March 21, 2024 • 28 mins
There are a great many emerging ideas to discuss, but sometimes these topics are just not big enough to fill out an entire podcast episode. So I decided to start something I call “Potpourri,” a collection of unconnected but interesting topics that may be helpful in guiding you in your health journey. I’d like to say “Ask your doctor about these issues,” but you and I know that they will, more than likely, know absolutely nothing about these questions because 1) it’s not a pharmaceutical or procedure, and 2) it will make no money for them. But just because your doctor is indifferent or ignorant does not mean that they don’t pack a wallop of potential health benefits for you.
So in this episode of the Defiant Health Podcast, I’d like to talk about hyaluronic acid, the sweetener allulose, and the relationship of Lactobacillus reuteri and reproductive health.
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Transcript
Episode Transcript
Available transcripts are automatically generated. Complete accuracy is not guaranteed.
Speaker 1 (00:06):
There are a great many emerging ideas that we can
discuss, but sometimes thesetopics are just not big enough
to fill out an entire podcastepisode.
So I decided to start somethingI call Poperie, a collection of
unconnected but interestingtopics that may be helpful in
guiding you in your healthjourney.
I'd like to say, ask yourdoctor about these issues, but
(00:29):
you and I know that it will morethan likely know absolutely
nothing about these questionsbecause 1.
It's not a pharmaceutical or aprocedure and 2.
It will make no money for them.
But just because your doctormay be indifferent or ignorant
does not mean that they don'tpack a wallop of potential
health benefits for you.
(00:50):
So in this episode of theDefiant Health Podcast, I'd like
to talk about hyaluronic acid,the sweetener allulose, and the
relationship of lactobacillusrhodorite and reproductive
health.
I'd like to also tell you aboutDefiant Health sponsors, paleo
Valley and Biodiquest.
Paleo Valley is our preferredsource for many excellent foods,
(01:10):
such as fermented beef, porkand chicken sticks sourced from
organic pastured animals, bonebroth, protein and delicious low
carb superfood bars.
Biodiquest is my preferredsource of quality probiotics
crafted by academicmicrobiologist Dr Raul Kenno,
probiotics created with theattention to collaborative
(01:33):
metabolic effects among microbesthe only probiotics available
with this built in feature.
So, as I mentioned in theopening comments, this episode
of Defiant Health Podcast willbe a series of shorter
conversations about some issuesthat are still very interesting,
just not big enough, perhaps,to fill out an entire Defiant
(01:54):
Health Podcast episode.
Let's start with this idea ofhyaluronic acid.
So hyaluronic acid is veryinteresting.
It has great potential to addsome major benefits to your
health program, not just in yourphysiology but also in your
appearance.
So lots of women know abouthyaluronic acid because they pay
a lot of money for thesehyaluronic acid serums, that is,
(02:17):
these topical products.
They're put around their eyes,for instance around their mouth,
and hyaluronic acid appliedtopically does indeed partially
reduce the depth of wrinkles,especially the finest wrinkles,
such as the crows, feet aroundthe eyes and the smile lines
around the mouth.
But if you apply that to thoseareas, what does it do for the
(02:38):
skin on your neck or the skin onyour thighs or your abdomen?
Nothing, of course, becauseit's a topical, local effect.
There's very little penetrationof that hyaluronic acid beneath
the epidermis.
The epidermis, of course, isthe external part of your skin.
Just below the epidermis is thedermis.
The epidermis is largely deadskin cells.
(02:59):
By the way, the dermis isliving and that's where skin
health is determined in thedermis, because that's where the
cells are that produce thecomponents of skin, like
collagen.
That's where moisture resides.
That's where hormone exertstheir effect, that's where
various inflammatory oranti-inflammatory factors exert
their effect.
All that action occurs in thedermis.
(03:22):
Can we increase the dermalcontent of hyaluronic acid?
Yes, you can, and you can do itdramatically.
But that means takinghyaluronic acid orally.
Now the odd thing, the greatiron about hyaluronic acid is it
is a common component of organmeats, especially brain, skin
and other organs.
(03:42):
Modern people, given the adviceto cut your fat and cholesterol
, have largely abandoned theconsumption of hyaluronic acid
as well as collagen, yet anotherimportant component of diet.
