April 13, 2025 • 46 mins
The Power of Berberine: A Natural Alternative to Ozempic for Metabolic Health
In this episode, Dr. Kundlas delves into the potent metabolic effects of Berberine, a natural supplement with properties comparable to those of the pharmaceutical drug Ozempic. He explains Berberine's impact on glucose, fat, protein metabolism, and how it aids in weight management. Dr. Kundlas emphasizes Berberine's traditional use in Ayurvedic and Chinese medicine and its modern applications. Learn how Berberine can improve metabolic health, lower cholesterol, enhance gut health, and serve as an alternative for managing diabetes and polycystic ovarian syndrome. The video is backed by evidence-based medicine and practical patient experiences. 00:00 Introduction to the Supplement with Metabolic Benefits 01:01 What is Berberine? 02:25 How Berberine Works in the Body 04:17 Berberine's Impact on Metabolism and Energy 05:28 Berberine and Blood Sugar Control 06:49 Berberine's Role in Gut Health 07:19 Cholesterol Management with Berberine 08:36 Comparing Berberine to Ozempic 11:23 How to Take Berberine 12:17 Clinical Uses and Benefits of Berberine 14:25 Safety, Side Effects, and Recommendations 15:27 Conclusion and Final Thoughts
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Transcript
Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
(00:00):
Hello, this is Dr.
Meatless.
Today I will reveal one supplement with eight powerful metabolic effects on proteins, fats, glucose and weight metabolism.
It is as good as natural ozempic.
(00:20):
We will be discussing Burberry.
Fortunately, I have been creating a lot of videos regarding cholesterol, and thanks to my patients who brought this gem of alternative medicine to my attention as a physician.
For last 27 years, I have been ignoring food, nutrition supplements, spices, and.
(00:47):
Since I started making YouTube video and interact with my patients on daily basis, they requested me to create a video about Burberry thanks to them, and it is dedicated to them.
What is Bur brain and I want to make sure that you understand.
(01:07):
I have spent a lot of time and I will present you the evidence.
Which has got a high certainty and you could count, you are getting evidence-based medicine and you could count that you're getting evidence-based information.
What is brine? Bourbon is a alkaloid or a sap coming from a plant.
(01:33):
Bures, Burgar, and this plant is unique.
It has.
Golden yellow flowers and also very powerful, which nature has given us.
Traditionally, this has been used in Ayurvedic medicine and Chinese medicine to treat infections and inflammation in modern medicine.
(01:59):
Now, since we have pretty much maximized the medications and there is a lot of push.
People are exploring alternative ways, and then now there is some money going into research to find out this natural products which exist, and if we incorporate into our day-to-day activities and food and nutrition, it can help.
(02:26):
We are interested how bourbon can help to control our metabolic health, blood sugar, cholesterol, and fat.
It is bright yellow the way it works, has a lot of chemical pathways.
It activates E-M-P-P-K.
That's a master switch.
The mitochondria, which are the energy powerhouse of each cell in you, and you are made up about 60 to 70 trillion cells that it affects you there.
(02:56):
It controls glucose metabolism, how much sugar muscles pick it up from your blood sugar, and also how much liver it's gonna make.
It also promotes art Fiji.
That all the gunk and the dead material, which we have collected in our body, it cleans it up and it improves our vitality and we feel good and we prevent caging and we live long.
(03:25):
Then it also enhances the muscles, which I have explained to pick up more glucose.
Above all, it improves gut microbiome and the inner lining of your gut.
That way it prevents a lot of infin, bowel disease, inflammation, and it's directly related to metabolic health.
(03:47):
It is like PCSK nine medication, which is very powerful to help your lower cholesterol, and inflammation.
This is the chart.
Which is a simplified version where it explains everything, how this thing works.
(04:10):
This is the chart where it explains how different organ systems get involved.
Let's dive deep into that first metabolism.
Remember I told you that body has a metabolic switch, which called A MBK.
All the anti-aging medications, research is geared towards how we could activate A MPK and your burp brain.
(04:37):
Does that naturally think A MPK as a body's fat burning switch, when A MPK gets activated, you start burning fat.
So I'm not saying that this is a panacea.
What I'm saying is these are the mechanisms.
We should explore and we should incorporate into our day-to-day life.
(05:00):
Further.
Also help you to convert this fat into energy so you feel more active, more vital, and you are more full of vitality.
How switching metabolism, promotes energy mitochondria become more efficient so that they start burning the fuel and you feel much, much better, and you start improving.
(05:29):
Berberine is known to lower your sugar.
It does by two things.
Number one, it makes your muscle pick up all the blood sugar from your blood.
Also, it promotes your liver to stop the process of conversion proteins and fats into sugar.
(05:49):
You might have a normal experience if you're diabetic, that you wake up in the morning, you have not eaten, and your blood sugar is high.
Your liver is converting your fat and protein into sugar, and berberine stops that berberine prevents aging? In aging? All these senescent cells and all the dead cells, they're just not cleaned out of the body.
(06:14):
They're just getting piled up, accumulated, leading to degenerative diseases, and by signaling the pathways, it cleans up the old gunk.
And your body becomes rejuvenated, revitalizes, and it improves.
I have went over in detail that it stimulates the receptors in the muscles.
(06:40):
They pick up sugar from the blood and then your blood sugar goes down and so all the complications of diabetes.
It's especially modern for gut health.
What it does is the inner lining of the cell, which we, there is a lot of interest in leaky gut syndrome or sibo.
(07:01):
It heals you further, it also promotes the good gut bacteria growth.
So once your gut is healthy, your mind is healthy, your mood is better, and you have lower metabolic.
Inflammation.
Is very effective in lowering cholesterol.
(07:23):
In cholesterol metabolism.
There are two parts to it.
Number one, liver is the which makes 80% of the cholesterol.
Then when the cholesterol gets released, whatever is used, that's taken the circulation, the extra cholesterol gets.
It's clogging up our arteries and our HDL cholesterol bring the bad, cholesterol back for recirculation reuse or destruction, the receptors which enable liver to pick up this extra cholesterol or bad cholesterol coming to the liver depends on PSK C.
(08:05):
PCSK protein and stimulates that.
Improving.
Cleaning up your extra cholesterol in the body.
Berberrine is very effective in lowering your cholesterol.
Berberrine decreases inflammation.
All the inflammatory markers, it reduces the production of them.
(08:29):
Inflammation goes down, pain goes down, chronic diseases down.
This is the buzz line is brine really natures ozempic and my honest view is this.
Ozempic is a very powerful drug and they both work on different places.
Ozempic works on a GLP receptors in the body and they improve your insulin, they decrease the stomach size.
(09:01):
They've improved the society, so it does everything that your sugar goes down.
Whereas Rine activates a MPK system and then it also it decreases the appetite.
So Ozempic, it's a halfway there.
They both decrease your appetite, but it is not as powerful as Ozempic, but.
(09:26):
If you combine them, I think the effect will be synergistic.
And I'm answering this question particularly to one of my patients who has been combining it, both of them, and he has a very good result and good part is he does not have any significant side effects.
