may
be, we're making sure, andsometimes, yeah, it's a little
messy.
I gotta have a lot of suction,but I'd so much rather it take
me a little bit longer so that Inever cut off that blood supply
to again, you know, ensure thatall those cells and all the
blood flow and it's gettingthere immediately.
SPEAKER_00 (12:17):
Yes, I agree, I agree with you.
So obviously, for those thatdon't know, epinephrine is also
known as adrenaline, and itcauses your small vessels to
constrict so you don't have asmuch blood flow.
So sometimes when you put in anumbing agent, right, you want
you the strategy is let's keepmore of that there by not
letting the bloodstream take itaway.
The problem is you need thosecapillaries open to do their
(12:38):
healing.
So so you have a little morebleeding uh during that
procedure, but that that you cancontrol, of course.
And um, it's almost, you know,this self-fulfilling prophecy,
you should not use theepinephrine, collect the blood,
and you can get your PRF fromthe blood.
You don't have to do a famousblood draw from the arm, right?
SPEAKER_01 (12:57):
Yes.
Exactly, I know.
Think about that.
I was thinking about the otherday because my slabotamus is out
for a month, and I was like, Iwas like, okay, I'm not, I don't
love doing this, but I have todo it.
But man, those hard cases, I'mlike, oh geez, yeah, let me just
take it from the extractionsite.
Possibly.
SPEAKER_00 (13:12):
Yeah, and of course, you're right.
The more vascular your tissues,and in this case your your gums
and local tissues, the betterpeople heal, the fewer diseases
they have, because the bloodflow brings the immune system,
clears things out, you know, andand and and does the job.
It's you know, people with poorblood supply have more
disease-type problems.
They have trouble healing aninfection, they have trouble
(13:32):
healing local bone, which is youknow relevant to the dental
industry, of course.
So I'm with you there.
It applies beyond the mouth,just for everyone listening.
This is this applies to the feetand the joints and the spine and
everything.
SPEAKER_01 (13:46):
So tell us about like, you know, you're got a
past of doing spine surgery.
So around, you know, with bones.
So somebody, you know, we I wework with a lot of people, you
know, they've got the cervicalspine.
Every time I take a 3D X-ray,you know, it's like I think nine
out of ten times the radiologistsays, mm, cervical changes,
spine, you know, we we hold somuch tension and pain and
everything in our neck.
(14:06):
And now with this forward neckposture and you know, modern
life.
So tell us a little bit howyou'd use stem cell cells in
like disc degeneration or orhowever you use it for that.
SPEAKER_00 (14:16):
So the spine has two dominant, not only, but two
dominant sources of pain.
One is problems with the discwhere the disc wears down, and
problems with the joints in theback of the spine called the
facet joints.
So first we need to confirm thesource of the pain or the
problem.
Sometimes it's one, sometimesit's the other, sometimes it's
both.
Facet joints tend to behave likeother joints in the body, knees,
(14:40):
shoulders, knuckles, what haveyou.
Typically, we can inject aroundthose joints with regenerative
biologics.
Now we're using the phrase stemcells here, but we've skipped
beyond the stem cells now.
Stem cells are really just adelivery vehicle.
Stem cells make the growthfactors and the exosomes.
We go right to those becausethey travel through tissue
better and they're lessexpensive.
(15:01):
So, and they are the businessend of the stem cells.
But we call it stem cellmedicine so people can
understand it, but we're notdelivering cells any any longer
often.
We still have some applications.
So we can inject around thosefacet joints, in the facet
joints, we're actually injectingthese days the bone because the
cartilage-forming cells, andthis may have some overlap in
(15:21):
your field, thecartilage-forming cells in the
joint that are you know, causingthe wearing of the cartilage,
the osteoarthritis of that areaare in the bone.
So people for years have beeninjecting the cartilage only to
find out the cartilage has veryfew cells, nothing to affect
it's sort of the result.
Just like hair is a protein madeby a follicle in your scalp,
(15:44):
cartilage is a protein made by achondrocyte cell in your bone.
So we inject the bone,obviously, a little sedation for
that because it's in the bone.
If we're dealing with the disc,it's a little more challenging.
And this is going to really beinteresting for the dental side
of things because disc is madeof two different types of
cartilage.
And the problems with disc inpart come from the bone above
(16:06):
and below.
So we can inject those just likewe do those facet joints and
other joints and get someimprovement in the regular
cartilage, but the deepernuclear cartilage, the part that
herniates out and gets worndown, is from a different part
of the embryo called theendoderm, which uh we don't have
a lot of body parts made of theendoderm.
Whereas in the dental side ofthings, teeth are interesting
(16:28):
from ectoderm and the brain andnervous system in the teeth and
a few glandular cells are fromthe ectoderm system.
So most of the rest of the body,structurally and organ-wise, is
from the middle layer of theembryo called the mesoderm, and
most stem cells stimulatemesoderm.
These stem cells are called MSCsor mesenchymal stromal cells,
(16:50):
and mesenchyme and mesoderm arekind of go together.
But as we become better atlearning how to use regenerative
medicine, we're finding in thedental side of things that we
need these ectoderm stimulatingexosomes and things like that.
So that is the key in thatarena.
We're looking at using differenttypes of stem cells called MUSE
cells, which are a subset ofstem cells to stimulate these
(17:12):
other embryonic origins likeectoderm and endoderm.
So I think you're gonna see thatin the dental side of things,
and we're just now using them todo a sandwich therapy for the
disc.
So MUSE cells to stimulate orMUSE cell exosomes to stimulate
the nucleus to, you know, bemore restorative and youthful,
and then the the regular uhmesodermal mesenchymal uh you
(17:35):
know amniotic exosomes andgrowth factors for the bone.
So the the disc is complex, iswhat I'm trying to say in all
this.
SPEAKER_01 (17:42):
But that's exciting because I mean exactly what
you're talking about.
You could you may be talkingabout the spine, but you're
equally talking about thetemporomandibular joint, right?
You know, we got people who alsohave TMD or TMJs, as we say,
right?
Um yes, you have two TMJs.
TMD, the professionals call ittemporomandibular dysfunction.
Um, and we, you know, we canlook at uh x-rays and uh, you
(18:03):
know, determine what's going on.
Is it a bone thing, disc thing,sometimes both?
But that, you know, again, justlike you said, first you gotta
figure out what's happening,right?
Because a lot of it ismusculature, right?
So you gotta calm down themuscles or the way the teeth are
hitting are causing the musclesto become dysfunctional and then
pulling the joint out ofalignment.
So um, you know, I use a lot ofuh the the prolosome therapy for
(18:25):
TMD patients, which isunbelievable.
I mean, it's it's it can lastover a year.
And we're not unlike Botox, I'mnot putting a toxin, you know,
right near your brain.
Um so that's that's exciting.
So I'm really excited to keeplearning more about and it's
exciting to know that thatdistinction, right, with the
ectodermal tissue that it has tobe a little bit different,
(18:47):
maybe.
SPEAKER_00 (18:47):
Yep.
Uh and and and we're we'reseeing that now because people
are using teeth or two or dentalstem cells, which are
ectodermal, neuroectoderma, toregrow teeth and in in the lab
and re and maybe regrow evensome part of the nervous system
since they they they have commonlineage, common parents or
grandparents in the cellularsense.
(19:08):
But tapping back into the TMD,TMJ conversation, what we're
doing is we will get a highquality MRI and with some
special sequences calledinversion recovery.
You have to order those specialfrom the secret menu.
And we will look at the boneadjacent to the disc on either
side, and we are seeing theinflammatory damage in the
(19:30):
chondrocytes that are supposedto create and support the disc,
you know, which which is likemany joints.
So we don't yet we're designinga specialized needle to get in
the bone because most of ourbone needles for knees and spine
are bit too big, right?
So we need a smaller needle.
So we're designing that now, andsoon we'll we'll be able to for
(19:53):
the patients that don't respondto the prolozone and and more,
you know, we'll call it easiertreatments, we we think we are
going to have something fortheir, you know, stimulating the
chondrocytes in there in thebone on either side of the disc.
So let's keep in touch on that.
SPEAKER_01 (20:08):
Yeah, that's that's really exciting.
Now let's say, is there anyalternative for stem cells to be
instead of being injected, arethere any other ways we can
signal increase stem cells inour body?
SPEAKER_00 (20:20):
Yeah.
So you don't you don't need tosee me, it's free to stimulate
your own stem cell activity.
Here are some ways you can doit.
You can fast, you can do hotsauna, real hot sauna, like you
know, 180 degrees for 20 minutesor more, five days a week, like
the fins do.
You can do cold plunge, you cando high intensity exercise, all
(20:41):
these things get rid of yoursenescent cells, your age cells,
and improve your own release ofstem cells.
You can do that because you wantto get rid of a lot of the older
boggy cells, the zombie cells.
So you can, you know, uh fastingis probably the easiest way to
do that.
A good three-day fast willreboot your immune system, your
bone marrow will be stimulated.
(21:02):
You can donate blood.
That's a good one.
Uh women tend to lose bloodmonthly and during their cycles.
So they they have that survivaladvantage.
Of course, you want women tohave survival advantage during
baby-making years, they're goingto have babies, of course.
So that's built in biologicallyand naturally.
And then you can, you know,there's certain supplements that
(21:24):
stimulate, you know, things.
You can also get exosomes innature.
You can get exosomes from bonebroth because it comes from the
bone marrow, the bone stock, youcan eat bone marrow.
And you some of those exosomeswill benefit you.
Uh, chicken soup.
Why does grandma make youchicken soup when you're sick?
Because it comes from thechicken stock, which is chicken
bone marrow, which has stemcells and exosomes, and some of
(21:45):
those survive and get into youand help you.
Colostrum and milk, whole milk,have exosomes, mammalian
exosomes.
And plants, would you believe,make exosomes and have stem
cells?
And those plant exosomes are howplants deliver their
phytonutrients.
So all the little chemical,biochemicals from plants you
hear about that are a big partof the supplement side of
(22:08):
things, because we don't reallyget enough in our diet, those
are in exosomes, and there's nowa product on the market that is
plant exosomes, which willdeliver those to you.