So the modern diet has almostno hyaluronic acid because of
the abandonment of eating suchthings as brain, skin and other
(04:02):
organs.
That means that skin aging isaccelerated.
So a restoration of hyaluronicacid can be very important.
Hyaluronic acid in the dermallayer of skin is responsible for
retaining water.
Hyaluronic acid is unique inits great capacity to retain
water.
Hyaluronic acid in the dermallayer also stimulates production
(04:24):
of collagen, so it stimulatesthe fibroblast cells to produce
more collagen.
So hyaluronic acid is a crucialcomponent of your skin, health
and appearance.
When taken orally, it does itin there, though, so hyaluronic
acid is also an importantcomponent of your joints, such
as your knees and hips, so yourlubricating fluid in your joints
(04:46):
is made largely of hyaluronicacid.
That is, the synovial fluid,that is, the lubricant in your
joints, is largely hyaluronicacid, and you can increase the
moisture and the lubrication ofyour joints by ingesting
hyaluronic acid.
This thing absent from moderndiet, and the increase in
hyaluronic acid also stimulateschondroblasts, cardilage cells,
(05:10):
to produce more cartilage, andso getting hyaluronic acid
orally is a big first step inrebuilding joint cartilage and
thereby preventing or evenreversing, at least in its early
phases, arthritis.
Another very interesting effectof hyaluronic acid is that it is
a component of the so-calledglyco-calix of your arteries.
(05:33):
This is a polysaccharide orsugar coating on your arteries
that determines how relaxed orconstricted your arteries are
the process called endothelialdysfunction.
It's called that because thethin lining of arteries, the
endothelium that contains thisglyco-calix that is the
principle determinant of howconstricted or how relaxed your
(05:56):
arteries are.
Thank you.
Chronic constriction ofarteries is a problem because it
leads to atherosclerosis aswell as hypertension, so we want
our arteries to be relaxed, andgetting hyaluronic acid
ingested orally rebuilds theglyco-calix, restores normal
arterial relaxation and therebyhelps prevent the development of
(06:20):
atherosclerosis.
Atherosclerosis is a processthat leads to such things as
heart attack, sudden cardiacdeath, the need for such things
as stents and bypassing yourarteries.
Now, yet another veryinteresting aspect of hyaluronic
acid is that the woman's uterus, cervix and vagina are largely
made of hyaluronic acid, andthere's emerging evidence to
(06:42):
suggest that a lack ofhyaluronic acid impairs a
woman's reproductive health, maylead to such things as vaginal
atrophy, dryness, irritation,pain upon penetration,
restoration of hyaluronic acidorally.
So remember that hyaluronicacid you put around your eyes
topically has no effect on thereproductive organs, so we're
going to ingest it orally and itincreases moisture in a woman's
(07:05):
reproductive system.
Now there's more a woman can doto reestablish vaginal health,
such as supplement the microbelactobacillus crispatus.
That's a conversation foranother day.
But know that the wisdom inmanaging reproductive health in
females, which is terrible.
Ladies have terrible choices,like whether they should take
estrogen in some form, some thatincreases risk for endometrial
(07:27):
cancer and thromboembolicdisease like deep vein
thrombosis.
Well, there are better choicesemerging and among them,
restoration of this factoredloss from the modern diet,
hyaluronic acid.
Now hyaluronic acid is kind of acommodity product.
You don't have to be tooparticular about brands Dose.
Most studies have used 120milligrams.
(07:49):
Those are studies examining theeffect on skin, on the dermal
layer of skin, also on jointpain and joint cartilage.
The few efforts that usedhigher doses don't seem to
suggest that higher doses yieldbetter effects.
So we're sitting with 120milligrams.
We always ask if 120 milligramsis good, is more better?
Well, let's ask how much didprimitive humans obtain when
(08:12):
they consumed organ meats?
Well, if you eat a four-outserving of sheep's brain or
other animal's brain, you getabout seven milligrams of
hyaluronic acid.
So 120 milligrams is reallykind of a very confident dose.
It's the equivalent of eatingfour pounds of an animal's brain
.
So I think 120 milligrams is avery confident dose.
(08:33):
That's subject to future updateas the science becomes better.
