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September 17, 2025 28 mins

Back in April, a company called Colossal Biosciences announced that they had brought dire wolves — ancient canines of Game of Thrones fame — back from extinction. The internet went wild. But while some media outlets proclaimed the return of a long-gone species, many scientists shot back on social media that these weren’t really dire wolves, they were just genetically engineered grey wolves. Suddenly everybody had an opinion on what de-extinction is, what it is not, and whether or not we should be doing things like this in the first place. In this episode, we talk to scientists who have been working in this area for a while, and they not only share their thoughts on these wolves — they completely change our understanding of the term “de-extinction.”

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