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September 20, 2025 4 mins
Welcome back to Ozempic Weightloss Unlocked, the podcast where we dive into the latest news and analysis about one of the most talked-about treatments for weight loss and metabolic health.

Let us jump right in with some breaking research. According to The Lancet Diabetes and Endocrinology, new clinical trial data shows that a triple-dose of Ozempic, meaning 7.2 milligrams weekly, resulted in almost nineteen percent average weight loss in adults without diabetes. That is a substantial jump compared to the sixteen percent with the standard 2.4 milligram dose, and only around four percent with a placebo. Nearly half of those on the higher dose lost at least twenty percent of their body weight, and a third saw weight reductions of twenty-five percent or more. Even among adults with type 2 diabetes, the higher dose achieved thirteen percent weight loss, compared to ten percent with the lower dose. Waistlines, blood pressure, blood sugar, and cholesterol all improved on the higher dose. Safety remained solid, with the most common side effects being manageable nausea and diarrhea that usually settled down over time. Importantly, there was no increase in serious adverse events.

Now, for lifestyle impacts and long-term use. A population-wide study presented at the European Association for the Study of Diabetes reports that half of people who start Ozempic for weight loss stop taking it within a year. Cost is a major factor, with the lowest dose costing around two thousand Euros a year in some areas. Younger adults and people from lower income neighborhoods were far more likely to discontinue, likely due to financial barriers. Adverse effects like nausea, and pre-existing conditions, played a role as well. The study found that men were more likely to stop early than women, and adherence was especially hard for those with a history of psychiatric conditions or chronic illness. That is concerning, since people with these conditions often need the benefits the most. Once people stop the medication, weight is often regained, showing just how important it is to find sustainable approaches to weight management.

On the topic of who benefits most, a study in Frontiers in Clinical Diabetes and Healthcare highlighted that emotional eating can reduce the effectiveness of Ozempic. The medication is best for people who overeat due to external cues like the smell or appearance of food, rather than for those who eat in response to boredom, anxiety, or sadness. Health experts now recommend that healthcare providers assess a person’s relationship with food before prescribing Ozempic or its counterparts. If emotional eating is a primary issue, psychological support may be necessary alongside medication.

For those worried about cardiovascular risks, the REACH study presented at the annual meeting of the European Association for the Study of Diabetes confirmed that Ozempic stands out for reducing cardiovascular risk, even among those with multiple chronic conditions. Large-scale, real-world data reinforce its value, particularly in older populations who often have comorbidities like heart disease.

Let us also touch on a warning that has emerged: rapid weight loss with medications like Ozempic can cause muscle loss, particularly in women and older adults. While the fat loses fast, it is essential to protect muscle mass with diet and exercise. Experts stress that lifestyle habits—good nutrition, adequate sleep, and physical activity—remain crucial for long-term results, even when taking medication.

To sum up, Ozempic continues to make headlines for its effectiveness, but sticking with the medication is a challenge for many due to cost, side effects, and complex eating habits. Emotional and physical health both need to be addressed for the best outcomes. As always, open discussion with healthcare professionals about individual goals, potential barriers, and long-term maintenance is vital.

Thank you for tuning in to Ozempic Weightloss Unlocked. Make sure to subscribe so you never miss an episode. This has been a quiet please production, for more check out quiet please dot ai.

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Transcript

Episode Transcript

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Speaker 1 (00:00):
Welcome back to Ozepic Weight Loss Unlocked, the podcast where
we dive into the latest news and analysis about one
of the most talked about treatments for weight loss and
metabolic health. Let us jump right in with some breaking research.
According to the Lancet Diabetes and Endochronology, new clinical trial
data shows that a triple dose of ozepic, meaning seven

(00:22):
point two milligrams weekly, resulted in almost nineteen per cent
average weight loss in adults without diabetes. That is a
substantial jump compared to the sixteen per cent with the
standard two point four milligram dose and only around four
per cent with a placebo. Really, half of those on
the higher dose lost at least twenty per cent of
their body weight, and a third saw weight reductions of

(00:44):
twenty five percent or more. Even among adults with type
two diabetes, the higher dose achieved thirteen percent weight loss
compared to ten per cent with the lower dose. Wastelines,
blood pressure, blood sugar, and cholesterol all improved on the
higher dose. Safety remained solid, with the most common side
effects being manageable nausea and diarrhea that usually settled down

(01:07):
over time. Importantly, there was no increase in serious adverse
events now for lifestyle impacts and long term use. A
population wide study presented at the European Association for the
Study of Diabetes reports that half of people who start
a zenpic for weight loss stop taking it within a year.
Cost is a major factor, with the lowest dose costing

(01:30):
around two thousand euros a year. In some areas. Younger
adults and people from lower income neighbourhoods were far more
likely to discontinue, likely due to financial barriers. Adverse effects
like nausea and pre existing conditions played a role as well.
The study found that men were more likely to stop
early than women, and adherence was especially hard for those

(01:51):
with a history of psychiatric conditions or chronic illness. That
is concerning since people with these conditions often need the
benefits of the monet. Once people stop the medication, weight
is often regained. Shank just how important it is to
find sustainable approaches to weight management. On the topic of
who benefits most, a study in Frontiers in Clinical Diabetes

(02:14):
and Healthcare highlighted that emotional eating can reduce the effectiveness
of ozempic. The medication is best for people who overeat
due to external cues like the smell or appearance of food,
rather than for those who eat in response to boredom, anxiety,
or sadness. Health experts now recommend that health care providers
assess a person's relationship with food before prescribing ozepic or

(02:37):
its counterparts. If emotional eating is a primary issue, psychological
support may be necessary alongside medication for those worried about
cardiovascular risks. The REACH study presented at the annual meeting
of the European Association for the Study of Diabetes confirmed
that ozempic stands out for reducing cardiovascular risk even among

(02:59):
those with multiple chronic conditions. Large scale, real world data
reinforce its value, particularly in older populations who often have
comorbidities like heart disease. Let us also touch on a
warning that has emerged. Rapid weight loss with medications like
ozeenpic can cause muscle loss, particularly in women and older adults.

(03:20):
While the fat loses fast, it is essential to protect
muscle mass with diet and exercise. Experts stress that lifestyle habits,
good nutrition, adequate sleep, and physical activity remain crucial for
long term results. Even when taking medication. To sum up,
ozempic continues to make headlines for its effectiveness, but sticking

(03:42):
with the medication is a challenge for many due to cost,
side effects and complex eating habits. Emotional and physical health
both need to be addressed for the best outcomes. As always,
open discussion with healthcare professionals about individual goals, potential barriers
and los long term maintenance is vital. Thank you for

(04:03):
tuning in to os N pick Weight Loss Unlocked. Make
sure to subscribe so you never miss an episode. This
has been a quiet please production. For more check out
quite please dot Ai
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