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January 5, 2026 61 mins
Today on Talk Python, the creators behind FastAPI, Flask, Django, Quart, and Litestar get practical about running apps based on their framework in production. Deployment patterns, async gotchas, servers, scaling, and the stuff you only learn at 2 a.m. when the pager goes off. For Django, we have Carlton Gibson and Jeff Triplet. For Flask, we have David Lord and Phil Jones, and on team Litestar we have Janek Nouvertné and Cody Fincher, and finally Sebastián Ramírez from FastAPI is here. Let’s jump in.

Episode sponsors

Talk Python Courses
Python in Production

Carlton Gibson - Django: github.com
Sebastian Ramirez - FastAPI: github.com
David Lord - Flask: davidism.com
Phil Jones - Flask and Quartz(async): pgjones.dev
Yanik Nouvertne - LiteStar: github.com
Cody Fincher - LiteStar: github.com
Jeff Triplett - Django: jefftriplett.com

Django: www.djangoproject.com
Flask: flask.palletsprojects.com
Quart: quart.palletsprojects.com
Litestar: litestar.dev
FastAPI: fastapi.tiangolo.com
Coolify: coolify.io
ASGI: asgi.readthedocs.io
WSGI (PEP 3333): peps.python.org
Granian: github.com
Hypercorn: github.com
uvicorn: uvicorn.dev
Gunicorn: gunicorn.org
Hypercorn: hypercorn.readthedocs.io
Daphne: github.com
Nginx: nginx.org
Docker: www.docker.com
Kubernetes: kubernetes.io
PostgreSQL: www.postgresql.org
SQLite: www.sqlite.org
Celery: docs.celeryq.dev
SQLAlchemy: www.sqlalchemy.org
Django REST framework: www.django-rest-framework.org
Jinja: jinja.palletsprojects.com
Click: click.palletsprojec

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