But right now if you buyhyaluronic acid as a powder or
as a capsule, 120 milligrams orthereabouts is a very confident
dose.
Another very interesting aspectof hyaluronic acid's behavior is
that it's a fiber.
Even though it's sourced fromanimal organs like brain and
(08:54):
skin, it is a fiber recognizedthat most fibers come from
plants, right from legumes androot vegetables and things like
that.
But hyaluronic acid is sourcedfrom animals, yet it is a fiber.
It's one of the very few fiberssourced from animal products.
When you consume hyaluronic acid, very interesting things happen
in the gastrointestinalmicrobiome.
(09:16):
First of all, there's a bloomin beneficial species.
These are species likefecalobacterium prusnitsii or
acromansium eucinophila, orspecies of lactosepiration or
rheumatic acacia.
Why is that important?
Well, those microbes, whenstimulated, when fed with
hyaluronic acid, in turn producea fatty acid called butyrate or
(09:38):
butyric acid.
And that fatty acid is themediator of multiple beneficial
effects in you, such asfacilitation of weight loss,
especially from abdominal,visceral fat, inflammatory fat,
reduction of blood sugar,reduction of blood pressure,
reduction in some resistance,preservation of cognition,
(09:58):
deeper sleep, vivid dreams.
So that boosts and butyratethat occurs from consumption of
hyaluronic acid is veryimportant.
It goes farther.
Hyaluronic acid also reducesfecal microbes or proteobacteria
in the small intestine andcolon.
Because fecal microbes workagainst us.
They're destructive, so we wantto keep them at bay, we want to
(10:19):
minimize them, and hyaluronicacid reduces the burden of fecal
microbes in the GI tract andthereby reduces endotoxemia.
Remember that when fecalmicrobes, especially when they
inhabit the small intestine,when they die, they release some
of their toxic compounds, suchas endotoxin.
That enters the bloodstreamthrough the very permeable small
(10:41):
intestine and you get a processcalled endotoxemia, which
drives high blood pressure, highblood sugar, weight gain,
especially in the abdomen,cognitive impairment, heart
disease risk, type 2 diabetes,autoimmune diseases, on and on
and on.
Well, hyaluronic acid reducesfecal microbes, reduces
endotoxemia, achieves awonderful panel of benefits.
(11:05):
And then, lastly, hyaluronicacid also reduces multiple
inflammatory mediators, whichprovides even greater advantage
in losing abdominal fat,reducing blood sugar and all
those other effects.
So hyaluronic acid veryimportant, now absent from the
modern dietary experiencerestore it and regain all the
(11:26):
health, shape and bodycomposition advantages that this
natural nutrient can provide.
Let's now shift gears and talkabout the natural sweetener,
alulose.
So those of you who've beenfollowing my conversations know
that we reject the syntheticnon-caloric sweeteners like
aspartame, niotame, acesulfame,saccharin and sucralose, because
(11:48):
they have been shown with goodevidence that they cause
distortions of thegastrointestinal microbiome,
such that it takes themicrobiome of a slender, healthy
person and makes it look morelike the GI microbiome of
someone who's obese and type 2diabetic and it pushes that
normal, slender person closer tobeing obese, closer to becoming
(12:08):
a type 2 diabetic.
So we don't use those syntheticsweeteners.
Now we have been using naturalsweeteners, especially monk
fruit, the various fractions ofstevia, which there are many.
In case you don't like thetaste, try another one.
Rithritol there's some issueswith the Rithritol, we'll
discuss in another time and thenalulose.
Well, we've been using thesethings.
(12:28):
They're delicious, they allowyou to recreate some dishes.
A lot of people in my communitysay well, we've lost our taste
for sweet dishes, we don't needthese things.
I learned long ago that if Ijust tell people eat whole
natural foods like eggs andavocados and salmon, and don't
limit fat and eat no wheat orgrains, holidays come around and
(12:49):
people would come back startingwith wonderful metabolic
markers and being slender andbeing freed of type 2 diabetes
and hypertension, all the otherkinds of common conditions.
They'd come back after, say,thanksgiving, 14 pounds heavier
and absolute disasters.