The major side effects of bine is gi, nausea, vomiting, diarrhea.
(09:51):
Those things can happen.
And if you're pregnant and.
Breastfeeding.
You should not use any berberine products.
Berberine.
These are the kind of a mechanisms which have went over already, like how it increases this healing or metabolic pathways is all these parts.
(10:15):
Promotes liver to produce good cholesterol.
Destroy bad cholesterol, stop conversion of fat and protein into glucose.
Makes muscles to pick up more sugar out of your blood, and that way these are the all the proper ways you are having.
(10:37):
This is another concept, which is very important that how Burberine helps nutrition, partitioning muscle versus fat.
See what happens when we eat the sugar, which gets into circulation.
It has two phase, okay? It can be used as energy by cells, especially our muscle cells, or it could be stored fat by improving MPK.
(11:05):
Pathway, it pushes the sugar into muscles so that they could burn it.
There is lesser fat and you lose weight.
The reason we use in polycystic ovarian syndrome How to take berberine.
Comes in.
(11:25):
Tablets and capsule each is about 500 and it's recommended take two to three times a day.
This berberine does not get absorbed from the gut quickly.
That's the reason you have to combine it with some other products.
We all might have heard milk thistle.
Combined which is in milk thistle.
(11:48):
They promote.
The absorption of usually it's recommended take for six to eight weeks, then stop for two weeks, and then circle back these are new supplements and they are trying to limit the side effects.
Can help you lose weight? Yes.
(12:09):
The research is very clear that it can help you to lose.
About on average four to five pounds in 12 weeks.
These are the different clinical uses, which we will go over so now comes in is point.
Can Rine, can berberrine help you lose weight? It definitely can help you lose weight.
(12:32):
In a clinical trial there was two to five kgs, but that's what, four to 10 pounds.
It improves all metabolic pathways.
Mobilizes fat does not let the fat deposition.
It makes muscle pickup more sugar, and above all, it decreases inflammation decreases appetite and helps.
(12:53):
Can you make berberine naturally? No.
Berberine only exists from the berry plant.
It acts as antimicrobial and it helps to promote normal gut flora.
It also decreases all the harm chemicals.
(13:14):
What these bacterias make, it improves the function of gut lining and also improves all the functions so that your gut is not leaking.
Can be used as a alternative to Metformin in these studies, which I could get? They have tried that and they were successful.
(13:35):
Trials positive, but I cannot make the recommendation replace one over the other.
But definitely improves insulin sensitivity, and by improving insulin sensitivity, it does improve symptoms of PCOS, and it could be either replaced or could be used with Metformin.
(13:56):
Lowers bad cholesterol.
Decreases triglycerides and total cholesterol.
It inhibits PCSK that's why more bad cholesterol could be picked up by receptors in the liver and lower your cholesterol.
And also it improves the function of inner lining of your blood vessels.
(14:18):
It is very good alternative in patients who are statin intolerant.
Safety and side effects.
Common side effects are gi, constipation and cramping.
We should not combine it with blood thinners and certain blood sugar lowering medications.
(14:40):
Pregnant women and breastfeeding and infant are absolutely contraindication.
It is recommended that people who are taking long term, they should have.
Liver sugar and cholesterol tested every six months to a year.
I have no formal recommendation way to buy.
My goal was to help you get the science behind this thing, but these are the good resources which I was able to find in nutshell.
(15:11):
Burberine could be helpful in treating type two diabetes, neuritis, polycystic ovarian syndrome.
High cholesterol, weight metabolism, weight loss, metabolic syndrome, gut information, and anti-aging.
I hope this video was helpful and informational.
My name is Dr.
(15:32):
KLEs signing off, and I will see you in next video.
Like here and subscribe to our channel Less md.
Thank you very much for your attention and thank you for my all patients who have been very helpful in getting my attention to these natural supplements and ingredients.
Thank you.
(15:53):
Blin is a alkaloid or a product for a SAP from a plant, which is called Bures Bulgaris.
This is used, this has been used for centuries in AIC medicines in India and Chinese medicine.
I've been a physician since 1997.
(16:16):
Because we are so wrapped up into disease medicines, I was not really up to these natural supplements, spices.
What are the effects and how if we could incorporate into our day to day routines, habits, food, how they can improve metabolic health by almost.
(16:42):
20 to 30% take any allopathic medication they're usually affecting in cutting down any kind of process, which they're intended for by 50%.
But if these natural supplements like Perrine, we incorporate their into a daily life, we are getting 15 to 20%.
(17:04):
And if we start exercising, eating right, managing stress, we believe we will manage without medications.
Let's dive into what Bine is and what when we do for how the, what's the mechanism of action.
These are the different places where Bine works and they are very important.
(17:29):
These are eight different metabolic places where it works.
I have deliberately not going over the this.
Process and boring you.
I'm gonna elaborate them these processes one by one, so that you understand that part how bur brain promotes metabolic health in your body.
(17:50):
In a metabolic health, there is a classic switch or a very rate limiting process, which is A MPK.
Once we activate this process.
Your body becomes a fuel consuming retic machine.
(18:14):
Bur brain acts on this metabolic switch and activates it and you start burning fat.
More effectively.
So whether that does it for same number of calories, ineffectively burn.
Versus effectively born, you are full of energy, you are strong, you're healthy.
(18:35):
Burberine also improves your energy efficiency.
The way it works out is in everybody's cells, there are energy powerhouses, which are mitochondria, and it improves how these chemical processes are taken care.
They become smarter, they become faster.
(18:56):
They not only burn excessive fuel, but are very effective.
Lowers your sugar that it works through two mechanisms.
Number one, your liver has a capacity to convert your fats and proteins into sugar and goes and stop that process.
(19:20):
You might have very notoriously seen that you wake up in the morning and suddenly your blood sugar goes up.
This is from the liver.
Also, berberine improves insulin sensitivity and helps clear up your sugar from the system.
(19:40):
Third, it goes your muscles and there are receptors.
It makes them upregulate them so they extract more glucose and burn it.
By improving insulin sensitivity and making your muscles more responsive to sugar, they lower your sugar.
Prevents aging.
(20:02):
What is aging? Senescent cells.
Lose vitality but still accumulate not recycled.
The difference between young and old? Old is a combination of senescent cells, activates, auto, do you get the same kind of effect when you do intermittent fasting or fasting and lot of other medications like.
(20:24):
Metformin is shown to prevent aging and also resveratrol in the red wine.
They all work through the same process of improving, rine makes muscles very responsive.
They extract more sugar from your system.
(20:45):
They lower your sugar and they're very effective.
Gut health.
This was the effect of which I never knew it since I start researching it and thank you to my patients because they educated me rather than me educating them.
Rine improved the inner lining of your gut cells, so you might have heard the leaky gut syndrome.
(21:10):
It improves that part further, it improves.
Good bugs in your gut.
The problem lies between good and bad bacteria and this help you to improve your good bacteria further.
All the chemicals these bacterias make, they decrease those harmful endotoxins and they help lower the inflammation and prevent.
(21:39):
Rine lowers your cholesterol.