SPEAKER_01 (22:17):
And if but if it's coming from a plant, how does
that help us as humans?
SPEAKER_00 (22:25):
No, no, we don't get the same signaling.
It's a delivery ofphytonutrients, and because it's
nature puts it in an exosome, itdelivers to your cell.
Got it.
Whereas if you went to thevitamin shop and got a bottle of
resvertraul, which is an exampleof a phytonutrient that you know
is known to stimulatecertuinantiaging gene activity,
(22:46):
that that is already extractedout of the exosome.
You lose some during thedigestion process, and once it
gets into your bloodstream, thatdoesn't mean it's getting into
your cells to do the work.
Whereas nature's already figuredthat out.
The difficulty was finding a labto extract the exosomes from the
plants, but we have that now.
SPEAKER_01 (23:02):
Yeah, that's exciting.
And that's that's a bigcontroversy, right?
In the supplements, you know.
Well, some doctors don't believein any of the supplements, is
ah, it's just expensive urine,which in many cases it can be,
right?
Because we've got all thissynthetic stuff.
We've got, you know, and thenlike you said, the ability, how
much actually, you know, this isa big controversy with
probiotics.
Like how much actually make itpast the stomach acid for it to
(23:25):
even be worthwhile, right?
So there's, you know, all thesedifferent mechanisms.
We've talked about, you know,now there's liposomal delivery
of stuff to try to absorbthrough the fatty layer of
cells.
And, you know, my one of myfavorite companies, cell core,
they have this carbontechnology, you know, that
allows things to so that'sinteresting that you say so.
It's it's in the packaging.
And like that's what we tell alot of patients, you know, yes,
(23:46):
ideally we should get all ournutrients from food because it's
in the right ratios, it's it'srecognized by our body.
Unfortunately, so much foodtoday is lacking, you know, in
things.
SPEAKER_00 (23:56):
You're completely correct.
I agree a hundred percent.
But you mentioned liposome,which is an improved way to
deliver nutrients through yourGI tract and into your cells.
Well, nature's already figuredthat out.
An exosome is, you know,nature's liposome.
A liposome is a syntheticexosome.
They're trying to recreatenature.
It's easier just to get it fromnature.
Now, it's hard to eat enoughdiverse fruits and vegetables in
(24:20):
a day to get this.
That's why now it's figured out.
SPEAKER_01 (24:23):
So if somebody is kind of interested in this, you
know, one, are there anycontraindications to exosome
therapy?
SPEAKER_00 (24:32):
Yeah, so we don't give standard regenerative
exosome therapy to anyone withcancer, not because it'll
stimulate the cancer, it'sbecause we just don't know if
it's safe enough or not.
And and that causes me to remindeveryone listening that the FDA
has not yet approved formarketing claims, which is what
the FDA does.
They approve marketing claims.
(24:52):
They have an unapproved ordisapproved, they just haven't
approved yet.
So it's sort of in limbo.
Uh PRF, PRP, stem cells, andexosomes.
All those things fall under thesame category.
Are we using them?
Absolutely.
Does your dentist maybe use PRF?
Yes.
Does your orthopedic use PRP?
Yes.
Can you get an amnio patch onyour cornea if if you have dry
(25:13):
eyes?
Yes.
All these things are available,but we have to give proper
informed consent.
Um, and we're not allowed tomake any claims that they cure
or treat.
So having said that, because wewant to maintain compliance,
it's still one of the jobs of aclinician like a dentist or
doctor to protect patients bymaking the latest and some of
the best things available tothem, right?
(25:33):
So that's part of our oath.
You guys have an oath?
Do you do a Hippocratic oath orsomething?
Okay.
So we're we're under the sameoath, and that transcends
everything.
Our duty to the patient uh is isutmost, always.
So those are the types of thingsthat we have to consider when
doing the informed consent.
And I lost track of of the exactquestion that you started.
SPEAKER_01 (25:55):
I was just asking about contraindication.
So you said cancer cancerpatients.
Don't know anyone.
SPEAKER_00 (26:00):
Yeah, we have that.
Obviously, anyone with a who'son a blood thinner, we can't
really, it's hard to inject aperson.
So we might have to take a dayoff the blood thinner, a couple
days off depends.
If it's really mild, uh, youknow, that someone who's on core
uh steroids, the regenerativesjust don't work well in the face
of immunosuppressants likesteroids.
(26:20):
So we try to flip people offsteroids.
We we have an interesting sidenote, if you allow, I treated a
woman for knee issues, and wedid some injections, and she
just wasn't making progress afew months later, which you know
I get concerned because mostlythey do, and the literature
suggests that.
By the way, in Europe they havelike 15-year follow-up.
We're just behind the times herein these states.
(26:41):
So this woman wasn't makingprogress.
So I I had a longer visit withher, and she tells me we went
over her medicines, which we haddone before, and I had asked her
to curtail this, but she hadn't.
Her her regular doctor put heron a steroid inhaler like two
years ago because she hadbronchitis and never stopped.
So she's on thisimmunosuppressant inhaler just
because it was like she was justdoing what her doctor told her.
(27:03):
So we stopped it, and thenwithin a few months her her knee
turned the corner.
Now, I I don't know if stoppingit was the difference maker.
You know, maybe it just finallygot better, but I'm worried and
we really try to make surethat's that sure is Yeah.
SPEAKER_01 (27:16):
So tell me, uh I guess I probably should have
started with the question like,what are the procedures or or
ailments or conditions that stemcells have have the longest
positive impact?
So you talk about knee.
So is it arthritis cases?
SPEAKER_00 (27:30):
Yep.
Well, I mean, we we misuse thatword, arthritis.
It really means generallyosteoarthritis, which is a
wearing and tearing of the boneand cartilage.
But but you go to see theorthopedic surgeon, they do an
x-ray and they say yourcartilage is wearing down,
you're almost bone on bone, youneed a joint replacement.
Well, it turns out that's reallya disease of the bone edge,
those chondrocytes on the boneedge.
(27:51):
So we treat the root cause, wedon't treat the cartilage.
That's like putting stem cellson your hair, hoping to grow
more hair.
That won't work.
You got to put them in the scalpwhere the cells are.
So that's the longest and someof the best results come in this
musculoskeletal joint,degenerative osteoarthritis,
bone on bone, cartilage wear andtear type situation.
And that's all the all thosewords fit together.
(28:13):
Whether your doctor just callsit arthritis to be quick and
simple with you, um, or youknow, you've heard the word
chondromalacia, which is reallythe wearing down of the
cartilage.
It's the result, not the cause.
Yes, tearing your cartilage doescause some accelerated
degeneration.
Yes, having a knee scope or ajoint scope to trim some
cartilage helps you in themoment, but does accelerate the
(28:36):
degenerative process.
That's where we come in.
That's probably across the boardthe low-hanging fruit.
SPEAKER_01 (28:41):
Yeah.
So I mean, I I think practicallyevery week, you know, I'm
signing off on uh the uh oralhealth person before they go in
for a total joint replacement.
Would you say, or can you giveus some examples of um patients?
Have you been able to, in yourexperience, prevent total joint
replacements?
SPEAKER_00 (28:58):
Yes.
So the lit I'm gonna quote theliterature first.
The French literature on thistopic, and when they looked at
knees and they have over 15-yearfollow-up shows, at 15 years,
they were able to save 82% ofpeople who needed a knee
replacement by doing injectionin the bone.
Uh, if they just injected in thecartilage, they only saved just
under 25%.
unknown (29:19):
Wow.
SPEAKER_00 (29:20):
So we are oh so that's why we do the bone.
Uh plus, we're targeting alittle more efficiently with
these MRI with the the inversionrecovery sequence.
It really shows you the bonychanges.
And we're getting similarresults.
Now, I've only been doing thisseven years, so I don't have
15-year follow-up, but our ourdata tracks we have about 700
joints, and only two people havegone on to do surgery.
SPEAKER_01 (29:42):
Wow.
SPEAKER_00 (29:42):
Of the 700 so far.
And we're tracking, maybe a fewmore will.
And of course, if someone's notdoing well, I want to relook at
them.
Maybe I didn't put enough.
Maybe we need to do some more,you know.
Let's not give up.
SPEAKER_01 (29:54):
I'd say that's really impressive because I
mean, there's so many lifestylefactors, right, that go into.
You know, the breakdown.
So the fact that you can use,you know, this one product and
have such d drastic results isamazing because most people
know, yes, I should lose weight,I should eat better, I should
stop all this stuff.
But, you know, let's be real.
A lot of us are like, pleasejust give me the quick clicks,
(30:15):
you know.
So maybe and if you ever watchany of those doctor shows, you
know, I swear every show has hadat least one episode where the
person is getting poisoned bytheir, you know, their titanium
hip or whatever the old stuff.
So so it's a real thing.
If we can prevent putting, youknow, heavy metals in the
person's body, like this isamazing.
And it's obviously a lot lessrecovery.
(30:38):
Like, what talk to me about theprocedure.
What it how long does it last?
SPEAKER_00 (30:42):
Yeah, let's let's do that.
But first, you you made merealize that we do work on the
whole person.
We get better results if if thepatients are improving their
lifestyle, their diet, theirsupplements, their sleep, their
mental state, their um, youknow, their supplements, uh uh,
you know, exercise, everything.
(31:02):
Everything has to be looked at.
It helps you heal.
And we look at hormoneoptimization.
We look at peptide use, allkinds of things.
So, but typically it's aone-and-done, a single
injection.
We do it under a littlesedation.
The results take six to twelvemonths to be fully manifest,
although some people haveimprovement in pain initially
because there's ananti-inflammatory benefit, like
(31:24):
a like a steroid injection, butwithout the downside, because
repeat steroid injections, ofcourse, can you know cause
long-term problems.
So that's typically what we see.
Knees are probably the littlehanging fruit.
We do all kinds of joints.
I do ankles and wrists andthumbs and toes and things like
that.
Anybody looking to avoid asurgery, we're probably the per
the group you want to talk to.
