BLA 120: ApoB: What It Is and Why You Should Care

In this episode of the Building Lifelong Athletes podcast we talk about apoB and why it is probably a better test than our standard lipid panel.

We cover the following topics
00:00 - Intro
00:40 - apoB Introduction
01:50 - apoB Structure and function
05:47 - apoB and atherosclerosis
07:29 - The Atherogenic Lipoprotein Particle Paradigm
11:14 - apoB Measurement in Practice
13:02 - apoB Target Goals
18:13 - apoB Treatment
19:51 - Arguments against apoB
23:22 - The Evidence Supporting apoB
26:43 - Conclusions
29:50 - Outro

Sign up for my free newsletter to receive analysis, reviews, and my interpretations of the most recent research to help you stay and active for life.
Click Here: www.jrennickemd.com

REFERENCES:

Behbodikhah, J., Ahmed, S., Elyasi, A., Kasselman, L. J., De Leon, J., Glass, A. D., & Reiss, A. B. (2021). Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target. Metabolites, 11(10), 690. https://doi.org/10.3390/metabo11100690 De Oliveira-Gomes, D., Joshi, P. H., Peterson, E. D., Rohatgi, A., Khera, A., & Navar, A. M. (2024). Apolipoprotein B: Bridging the Gap Between Evidence and Clinical Practice. Circulation, 150(1), 62–79. https://doi.org/10.1161/CIRCULATIONAHA.124.068885 Glavinovic, T., Thanassoulis, G., de Graaf, J., Couture, P., Hegele, R. A., & Sniderman, A. D. (2022). Physiological Bases for the Superiority of Apolipoprotein B Over Low‐Density Lipoprotein Cholesterol and Non–High‐Density Lipoprotein Cholesterol as a Marker of Cardiovascular Risk. Journal of the American Heart Association, 11(20), e025858. https://doi.org/10.1161/JAHA.122.025858 Li, C., Zhang, Y., Mei, L., Jin, A., Cai, X., Pan, Y., Jing, J., Wang, S., Meng, X., Li, S., Wang, M., Wei, T., Wang, Y., Chen, R., & Tian, Y. (2023). Discordantly high Apo B with LDL-C or non-HDL-C in relation to presence and burden of cerebral atherosclerotic plaques. Journal of Clinical Lipidology, 17(4), 519–528. https://doi.org/10.1016/j.jacl.2023.05.104 Sniderman, A. D., Thanassoulis, G., Glavinovic, T., Navar, A. M., Pencina, M., Catapano, A., & Ference, B. A. (2019). Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. JAMA Cardiology, 4(12), 1287. https://doi.org/10.1001/jamacardio.2019.3780 Soffer, D. E., Marston, N. A., Maki, K. C., Jacobson, T. A., Bittner, V. A., Peña, J. M., Thanassoulis, G., Martin, S. S., Kirkpatrick, C. F., Virani, S. S., Dixon, D. L., Ballantyne, C. M., & Remaley, A. T. (2024). Role of apolipoprotein B in the clinical management of cardiovascular risk in adults: An Expert Clinical Consensus from the National Lipid Association. Journal of Clinical Lipidology, 18(5), e647–e663. https://doi.org/10.1016/j.jacl.2024.08.013 .css-j9qmi7{display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-flex-direction:row;-ms-flex-direction:row;flex-direction:row;font-weight:700;margin-bottom:1rem;margin-top:2.8rem;width:100%;-webkit-box-pack:start;-ms-flex-pack:start;-webkit-justify-content:start;justify-content:start;padding-left:5rem;}@media only screen and (max-width: 599px){.css-j9qmi7{padding-left:0;-webkit-box-pack:center;-ms-flex-pack:center;-webkit-justify-content:center;justify-content:center;}}.css-j9qmi7 svg{fill:#27292D;}.css-j9qmi7 .eagfbvw0{-webkit-align-items:center;-webkit-box-align:center;-ms-flex-align:center;align-items:center;color:#27292D;}