Your liver makes 80% of the cholesterol and it is responsible recycling almost a hundred percent of the cycle.
The cholesterol, there is a process or a protein, which called PCSK nine, that is the one when the cholesterol is brought back from the circulation to the liver to destroy Berberine there and helps to remove excessive.
(22:06):
Cholesterol in the body.
Rine works on all the chemicals, whether it's interleukins, tumor, necrosis factor, and decreases the inflammation By affecting those processes, you lose weight, your heart improves, and your metabolic health improves.
(22:27):
This is a somatic, which I put together.
Works by boosting your metabolism through a MP mechanism.
It makes your cells more effective in using energy.
Lowers blood sugar through liver mechanisms.
It promotes cleaning up the old senescent unhealthy cells.
(22:49):
It makes your muscles more effective in picking up the sugar from the circulation.
And it lowers cholesterol, I honestly believe should be used properly.
The evidence is pretty decent in helping you decide whether you should use it or not.
(23:13):
It comes in a pills.
It's about 500 milligram pill taken two to three times a day.
Burberine doesn't get absorbed in the gut very quickly, so that's why you have to take two and three.
And if you combine with other supplements like milk thistle, improves absorption I hope I was able to convince you look into the science.
(23:35):
I'll provide.
More evidence like, share and subscribe to our channel and please do comment and I'll provide you more information in the comment section if you have.
Thank you very much.
Is bourbon really nature pic? This has been a theme in my office where multiple people asked me to explain my name is, and recently we had a live session regarding.
(24:04):
How to lower your cholesterol naturally and from comments and later on, the patient coming to the office, they asked this question, how does bourbon affect my sugar? This was a very intriguing question, and I have to plead my ignorance.
(24:26):
Being a physician, I was always into cutting edge medicine.
Looking at the evidence, never the natural part of medicine.
Recently creating YouTube videos, I figured out life is more than medicine and in the nature.
(24:46):
We have a lot of products which work pretty much either through the same chemical mechanisms or through indirect mechanism, and they produce, if not comparable, at least 50% of the effect of the medication.
Rine is not as effective as pic.
(25:12):
But it does what Ozempic can accomplish.
Rine goes to your liver and stops the conversion of fat and protein into glucose.
Number two, it goes to your muscles and make them pick up more sugar from blood sugar.
(25:34):
Pick up more blood sugar from the bloodstream and uses that energy.
Number three, it improves the insulin sensitive.
If you look at diabetes, these are the three problems which we have.
Insulin resistance, muscles not responding to pick up the sugar and.
(25:56):
We call it process gluconeogenesis, meaning your liver is converting your proteins and fats into glucose, and this processes keep on going and on.
Bine affects those processes.
It stops the conversion, it improves insulin sensitivity, and it makes muscle, both of them work through different mechanisms.
(26:21):
PIC works through GLP one, as it's the agonist of the receptors, and it improves the whole dynamics.
It leads to more insulin decreases glucagon level.
It goes to the brain and decreases appetite.
It goes to your stomach and shrinks it.
So I call it like a chemical gastric bypass.
(26:45):
It definitely goes to your brain and cut down your appetite, but it does not have anything to do with the GLP, but it has to do with improving insulin sensitivity.
Second, it also shutting down gluconeogenesis and also by improving your muscles, and those are the things which Ozempic doesn't do.
(27:08):
I had a patient who has been combining these two medications and he definitely significant synergistic results, his blood sugar and three month average blood sugar.
Hemoglobin A1C has been significantly down, so I would say safely is not as strong or potent as a pharmaceutical pic, but you could achieve.
(27:35):
About 15 to 20% of what Ozempic can do.
It'll cut down your appetite.
It'll do everything else in the body.
And if you combine with proper diabetic diet, exercise, manage your sleep and manage your stress, you definitely can achieve what Ozempic does in the body.
(27:59):
You could achieve it.
I hope this video was helpful.
My name is Dr.
Les and I'm a primary care physician for 27 years.
The goal of our channel is to simplify healthcare please share and comment thank you which they can, what needs to be done, which will lead to increased longevity of life being healthy.
(28:25):
Happy and full of energy that master switch in our metabolic pathway is A MPK.
All the pharmaceutical industries they are working towards to activate this.
A MPK switch is a metabolic switch.
Once a M PK gets stimulated, you have.
(28:49):
Everything what you want.
Your sugar goes down, cholesterol goes down, proteins are preserved.
Old senescent cells, are recycled and you're full of energy.
Your system works efficiently.
This metabolic switch is where Berberine works and activates a MP.
(29:14):
You might have heard there was a very famous book by Dr.
Sinclair where he describes health span and lifespan and all those processes.
And after his book, Metformin, people start out taking it left and right.
(29:35):
And also people who are not even alcoholics or they don't like to drink, they all start drinking.
Red wine because Redwine has the respiratory and metformin.
They all work on activating this A MPK switch and INE does it without any problems.
(29:58):
If you take ine, you could anticipate that your sugar will go down because.
It'll stop gluconeogenesis.
It will mobilize your stored fat and burn as energy, it makes your mitochondria more efficient so you're full of energy it improves insulin sensitivity.
(30:21):
Muscles become more sensitive.
Rine helps us to clear the old sensor cells, all the stored gunk in our body to get a recycle, and we become healthy and renate.
My name is Dr.
Les.
Our channel Les Mt.
Is dedicated to simplify healthcare information.
(30:44):
Please share and subscribe to our channel.
I will see you in one of our next videos.
Thank you.
Hello, this is Dr.
And I'm a primary care physician For the last 27 years, I have many patients who have polycystic ovarian syndrome and they are either intolerant of metformin or they want to take it, and they were looking for, and I'm happy to report now we have.
(31:12):
Which works naturally in your body and could be as effective the biggest process is insulin resistance.
Anything which can lower insulin resistance will be helpful in this polycystic ovarian disease.
It is a very complicated disease and has been a big problem for our healthcare and especially.
(31:36):
When patients do not want medications, in polycystic ovarian disease you are glucose intolerant have insulin resistance that leads to weight gain and missing periods, and the periods are atory.
Rine works on the metabolic pathways that it shut down gluconeogenesis.
(31:59):
A process innovates your fats and protein gets converted into sugar.
Number two, it makes your muscles very sensitive and pick up the sugar and use it for energy.
Number three, it decreases insulin resistance.
So by doing these three processes, it could be a alternative and it helps you to take care of some symptoms.
(32:27):
Polycystic ovarian syndrome.
Nobody has done any head-to-head trial comparing berberine with metformin, but this Burberine has a use for the ladies who do not want to take Mefor or cannot take the Mefor.
This is a good natural replacement, which you could use.
(32:49):
Share and subscribe to our channel md.
I will see you one of our next videos.
Thank you very much.
About 30% of the patient who have high cholesterol cannot take cholesterol medications, cannot take statins, and they are really have.
(33:09):
Hello, this is Dr.
I've been a primary care physician.
In one of the estimation, about 15 to 20% of the patients who have high cholesterol and they meet all clinical guidelines of needing cholesterol medication.
They cannot take medication because of side effects, or are psychologically reluctant push how we could control cholesterol with natural methods.
