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October 18, 2025 4 mins
Welcome to Ozempic Weightloss Unlocked, your podcast for the latest news, research, and practical insights on Ozempic, its medical uses, and the impact on lifestyle and health.

Ozempic, known generically as semaglutide, was originally developed for type two diabetes but is now widely prescribed for weight management. According to Women’s Health Research Cluster, Ozempic works by mimicking a hormone called glucagon-like peptide-1 that helps you feel fuller longer and slows down how quickly the stomach empties. These effects not only help reduce appetite, but also keep blood sugar stable. That is why demand for these medications has skyrocketed over the past few years.

Clinical trials consistently show notable results. Multiple large studies, as summarized in the National Library of Medicine, reveal that up to 14 to 16 percent body weight loss can be sustained for more than a year. Even higher percentages are seen when combined with behavioral therapy and a low-calorie diet. Some studies on similar drugs, like tirzepatide, report weight loss as high as 20 percent over seventy-two weeks. These numbers put Ozempic and its peers at the center of conversation around obesity and metabolic health.

Real-world factors do impact results. New York University research presented at the American Society for Metabolic and Bariatric Surgery compared Ozempic and similar drugs to bariatric surgery. Surgery produced five times the weight loss of medication, averaging more than 25 percent body weight lost over two years. Researchers noted that regardless of the method, consistency is key. Medications only work as long as they are taken, while surgery is a permanent change.

For those considering Ozempic, there are some noticeable bodily effects. Medical News Today discusses “Ozempic legs,” a term for changes in leg appearance during rapid weight loss, such as thinner or frailer legs and sometimes loose skin. This can result from losing both fat and muscle. Up to forty percent of weight lost on semaglutide may come from lean body mass, not just fat. To address this, experts recommend eating enough protein, incorporating regular strength training, and losing weight gradually to preserve muscle and skin elasticity.

Another area of emerging research is how these GLP-1 drugs affect alcohol metabolism. The Fralin Biomedical Research Institute found that medications like Ozempic can slow how quickly alcohol enters the bloodstream, delay its effects on the brain, and potentially reduce alcohol use. These findings suggest the drugs may play a future role in addiction treatment.

In terms of safety and tolerability, gastrointestinal symptoms are the most common side effects, such as nausea or upset stomach. These are usually mild or moderate and tend to fade with time. For people with psychiatric conditions such as schizophrenia, data published by National Library of Medicine indicate Ozempic led to significant weight loss without worsening mental health or interfering with medications.

When stopping these medications, Women’s Health Research Cluster points out weight regain is very likely, as the body’s metabolic adaptations revert without continued GLP-1 stimulation. Long-term studies are ongoing to better understand risks and benefits over many years.

There is also growing attention on rare, “unusual” side effects. The Independent and other outlets note that advanced imaging scans became necessary to rule out suspicious findings linked to rapid weight changes when doctors were assessing patients on these drugs. Researchers emphasize this does not mean the drugs cause cancer or other conditions, but it is an important side effect to keep monitoring as usage increases.

While Ozempic has made headlines as a “miracle” weight loss medication, experts urge listeners to use it as part of a broader lifestyle approach, including healthy eating, physical activity, and regular medical check-ins. As with any medication, speak with your health care provider about the risks, benefits, and whether this option fits your specific goals and conditions.

Thanks for tuning in to Ozempic Weightloss Unlocked. Remember to subscribe so you never miss an update on the latest research and real-world experiences on Ozempic and metabolic health. This has been a quiet please production, for more check out quiet please dot ai.

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Transcript

Episode Transcript

Available transcripts are automatically generated. Complete accuracy is not guaranteed.
Speaker 1 (00:00):
Welcome to Ozepic Weight Loss Unlocked, your podcast for the
latest news, research, and practical insights on ozepic, its medical uses,
and the impact on lifestyle and health. Ozempic, known generically
as semaglutide, was originally developed for type two diabetes, but
is now widely prescribed for weight management. According to Women's

(00:21):
Health Research Cluster, ozepic works by mimicking a hormone called
glucagan like peptide one that helps you feel fuller, longer,
and slows down her quickly the stomach empties. These effects
not only help reduce appetite, but also keep blood sugar stable.
That is why demand for these medications has skyrocketed over
the past few years. Clinical trials consistently show notable results.

(00:45):
Multiple large studies, as summarized in the National Library of Medicine,
reveal that up to fourteen to sixteen percent body weight
loss can be sustained for more than a year. Even
higher percentages are seen when combined with behavioral therapy and
a low color diet. Some studies on similar drugs like tyrazepetide,
report weight losses high as twenty percent over seventy two weeks.

(01:08):
These numbers put ozempic and its peers at the center
of conversation around obesity and metabolic health. Real world factors
do impact results. New York University research presented at the
American Society for Metabolic and Bariatric Surgery compared ozempic and
similar drugs to bariatric surgery. Surgery produced five times the
weight loss of medication, averaging more than twenty five percent

(01:31):
body weight loss over two years. Researchers noted that regardless
of the method, consistency is key. Medications only work as
long as they are taken, while surgery is a permanent change.
For those considering ozepic, there are some noticeable bodily effects.
Medical News Today discusses ozepic legs, a term for changes

(01:52):
in leg appearance during rapid weight loss, such as thinner
or frailer legs and sometimes loose skin. This can result
from luke using both fat and muscle. Up to forty
percent of weight loss on semaglutide may come from lean
body mass, not just fat. To address this, experts recommend
eating enough protein, incorporating regular strength training, and losing weight

(02:14):
gradually to preserve muscle and skin elasticity. Another area of
emerging research is how these GLP one drugs affect alcohol metabolism.
The fral And Biomedical Research Institute found that medications like
ozempic can slow how quickly alcohol enters the bloodstream, delay
its effects on the brain, and potentially reduce alcohol use.

(02:34):
These findings suggest the drugs may play a future role
in addiction treatment. In terms of safety and tolerability, dastri
andtestinal symptoms are the most common side effects, such as
nausea or upset stomach. These are usually mild or moderate
and tend to fade with time for people with psychiatric
conditions such as schizophralia. Data published by National Library of

(02:56):
Medicine indicate ozempic led to significant weight loss without worsening
mental health or interfering with medications when stopping these medications.
Women's Health Research Cluster points out weight we gain is
very likely as the body's metabolic adaptations revert without continued
GLP one stimulation. Long term studies are ongoing to better

(03:17):
understand risks and benefits over many years. There is also
growing attention on rare unusual side effects. The Independent and
other outlets note that advanced imaging scans became necessary to
rule out suspicious findings linked to rapid weight changes when
doctors were assessing patients on these drugs. Researchers emphasize this

(03:39):
does not mean the drugs cause cancer or other conditions,
but it is an important side effect to keep monitoring
as usage increases. While ozeenpic has made headlines as a
miracle weight loss medication, experts urge listeners to use it
as part of a broader lifestyle approach, including healthy eating,
physical activity, and regular medical check ins. As with any medication,

(04:01):
speak with your healthcare provider about the risks, benefits, and
whether this option fits your specific goals and conditions. Thanks
for tuning in to ozempic weight Loss Unlocked. Remember to
subscribe so you never miss an update on the latest
research and real world experiences on ozempic and metabolic health.
This has been a quiet please production. For more check

(04:21):
out Quiet please dot ai
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