Maybe they dropped theirtriglycerides from 200 to 47 and
(13:11):
they come back after anindulgent Thanksgiving with
triglycerides of 300 or anexplosion in the small LDL
particles that actually causeheart disease.
So maybe their small LDL was2400 nanomoles per liter, very
high level, dropped to zero withthe program and now it's 1800.
Now you expose yourself toextravagant risk for heart
(13:32):
attack and death that lasts forweeks.
So I learned that in order tohelp people navigate holidays
where you have kids andgrandkids and company and
neighbors and entertaining, that, it helps to provide you with
alternatives, ways to recreate,for instance, a cheesecake or
biscuits and gravy usingalternative ingredients.
(13:54):
So instead of using wheat flour, for instance, we'll use almond
flour, coconut flour, groundgolden flax seed and other
ingredients.
But for sweeteners, in case youwant to make some muffins or
cookies or cheesecake, we'regoing to use safe, non-caloric
or minimally caloric sweetenersand that has worked out very
well for us.
Well, there's been the recentemergence of a new sweetener, a
natural sweetener that you canfind alulose.
(14:16):
You can find it in raisins,maple syrup and some fruits in
small quantities, but it's anaturally occurring sweetener in
many of those sources.
Well, alulose is proven to bedifferent in that it's not just
safe and does not provokeglucose or insulin, as some of
those synthetic sweeteners do,but actually reduces blood
(14:38):
glucose, reduces insulin, not alittle bit, but quite
dramatically.
So several studies, forinstance, have shown that
alulose a dose of approximately8.5 to 10 milliliters or grams
that's about two teaspoons worthof liquid or powder you can get
either form reduces bloodglucose by about 10 to 20
(14:58):
milligrams, which is huge.
It also reduces insulin.
When you consume something thatraises blood glucose it
provokes a rise in insulin andwith alulose in the vicinity it
reduced that rise in insulin byabout a third, about 35%.
So it's dramatic.
And it reduced wastecircumference.
Now it seems to be selective,more for the subcutaneous fat,
(15:21):
fat just below the skin surface,not so much for the more
problematic visceral fat andthat's kind of a curiosity I'm
not sure anyone understands yet.
But it does help you loseabdominal fat and it reduces
triglycerides quite dramaticallyand reduces blood pressure
systolic blood pressure by aboutseven millimeters, diastolic
blood pressure about fivemillimeters, which equals the
(15:44):
effect of most anti-hypertensivemedications with none of the
side effects.
So alulose very benign,non-chloric and has some pretty
surprisingly spectacular effectson reducing body fat, reducing
blood glucose, reducing insulinand reducing blood pressure.
So alulose has become mysweetener of choice and it's
(16:07):
very soft, it has a good flavor,doesn't have funny aftertastes.
If you're interested in takingadvantage of this sweetener for
its beneficial metabolic andbody shaping effects, the intake
is a teaspoon or two per day orper meal.
It's not a supplement, ofcourse, it's a sweetener.
So use it as a sweetener.
Please don't hear that I'mtrying to advocate this part of
(16:28):
our program.
It's just something you have anoption to use for further
advantage.
Now, before I talk aboutlactobacillus rhodorite and
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Now let's get back to ourdiscussion.
Let's now shift gears onceagain and talk about a very
important topic, that is, therelationship of this microbe,
lactobacillus rotari, withfemale reproductive health.
(19:48):
Now, if you're a guy and maynot care too much about female
reproductive health, I urge youstill to listen, because I'm
sure you have a woman close toyou or a female close to you,
such as your wife, your daughter, your girlfriend, your
granddaughter someone who couldbenefit from this information,
because it's not being passed onby the great majority of
gynecologists or primary caredoctors.
(20:09):
Yet these are very, verycrucial issues.
Now, there's more toreproductive health, female
reproductive health andlactobacillus rotari, but let's
start that conversation withthis microbe.
There are other microbes thatare very important for female
health, but lactobacillus rotariplays a central role.
So, one of the effects oflactobacillus rotari as you
recall, this microbe lost by thegreat majority of people
(20:32):
because it's susceptible toantibiotics like amoxicillinate
you may have taken 10, 20, or 30years ago, but thereby lost
this microbe.