(33:39):
We had a YouTube live session last week and we had a significant interest in this topic from our patients, and I got questions about Burberine, how it can lower cholesterol.
Rine is alk, used in India.
In Ayurvedic medicine for centuries, for health reasons, especially decreasing chronic inflammation and sometime as an antibiotics are for the anti infectious agent.
(34:12):
Cholesterol is a very tricky 80% of cholesterol, in your blood is made by the liver, your diet contributes only 20%.
So liver is the main action.
Certain chemical processes are triggered by bad habits, whether we are eating too much of process meats and process food, which hijack our normal homeostatic mechanism.
(34:40):
Body has infinite wisdom where it controls how much cholesterol should make from the.
And how much it should absorb from the cholesterol and how much cholesterol it should absorb from the gut.
But when we start consuming this process meats, increased salt additives, and also simple sugar, hijacks the body's intelligence.
(35:09):
And shift everything to our producing increased bad cholesterol or the LDL cholesterol.
Cholesterol is needed to make every cell.
The cell membrane is made up of cholesterol.
It is used to make hormone vitamin D to digest your food.
It has a lot of function, but the excessive cholesterol.
(35:32):
Which we have hijacked our physiology, gets dumped into blood and gets into our arteries and clogger them up.
That is the bad one, which happens.
Then there is another kind of a cholesterol, which we call good cholesterol, HDL cholesterol, which brings the cholesterol back from the body into the liver to recycle it, destroy it, and when it brings it back.
(36:00):
This cholesterol needs to be picked up by the receptors and for those receptors then in Gulf, this brought back cholesterol and do what they're supposed to do.
There is a protein, PSK nine.
That receptor is responsible.
How many receptors are available to accept cholesterol ine X it inhibits PCSK nine and that's how it increases the receptor activity and lower the cholesterol.
(36:31):
You know the net there is a medication which few of you might have called Repatha, that is about $1,400 every two weeks.
And this medication probably couple of hundred dollars.
The rented pharmaceutically produced medication.
(36:53):
It's probably a hundred times more potent versus this one.
But if you combine with good dietary habit, exercise, sleep, managing your stress, and you have this process working for you, you lower your cholesterol normally.
Further, it decreases the production of LDL cholesterol, triglycerides, and total cholesterol like statins.
(37:20):
It promotes the endothelial function, the inner lining of the your arteries via production of nit oxide.
You might have heard whenever you have a heart problem, doctor give you nitroglycerin.
This promotes natural or release of nitroglycerin by your endothelial cells.
(37:40):
It is a viable option in patients who are intolerant to.
Statins.
Other things which you could do, as I mentioned, diet, exercise, sleep, rest, and managing your stress.
Please watch our other video regarding how to lower your cholesterol naturally.
(38:02):
Red is rise is very effective.
We have another video on red rice and how you could use it to lower your cholesterol.
It definitely is scientific.
It evidence is pretty decent regarding this use.
It is not replacement for pharmacological therapy, but people who are intolerant of statins and they cannot afford this expensive PCSK nine inhibitor medication.
(38:32):
Let's combine our lifestyle change plus this one to help lower your cholesterol.
Thank you very much like and subscribe to our channel see you in our next videos.
Can one natural compound help with controlling diabetes, lowering our cholesterol, lowering our blood pressure, losing weight? Yes.
(38:56):
In modern medicine, there are natural supplements which could accomplish everything.
Let me introduce you to INE and its metabolic effects.
It affects glucose metabolism, INE affects carbohydrate, metabolism, fat metabolism.
(39:17):
Protein metabolism, it affects your gut health.
Let's all explore how this natural supplement can help us achieve all these.
Now, utopian goals by bottom medicine type two diabetes colitis bring can reduce your fasting blood sugar by 20 to 30 points on an average 0.9%
(39:45):
drop off your hemoglobin A1C over the period of three to six months.
On average different classes of diabetic medication on an average other than insulin and diet and exercise, lead to 0.75%
drop in hemoglobin A1C in my experience.
(40:09):
Though it's limited and my personal medication armar, I've seen this.
Point nine is almost comes through high cholesterol.
Can reduce your bad cholesterol or LDL cholesterol by 20 to 50%.
It can decrease your triglycerides by another 15 and 20%.
(40:32):
The way it works is it inhibits PSKP, it inhibits PCSK nine gene expression.
Those are the one which lead to more LDL receptors, and they could pick up more para cholesterol from your circulation in the liver, recirculate reuse them, and lower your LD cholesterol.
(40:56):
Patha.
The medication which pharmaceutically produced which inhibitor PSK nine gene expression costs about $1,400 for dose, and this one can help you to lower natural.
It is not as effective ASIC because I've been asked by many patients this.
(41:17):
Rine is modern day ozempic.
In my experience in large of literature search, I did not find it to be true, but you could expect four to five kgs of weight loss, if you're doing everything else and you start doing this is addendum and synergistic.
It'll help you a lot further in fatty liver disease, N-A-F-L-D.
(41:44):
Non acholic fatty liver disease.
This has been very effective and there is a lot of data that it reduces or decreases liver enzymes.
It does.
By improving glucose.
It does by improving insulin sensitivity, and it also acts as an antioxidant in polycystic ovarian disease.
(42:08):
It lowers sugar, improves insulin sensitivity.
And it has been very effective in helping you with the same.
Further, it improve your gut microbiome.
There is not a medical literature.
There is not a medical article.
(42:30):
Without talking about gut microbiome, what we know is it alters the gut microbiome towards what it should be, in your gut, you have trillions of bacteria viruses and fungi.
They're living inside you, and there is a competition and ratio of species.
(42:53):
Studies found perine brain alters towards the normal metabolic way it should be.
That reduces inflammatory load.
It improves your mental health.
It improves to decrease your activity.
You all have heard the condition, sibo, A BS, and diarrhea, and they have found that people who have been on antibody for a long time supplement can help you a lot further.
(43:23):
It has also been tried in people who already have dementia.
They're progressing toward dementia, so the research is already going on in Alzheimer's disease and Parkinson's disease.
It also has some anti-cancer drug because it improves artage that you clear the old senescent dirty cells, which are there are making you old.
(43:54):
But there is no trial data available, but it has been tried.
And has been shown to be helpful.
It definitely known to modulate our immune system.
All the chemicals which we have in the immune system, they go down and your inflammation goes down.
So in nutshell, it affects your liver, skeletal muscle, adipose tissue, your pancreas, your hypoth, your heart, your endothelial cells.
(44:25):
It is affecting.
Everything so clinically it has a use in diabetes, polycystic ovarian disease, high cholesterol, weight management, gut inflammation, and longevity.
That's a pretty impressive resume for a supplement.
I have to plead my ignorance that being a physician, I was not up to date on naturally occurring compounds.
(44:52):
Thanks to YouTube and my patients, since I start creating YouTube videos, it has made me think different, read more read in a holistic way, because not everybody wants to take the medications, we prescribe.
If we could have a good lifestyle, no matter which disease you pick, these themes will come over and over.