(31:45):
I'm probably the guy you want tohave a have a video consultation
with.
And and most of our patients arefrom somewhere else.
We're based in Las Vegas,Nevada, but through the magic of
what we're doing here, we'redoing a video.
In the post-COVID world, so manyof our visits are by video.
We can order MRIs remotely, wecan look at them, I can share my
screen and show them to people.
So we only invite people here ifthey're a good candidate for a
(32:08):
treatment.
Uh, and that's kind of how itworks.
And we follow them out for atleast a year.
SPEAKER_01 (32:13):
So that's like so relative, and what's the
downtime?
Let's say you inject the knee.
SPEAKER_00 (32:18):
Are they downtime?
No downtime.
You know, you'll be sore fromthe injection because it's in
your bone, you know, like likeyou might be from a dental
procedure be sore, but you know,most people we want up and using
the joint, stimulating thejoint, you know, getting the
mechanoreceptors going and whichwhich cause those cells to
release, you know, cytokines,little proteins that call for
(32:40):
the healing.
Um, we want people right back attheir activities.
Uh, you don't necessarily haveto do physical therapy as long
as you, you know, you use thejoint properly and and well.
And I mean, we've had people, Idid I did a guy's shoulder and
he played golf the next day.
Now, I I don't know that I wouldhave recommended that, but he's
he had a great tea time.
He didn't want to miss it.
(33:01):
And he told me later, he's like,I was sore.
I probably shouldn't have thatday, but I had to.
SPEAKER_01 (33:05):
That's great.
So joints, that's kind of thenumber one thing that they've
been used for.
What are the other umindications?
SPEAKER_00 (33:12):
So we use the same regenerative biologics, you
know, these amniotic fluidproducts for inflammatory
issues.
So people with autoimmuneissues, maybe long infections
with that have a biginflammatory component, like a
long COVID or a Limes orpost-Lyme syndrome, any disease
that has an inflammatorycomponent, we seek to help the
(33:34):
cells fight the inflammationinflammatory issues.
So a lot of the diseases ofaging are diseases of
inflammation.
Well, that makes sense sinceinflammation and aging go hand
in hand.
So, you know, we we've looked atpeople with MS and Alzheimer's
and, of course, diffuseosteoarthritis.
If you have it in every joint,we're not going to inject every
joint, right?
So sometimes we start with anIV.
We have addressed organ failure.
(33:56):
We've had people that wereborderline needing dialysis and
helped their kidney function,prevented dialysis.
It helps.
We've seen the improvement ininsulin sensitivity.
So if you're looking at maybe adiabetes where you're you're
facing a potential use ofinsulin, we might be able to
help there.
Again, I'm not allowed to makeclaims, but it's worth trying.
SPEAKER_01 (34:17):
Yep.
SPEAKER_00 (34:18):
We and some people like myself, we do the IVs just
to get a little boost, uh,suppress inflammatory damage,
kind of a longevity thing welike to do.
Biohacking.
So I do it four times a year.
My wife does it.
My mother comes in, flies infor, and father do it uh twice a
year.
So um it it can help give youenergy, improve your mental
(34:40):
speed and sharpness, uh, helpyou fight infection.
We also do breathing treatmentswith the biologics, where we've
had someone who is oxygendependent.
We gave them a breathingtreatment, and now they're no
longer requiring the oxygentank.
I mean, we all require oxygen,but she doesn't have to roll
around the little tank.
Right.
So uh what else?
(35:01):
We we have a nasal sprayapplication for brain health
because the exosomes are smallenough to cross the blood-brain
barrier, whereas stem cells donot cross.
So, and let's think about this.
You you know, you've hadchildren, you know, other people
who are pregnant.
Pregnant women will tell youtheir skin is glowing, their
hair is growing.
And why is that?
(35:22):
They're getting a daily dose ofexosomes through the placental
membrane.
They're not getting stem cells.
You can't have stem cells crossthe placenta.
SPEAKER_01 (35:30):
Plus, those stems often say that women's, you
know, their autoimmune conditionwill go away during pregnancy.
Yes.
SPEAKER_00 (35:36):
This is a test dose of exosomes from their own baby.
And they can't get stem cellsfrom the baby because the baby
is genetically half foreign tothem.
They don't want to reject thebaby.
So the exosomes are so naive andneutral, there's there's there's
no cell, there's no reallyappreciable DNA or anything.
Exosomes contain peptides andgrowth factors and and uh
(35:59):
microRNAs, baby making magic.
So that's why we love these.
And parenthetically, we getthese from labs that are
ironically FDA certified andcompliant.
And the labs get them fromAmerican Tissue Bank Donor
Services.
So you've probably used somebone graft material in the past
for some procedures that you getfrom the donor bank.
(36:21):
And the particular lab we usegets the amniotic fluid from
non-COVID vaccinated mothers.
Why?
Because we don't want to, wedon't know what that variable
means fully, let's be honest.
These are from healthy mothers,they don't drink, smoke, or use
drugs, they're allowed oneromantic partner during the
pregnancy only, so they're notout goofing around too much.
And they have to be healthy,they have to be taking prenatal
(36:43):
vitamins, and they're screenedagain at the time of their
C-section, has to be a C-sectionbecause it's sterile.
You know, like you mentionedearlier, the mouth is not
sterile.
But luckily, it's got good bloodflow generally.
Same thing, a vaginal deliveryis not a sterile delivery.
So we don't it has to be aC-section, and they have exactly
60 seconds to suction theamniotic fluid before they
(37:05):
deliver the baby.
So this is very highlycontrolled.
It goes right to ice, right tothe lab where it's tested and
screened again, and we get themfresh frozen.
So nothing's powdered or cooked.
It's all fresh frozen amnioticfluid.
That's really what we're using.
Rich in exosomes from stemcells, rich in growth factors,
proteins, peptides.
SPEAKER_01 (37:24):
I heard you mention earlier though something that
you can put on the eye for dryeye.
Something I'm suffering from isdriving me bananas.
I'm like, tell me what this.
SPEAKER_00 (37:32):
Well, it's something that the eye doctors use.
It's an amniopatch, it's fromthe amniotic membrane.
So there are a couple differentthings you can do.
Dry dry eyes is complex, right?
We see this in women withchanging hormones.
So you gotta you gotta maintainthe hormone, bioidentical
hormone management, uh you andyou know, hydration, and you
want to re-stimulate thesemybomium glands.
Some of the times they're justgunked up, they're little
(37:55):
duct-like glands, and they needto be expressed or squeezed out.
And uh sometimes you do that afew times.
They can do what's called IPL,which is a laser, and and kind
of warm and melt the the goothat we create, we just we just
block those ducts, and you justneed to express them a few
times.
Sometimes that's all you need.
We've have injected exosomesinto the eyelid, not the eye,
(38:15):
the eyelid, because that's wherethose glands live.
And and we've seen someimprovement.
We haven't had it last more thansix months, though, and it's
kind of an annoying thing to doevery six months.
Yeah.
So, but the eye doctors have anamniopatch they put on the
cornea, and it it's supposed tohelp.
Doesn't it it might it's anoption, it's an easy thing to
do.
They just lay it on there.
SPEAKER_01 (38:35):
Interesting.
Yeah, definitely in thathormonal swing right now.
So trying to dial those all in.
SPEAKER_00 (38:40):
Fight, fight, fight.
You got you gotta make sure youmanage that because you will age
a lot slower if you do.
You will maintain your bonedensity, you will maintain your
muscle mass, you will slow therisk of dementia and
cardiovascular disease if youcan maintain your youthful
profile.
And we know this women who havelate menses, late pregnancies
live longer.
SPEAKER_01 (39:00):
Interesting.
Yeah, yeah, makes sense.
You have all those goodhormones, you know, flooding the
that's I I tell a lot of mywomen, you know, it's hard to
find the doctors really whounderstand how to do it
properly, right?
That's that's can some of thethings that you're gonna do.
SPEAKER_00 (39:13):
Yes, and it has to be bioidentical.
You can't take these syntheticor horse urine-based things that
they are the problem.
And a lot of the myths relatedto using these hormones have
been debunked.
So if you're out there and yourdoctor is scared to use them,
you you need to find someone todo it for you, ladies.
SPEAKER_01 (39:29):
Absolutely.
And there are people out there,but so they're out there.
Contact me, I'll put you intouch with the right people.
SPEAKER_00 (39:35):
And not just ladies.
Let's be fair, guys.
We're seeing lower testosteroneearlier and earlier in 30s and
40-year-olds, and you will loseyour muscle mass and you will
wither away, and you will nothave a longevity.
You have to have a longevityplan.
You have to script it out andfollow it early.
That's the that's preventativemedicine 3.0.
(39:56):
You have to do that.
SPEAKER_01 (39:57):
It's just crazy to think how many uh, you know, the
fertility clinics areoverflowing these days.
I mean, it's it's nuts.
I have two sisters, they've bothhad fertility, you know,
treatments and young, healthypeople, you know, it's just
crazy the world we live intoday.
So it is.
SPEAKER_00 (40:12):
It is.
Yeah.
But there are answers, and a lotof those answers are natural,
holistic.
Um, and you know, I haven'tfound any issues with them, but
I'm not allowed to make theclaim they're safe because the
FDA tells me that I can't makethat until they tell me I can
make that.
So in Europe, they're approved.
They're safe in Europe, but whenyou fly from Europe to the US,
we can't say that.
SPEAKER_01 (40:32):
Yes, like a lot of great, you know, biologic things
that that we're doing too.
So I think it's really exciting.
And what I'm, you know, thinkingabout the patient I had
yesterday who said, Well, okay,but if you get rid of all these
heavy metals and you get rid ofall the infections in my mouth,
can you regrow my bone?
And I'm like, I just I haven'tseen it yet.
You know, I'm not to say thatyou're gonna do it, but uh with
with exosomes, you know, thatseems like a promising way to go
(40:54):
about it.
SPEAKER_00 (40:55):
Yeah, and and exosomes may only be part of it,
right?
You you need uh some some goodbone matrix.
You know, uh I don't know if youuse bone morphogenic protein to
help grow bone.
