Biome Boosted Microneedling

In this episode of The Skin Science Podcast, Thomas M. Hitchcock, Ph.D., Chief Science Officer, speaks with Angela Wilson McDonald, Global VP, Education and Customer Success, and Brian Jones, Ph.D., VP, R&D and Biomedical Innovation, about biome boosted microneedling and the clinical study to support it. 

The Skin Science Podcast is intended to provide listeners with information regarding various topics in the field of skin science. None of the content in this podcast should be interpreted or construed as professional or medical advice. Further, the views and opinions expressed by guests are their own and do not represent those of Crown Laboratories, Inc., and the appearance of any guest on the podcast does not imply an endorsement of the guest or any particular entity they represent.


0:00 Introduction
2:50 Before/after photo from Crown "Biome-boosted microneedling" clinical study 
6:34 Story behind the SkinPen + BIOJUVE biome-boosted microneedling study 
9:50 Treatment of acne scars
13:08 Optimal environment for skin remodeling 
16:40 Philosophy of the BIOJUVE regimen
19:00 How topicals influence skin physiology 
23:03 Study design and rationale
28:20 Results 
30:30 Before/after photos 
33:20 Opportunity to enhance microneedling results 
38:25 Improvement beyond acne scarring
40:20 Remodeling process
43:50 Closing remarks


Alqam, M. L., Jones, B. C., & Hitchcock, T. M. (2023). Topical application of skin biome care regimen containing live cultures and ferments of Cutibacterium acnes defendens strain XYCM42 and the impact on clinical outcomes following microneedle-induced skin remodeling. Journal of Clinical and Aesthetic Dermatology, 16(12), 18–30. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729805/pdf/jcad_16_12_18.pdf