(45:20):
Eat ballast diet, which is primarily plant-based quality, fat, quality protein, whole grains legumes fruits and vegetables, and exercise, 30 minutes, five times a week, preferably seven.
Sleep seven to eight hours.
(45:41):
Manage your stress.
Have good relationship with yourself and with others.
They all have shown to improve your health.
If we have a hold of our lifestyle and we're living a good conscious life and you add these supplements, I think combination could be very powerful.
(46:05):
I am not.
Preaching that we could replace pharmacological treatment.
For patients who do not want to take the medications or they're intolerant, I think this is a definitely a valid choice.
This is Dr.
And I am signing up from this video and I will see you in our next videos.
Hello, this is Dr.
Meatless.
Today I will reveal one supplement with eight powerful metabolic effects on proteins, fats, glucose and weight metabolism.
It is as good as natural ozempic.
(00:20):
We will be discussing Burberry.
Fortunately, I have been creating a lot of videos regarding cholesterol, and thanks to my patients who brought this gem of alternative medicine to my attention as a physician.
For last 27 years, I have been ignoring food, nutrition supplements, spices, and.
(00:47):
Since I started making YouTube video and interact with my patients on daily basis, they requested me to create a video about Burberry thanks to them, and it is dedicated to them.
What is Bur brain and I want to make sure that you understand.
(01:07):
I have spent a lot of time and I will present you the evidence.
Which has got a high certainty and you could count, you are getting evidence-based medicine and you could count that you're getting evidence-based information.
What is brine? Bourbon is a alkaloid or a sap coming from a plant.
(01:33):
Bures, Burgar, and this plant is unique.
It has.
Golden yellow flowers and also very powerful, which nature has given us.
Traditionally, this has been used in Ayurvedic medicine and Chinese medicine to treat infections and inflammation in modern medicine.
(01:59):
Now, since we have pretty much maximized the medications and there is a lot of push.
People are exploring alternative ways, and then now there is some money going into research to find out this natural products which exist, and if we incorporate into our day-to-day activities and food and nutrition, it can help.
(02:26):
We are interested how bourbon can help to control our metabolic health, blood sugar, cholesterol, and fat.
It is bright yellow the way it works, has a lot of chemical pathways.
It activates E-M-P-P-K.
That's a master switch.
The mitochondria, which are the energy powerhouse of each cell in you, and you are made up about 60 to 70 trillion cells that it affects you there.
(02:56):
It controls glucose metabolism, how much sugar muscles pick it up from your blood sugar, and also how much liver it's gonna make.
It also promotes art Fiji.
That all the gunk and the dead material, which we have collected in our body, it cleans it up and it improves our vitality and we feel good and we prevent caging and we live long.
(03:25):
Then it also enhances the muscles, which I have explained to pick up more glucose.
Above all, it improves gut microbiome and the inner lining of your gut.
That way it prevents a lot of infin, bowel disease, inflammation, and it's directly related to metabolic health.
(03:47):
It is like PCSK nine medication, which is very powerful to help your lower cholesterol, and inflammation.
This is the chart.
Which is a simplified version where it explains everything, how this thing works.
(04:10):
This is the chart where it explains how different organ systems get involved.
Let's dive deep into that first metabolism.
Remember I told you that body has a metabolic switch, which called A MBK.
All the anti-aging medications, research is geared towards how we could activate A MPK and your burp brain.
(04:37):
Does that naturally think A MPK as a body's fat burning switch, when A MPK gets activated, you start burning fat.
So I'm not saying that this is a panacea.
What I'm saying is these are the mechanisms.
We should explore and we should incorporate into our day-to-day life.
(05:00):
Further.
Also help you to convert this fat into energy so you feel more active, more vital, and you are more full of vitality.
How switching metabolism, promotes energy mitochondria become more efficient so that they start burning the fuel and you feel much, much better, and you start improving.
(05:29):
Berberine is known to lower your sugar.
It does by two things.
Number one, it makes your muscle pick up all the blood sugar from your blood.
Also, it promotes your liver to stop the process of conversion proteins and fats into sugar.
(05:49):
You might have a normal experience if you're diabetic, that you wake up in the morning, you have not eaten, and your blood sugar is high.
Your liver is converting your fat and protein into sugar, and berberine stops that berberine prevents aging? In aging? All these senescent cells and all the dead cells, they're just not cleaned out of the body.
(06:14):
They're just getting piled up, accumulated, leading to degenerative diseases, and by signaling the pathways, it cleans up the old gunk.
And your body becomes rejuvenated, revitalizes, and it improves.
I have went over in detail that it stimulates the receptors in the muscles.
(06:40):
They pick up sugar from the blood and then your blood sugar goes down and so all the complications of diabetes.
It's especially modern for gut health.
What it does is the inner lining of the cell, which we, there is a lot of interest in leaky gut syndrome or sibo.
(07:01):
It heals you further, it also promotes the good gut bacteria growth.
So once your gut is healthy, your mind is healthy, your mood is better, and you have lower metabolic.
Inflammation.
Is very effective in lowering cholesterol.
(07:23):
In cholesterol metabolism.
There are two parts to it.
Number one, liver is the which makes 80% of the cholesterol.
Then when the cholesterol gets released, whatever is used, that's taken the circulation, the extra cholesterol gets.
It's clogging up our arteries and our HDL cholesterol bring the bad, cholesterol back for recirculation reuse or destruction, the receptors which enable liver to pick up this extra cholesterol or bad cholesterol coming to the liver depends on PSK C.
(08:05):
PCSK protein and stimulates that.
Improving.
Cleaning up your extra cholesterol in the body.
Berberrine is very effective in lowering your cholesterol.
Berberrine decreases inflammation.
All the inflammatory markers, it reduces the production of them.
(08:29):
Inflammation goes down, pain goes down, chronic diseases down.
This is the buzz line is brine really natures ozempic and my honest view is this.
Ozempic is a very powerful drug and they both work on different places.
Ozempic works on a GLP receptors in the body and they improve your insulin, they decrease the stomach size.
(09:01):
They've improved the society, so it does everything that your sugar goes down.
Whereas Rine activates a MPK system and then it also it decreases the appetite.
So Ozempic, it's a halfway there.
They both decrease your appetite, but it is not as powerful as Ozempic, but.
(09:26):
If you combine them, I think the effect will be synergistic.
And I'm answering this question particularly to one of my patients who has been combining it, both of them, and he has a very good result and good part is he does not have any significant side effects.
The major side effects of bine is gi, nausea, vomiting, diarrhea.
(09:51):
Those things can happen.
And if you're pregnant and.
Breastfeeding.
You should not use any berberine products.
Berberine.
These are the kind of a mechanisms which have went over already, like how it increases this healing or metabolic pathways is all these parts.
(10:15):
Promotes liver to produce good cholesterol.
Destroy bad cholesterol, stop conversion of fat and protein into glucose.
Makes muscles to pick up more sugar out of your blood, and that way these are the all the proper ways you are having.
(10:37):
This is another concept, which is very important that how Burberine helps nutrition, partitioning muscle versus fat.
See what happens when we eat the sugar, which gets into circulation.