I mean, that can be quite a uh auseful thing.
Yeah, it costs a couple thousanddollars a dose, but if you want
to grow bone quickly and be ableto do whatever restoration
(41:15):
you're doing, that's a a shorterpath for sure.
I've seen it.
SPEAKER_01 (41:20):
Yeah.
So exciting.
Yes.
And and the more common itbecomes, you know, the the price
will come down, hopefully.
So we can, you know, but that'swhat I'm excited to see, you
know, is is is regenerate.
Like I said, I don't ever wantto have to pick up my drill ever
again.
You know, I want to do all thisregenerative and preventative,
you know, type of work, reallyhaving people understand what is
the root of decay, what youknow, how and even talking about
(41:42):
that, you know, to me, the morethat I see it, there's so much
where the the immune system, youknow, is getting bogged down.
We talk about, oh, you didn'tbrush it in and flus.
You know, you get admonished byyour your hygienist for not
doing good uh oral care, andthat's just that's not it, you
know.
That's such a small fragment ofwhat's going on at the deeper
level.
SPEAKER_00 (42:00):
So oh yeah.
And we're learning more all thetime.
We're learning about theseindividual peptides and things
that that have benefits anddifferent types of exosomes.
I mean, this is just thebeginning.
You're right.
SPEAKER_01 (42:11):
It's really exciting.
So we're about coming up on ourtime.
Is there any anything elseexciting around the whole
science of of exosomes orsomething that you think is
gonna be the next next greatthing?
SPEAKER_00 (42:23):
Yeah, we're looking at, like I told you, the
tissue-specific lineageexosomes, being more specific
about different things we applythem for.
Uh, we're looking at a betteruse of the muse cells and their
exosomes.
We're looking at differentpeptides and and proteins and
growth factors strategically.
Some are anti-aging, like theclotho and the FOXO4, things
(42:44):
like this.
So these are things that will beavailable.
Some of them are, notnecessarily here, but we're, you
know, trying to foster pathwaysto protect our patients' access
to want to try these things.
We're looking at, you know, wehave some things we're working
on on the cancer side of thingsusing natural killer cell
exosomes, which we didn't reallydelve into, but we do have that.
(43:07):
And you know, we're looking atdesigner exosomes.
They have these in China, wedon't have them here yet.
But for example, exosomes thatwill deliver more mitochondria
to donate to your cells so theycan be more efficient
metabolically and make moremuscle, all kinds of fun things
coming.
SPEAKER_01 (43:21):
Yeah, but it's it's very exciting and uh it's
definitely you know kind of onthat cutting edge, but it is
available now.
So if somebody was really wantedis interested, wants to learn
more about you, your company,where you're located, how do
they reach out to you?
SPEAKER_00 (43:33):
Well, our company is called Recelebrate, R-E-C-E-L-L
E-B-R-A-T-E, because we'recelebrating the renewal of your
cells.
So that's our fun name.
And if you put that in your uhweb browser and search it, we
will probably come up because wemade up the word, and I think we
cornered the internet on theword.
So re-celebrate.com, ourInstagram is at re-celebrate.
(43:56):
You can find us on all the majorsocial networks and Facebook and
what have you.
So just check us out, reach out.
We'd love to meet new people, behappy to have a conversation,
talk about any we love we'd loveto look into new issues too.
We do the homework, we look atthe research, we see what's out
there.
We're not just shooting from thehip.
SPEAKER_01 (44:13):
Yeah.
Yeah, it's exciting.
And you know, people who arelistening to this podcast are,
you know, want the more naturalalternative.
They want to try to avoid those,you know, the hip replacements,
the tooth replacements, allthose kind of things.
So I really appreciate your timetoday.
Everybody, you've got that, uh,we'll also copy down the site
for you in the show notes.
So if you didn't catch it, ifyou're just listening, it'll be
(44:33):
there for you.
So thank you so much.
Dr.
Jeff.
We appreciate your time.
I hope everybody enjoyedlearning something new, perhaps.
And please reach out to Dr.
Gross if you want to learn moreabout stem cells and exosomes.
And otherwise we'll just catchyou on the next episode,
everyone.
Have a great day.
Hello, everybody.
Welcome back to another episodeof The Root of the Matter.
I am your host, Dr.
Rachel Carver, and today this isa very exciting, really
interesting new topic that I'mI'm really excited to dig into.
We are fortunate to have Dr.
Jeff Gross with us today, who isthe founder of Re-Celebrate and
pioneer in regenerative stemcell and exosome medicine.
(00:22):
So I'm sure everyone's kind ofheard of the idea of stem cells,
maybe exosomes, not so much.
So we'll kind of talk about thedifference there.
And, you know, what is this goodfor?
Who can use it?
How do we use it?
How does it relate to oralhealth?
So, Dr.
Gross, thank you for uh joiningus.
Maybe just talk to us a littlebit about your background, how
you got into this, and uh whyyou founded the company.
SPEAKER_00 (00:44):
Great.
Yeah, thank you for having me.
Uh it's great to be here.
Please just call me Jeff.
So I I'm a recoveringneurosurgeon.
I'm a spine surgeon by training.
I had a fellowship in that.
And for decades I treatedpatients with neck and back
problems, nerve problems, discissues, things like that.
And I had always been sort ofbutting my head up against the
(01:04):
sick care system, theinsurance-driven cookbook,
Kool-Aid drinking nonsense, andhad always tried to find new and
better ways for patients.
As a surgeon, I was, you know,you learn to do surgery in your
residency.
And then the first thing youlearn when you get out of your
residency is how not to do it.
So always tried making that thelast thing, right?
(01:26):
So I had so many patients Itreated over the years that they
were in between the non-surgicaltreatments and the surgical
treatments.
So they they tried therapies,they tried maybe some
medications, someanti-inflammatories, they tried
some injections, and they cometo me and say, Yeah, those
things helped a little ortemporarily, but um I'm still
(01:46):
having these issues.
I say, Well, gosh, the nextthing on the menu is to talk
about surgery.
And they go, Oh, wait a minute,I'm not ready for that.
I'd say, great, because I reallydidn't want to have to offer it
to you.
But in the modern era with MRIsand things, we catch these
things earlier.
So we catch people in this limbobetween non-surgical and
surgical, and uh they're stuckthere.
So they ask, what about this?
(02:06):
What about that?
What about stem cells?
So you hear that enough, you'refrustrated enough, and chance
favors the prepared mind.
So luckily I have someundergraduate background in
molecular biology, biochemistry.
And I said, you know what?
I know that these athletes havebeen going to Europe to get stem
cells, you know, Tiger Woods,Peyton Manning, these other
(02:26):
guys, you know, for years youhear about this.
Something's going on.
Something must be happeningthere.
A lot must have happened since Iwent to college.
So I decided one year, insteadof going to these stuffy
neurosurgery conferences, Idon't know if you go to the
dental ones, but it's it's thesame academic bowtie wearing
knuckleheads, patting themselveson the back for doing the same
old thing year after year,publishing the same thing that
(02:49):
they published 50 years ago.
Nothing's changing.
It's stagnation.
We don't do anything differentlysurgically than we were doing in
the 1940s and 50s.
Yeah, there's a new widget orgadget, but it's the same thing.
So I said, screw that, I'm goingto learn something new and
better.
So I started going to stem cellconferences and re-educated
myself and took courses and readand read and read and did the
(03:12):
homework and did the research.
Luckily, the internet affords usaccess to a lot of the journal
articles now, you know.
So you don't have to go sit inthe library and pull a bound
journal.
Uh, it became clear to me that Iwanted to offer this as a tool
for my spine patients, but ithas blossomed into so much more.
And uh it's all I do now.
(03:33):
And if I never do another spinesurgery, you know, I enjoy it,
I'm good at it, but uh it'sprobably a service to most
people.
So that's kind of where we are.
SPEAKER_01 (03:41):
Well it's funny because I say that too.
I'm looking forward to the daywhere I never pick up a drill
ever again because I will haveprevented all disease.
And so that's why the whole ideaof stem cells, right, it's very
exciting.
So maybe for those of us whoaren't really familiar, what is
a stem cell?
Why is it important?
Why as we get older we havefewer and fewer?
(04:01):
So why is it a good repairmechanism?
SPEAKER_00 (04:03):
So let's talk about that.
Stem cells created us.
When you're when you're afertilized egg in your mother's
womb, you are a single stemcell.
You are the master stem cellfrom which all other cells will
stem, hence its name.
And from there you develop intoa uh you know, a fe uh an embryo
and a fetus, and you have thesedifferent types of stem cells.
So stem cells just not onething, but we have different
(04:26):
types of stem cells, andeventually become almost ready
to be born.
You're this full-grown fetalbaby, and you still have lots of
stem cells, and they're floatingaround the amniotic fluid, and
they're doing all kinds of magicto create you.
Then you're born, and you'reyou're born and you maintain
many stem cells throughout yourbody, mostly in your bone marrow
and your fat and other places,but uh, you know, those are the
(04:49):
main stores.
And during your growth, you'reusing those stem cells to grow
and make new cells and developand become an adult.
And even as an adult to renewand repair and restore and heal,
you're tapping into stem cellsto do that.
Well, aging is this accumulationof cellular, chronic,
inflammatory changes, and allour cells get affected by what's
(05:10):
in our diet, what's in ourwater, what's not in our diet,
what's, you know, theelectromagnetic forces around
us, maybe mental stress, allkinds of bad stuff that we can't
always control.
So our cells get, you know, theyget rusty internally, they get
oxidized, they don't function aswell.
And that's aging.
It's called inflammation, if youwant to be cute about it.
(05:32):
And our stem cells are alsoaffected by those same things.
They become less functional.
You mentioned earlier, theybecome fewer of them.
That's true.
You do exhaust the numbers, butyou also exhaust the function.
And that's why you can't healand repair like a
three-year-old.
You're you're made of the samegenes you were when you were
three.
And if you fell down and scrapedyour knee when you were three,
(05:53):
and your mother would clean itup, you know, put some back teen
on it, maybe a band-aid, kissit, and send you on your way.
