Midlife Mayhem

Joanne Lee Cornish explores two massive wellness categories — green powders and fiber supplements — breaking down real science, real efficacy, and real value. She helps you make informed decisions, avoid marketing fluff, and invest in what actually works.

• The manufacturing differences between whole-plant powders, juice powders, and cheap heat-dried powders

• Why processing method deter...

Most women only hear about PCOS in their teens or twenties — when cycles are irregular, acne is flaring, weight is piling onto the midsection, and fertility becomes a concern. But here’s the truth:

👉 PCOS does NOT disappear. 👉 Symptoms simply shift. 👉 And midlife can amplify everything that was simmering beneath the surface for decades.

...

In this episode of Midlife Mayhem, Joanne dives into one of the wildest cultural shifts in modern health and fitness: how we went from terrified of needles to injecting everything in sight — from weight loss medications to peptides, and now, even experimental compounds.

A few years ago, the idea of self-injecting anything was unthinkable. Today?...

“Sore but Not Growing: Why Pain Isn’t Proof of Progress”

We’ve been taught to wear soreness like a badge of honor. If you can’t sit down after leg day, that’s proof you “did it right,” right? Wrong.

Soreness is inflammation — not progress. It’s a sign your muscles are repairing micro-tears, not necessarily adapting or growing stronger. In fact, constant soreness can be a red...

“Hormones Off the Hook: What the FDA’s New Decision Means for Women, HRT, and the Future of Menopause Care”

For decades, women have been warned that hormone replacement therapy (HRT) is risky business — linked to heart disease, cancer, and every imaginable midlife horror story.

But that narrative just flipped.

In a landmark move, the FDA has lifted the black box warnings from many HRT product...

Rewriting My Midlife Brand, Metabolism & Fasting: Why I’m Becoming JoanneLee.com

Episode Description In this episode, I pull back the curtain on a big shift: after 30 years as The Shrink Shop, I’m moving everything under JoanneLee.com and fully owning the work I actually do — high-level body composition and midlife coaching that goes way beyond “just weight loss.”

We’ll dive into why I’m rebranding, how my coaching has evolved...

Most women are never told what to expect as they approach menopause. There’s no handbook, no clear roadmap — just years of confusion, self-blame, and frustration as symptoms slowly appear. It’s heartbreaking that we enter one of the biggest biological transitions of our lives unprepared — often told to “just get on with it.”

In this episode, Joanne breaks down the menopause journey — a stage-by-stage guide explaining what’s happeni...

We’ve all heard the phrase “The mitochondria is the powerhouse of the cell” — probably in high school biology, on a meme, or even on a T-shirt. But what most people don’t realize is that this isn’t just trivia. This is the foundation of how you age, how you feel, and how your body performs every single day.

In this episode, Joanne breaks down what cellular health really means — in plain English — and why the...

Why the FDA Reclassified 17 Peptides — and What It Really Means”

The headlines said the FDA “banned 17 peptides.” But the truth? It’s not a sudden ban — it’s the inevitable fallout of peptides becoming too popular for their own good.

In this episode, Joanne Lee Cornish breaks down what really happened in July, why it started with the GLP-1 explosion, and how the FDA’s new classification is reshaping the pept...

Episode summary Your waist isn’t just “aesthetic”—it’s a metabolic dashboard. In this episode, Joanne breaks down why central fat (especially visceral fat) screams insulin resistance, tanks testosterone in men, drives unfavorable estrogen dynamics in women, and turns up the dial on inflammation, fatty liver, and long-term disease risk. You’ll learn simple ways to measure risk a...

👉 Mastering Midlife starts this Sunday! This is my most in-depth program of the year, and inside we’ll cover everything from hormones to metabolism to why weight loss feels harder in midlife. In this episode, I’ll also give you a sneak peek into one of our topics: plateaus—why they happen, and what to do when your body stalls. If you’re ready to finally understand your body in midlife (instead of fighting it), join us at www.midli...

Episode Title: Why the WHI Study Still Misguides Midlife Women + Why Birth Control Isn’t Hormone Therapy

Mastering Midlife starts on SUNDAY (Sept 21) www.midlifemonth.com

In this episode of Midlife Mayhem, Joanne Lee Cornish breaks down one of the most damaging studies in women’s health history—the Women’s Health Initiative (WHI)—and explains how its flawed design still shapes the way doctors approach hormone rep...

Welcome to Midlife Mayhem! For the first time, I’m not just talking to you through your headphones — I’m also filming this for YouTube. So if you’d rather see me chatting through today’s episode, head over to (joanne lee cornish)  my YouTube channel. 

Today, I want to share some of the lesser-known supplement pairings I personally use and keep on hand. These aren’t your typical multivitamins or fish oils — they’re unique stacks tha...

Recorded: September 6 (rainy morning in Idaho 🌧️) Host: Joanne Lee Cornish Theme: Cutting through the “too simple” and the “too complex” to the useful middle—so you actually know what to do and why it works.

There’s a giant gap in health education: on one side, fluffy tips (“eat healthy fats!”); on the other, firehose-science that sounds impressive but leaves you asking, …now what? This episode lives in th...

Episode Type: Venting / Educational Rant Program Mentioned: Mastering Midlife (Sept 21 – Nov 1) → www.midlifemonth.com

In this episode, Joanne takes aim at a recent Telegraph article that claimed you can lose weight without losing muscle by following outdated and misleading advice. From the laughably low protein recommendations (45g/day for women) to the suggestion that ligh...

SLU-PP-332, 5-Amino-1MQ, and the Truth About Midlife Muscle & Fat

Hey friends, welcome back to Midlife Mayhem! I’ve just returned from a whirlwind trip through England and Greece—a mix of family remembrance, laughter, tears, chaos, and joy. I’m running on jet lag fumes, but I wanted to sit down and share something important with you today: two breakthrough compounds that could be absolute game-c...

We tend to think of the liver as “the detox organ.” We imagine green juice cleanses, detox teas, and vague ideas about “flushing toxins.” But your liver is so much more than that — it’s a powerhouse that affects every aspect of your body composition, from how much fat you store to how much energy you have.

And while the liver is incredibly resilient (it can literally regrow after being partially removed), modern lifestyles are push...

We’ve all heard the term GMO — genetically modified organisms — and most of us know it’s controversial. But there’s a newer, slicker technology making its way into our food supply that’s flying under the radar: gene editing. It’s marketed as “natural,” it’s not always labeled, and it’s already on supermarket shelves. The problem? Most consumers have no idea it’s there… or what it could mean for our health.

In this episode, I pull b...

If you’ve ever left Starbucks feeling bloated, sluggish, or… ahem… blocked up for days, you’re not imagining things. In this episode, I dive deep into why Starbucks hits your gut differently than your local coffee shop. From dark roasted beans and ultra-pasteurized milk to highly processed plant-based alternatives and the whole A1 vs A2 milk debate, I break down exactly what’s going on — and why it matters for your digestion, energ...