Dr Michelle Dickinson discusses the science, complications, and potential new-ground with using stem cells to combat diabetes.
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Speaker 1 (00:06):
You're listening to the Sunday Session podcast with Francesca Rudgin
from News Talks EDB.
Speaker 2 (00:12):
And it is time to talk science, and doctor Michel
Dikinson joins us. Now, good morning, Good morning. This is
really fascinating what scientists are using stem cells for, especially
when it comes to type one diabetes.
Speaker 3 (00:29):
There's a couple of parts of the stories that are
world changing. We're going to talk about the brands. One
is what they're doing with it, and number two is
where they're getting them from. We'll get there. So this
is published in the journal Cell, and basically they are
reporting this week the world's first medical procedure that has
totally reversed type one diabetes. Now it's earning on one
patient and this patient has now been studied for a year,
(00:51):
and it seems like she is I would call it
fully cured of diabetes. She now makes her own InterLAN,
she doesn't rely on anything, she can eat sugar, and
it's going to give hope to millions of people who
suffer with type one diabetes who have to usually manage
it by injecting insulin and measuring their blood every single day.
(01:11):
And type one diabetes it usually starts in childhood. So
what happens is your immune system for some reason, I
think you're pancreas is bad for you and starts to
attack your own pancreas. And inside your pancreas are these cells.
They're called islet cells, and they're the ones that make insulin,
and insulin is the thing that helps you to control
your blood sugar. And usually don't notice it in childhood,
(01:32):
and by the time you've noticed it, it's done permanent
damage and so you cannot have your body produce insulin anymore.
So this is what's amazing about this study. What they
did is they cook. Now, you can take stem cells
from lots of weird and wonderful places, but they took
stem cells from this patient body fat They literally gave
her liposuction. I just feel like this is a win
(01:52):
win in this study. They gave a liposection, they took
out her cells that are at cells, and then they
cannotally induce them so that they became what we call
poory potent cells, which are stem cells, which you can
then tell to become any type of cells in your body.
So they took us at selves. They chemically induced them,
and they said please become eye looks fans, which are
(02:14):
the ones reduced instruments, and then all they did was
inject them into her abdomen and left her for three months.
And three months later, these stem cells have worked their
way to the penguins. They had rebuilt islet cells, and
here she is producing her own insulin as if she'd
never had diabetes since she was twenty five age device
(02:34):
is a young patient and that was fixed. And so
they've monitored her now for a year, no need for insulin,
no need for anything. Her bloods of growth amazing. These
islet cells are working really well. And this is totally
nuts if you think about how big diabetes is a
for challenge, but also how long term this is one
(02:55):
procedure that literally only required a little bit of LiPo.
Speaker 2 (02:59):
Well, I mean it's a bit of an intervention there,
But I mean if we take this and we try
and tun it into a cure for diabetes, how easy
is it to do that and reach you know, so
many people.
Speaker 3 (03:14):
Well, this isn't any problem once, but if there only
one patient has been tested and the similar group recently
did something different where they took islet transplants, and so
that was going to be the next stage only in April,
where they were going to take a tack islet cells
from a transplant and then put them into your pancreas,
and that was working. In the big problem they said
(03:35):
it was, Look, there's no enough donors. You know, it's
the same with all organ donation, is that we don't
have enough. So this actually the thing that's special about
this is it's taking yourself from your own body, so
there's no challenge around the source. So what this group
is now doing is going, how do we make it
easy to literally do a little bit of lico, give
you the right chemicals and get you to grow your
(03:56):
own stentles. But the nice thing about this treatment is
it doesn't require anybody else. They're your own cells, which
means there's no miskod rejection. You don't have to go
on different drugs to try and worry about inject. So
that's what's really world breaking about this. It's the first
time I've seen as sturdy that actually has looked at
a solution where you're not having to rely on anything
else other than a couple of chemicals in a lab
(04:17):
to induce yourself. So I think this is going to
be more it's huge.
Speaker 2 (04:20):
That's the thing. I just want science to move fast.
To Michelle, I'm like, great, let's do us. It would
just be bring such a relate to so many people.
Thank you so much. And of course you can think
of all the other potential applications of stem cell therapy
and other autoimmune diseases as well. Thank you so much.
Michelle will catch up next to a week. Mike van
Elsen's up nixt was initially a really useful.
Speaker 1 (04:42):
Recipe for more from the Sunday session with Francesca Rudkin.