Three days later in the bathtub,that band-aid comes off and your
scab's almost almost healed,done.
And if, you know, if and now ifyou bang your arm on something,
you got to bruise for like aweek and a half, two weeks.
Well, wait a minute, how comeyou can't heal as fast?
Because your stem cellrestorative functions just
(06:14):
aren't there.
So that's where we tap into thestrategy of stem cell medicine
or what we call regenerativemedicine to help regenerate you,
to leverage that youthfulhealing ability in someone who
needs it.
That's that's the magic.
SPEAKER_01 (06:29):
Yeah.
And that's again what's excitingfor those of us who are hoping
to, you know, not just livelonger, but live better.
You know, that's what we need todo, right?
How do we maintain a robustimmune system?
How do we heal?
You know, I used to always weara badge of honor, like, I never
get sick.
And then I kind of learned,well, hmm, that's not
necessarily the goal.
The goal is if you and when youget sick, you heal quickly,
(06:51):
right?
I remember my kids when theywere little, you know, they had
great diet, great exercise, allthe things, and they'd get sick
24 hours.
Now, as teenagers, and they'reeating all the junk and they're
staying up late and they got thecell phones, right?
They can be down for a week,right?
Um and so that's the thing.
Like, how do we how do we buildresilience?
And there are some things thatare, you know, it's challenging,
(07:13):
and and maybe we have to have anine to five, 40 hour job, and
we can't go in the sunshine, wecan't do all the we can't
meditate for two hours, youknow, every day.
So this is where, you know, thatthe the science and the and the
spirituality can kind ofcombine, right?
Where we can, you know, we needsometimes help, you know.
I've I've even evolved too.
It's like, hey, you know, I wasso resistant to antibiotics for
(07:35):
a while after learning all thisbiological, but at the same
time, it's like, well, sometimeswe actually need them, you know.
So I should uh, you know, eitheror but an and.
So um, and I know when I startedlearning extractions and started
learning about platelet-richfibrin, we were told, you know,
oh, this is great, you know,that's you want the stem cells
from the platelets, right?
(07:56):
And and it's gonna helpeverything grow faster.
And I have to say, the healingof the soft tissue is oh my god,
like 10 to 100 times faster.
It's just amazing how in a fewweeks it looks like what it
maybe would look like typicallyif I didn't use PRF, you know,
in 12 weeks.
So it's it's really incredible.
But then I start feeling, well,you know, after 40, maybe our
(08:17):
stem cells aren't so great, youknow.
So is it really the stem cells?
I mean, again, it's your ownbody, so it's good healing, but
am I getting what I originallythought, right?
Am I really putting stem cellsin there?
Or are there better ways?
So I'd love to tell you, haveyou tell us a little bit how to
use stem cells, whether it's inan extraction site or, you know,
(08:38):
in a degenerative um spine boneissue.
SPEAKER_00 (08:42):
Well, this this is uh this is evolved.
So I'm gonna speak at the the2025 best and latest knowledge.
Uh, a lot of doctors arepracticing stem cell medicine,
are still practicing in the inthe 1990s, where they are
harvesting stem cells from thebone in your hip and things like
that.
And that's fine.
There's nothing wrong with that.
Uh, but it's certainly not themost active and most efficient
(09:03):
way to do it these days.
We've learned something uh inthat to get the benefit of a
regenerative biologic, a stemcell or something like that,
that the benefits come from thecell signaling.
So a stem cell messages ourcells.
And at the end of the day, ourcells do the work.
The bone in the jaw, if you wantto deposit more bone, has to be
(09:26):
reinvigorated, or like you said,the gum and and the soft things
around that area have to besignaled to heal like a younger
person, right?
So the cells give off two kindsof signaling.
Signaling number one is growthfactors, little proteins that
stimulate the laying down of newvessels and capillaries and the
(09:47):
healing.
And you find these robust in theamniotic fluid.
You find them in platelet-richplasma or platelet-rich fibrin,
which you use in the dentalindustry.
And these come from the ownbody.
But you're right, if they comefrom a 70-year-old body in the
blood, they're not as robust aswhen that 70-year-old was, you
(10:08):
know, five.
So we like to tap into theyouthful sources.
Then the other signaling fromstem cells in the regenerative
capacity is called extracellularvesicles, or for short,
exosomes.
And for those of you watchingthis broadcast and not just
listening to it, at the bottomof my of my screen, it says Dr.
Jeff exosomes.
(10:28):
And that's the short word forthese vesicles.
All cells make exosomes.
All cells signal theirneighbors.
They're always talking, they'realways communicating.
Think about the movie Avatar,where all the trees and nature
were communicating with eachother through the rootlets and
things.
So, so cells are constantlytelling their neighbors what's
going on and trying to influencethem.
(10:48):
Well, what we want here in aregenerative approach is that
regenerative, useful,restorative signal.
So we can tap into that throughthe exosomes and the growth
factors.
These are, again, robust whenyou in the bloodstream, in the
bone marrow, in amniotic fluid,in umbilical cord jelly called
Wharton's jelly.
(11:09):
All these things have it.
And you have some of these inplatelet-rich plasma,
platelet-rich fibrin.
They can come in many ways.
SPEAKER_01 (11:17):
Yeah, it's it's it's really fascinating.
This is why I love ozone.
It's another one of thosesignaling molecules.
That's why I tell patients, youknow, it's when I first learned
I was like, oh, this is thegreatest thing ever, it's gonna
cure everything.
But you have to remembersomething with natural, it's not
a steroid.
It's not stopping something,it's actually signaling your
cells to heal themselves.
And that's why there's no sideeffects, no contraindications.
(11:38):
Like this is a natural process.
And that's where we get realhealing.
What you say about the growthfactor, right?
The blood supply, this isanother reason I don't use any
epinephrine in any of mypatients.
Right.
So I think that is a really bigreason why my extractions, they
heal so well.
Not only the ozone and my laserand all the things, but by not
(11:58):
shutting down the blood flow for90 minutes or whatever it may
be, we're making sure, andsometimes, yeah, it's a little
messy.
I gotta have a lot of suction,but I'd so much rather it take
me a little bit longer so that Inever cut off that blood supply
to again, you know, ensure thatall those cells and all the
blood flow and it's gettingthere immediately.
SPEAKER_00 (12:17):
Yes, I agree, I agree with you.
So obviously, for those thatdon't know, epinephrine is also
known as adrenaline, and itcauses your small vessels to
constrict so you don't have asmuch blood flow.
So sometimes when you put in anumbing agent, right, you want
you the strategy is let's keepmore of that there by not
letting the bloodstream take itaway.
The problem is you need thosecapillaries open to do their
(12:38):
healing.
So so you have a little morebleeding uh during that
procedure, but that that you cancontrol, of course.
And um, it's almost, you know,this self-fulfilling prophecy,
you should not use theepinephrine, collect the blood,
and you can get your PRF fromthe blood.
You don't have to do a famousblood draw from the arm, right?
SPEAKER_01 (12:57):
Yes.
Exactly, I know.
Think about that.
I was thinking about the otherday because my slabotamus is out
for a month, and I was like, Iwas like, okay, I'm not, I don't
love doing this, but I have todo it.
But man, those hard cases, I'mlike, oh geez, yeah, let me just
take it from the extractionsite.
Possibly.
SPEAKER_00 (13:12):
Yeah, and of course, you're right.
The more vascular your tissues,and in this case your your gums
and local tissues, the betterpeople heal, the fewer diseases
they have, because the bloodflow brings the immune system,
clears things out, you know, andand and and does the job.
It's you know, people with poorblood supply have more
disease-type problems.
They have trouble healing aninfection, they have trouble
(13:32):
healing local bone, which is youknow relevant to the dental
industry, of course.
So I'm with you there.
It applies beyond the mouth,just for everyone listening.
This is this applies to the feetand the joints and the spine and
everything.
SPEAKER_01 (13:46):
So tell us about like, you know, you're got a
past of doing spine surgery.
So around, you know, with bones.
So somebody, you know, we I wework with a lot of people, you
know, they've got the cervicalspine.
Every time I take a 3D X-ray,you know, it's like I think nine
out of ten times the radiologistsays, mm, cervical changes,
spine, you know, we we hold somuch tension and pain and
everything in our neck.
(14:06):
And now with this forward neckposture and you know, modern
life.
So tell us a little bit howyou'd use stem cell cells in
like disc degeneration or orhowever you use it for that.
SPEAKER_00 (14:16):
So the spine has two dominant, not only, but two
dominant sources of pain.
One is problems with the discwhere the disc wears down, and
problems with the joints in theback of the spine called the
facet joints.
So first we need to confirm thesource of the pain or the
problem.
Sometimes it's one, sometimesit's the other, sometimes it's
both.
Facet joints tend to behave likeother joints in the body, knees,
(14:40):
shoulders, knuckles, what haveyou.
Typically, we can inject aroundthose joints with regenerative
biologics.
Now we're using the phrase stemcells here, but we've skipped
beyond the stem cells now.
Stem cells are really just adelivery vehicle.
Stem cells make the growthfactors and the exosomes.
We go right to those becausethey travel through tissue
better and they're lessexpensive.
(15:01):
So, and they are the businessend of the stem cells.
But we call it stem cellmedicine so people can
understand it, but we're notdelivering cells any any longer
often.
We still have some applications.
So we can inject around thosefacet joints, in the facet
joints, we're actually injectingthese days the bone because the
cartilage-forming cells, andthis may have some overlap in
(15:21):
your field, thecartilage-forming cells in the
joint that are you know, causingthe wearing of the cartilage,
the osteoarthritis of that areaare in the bone.
So people for years have beeninjecting the cartilage only to
find out the cartilage has veryfew cells, nothing to affect
it's sort of the result.
Just like hair is a protein madeby a follicle in your scalp,
(15:44):
cartilage is a protein made by achondrocyte cell in your bone.
So we inject the bone,obviously, a little sedation for
that because it's in the bone.
If we're dealing with the disc,it's a little more challenging.
