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November 5, 2025 70 mins

Revolutionising Liver Health: The Link Between Gut Health, Genetics, and Lifestyle

In this episode, we dive deep into the intricate connections between liver health, gut health, genetic predispositions, and lifestyle factors. Our guest, Gary, a seasoned physician and entrepreneur, shares his extensive experience from pioneering liver disease research in the 90s to running a successful metabolic clinic focused on functional medicine today. Learn about the evolution of understanding fatty liver diseases like NASH and MASH, the impact of processed foods, and the groundbreaking treatments emerging, including the promising effects of GLP-1 therapies. Gary also discusses the pivotal role of a clean diet, exercise, and quality sleep in managing liver health, and the challenges of implementing these changes in a clinical setting. Don't miss this insightful conversation packed with practical advice and forward-thinking approaches to improving liver and overall metabolic health.

00:00 The State of Food Quality in America vs Scotland 02:39 Understanding Fatty Liver Disease: Past and Present 05:29 Genetic and Environmental Factors in Fatty Liver Disease 08:13 The Evolution of MASH: From NASH to Metabolic Health 10:46 Emerging Treatments and Medications for Liver Disease 13:35 The Role of GLP-1s in Managing Liver Health 16:18 The Gut–Liver Connection: A Historical Perspective 19:07 Building a Successful Liver Clinic: Insights and Challenges 33:52 Understanding Metabolic Health and Genetic Testing 35:13 The Importance of Gut Health 37:39 Transforming Workplace Wellness Initiatives 45:48 The Future of Functional Medicine 51:30 Addressing Liver Health and Alcohol Consumption

Takeaways

  • The quality of food in America is declining, impacting health.
  • Fatty liver disease is increasingly common, especially among those with higher body mass indexes.
  • Genetic predisposition plays a significant role in liver disease.
  • MASH is a critical condition that combines fatty liver with inflammation.
  • Advancements in GLP-1 medications show promise for treating liver disease.
  • Gut health is essential for overall wellness and liver health.
  • Guy Neff's journey reflects a blend of medicine and business acumen.
  • Building a successful liver clinic requires navigating numerous challenges.
  • Functional medicine is gaining traction as a holistic approach to health.
  • Routine testing for liver health is crucial for early detection and intervention.

You must not rely on the information in this video as an alternative to medical advice from your doctor or other professional healthcare provider. If you have any specific questions about any medical matter you should consult your doctor or other professional healthcare provider. If you think you may be suffering from any medical condition you should seek immediate medical attention. You should never delay seeking medical advice, disregard medical advice, or discontinue medical treatment because of the information in this podcast.

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