It has two phase, okay? It can be used as energy by cells, especially our muscle cells, or it could be stored fat by improving MPK.
(11:05):
Pathway, it pushes the sugar into muscles so that they could burn it.
There is lesser fat and you lose weight.
The reason we use in polycystic ovarian syndrome How to take berberine.
Comes in.
(11:25):
Tablets and capsule each is about 500 and it's recommended take two to three times a day.
This berberine does not get absorbed from the gut quickly.
That's the reason you have to combine it with some other products.
We all might have heard milk thistle.
Combined which is in milk thistle.
(11:48):
They promote.
The absorption of usually it's recommended take for six to eight weeks, then stop for two weeks, and then circle back these are new supplements and they are trying to limit the side effects.
Can help you lose weight? Yes.
(12:09):
The research is very clear that it can help you to lose.
About on average four to five pounds in 12 weeks.
These are the different clinical uses, which we will go over so now comes in is point.
Can Rine, can berberrine help you lose weight? It definitely can help you lose weight.
(12:32):
In a clinical trial there was two to five kgs, but that's what, four to 10 pounds.
It improves all metabolic pathways.
Mobilizes fat does not let the fat deposition.
It makes muscle pickup more sugar, and above all, it decreases inflammation decreases appetite and helps.
(12:53):
Can you make berberine naturally? No.
Berberine only exists from the berry plant.
It acts as antimicrobial and it helps to promote normal gut flora.
It also decreases all the harm chemicals.
(13:14):
What these bacterias make, it improves the function of gut lining and also improves all the functions so that your gut is not leaking.
Can be used as a alternative to Metformin in these studies, which I could get? They have tried that and they were successful.
(13:35):
Trials positive, but I cannot make the recommendation replace one over the other.
But definitely improves insulin sensitivity, and by improving insulin sensitivity, it does improve symptoms of PCOS, and it could be either replaced or could be used with Metformin.
(13:56):
Lowers bad cholesterol.
Decreases triglycerides and total cholesterol.
It inhibits PCSK that's why more bad cholesterol could be picked up by receptors in the liver and lower your cholesterol.
And also it improves the function of inner lining of your blood vessels.
(14:18):
It is very good alternative in patients who are statin intolerant.
Safety and side effects.
Common side effects are gi, constipation and cramping.
We should not combine it with blood thinners and certain blood sugar lowering medications.
(14:40):
Pregnant women and breastfeeding and infant are absolutely contraindication.
It is recommended that people who are taking long term, they should have.
Liver sugar and cholesterol tested every six months to a year.
I have no formal recommendation way to buy.
My goal was to help you get the science behind this thing, but these are the good resources which I was able to find in nutshell.
(15:11):
Burberine could be helpful in treating type two diabetes, neuritis, polycystic ovarian syndrome.
High cholesterol, weight metabolism, weight loss, metabolic syndrome, gut information, and anti-aging.
I hope this video was helpful and informational.
My name is Dr.
(15:32):
KLEs signing off, and I will see you in next video.
Like here and subscribe to our channel Less md.
Thank you very much for your attention and thank you for my all patients who have been very helpful in getting my attention to these natural supplements and ingredients.
Thank you.
(15:53):
Blin is a alkaloid or a product for a SAP from a plant, which is called Bures Bulgaris.
This is used, this has been used for centuries in AIC medicines in India and Chinese medicine.
I've been a physician since 1997.
(16:16):
Because we are so wrapped up into disease medicines, I was not really up to these natural supplements, spices.
What are the effects and how if we could incorporate into our day to day routines, habits, food, how they can improve metabolic health by almost.
(16:42):
20 to 30% take any allopathic medication they're usually affecting in cutting down any kind of process, which they're intended for by 50%.
But if these natural supplements like Perrine, we incorporate their into a daily life, we are getting 15 to 20%.
(17:04):
And if we start exercising, eating right, managing stress, we believe we will manage without medications.
Let's dive into what Bine is and what when we do for how the, what's the mechanism of action.
These are the different places where Bine works and they are very important.
(17:29):
These are eight different metabolic places where it works.
I have deliberately not going over the this.
Process and boring you.
I'm gonna elaborate them these processes one by one, so that you understand that part how bur brain promotes metabolic health in your body.
(17:50):
In a metabolic health, there is a classic switch or a very rate limiting process, which is A MPK.
Once we activate this process.
Your body becomes a fuel consuming retic machine.
(18:14):
Bur brain acts on this metabolic switch and activates it and you start burning fat.
More effectively.
So whether that does it for same number of calories, ineffectively burn.
Versus effectively born, you are full of energy, you are strong, you're healthy.
(18:35):
Burberine also improves your energy efficiency.
The way it works out is in everybody's cells, there are energy powerhouses, which are mitochondria, and it improves how these chemical processes are taken care.
They become smarter, they become faster.
(18:56):
They not only burn excessive fuel, but are very effective.
Lowers your sugar that it works through two mechanisms.
Number one, your liver has a capacity to convert your fats and proteins into sugar and goes and stop that process.
(19:20):
You might have very notoriously seen that you wake up in the morning and suddenly your blood sugar goes up.
This is from the liver.
Also, berberine improves insulin sensitivity and helps clear up your sugar from the system.
(19:40):
Third, it goes your muscles and there are receptors.
It makes them upregulate them so they extract more glucose and burn it.
By improving insulin sensitivity and making your muscles more responsive to sugar, they lower your sugar.
Prevents aging.
(20:02):
What is aging? Senescent cells.
Lose vitality but still accumulate not recycled.
The difference between young and old? Old is a combination of senescent cells, activates, auto, do you get the same kind of effect when you do intermittent fasting or fasting and lot of other medications like.
(20:24):
Metformin is shown to prevent aging and also resveratrol in the red wine.
They all work through the same process of improving, rine makes muscles very responsive.
They extract more sugar from your system.
(20:45):
They lower your sugar and they're very effective.
Gut health.
This was the effect of which I never knew it since I start researching it and thank you to my patients because they educated me rather than me educating them.
Rine improved the inner lining of your gut cells, so you might have heard the leaky gut syndrome.
(21:10):
It improves that part further, it improves.
Good bugs in your gut.
The problem lies between good and bad bacteria and this help you to improve your good bacteria further.
All the chemicals these bacterias make, they decrease those harmful endotoxins and they help lower the inflammation and prevent.
(21:39):
Rine lowers your cholesterol.
Your liver makes 80% of the cholesterol and it is responsible recycling almost a hundred percent of the cycle.
The cholesterol, there is a process or a protein, which called PCSK nine, that is the one when the cholesterol is brought back from the circulation to the liver to destroy Berberine there and helps to remove excessive.
(22:06):
Cholesterol in the body.
Rine works on all the chemicals, whether it's interleukins, tumor, necrosis factor, and decreases the inflammation By affecting those processes, you lose weight, your heart improves, and your metabolic health improves.
(22:27):
This is a somatic, which I put together.
Works by boosting your metabolism through a MP mechanism.
It makes your cells more effective in using energy.
Lowers blood sugar through liver mechanisms.