And this is going to really beinteresting for the dental side
of things because disc is madeof two different types of
cartilage.
And the problems with disc inpart come from the bone above
(16:06):
and below.
So we can inject those just likewe do those facet joints and
other joints and get someimprovement in the regular
cartilage, but the deepernuclear cartilage, the part that
herniates out and gets worndown, is from a different part
of the embryo called theendoderm, which uh we don't have
a lot of body parts made of theendoderm.
Whereas in the dental side ofthings, teeth are interesting
(16:28):
from ectoderm and the brain andnervous system in the teeth and
a few glandular cells are fromthe ectoderm system.
So most of the rest of the body,structurally and organ-wise, is
from the middle layer of theembryo called the mesoderm, and
most stem cells stimulatemesoderm.
These stem cells are called MSCsor mesenchymal stromal cells,
(16:50):
and mesenchyme and mesoderm arekind of go together.
But as we become better atlearning how to use regenerative
medicine, we're finding in thedental side of things that we
need these ectoderm stimulatingexosomes and things like that.
So that is the key in thatarena.
We're looking at using differenttypes of stem cells called MUSE
cells, which are a subset ofstem cells to stimulate these
(17:12):
other embryonic origins likeectoderm and endoderm.
So I think you're gonna see thatin the dental side of things,
and we're just now using them todo a sandwich therapy for the
disc.
So MUSE cells to stimulate orMUSE cell exosomes to stimulate
the nucleus to, you know, bemore restorative and youthful,
and then the the regular uhmesodermal mesenchymal uh you
(17:35):
know amniotic exosomes andgrowth factors for the bone.
So the the disc is complex, iswhat I'm trying to say in all
this.
SPEAKER_01 (17:42):
But that's exciting because I mean exactly what
you're talking about.
You could you may be talkingabout the spine, but you're
equally talking about thetemporomandibular joint, right?
You know, we got people who alsohave TMD or TMJs, as we say,
right?
Um yes, you have two TMJs.
TMD, the professionals call ittemporomandibular dysfunction.
Um, and we, you know, we canlook at uh x-rays and uh, you
(18:03):
know, determine what's going on.
Is it a bone thing, disc thing,sometimes both?
But that, you know, again, justlike you said, first you gotta
figure out what's happening,right?
Because a lot of it ismusculature, right?
So you gotta calm down themuscles or the way the teeth are
hitting are causing the musclesto become dysfunctional and then
pulling the joint out ofalignment.
So um, you know, I use a lot ofuh the the prolosome therapy for
(18:25):
TMD patients, which isunbelievable.
I mean, it's it's it can lastover a year.
And we're not unlike Botox, I'mnot putting a toxin, you know,
right near your brain.
Um so that's that's exciting.
So I'm really excited to keeplearning more about and it's
exciting to know that thatdistinction, right, with the
ectodermal tissue that it has tobe a little bit different,
(18:47):
maybe.
SPEAKER_00 (18:47):
Yep.
Uh and and and we're we'reseeing that now because people
are using teeth or two or dentalstem cells, which are
ectodermal, neuroectoderma, toregrow teeth and in in the lab
and re and maybe regrow evensome part of the nervous system
since they they they have commonlineage, common parents or
grandparents in the cellularsense.
(19:08):
But tapping back into the TMD,TMJ conversation, what we're
doing is we will get a highquality MRI and with some
special sequences calledinversion recovery.
You have to order those specialfrom the secret menu.
And we will look at the boneadjacent to the disc on either
side, and we are seeing theinflammatory damage in the
(19:30):
chondrocytes that are supposedto create and support the disc,
you know, which which is likemany joints.
So we don't yet we're designinga specialized needle to get in
the bone because most of ourbone needles for knees and spine
are bit too big, right?
So we need a smaller needle.
So we're designing that now, andsoon we'll we'll be able to for
(19:53):
the patients that don't respondto the prolozone and and more,
you know, we'll call it easiertreatments, we we think we are
going to have something fortheir, you know, stimulating the
chondrocytes in there in thebone on either side of the disc.
So let's keep in touch on that.
SPEAKER_01 (20:08):
Yeah, that's that's really exciting.
Now let's say, is there anyalternative for stem cells to be
instead of being injected, arethere any other ways we can
signal increase stem cells inour body?
SPEAKER_00 (20:20):
Yeah.
So you don't you don't need tosee me, it's free to stimulate
your own stem cell activity.
Here are some ways you can doit.
You can fast, you can do hotsauna, real hot sauna, like you
know, 180 degrees for 20 minutesor more, five days a week, like
the fins do.
You can do cold plunge, you cando high intensity exercise, all
(20:41):
these things get rid of yoursenescent cells, your age cells,
and improve your own release ofstem cells.
You can do that because you wantto get rid of a lot of the older
boggy cells, the zombie cells.
So you can, you know, uh fastingis probably the easiest way to
do that.
A good three-day fast willreboot your immune system, your
bone marrow will be stimulated.
(21:02):
You can donate blood.
That's a good one.
Uh women tend to lose bloodmonthly and during their cycles.
So they they have that survivaladvantage.
Of course, you want women tohave survival advantage during
baby-making years, they're goingto have babies, of course.
So that's built in biologicallyand naturally.
And then you can, you know,there's certain supplements that
(21:24):
stimulate, you know, things.
You can also get exosomes innature.
You can get exosomes from bonebroth because it comes from the
bone marrow, the bone stock, youcan eat bone marrow.
And you some of those exosomeswill benefit you.
Uh, chicken soup.
Why does grandma make youchicken soup when you're sick?
Because it comes from thechicken stock, which is chicken
bone marrow, which has stemcells and exosomes, and some of
(21:45):
those survive and get into youand help you.
Colostrum and milk, whole milk,have exosomes, mammalian
exosomes.
And plants, would you believe,make exosomes and have stem
cells?
And those plant exosomes are howplants deliver their
phytonutrients.
So all the little chemical,biochemicals from plants you
hear about that are a big partof the supplement side of
(22:08):
things, because we don't reallyget enough in our diet, those
are in exosomes, and there's nowa product on the market that is
plant exosomes, which willdeliver those to you.
SPEAKER_01 (22:17):
And if but if it's coming from a plant, how does
that help us as humans?
SPEAKER_00 (22:25):
No, no, we don't get the same signaling.
It's a delivery ofphytonutrients, and because it's
nature puts it in an exosome, itdelivers to your cell.
Got it.
Whereas if you went to thevitamin shop and got a bottle of
resvertraul, which is an exampleof a phytonutrient that you know
is known to stimulatecertuinantiaging gene activity,
(22:46):
that that is already extractedout of the exosome.
You lose some during thedigestion process, and once it
gets into your bloodstream, thatdoesn't mean it's getting into
your cells to do the work.
Whereas nature's already figuredthat out.
The difficulty was finding a labto extract the exosomes from the
plants, but we have that now.
SPEAKER_01 (23:02):
Yeah, that's exciting.
And that's that's a bigcontroversy, right?
In the supplements, you know.
Well, some doctors don't believein any of the supplements, is
ah, it's just expensive urine,which in many cases it can be,
right?
Because we've got all thissynthetic stuff.
We've got, you know, and thenlike you said, the ability, how
much actually, you know, this isa big controversy with
probiotics.
Like how much actually make itpast the stomach acid for it to
(23:25):
even be worthwhile, right?
So there's, you know, all thesedifferent mechanisms.
We've talked about, you know,now there's liposomal delivery
of stuff to try to absorbthrough the fatty layer of
cells.
And, you know, my one of myfavorite companies, cell core,
they have this carbontechnology, you know, that
allows things to so that'sinteresting that you say so.
It's it's in the packaging.
And like that's what we tell alot of patients, you know, yes,
(23:46):
ideally we should get all ournutrients from food because it's
in the right ratios, it's it'srecognized by our body.
Unfortunately, so much foodtoday is lacking, you know, in
things.
SPEAKER_00 (23:56):
You're completely correct.
I agree a hundred percent.
But you mentioned liposome,which is an improved way to
deliver nutrients through yourGI tract and into your cells.
Well, nature's already figuredthat out.
An exosome is, you know,nature's liposome.
A liposome is a syntheticexosome.
They're trying to recreatenature.
It's easier just to get it fromnature.
Now, it's hard to eat enoughdiverse fruits and vegetables in
(24:20):
a day to get this.
That's why now it's figured out.
SPEAKER_01 (24:23):
So if somebody is kind of interested in this, you
know, one, are there anycontraindications to exosome
therapy?
SPEAKER_00 (24:32):
Yeah, so we don't give standard regenerative
exosome therapy to anyone withcancer, not because it'll
stimulate the cancer, it'sbecause we just don't know if
it's safe enough or not.
And and that causes me to remindeveryone listening that the FDA
has not yet approved formarketing claims, which is what
the FDA does.
They approve marketing claims.
(24:52):
They have an unapproved ordisapproved, they just haven't
approved yet.
So it's sort of in limbo.
Uh PRF, PRP, stem cells, andexosomes.
All those things fall under thesame category.
Are we using them?
Absolutely.
Does your dentist maybe use PRF?
Yes.
Does your orthopedic use PRP?
Yes.
Can you get an amnio patch onyour cornea if if you have dry
(25:13):
eyes?
Yes.
All these things are available,but we have to give proper
informed consent.
Um, and we're not allowed tomake any claims that they cure
or treat.
So having said that, because wewant to maintain compliance,
it's still one of the jobs of aclinician like a dentist or
doctor to protect patients bymaking the latest and some of
the best things available tothem, right?
(25:33):
So that's part of our oath.
You guys have an oath?
Do you do a Hippocratic oath orsomething?
Okay.
So we're we're under the sameoath, and that transcends
everything.
Our duty to the patient uh is isutmost, always.
So those are the types of thingsthat we have to consider when
doing the informed consent.
And I lost track of of the exactquestion that you started.
SPEAKER_01 (25:55):
I was just asking about contraindication.
So you said cancer cancerpatients.
Don't know anyone.
SPEAKER_00 (26:00):
Yeah, we have that.
Obviously, anyone with a who'son a blood thinner, we can't
really, it's hard to inject aperson.