Listen live to use talks. It'd be from nine am Sunday,
or follow the podcast on iHeartRadio
You're listening to the Sunday Session podcast with Francesca Rudgin
from News Talks EDB.
Speaker 2 (00:12):
And it is time to talk science, and doctor Michel
Dikinson joins us. Now, good morning, Good morning. This is
really fascinating what scientists are using stem cells for, especially
when it comes to type one diabetes.
Speaker 3 (00:29):
There's a couple of parts of the stories that are
world changing. We're going to talk about the brands. One
is what they're doing with it, and number two is
where they're getting them from. We'll get there. So this
is published in the journal Cell, and basically they are
reporting this week the world's first medical procedure that has
totally reversed type one diabetes. Now it's earning on one
patient and this patient has now been studied for a year,
(00:51):
and it seems like she is I would call it
fully cured of diabetes. She now makes her own InterLAN,
she doesn't rely on anything, she can eat sugar, and
it's going to give hope to millions of people who
suffer with type one diabetes who have to usually manage
it by injecting insulin and measuring their blood every single day.
(01:11):
And type one diabetes it usually starts in childhood. So
what happens is your immune system for some reason, I
think you're pancreas is bad for you and starts to
attack your own pancreas. And inside your pancreas are these cells.
They're called islet cells, and they're the ones that make insulin,
and insulin is the thing that helps you to control
your blood sugar. And usually don't notice it in childhood,
(01:32):
and by the time you've noticed it, it's done permanent
damage and so you cannot have your body produce insulin anymore.
So this is what's amazing about this study. What they
did is they cook. Now, you can take stem cells
from lots of weird and wonderful places, but they took
stem cells from this patient body fat They literally gave
her liposuction. I just feel like this is a win
(01:52):
win in this study. They gave a liposection, they took
out her cells that are at cells, and then they
cannotally induce them so that they became what we call
poory potent cells, which are stem cells, which you can
then tell to become any type of cells in your body.
So they took us at selves. They chemically induced them,
and they said please become eye looks fans, which are
(02:14):
the ones reduced instruments, and then all they did was
inject them into her abdomen and left her for three months.
And three months later, these stem cells have worked their
way to the penguins. They had rebuilt islet cells, and
here she is producing her own insulin as if she'd
never had diabetes since she was twenty five age device
(02:34):
is a young patient and that was fixed. And so
they've monitored her now for a year, no need for insulin,
no need for anything. Her bloods of growth amazing. These
islet cells are working really well. And this is totally
nuts if you think about how big diabetes is a
for challenge, but also how long term this is one
(02:55):
procedure that literally only required a little bit of LiPo.
Speaker 2 (02:59):
Well, I mean it's a bit of an intervention there,
But I mean if we take this and we try
and tun it into a cure for diabetes, how easy
is it to do that and reach you know, so
many people.
Speaker 3 (03:14):
Well, this isn't any problem once, but if there only
one patient has been tested and the similar group recently
did something different where they took islet transplants, and so
that was going to be the next stage only in April,
where they were going to take a tack islet cells
from a transplant and then put them into your pancreas,
and that was working. In the big problem they said
(03:35):
it was, Look, there's no enough donors. You know, it's
the same with all organ donation, is that we don't
have enough. So this actually the thing that's special about
this is it's taking yourself from your own body, so
there's no challenge around the source. So what this group
is now doing is going, how do we make it
easy to literally do a little bit of lico, give
you the right chemicals and get you to grow your
(03:56):
own stentles. But the nice thing about this treatment is
it doesn't require anybody else. They're your own cells, which
means there's no miskod rejection. You don't have to go
on different drugs to try and worry about inject. So
that's what's really world breaking about this. It's the first
time I've seen as sturdy that actually has looked at
a solution where you're not having to rely on anything
else other than a couple of chemicals in a lab
(04:17):
to induce yourself. So I think this is going to
be more it's huge.
Speaker 2 (04:20):
That's the thing. I just want science to move fast.
To Michelle, I'm like, great, let's do us. It would
just be bring such a relate to so many people.
Thank you so much. And of course you can think
of all the other potential applications of stem cell therapy
and other autoimmune diseases as well. Thank you so much.
Michelle will catch up next to a week. Mike van
Elsen's up nixt was initially a really useful.
Speaker 1 (04:42):
Recipe for more from the Sunday session with Francesca Rudkin.
Listen live to use talks. It'd be from nine am Sunday,
or follow the podcast on iHeartRadio
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