It promotes cleaning up the old senescent unhealthy cells.
(22:49):
It makes your muscles more effective in picking up the sugar from the circulation.
And it lowers cholesterol, I honestly believe should be used properly.
The evidence is pretty decent in helping you decide whether you should use it or not.
(23:13):
It comes in a pills.
It's about 500 milligram pill taken two to three times a day.
Burberine doesn't get absorbed in the gut very quickly, so that's why you have to take two and three.
And if you combine with other supplements like milk thistle, improves absorption I hope I was able to convince you look into the science.
(23:35):
I'll provide.
More evidence like, share and subscribe to our channel and please do comment and I'll provide you more information in the comment section if you have.
Thank you very much.
Is bourbon really nature pic? This has been a theme in my office where multiple people asked me to explain my name is, and recently we had a live session regarding.
(24:04):
How to lower your cholesterol naturally and from comments and later on, the patient coming to the office, they asked this question, how does bourbon affect my sugar? This was a very intriguing question, and I have to plead my ignorance.
(24:26):
Being a physician, I was always into cutting edge medicine.
Looking at the evidence, never the natural part of medicine.
Recently creating YouTube videos, I figured out life is more than medicine and in the nature.
(24:46):
We have a lot of products which work pretty much either through the same chemical mechanisms or through indirect mechanism, and they produce, if not comparable, at least 50% of the effect of the medication.
Rine is not as effective as pic.
(25:12):
But it does what Ozempic can accomplish.
Rine goes to your liver and stops the conversion of fat and protein into glucose.
Number two, it goes to your muscles and make them pick up more sugar from blood sugar.
(25:34):
Pick up more blood sugar from the bloodstream and uses that energy.
Number three, it improves the insulin sensitive.
If you look at diabetes, these are the three problems which we have.
Insulin resistance, muscles not responding to pick up the sugar and.
(25:56):
We call it process gluconeogenesis, meaning your liver is converting your proteins and fats into glucose, and this processes keep on going and on.
Bine affects those processes.
It stops the conversion, it improves insulin sensitivity, and it makes muscle, both of them work through different mechanisms.
(26:21):
PIC works through GLP one, as it's the agonist of the receptors, and it improves the whole dynamics.
It leads to more insulin decreases glucagon level.
It goes to the brain and decreases appetite.
It goes to your stomach and shrinks it.
So I call it like a chemical gastric bypass.
(26:45):
It definitely goes to your brain and cut down your appetite, but it does not have anything to do with the GLP, but it has to do with improving insulin sensitivity.
Second, it also shutting down gluconeogenesis and also by improving your muscles, and those are the things which Ozempic doesn't do.
(27:08):
I had a patient who has been combining these two medications and he definitely significant synergistic results, his blood sugar and three month average blood sugar.
Hemoglobin A1C has been significantly down, so I would say safely is not as strong or potent as a pharmaceutical pic, but you could achieve.
(27:35):
About 15 to 20% of what Ozempic can do.
It'll cut down your appetite.
It'll do everything else in the body.
And if you combine with proper diabetic diet, exercise, manage your sleep and manage your stress, you definitely can achieve what Ozempic does in the body.
(27:59):
You could achieve it.
I hope this video was helpful.
My name is Dr.
Les and I'm a primary care physician for 27 years.
The goal of our channel is to simplify healthcare please share and comment thank you which they can, what needs to be done, which will lead to increased longevity of life being healthy.
(28:25):
Happy and full of energy that master switch in our metabolic pathway is A MPK.
All the pharmaceutical industries they are working towards to activate this.
A MPK switch is a metabolic switch.
Once a M PK gets stimulated, you have.
(28:49):
Everything what you want.
Your sugar goes down, cholesterol goes down, proteins are preserved.
Old senescent cells, are recycled and you're full of energy.
Your system works efficiently.
This metabolic switch is where Berberine works and activates a MP.
(29:14):
You might have heard there was a very famous book by Dr.
Sinclair where he describes health span and lifespan and all those processes.
And after his book, Metformin, people start out taking it left and right.
(29:35):
And also people who are not even alcoholics or they don't like to drink, they all start drinking.
Red wine because Redwine has the respiratory and metformin.
They all work on activating this A MPK switch and INE does it without any problems.
(29:58):
If you take ine, you could anticipate that your sugar will go down because.
It'll stop gluconeogenesis.
It will mobilize your stored fat and burn as energy, it makes your mitochondria more efficient so you're full of energy it improves insulin sensitivity.
(30:21):
Muscles become more sensitive.
Rine helps us to clear the old sensor cells, all the stored gunk in our body to get a recycle, and we become healthy and renate.
My name is Dr.
Les.
Our channel Les Mt.
Is dedicated to simplify healthcare information.
(30:44):
Please share and subscribe to our channel.
I will see you in one of our next videos.
Thank you.
Hello, this is Dr.
And I'm a primary care physician For the last 27 years, I have many patients who have polycystic ovarian syndrome and they are either intolerant of metformin or they want to take it, and they were looking for, and I'm happy to report now we have.
(31:12):
Which works naturally in your body and could be as effective the biggest process is insulin resistance.
Anything which can lower insulin resistance will be helpful in this polycystic ovarian disease.
It is a very complicated disease and has been a big problem for our healthcare and especially.
(31:36):
When patients do not want medications, in polycystic ovarian disease you are glucose intolerant have insulin resistance that leads to weight gain and missing periods, and the periods are atory.
Rine works on the metabolic pathways that it shut down gluconeogenesis.
(31:59):
A process innovates your fats and protein gets converted into sugar.
Number two, it makes your muscles very sensitive and pick up the sugar and use it for energy.
Number three, it decreases insulin resistance.
So by doing these three processes, it could be a alternative and it helps you to take care of some symptoms.
(32:27):
Polycystic ovarian syndrome.
Nobody has done any head-to-head trial comparing berberine with metformin, but this Burberine has a use for the ladies who do not want to take Mefor or cannot take the Mefor.
This is a good natural replacement, which you could use.
(32:49):
Share and subscribe to our channel md.
I will see you one of our next videos.
Thank you very much.
About 30% of the patient who have high cholesterol cannot take cholesterol medications, cannot take statins, and they are really have.
(33:09):
Hello, this is Dr.
I've been a primary care physician.
In one of the estimation, about 15 to 20% of the patients who have high cholesterol and they meet all clinical guidelines of needing cholesterol medication.
They cannot take medication because of side effects, or are psychologically reluctant push how we could control cholesterol with natural methods.
(33:39):
We had a YouTube live session last week and we had a significant interest in this topic from our patients, and I got questions about Burberine, how it can lower cholesterol.
Rine is alk, used in India.
In Ayurvedic medicine for centuries, for health reasons, especially decreasing chronic inflammation and sometime as an antibiotics are for the anti infectious agent.
(34:12):
Cholesterol is a very tricky 80% of cholesterol, in your blood is made by the liver, your diet contributes only 20%.
So liver is the main action.
Certain chemical processes are triggered by bad habits, whether we are eating too much of process meats and process food, which hijack our normal homeostatic mechanism.
