Midlife Mayhem

Why the FDA Reclassified 17 Peptides — and What It Really Means”

The headlines said the FDA “banned 17 peptides.” But the truth? It’s not a sudden ban — it’s the inevitable fallout of peptides becoming too popular for their own good.

In this episode, Joanne Lee Cornish breaks down what really happened in July, why it started with the GLP-1 explosion, and how the FDA’s new classification is reshaping the pept...

Episode summary Your waist isn’t just “aesthetic”—it’s a metabolic dashboard. In this episode, Joanne breaks down why central fat (especially visceral fat) screams insulin resistance, tanks testosterone in men, drives unfavorable estrogen dynamics in women, and turns up the dial on inflammation, fatty liver, and long-term disease risk. You’ll learn simple ways to measure risk a...

👉 Mastering Midlife starts this Sunday! This is my most in-depth program of the year, and inside we’ll cover everything from hormones to metabolism to why weight loss feels harder in midlife. In this episode, I’ll also give you a sneak peek into one of our topics: plateaus—why they happen, and what to do when your body stalls. If you’re ready to finally understand your body in midlife (instead of fighting it), join us at www.midli...

Episode Title: Why the WHI Study Still Misguides Midlife Women + Why Birth Control Isn’t Hormone Therapy

Mastering Midlife starts on SUNDAY (Sept 21) www.midlifemonth.com

In this episode of Midlife Mayhem, Joanne Lee Cornish breaks down one of the most damaging studies in women’s health history—the Women’s Health Initiative (WHI)—and explains how its flawed design still shapes the way doctors approach hormone rep...

Welcome to Midlife Mayhem! For the first time, I’m not just talking to you through your headphones — I’m also filming this for YouTube. So if you’d rather see me chatting through today’s episode, head over to (joanne lee cornish)  my YouTube channel. 

Today, I want to share some of the lesser-known supplement pairings I personally use and keep on hand. These aren’t your typical multivitamins or fish oils — they’re unique stacks tha...

Recorded: September 6 (rainy morning in Idaho 🌧️) Host: Joanne Lee Cornish Theme: Cutting through the “too simple” and the “too complex” to the useful middle—so you actually know what to do and why it works.

There’s a giant gap in health education: on one side, fluffy tips (“eat healthy fats!”); on the other, firehose-science that sounds impressive but leaves you asking, …now what? This episode lives in th...

Episode Type: Venting / Educational Rant Program Mentioned: Mastering Midlife (Sept 21 – Nov 1) → www.midlifemonth.com

In this episode, Joanne takes aim at a recent Telegraph article that claimed you can lose weight without losing muscle by following outdated and misleading advice. From the laughably low protein recommendations (45g/day for women) to the suggestion that ligh...

SLU-PP-332, 5-Amino-1MQ, and the Truth About Midlife Muscle & Fat

Hey friends, welcome back to Midlife Mayhem! I’ve just returned from a whirlwind trip through England and Greece—a mix of family remembrance, laughter, tears, chaos, and joy. I’m running on jet lag fumes, but I wanted to sit down and share something important with you today: two breakthrough compounds that could be absolute game-c...

We tend to think of the liver as “the detox organ.” We imagine green juice cleanses, detox teas, and vague ideas about “flushing toxins.” But your liver is so much more than that — it’s a powerhouse that affects every aspect of your body composition, from how much fat you store to how much energy you have.

And while the liver is incredibly resilient (it can literally regrow after being partially removed), modern lifestyles are push...

We’ve all heard the term GMO — genetically modified organisms — and most of us know it’s controversial. But there’s a newer, slicker technology making its way into our food supply that’s flying under the radar: gene editing. It’s marketed as “natural,” it’s not always labeled, and it’s already on supermarket shelves. The problem? Most consumers have no idea it’s there… or what it could mean for our health.

In this episode, I pull b...

If you’ve ever left Starbucks feeling bloated, sluggish, or… ahem… blocked up for days, you’re not imagining things. In this episode, I dive deep into why Starbucks hits your gut differently than your local coffee shop. From dark roasted beans and ultra-pasteurized milk to highly processed plant-based alternatives and the whole A1 vs A2 milk debate, I break down exactly what’s going on — and why it matters for your digestion, energ...

If you’ve hit a plateau with your workouts… if you're gaining fat despite training hard… or if you're feeling constantly tired and inflamed, your bloodwork might have the answers.

In this episode, we dive into:

• What the DHEA-to-cortisol ratio really tells you about stress, recovery, and resilience

• The exact numbers you want to see (with examples)

• Key blood markers like CK, AST, LDH, CRP, and what they reveal about muscle ...

Midlife Mayhem Podcast – Episode Title: "Midlife Thermostat: Why You're Sweating, Freezing, and Waking Up at 3 A.M."

Hosted by: Joanne Lee Cornish

In this packed episode, Joanne tackles one of the most frustrating but misunderstood midlife symptoms: temperature dysregulation. Whether you're a woman waking up drenched in sweat or a man with freezing hands and sleepless nights, your body's thermostat might be wo...

I have been meaning to do this podcast for months!

And although I am talking about men and testosterone, ladies please pay attention. Too many men are suffering in silence as their version of menopause (Andropause) is sneaky and subtle and often dismissed.

Testosterone isn't just about muscle or libido — it's the foundation of a man’s vitality, strength, confidence, and health. But what happens when it starts to decline… and how ...

🔥 JULY 4TH FLASH DEAL – ENDS MONDAY! Buy 1 bottle of 5-Amino-1MQ and get the 2nd for $100 – that’s a $39 savings! 🧬 Boost fat loss, protect muscle, and optimize your body’s performance. 👉 Use code JULY4 at checkout at www.5amino.com Expires Monday at noon (MST) – don’t miss it!

This episode is bold, necessary, and deeply personal.

We’re diving into the truth about HRT (Hormone Replacement Therapy) and HGH (Human Growth Hormone)...

This 28-day program is all about reclaiming food quality, reducing inflammation, and resetting your understanding of nourishment. It’s soy-, dairy-, gluten-, and added sugar–free. Learn more at www.tight28.com

In this episode, Joanne breaks down the two dominant eating models:

• Homeostatic Eating: eating driven by biological hunger cues

• Hedonic Eating: eating driven by pleasu...

🎙️ Midlife Mayhem Show Notes: Zonulin & Leaky Gut — Why You Can’t Not Be Affected

📆 Tight28 starts July 6–August 2! Enjoy your gluten-filled 4th of July… then join us for 28 days of discovery, education, and possibly the biggest physical and mental relief you didn’t know you needed. 👉 Tight28.com

In today’s episode, we’re getting real about z...

Tight28 starts July 6 — only offered once a year in LIVE format. This isn’t a gut reset or an elimination diet. It’s a discovery program for anyone who knows they don’t feel as great as they could. Join now → WWW.TIGHT28.COM

In this episode, Joanne takes a deep dive into a topic that's rarely discussed but highly impactful: histamine intolerance. Often mistaken for allergies or hormone issues, histamine overlo...

Join me for Tight28, starting July 6th – a deep dive into food sensitivities, inflammation, and organ health that could be the missing link in your journey to looking and feeling your absolute best.

Tight28 isn’t just a meal plan. It’s 28 days of discovery – uncovering how certain foods may be silently sabotaging your health, comfort, and body composition. This is the onl...