So we might have to take a dayoff the blood thinner, a couple
days off depends.
If it's really mild, uh, youknow, that someone who's on core
uh steroids, the regenerativesjust don't work well in the face
of immunosuppressants likesteroids.
(26:20):
So we try to flip people offsteroids.
We we have an interesting sidenote, if you allow, I treated a
woman for knee issues, and wedid some injections, and she
just wasn't making progress afew months later, which you know
I get concerned because mostlythey do, and the literature
suggests that.
By the way, in Europe they havelike 15-year follow-up.
We're just behind the times herein these states.
(26:41):
So this woman wasn't makingprogress.
So I I had a longer visit withher, and she tells me we went
over her medicines, which we haddone before, and I had asked her
to curtail this, but she hadn't.
Her her regular doctor put heron a steroid inhaler like two
years ago because she hadbronchitis and never stopped.
So she's on thisimmunosuppressant inhaler just
because it was like she was justdoing what her doctor told her.
(27:03):
So we stopped it, and thenwithin a few months her her knee
turned the corner.
Now, I I don't know if stoppingit was the difference maker.
You know, maybe it just finallygot better, but I'm worried and
we really try to make surethat's that sure is Yeah.
SPEAKER_01 (27:16):
So tell me, uh I guess I probably should have
started with the question like,what are the procedures or or
ailments or conditions that stemcells have have the longest
positive impact?
So you talk about knee.
So is it arthritis cases?
SPEAKER_00 (27:30):
Yep.
Well, I mean, we we misuse thatword, arthritis.
It really means generallyosteoarthritis, which is a
wearing and tearing of the boneand cartilage.
But but you go to see theorthopedic surgeon, they do an
x-ray and they say yourcartilage is wearing down,
you're almost bone on bone, youneed a joint replacement.
Well, it turns out that's reallya disease of the bone edge,
those chondrocytes on the boneedge.
(27:51):
So we treat the root cause, wedon't treat the cartilage.
That's like putting stem cellson your hair, hoping to grow
more hair.
That won't work.
You got to put them in the scalpwhere the cells are.
So that's the longest and someof the best results come in this
musculoskeletal joint,degenerative osteoarthritis,
bone on bone, cartilage wear andtear type situation.
And that's all the all thosewords fit together.
(28:13):
Whether your doctor just callsit arthritis to be quick and
simple with you, um, or youknow, you've heard the word
chondromalacia, which is reallythe wearing down of the
cartilage.
It's the result, not the cause.
Yes, tearing your cartilage doescause some accelerated
degeneration.
Yes, having a knee scope or ajoint scope to trim some
cartilage helps you in themoment, but does accelerate the
(28:36):
degenerative process.
That's where we come in.
That's probably across the boardthe low-hanging fruit.
SPEAKER_01 (28:41):
Yeah.
So I mean, I I think practicallyevery week, you know, I'm
signing off on uh the uh oralhealth person before they go in
for a total joint replacement.
Would you say, or can you giveus some examples of um patients?
Have you been able to, in yourexperience, prevent total joint
replacements?
SPEAKER_00 (28:58):
Yes.
So the lit I'm gonna quote theliterature first.
The French literature on thistopic, and when they looked at
knees and they have over 15-yearfollow-up shows, at 15 years,
they were able to save 82% ofpeople who needed a knee
replacement by doing injectionin the bone.
Uh, if they just injected in thecartilage, they only saved just
under 25%.
unknown (29:19):
Wow.
SPEAKER_00 (29:20):
So we are oh so that's why we do the bone.
Uh plus, we're targeting alittle more efficiently with
these MRI with the the inversionrecovery sequence.
It really shows you the bonychanges.
And we're getting similarresults.
Now, I've only been doing thisseven years, so I don't have
15-year follow-up, but our ourdata tracks we have about 700
joints, and only two people havegone on to do surgery.
SPEAKER_01 (29:42):
Wow.
SPEAKER_00 (29:42):
Of the 700 so far.
And we're tracking, maybe a fewmore will.
And of course, if someone's notdoing well, I want to relook at
them.
Maybe I didn't put enough.
Maybe we need to do some more,you know.
Let's not give up.
SPEAKER_01 (29:54):
I'd say that's really impressive because I
mean, there's so many lifestylefactors, right, that go into.
You know, the breakdown.
So the fact that you can use,you know, this one product and
have such d drastic results isamazing because most people
know, yes, I should lose weight,I should eat better, I should
stop all this stuff.
But, you know, let's be real.
A lot of us are like, pleasejust give me the quick clicks,
(30:15):
you know.
So maybe and if you ever watchany of those doctor shows, you
know, I swear every show has hadat least one episode where the
person is getting poisoned bytheir, you know, their titanium
hip or whatever the old stuff.
So so it's a real thing.
If we can prevent putting, youknow, heavy metals in the
person's body, like this isamazing.
And it's obviously a lot lessrecovery.
(30:38):
Like, what talk to me about theprocedure.
What it how long does it last?
SPEAKER_00 (30:42):
Yeah, let's let's do that.
But first, you you made merealize that we do work on the
whole person.
We get better results if if thepatients are improving their
lifestyle, their diet, theirsupplements, their sleep, their
mental state, their um, youknow, their supplements, uh uh,
you know, exercise, everything.
(31:02):
Everything has to be looked at.
It helps you heal.
And we look at hormoneoptimization.
We look at peptide use, allkinds of things.
So, but typically it's aone-and-done, a single
injection.
We do it under a littlesedation.
The results take six to twelvemonths to be fully manifest,
although some people haveimprovement in pain initially
because there's ananti-inflammatory benefit, like
(31:24):
a like a steroid injection, butwithout the downside, because
repeat steroid injections, ofcourse, can you know cause
long-term problems.
So that's typically what we see.
Knees are probably the littlehanging fruit.
We do all kinds of joints.
I do ankles and wrists andthumbs and toes and things like
that.
Anybody looking to avoid asurgery, we're probably the per
the group you want to talk to.
(31:45):
I'm probably the guy you want tohave a have a video consultation
with.
And and most of our patients arefrom somewhere else.
We're based in Las Vegas,Nevada, but through the magic of
what we're doing here, we'redoing a video.
In the post-COVID world, so manyof our visits are by video.
We can order MRIs remotely, wecan look at them, I can share my
screen and show them to people.
So we only invite people here ifthey're a good candidate for a
(32:08):
treatment.
Uh, and that's kind of how itworks.
And we follow them out for atleast a year.
SPEAKER_01 (32:13):
So that's like so relative, and what's the
downtime?
Let's say you inject the knee.
SPEAKER_00 (32:18):
Are they downtime?
No downtime.
You know, you'll be sore fromthe injection because it's in
your bone, you know, like likeyou might be from a dental
procedure be sore, but you know,most people we want up and using
the joint, stimulating thejoint, you know, getting the
mechanoreceptors going and whichwhich cause those cells to
release, you know, cytokines,little proteins that call for
(32:40):
the healing.
Um, we want people right back attheir activities.
Uh, you don't necessarily haveto do physical therapy as long
as you, you know, you use thejoint properly and and well.
And I mean, we've had people, Idid I did a guy's shoulder and
he played golf the next day.
Now, I I don't know that I wouldhave recommended that, but he's
he had a great tea time.
He didn't want to miss it.
(33:01):
And he told me later, he's like,I was sore.
I probably shouldn't have thatday, but I had to.
SPEAKER_01 (33:05):
That's great.
So joints, that's kind of thenumber one thing that they've
been used for.
What are the other umindications?
SPEAKER_00 (33:12):
So we use the same regenerative biologics, you
know, these amniotic fluidproducts for inflammatory
issues.
So people with autoimmuneissues, maybe long infections
with that have a biginflammatory component, like a
long COVID or a Limes orpost-Lyme syndrome, any disease
that has an inflammatorycomponent, we seek to help the
(33:34):
cells fight the inflammationinflammatory issues.
So a lot of the diseases ofaging are diseases of
inflammation.
Well, that makes sense sinceinflammation and aging go hand
in hand.
So, you know, we we've looked atpeople with MS and Alzheimer's
and, of course, diffuseosteoarthritis.
If you have it in every joint,we're not going to inject every
joint, right?
So sometimes we start with anIV.
We have addressed organ failure.
(33:56):
We've had people that wereborderline needing dialysis and
helped their kidney function,prevented dialysis.
It helps.
We've seen the improvement ininsulin sensitivity.
So if you're looking at maybe adiabetes where you're you're
facing a potential use ofinsulin, we might be able to
help there.
Again, I'm not allowed to makeclaims, but it's worth trying.
SPEAKER_01 (34:17):
Yep.
SPEAKER_00 (34:18):
We and some people like myself, we do the IVs just
to get a little boost, uh,suppress inflammatory damage,
kind of a longevity thing welike to do.
Biohacking.
So I do it four times a year.
My wife does it.
My mother comes in, flies infor, and father do it uh twice a
year.
So um it it can help give youenergy, improve your mental
(34:40):
speed and sharpness, uh, helpyou fight infection.
We also do breathing treatmentswith the biologics, where we've
had someone who is oxygendependent.
We gave them a breathingtreatment, and now they're no
longer requiring the oxygentank.
I mean, we all require oxygen,but she doesn't have to roll
around the little tank.
Right.
So uh what else?
(35:01):
We we have a nasal sprayapplication for brain health
because the exosomes are smallenough to cross the blood-brain
barrier, whereas stem cells donot cross.
So, and let's think about this.
You you know, you've hadchildren, you know, other people
who are pregnant.
Pregnant women will tell youtheir skin is glowing, their
hair is growing.
And why is that?
(35:22):
They're getting a daily dose ofexosomes through the placental
membrane.
They're not getting stem cells.
You can't have stem cells crossthe placenta.
SPEAKER_01 (35:30):
Plus, those stems often say that women's, you
know, their autoimmune conditionwill go away during pregnancy.
Yes.
SPEAKER_00 (35:36):
This is a test dose of exosomes from their own baby.