(34:40):
Body has infinite wisdom where it controls how much cholesterol should make from the.
And how much it should absorb from the cholesterol and how much cholesterol it should absorb from the gut.
But when we start consuming this process meats, increased salt additives, and also simple sugar, hijacks the body's intelligence.
(35:09):
And shift everything to our producing increased bad cholesterol or the LDL cholesterol.
Cholesterol is needed to make every cell.
The cell membrane is made up of cholesterol.
It is used to make hormone vitamin D to digest your food.
It has a lot of function, but the excessive cholesterol.
(35:32):
Which we have hijacked our physiology, gets dumped into blood and gets into our arteries and clogger them up.
That is the bad one, which happens.
Then there is another kind of a cholesterol, which we call good cholesterol, HDL cholesterol, which brings the cholesterol back from the body into the liver to recycle it, destroy it, and when it brings it back.
(36:00):
This cholesterol needs to be picked up by the receptors and for those receptors then in Gulf, this brought back cholesterol and do what they're supposed to do.
There is a protein, PSK nine.
That receptor is responsible.
How many receptors are available to accept cholesterol ine X it inhibits PCSK nine and that's how it increases the receptor activity and lower the cholesterol.
(36:31):
You know the net there is a medication which few of you might have called Repatha, that is about $1,400 every two weeks.
And this medication probably couple of hundred dollars.
The rented pharmaceutically produced medication.
(36:53):
It's probably a hundred times more potent versus this one.
But if you combine with good dietary habit, exercise, sleep, managing your stress, and you have this process working for you, you lower your cholesterol normally.
Further, it decreases the production of LDL cholesterol, triglycerides, and total cholesterol like statins.
(37:20):
It promotes the endothelial function, the inner lining of the your arteries via production of nit oxide.
You might have heard whenever you have a heart problem, doctor give you nitroglycerin.
This promotes natural or release of nitroglycerin by your endothelial cells.
(37:40):
It is a viable option in patients who are intolerant to.
Statins.
Other things which you could do, as I mentioned, diet, exercise, sleep, rest, and managing your stress.
Please watch our other video regarding how to lower your cholesterol naturally.
(38:02):
Red is rise is very effective.
We have another video on red rice and how you could use it to lower your cholesterol.
It definitely is scientific.
It evidence is pretty decent regarding this use.
It is not replacement for pharmacological therapy, but people who are intolerant of statins and they cannot afford this expensive PCSK nine inhibitor medication.
(38:32):
Let's combine our lifestyle change plus this one to help lower your cholesterol.
Thank you very much like and subscribe to our channel see you in our next videos.
Can one natural compound help with controlling diabetes, lowering our cholesterol, lowering our blood pressure, losing weight? Yes.
(38:56):
In modern medicine, there are natural supplements which could accomplish everything.
Let me introduce you to INE and its metabolic effects.
It affects glucose metabolism, INE affects carbohydrate, metabolism, fat metabolism.
(39:17):
Protein metabolism, it affects your gut health.
Let's all explore how this natural supplement can help us achieve all these.
Now, utopian goals by bottom medicine type two diabetes colitis bring can reduce your fasting blood sugar by 20 to 30 points on an average 0.9%
(39:45):
drop off your hemoglobin A1C over the period of three to six months.
On average different classes of diabetic medication on an average other than insulin and diet and exercise, lead to 0.75%
drop in hemoglobin A1C in my experience.
(40:09):
Though it's limited and my personal medication armar, I've seen this.
Point nine is almost comes through high cholesterol.
Can reduce your bad cholesterol or LDL cholesterol by 20 to 50%.
It can decrease your triglycerides by another 15 and 20%.
(40:32):
The way it works is it inhibits PSKP, it inhibits PCSK nine gene expression.
Those are the one which lead to more LDL receptors, and they could pick up more para cholesterol from your circulation in the liver, recirculate reuse them, and lower your LD cholesterol.
(40:56):
Patha.
The medication which pharmaceutically produced which inhibitor PSK nine gene expression costs about $1,400 for dose, and this one can help you to lower natural.
It is not as effective ASIC because I've been asked by many patients this.
(41:17):
Rine is modern day ozempic.
In my experience in large of literature search, I did not find it to be true, but you could expect four to five kgs of weight loss, if you're doing everything else and you start doing this is addendum and synergistic.
It'll help you a lot further in fatty liver disease, N-A-F-L-D.
(41:44):
Non acholic fatty liver disease.
This has been very effective and there is a lot of data that it reduces or decreases liver enzymes.
It does.
By improving glucose.
It does by improving insulin sensitivity, and it also acts as an antioxidant in polycystic ovarian disease.
(42:08):
It lowers sugar, improves insulin sensitivity.
And it has been very effective in helping you with the same.
Further, it improve your gut microbiome.
There is not a medical literature.
There is not a medical article.
(42:30):
Without talking about gut microbiome, what we know is it alters the gut microbiome towards what it should be, in your gut, you have trillions of bacteria viruses and fungi.
They're living inside you, and there is a competition and ratio of species.
(42:53):
Studies found perine brain alters towards the normal metabolic way it should be.
That reduces inflammatory load.
It improves your mental health.
It improves to decrease your activity.
You all have heard the condition, sibo, A BS, and diarrhea, and they have found that people who have been on antibody for a long time supplement can help you a lot further.
(43:23):
It has also been tried in people who already have dementia.
They're progressing toward dementia, so the research is already going on in Alzheimer's disease and Parkinson's disease.
It also has some anti-cancer drug because it improves artage that you clear the old senescent dirty cells, which are there are making you old.
(43:54):
But there is no trial data available, but it has been tried.
And has been shown to be helpful.
It definitely known to modulate our immune system.
All the chemicals which we have in the immune system, they go down and your inflammation goes down.
So in nutshell, it affects your liver, skeletal muscle, adipose tissue, your pancreas, your hypoth, your heart, your endothelial cells.
(44:25):
It is affecting.
Everything so clinically it has a use in diabetes, polycystic ovarian disease, high cholesterol, weight management, gut inflammation, and longevity.
That's a pretty impressive resume for a supplement.
I have to plead my ignorance that being a physician, I was not up to date on naturally occurring compounds.
(44:52):
Thanks to YouTube and my patients, since I start creating YouTube videos, it has made me think different, read more read in a holistic way, because not everybody wants to take the medications, we prescribe.
If we could have a good lifestyle, no matter which disease you pick, these themes will come over and over.
(45:20):
Eat ballast diet, which is primarily plant-based quality, fat, quality protein, whole grains legumes fruits and vegetables, and exercise, 30 minutes, five times a week, preferably seven.
Sleep seven to eight hours.
(45:41):
Manage your stress.
Have good relationship with yourself and with others.
They all have shown to improve your health.
If we have a hold of our lifestyle and we're living a good conscious life and you add these supplements, I think combination could be very powerful.
(46:05):
I am not.
Preaching that we could replace pharmacological treatment.
For patients who do not want to take the medications or they're intolerant, I think this is a definitely a valid choice.
This is Dr.
And I am signing up from this video and I will see you in our next videos.
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