And they can't get stem cellsfrom the baby because the baby
is genetically half foreign tothem.
They don't want to reject thebaby.
So the exosomes are so naive andneutral, there's there's there's
no cell, there's no reallyappreciable DNA or anything.
Exosomes contain peptides andgrowth factors and and uh
(35:59):
microRNAs, baby making magic.
So that's why we love these.
And parenthetically, we getthese from labs that are
ironically FDA certified andcompliant.
And the labs get them fromAmerican Tissue Bank Donor
Services.
So you've probably used somebone graft material in the past
for some procedures that you getfrom the donor bank.
(36:21):
And the particular lab we usegets the amniotic fluid from
non-COVID vaccinated mothers.
Why?
Because we don't want to, wedon't know what that variable
means fully, let's be honest.
These are from healthy mothers,they don't drink, smoke, or use
drugs, they're allowed oneromantic partner during the
pregnancy only, so they're notout goofing around too much.
And they have to be healthy,they have to be taking prenatal
(36:43):
vitamins, and they're screenedagain at the time of their
C-section, has to be a C-sectionbecause it's sterile.
You know, like you mentionedearlier, the mouth is not
sterile.
But luckily, it's got good bloodflow generally.
Same thing, a vaginal deliveryis not a sterile delivery.
So we don't it has to be aC-section, and they have exactly
60 seconds to suction theamniotic fluid before they
(37:05):
deliver the baby.
So this is very highlycontrolled.
It goes right to ice, right tothe lab where it's tested and
screened again, and we get themfresh frozen.
So nothing's powdered or cooked.
It's all fresh frozen amnioticfluid.
That's really what we're using.
Rich in exosomes from stemcells, rich in growth factors,
proteins, peptides.
SPEAKER_01 (37:24):
I heard you mention earlier though something that
you can put on the eye for dryeye.
Something I'm suffering from isdriving me bananas.
I'm like, tell me what this.
SPEAKER_00 (37:32):
Well, it's something that the eye doctors use.
It's an amniopatch, it's fromthe amniotic membrane.
So there are a couple differentthings you can do.
Dry dry eyes is complex, right?
We see this in women withchanging hormones.
So you gotta you gotta maintainthe hormone, bioidentical
hormone management, uh you andyou know, hydration, and you
want to re-stimulate thesemybomium glands.
Some of the times they're justgunked up, they're little
(37:55):
duct-like glands, and they needto be expressed or squeezed out.
And uh sometimes you do that afew times.
They can do what's called IPL,which is a laser, and and kind
of warm and melt the the goothat we create, we just we just
block those ducts, and you justneed to express them a few
times.
Sometimes that's all you need.
We've have injected exosomesinto the eyelid, not the eye,
(38:15):
the eyelid, because that's wherethose glands live.
And and we've seen someimprovement.
We haven't had it last more thansix months, though, and it's
kind of an annoying thing to doevery six months.
Yeah.
So, but the eye doctors have anamniopatch they put on the
cornea, and it it's supposed tohelp.
Doesn't it it might it's anoption, it's an easy thing to
do.
They just lay it on there.
SPEAKER_01 (38:35):
Interesting.
Yeah, definitely in thathormonal swing right now.
So trying to dial those all in.
SPEAKER_00 (38:40):
Fight, fight, fight.
You got you gotta make sure youmanage that because you will age
a lot slower if you do.
You will maintain your bonedensity, you will maintain your
muscle mass, you will slow therisk of dementia and
cardiovascular disease if youcan maintain your youthful
profile.
And we know this women who havelate menses, late pregnancies
live longer.
SPEAKER_01 (39:00):
Interesting.
Yeah, yeah, makes sense.
You have all those goodhormones, you know, flooding the
that's I I tell a lot of mywomen, you know, it's hard to
find the doctors really whounderstand how to do it
properly, right?
That's that's can some of thethings that you're gonna do.
SPEAKER_00 (39:13):
Yes, and it has to be bioidentical.
You can't take these syntheticor horse urine-based things that
they are the problem.
And a lot of the myths relatedto using these hormones have
been debunked.
So if you're out there and yourdoctor is scared to use them,
you you need to find someone todo it for you, ladies.
SPEAKER_01 (39:29):
Absolutely.
And there are people out there,but so they're out there.
Contact me, I'll put you intouch with the right people.
SPEAKER_00 (39:35):
And not just ladies.
Let's be fair, guys.
We're seeing lower testosteroneearlier and earlier in 30s and
40-year-olds, and you will loseyour muscle mass and you will
wither away, and you will nothave a longevity.
You have to have a longevityplan.
You have to script it out andfollow it early.
That's the that's preventativemedicine 3.0.
(39:56):
You have to do that.
SPEAKER_01 (39:57):
It's just crazy to think how many uh, you know, the
fertility clinics areoverflowing these days.
I mean, it's it's nuts.
I have two sisters, they've bothhad fertility, you know,
treatments and young, healthypeople, you know, it's just
crazy the world we live intoday.
So it is.
SPEAKER_00 (40:12):
It is.
Yeah.
But there are answers, and a lotof those answers are natural,
holistic.
Um, and you know, I haven'tfound any issues with them, but
I'm not allowed to make theclaim they're safe because the
FDA tells me that I can't makethat until they tell me I can
make that.
So in Europe, they're approved.
They're safe in Europe, but whenyou fly from Europe to the US,
we can't say that.
SPEAKER_01 (40:32):
Yes, like a lot of great, you know, biologic things
that that we're doing too.
So I think it's really exciting.
And what I'm, you know, thinkingabout the patient I had
yesterday who said, Well, okay,but if you get rid of all these
heavy metals and you get rid ofall the infections in my mouth,
can you regrow my bone?
And I'm like, I just I haven'tseen it yet.
You know, I'm not to say thatyou're gonna do it, but uh with
with exosomes, you know, thatseems like a promising way to go
(40:54):
about it.
SPEAKER_00 (40:55):
Yeah, and and exosomes may only be part of it,
right?
You you need uh some some goodbone matrix.
You know, uh I don't know if youuse bone morphogenic protein to
help grow bone.
I mean, that can be quite a uh auseful thing.
Yeah, it costs a couple thousanddollars a dose, but if you want
to grow bone quickly and be ableto do whatever restoration
(41:15):
you're doing, that's a a shorterpath for sure.
I've seen it.
SPEAKER_01 (41:20):
Yeah.
So exciting.
Yes.
And and the more common itbecomes, you know, the the price
will come down, hopefully.
So we can, you know, but that'swhat I'm excited to see, you
know, is is is regenerate.
Like I said, I don't ever wantto have to pick up my drill ever
again.
You know, I want to do all thisregenerative and preventative,
you know, type of work, reallyhaving people understand what is
the root of decay, what youknow, how and even talking about
(41:42):
that, you know, to me, the morethat I see it, there's so much
where the the immune system, youknow, is getting bogged down.
We talk about, oh, you didn'tbrush it in and flus.
You know, you get admonished byyour your hygienist for not
doing good uh oral care, andthat's just that's not it, you
know.
That's such a small fragment ofwhat's going on at the deeper
level.
SPEAKER_00 (42:00):
So oh yeah.
And we're learning more all thetime.
We're learning about theseindividual peptides and things
that that have benefits anddifferent types of exosomes.
I mean, this is just thebeginning.
You're right.
SPEAKER_01 (42:11):
It's really exciting.
So we're about coming up on ourtime.
Is there any anything elseexciting around the whole
science of of exosomes orsomething that you think is
gonna be the next next greatthing?
SPEAKER_00 (42:23):
Yeah, we're looking at, like I told you, the
tissue-specific lineageexosomes, being more specific
about different things we applythem for.
Uh, we're looking at a betteruse of the muse cells and their
exosomes.
We're looking at differentpeptides and and proteins and
growth factors strategically.
Some are anti-aging, like theclotho and the FOXO4, things
(42:44):
like this.
So these are things that will beavailable.
Some of them are, notnecessarily here, but we're, you
know, trying to foster pathwaysto protect our patients' access
to want to try these things.
We're looking at, you know, wehave some things we're working
on on the cancer side of thingsusing natural killer cell
exosomes, which we didn't reallydelve into, but we do have that.
(43:07):
And you know, we're looking atdesigner exosomes.
They have these in China, wedon't have them here yet.
But for example, exosomes thatwill deliver more mitochondria
to donate to your cells so theycan be more efficient
metabolically and make moremuscle, all kinds of fun things
coming.
SPEAKER_01 (43:21):
Yeah, but it's it's very exciting and uh it's
definitely you know kind of onthat cutting edge, but it is
available now.
So if somebody was really wantedis interested, wants to learn
more about you, your company,where you're located, how do
they reach out to you?
SPEAKER_00 (43:33):
Well, our company is called Recelebrate, R-E-C-E-L-L
E-B-R-A-T-E, because we'recelebrating the renewal of your
cells.
So that's our fun name.
And if you put that in your uhweb browser and search it, we
will probably come up because wemade up the word, and I think we
cornered the internet on theword.
So re-celebrate.com, ourInstagram is at re-celebrate.
(43:56):
You can find us on all the majorsocial networks and Facebook and
what have you.
So just check us out, reach out.
We'd love to meet new people, behappy to have a conversation,
talk about any we love we'd loveto look into new issues too.
We do the homework, we look atthe research, we see what's out
there.
We're not just shooting from thehip.
SPEAKER_01 (44:13):
Yeah.
Yeah, it's exciting.
And you know, people who arelistening to this podcast are,
you know, want the more naturalalternative.
They want to try to avoid those,you know, the hip replacements,
the tooth replacements, allthose kind of things.
So I really appreciate your timetoday.
Everybody, you've got that, uh,we'll also copy down the site
for you in the show notes.
So if you didn't catch it, ifyou're just listening, it'll be
(44:33):
there for you.
So thank you so much.
Dr.
Jeff.
We appreciate your time.
I hope everybody enjoyedlearning something new, perhaps.
And please reach out to Dr.
Gross if you want to learn moreabout stem cells and exosomes.
And otherwise we'll just catchyou on the next episode,
everyone.
Have a great day.
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