Well, lactobacillus rotaritakes up residence in the GI
tract and one of the things itdoes is it stimulates
contraction of the uterus attime of delivery.
That's why, when a woman wantsto deliver a child at a specific
(20:54):
time, she schedules herdelivery, let's say Wednesday,
august 23rd, at 8 am.
She comes into the hospital,they put an IV in and they give
her an infusion of oxytocin,often called pitocin.
It's the same thing that causesa uterus receptive to
contraction to contract and thecervix to relax, and the child
(21:15):
is delivered.
So that for many years wasthought to be the only primary
application of oxytocin.
That couldn't be farthest fromthe truth.
So the higher levels ofoxytocin that develop at time of
delivery, or supposed todevelop at time of delivery,
have largely been lost.
Because if we've lostlactobacillus rotari, we've
thereby lost the capacity to getthis extra high boost of
(21:38):
oxytocin.
What that means is a womandelivers her child, often with
the artificial support ofintravenous oxytocin, and then
relies on breastfeeding.
Well, the process of releasingmilk for breastfeeding requires
oxytocin.
So a common cause of failedbreastfeeding, which is a very
that's a major impairment to achild, because breastfeeding is
(22:00):
a major advantage that child'sdevelopment, especially
neurological maturation andimmunological maturation.
So depriving a child ofbreastfeeding is a major
detriment to that child's health.
So not being able to breastfeed, as often happens in modern
females, is a major problem.
So restoration of rotari, andthereby the boost in oxytocin,
(22:22):
is instrumental in allowing awoman to breastfeed, to release
milk from her breast.
Another factor is that theoxytocin boost that you get from
rotari also increases theno-transcript cultivates the
mother-child relationship.
Ladies who are low in oxytocincan often experience postpartum
depression.
That's a major problem becauseit threatens the survival and
(22:45):
health of the child.
If the mother can't seem togenerate a bond, it doesn't pay
attention to the child's needs.
That can be a major threat tothat child's welfare.
So having lactobacillus rotariand thereby oxytocin at the
postpartum period can be veryimportant in generating that
very important bond betweenmother and child.
Now lactobacillus rotari andoxytocin play roles outside of
(23:08):
the delivery period.
It also plays a role in vaginalmoisture.
So we know that oxytocin isinstrumental in increasing
vaginal moisture and restoring anormal lining to the vagina.
So as women age, as females age, especially into their mid and
late 60s, it becomes very common, virtually universal, for a
(23:29):
woman to experience vaginalatrophy, that is, loss of the
lining of the vagina becomescoarse and dry.
It's prone to developdischarges and odd scents or
smells and also cause pain withpenetration of any sort.
Another aspect of rotari andoxytocin is that as women age,
(23:49):
many lose libido or sexualinterest.
Now that's some that interestyou.
You want to regain.
So not everybody does.
But if you do, the choices arevery poor.
There are two prescription drugsthat purport to restore libido
but hardly provide any effect atall.
There's an oral drug, there'san injectable drug.
The injectable drug, forinstance, called phlebancerin.
(24:10):
You have to inject it into yourthigh 40 minutes before
anticipated sexual activity.
Who knows how to do that right?
Who knows how to anticipatethat precisely sexual activity?
And it increased libido barelyat all.
In fact, these two drugs are soineffective that the FDA is
contemplating withdrawing theirapprovals.
(24:31):
There's also DHEA, which canhelp a little bit, testosterone,
which does help some ladies,but we're talking about not very
good choices If it's estrogen,whether it's intravaginal,
topical or oral.
Once again a woman has to make achoice.
Does she regain libido at thecost of risking endometrial
cancer and thrombombolic disease, blood clot diseases?
(24:54):
So it's a very poor choice thatwomen have.
Well, now we have the choice ofrotari and oxytocin, because we
know that oxytocin boostslibido.
That's true also in males, butit's very true in females.
So now ladies have a key tomany aspects of reproductive
health, whether it'sfacilitating delivery,
(25:15):
breastfeeding, generating lovefor her and attachment for her
infant or whether it'srestoration of vaginal health in
a mature woman.
Now just one caution we restorerotari by fermenting it as a
yogurt.
It's not yogurt, of course, itlooks and smells like yogurt.
But we use prolongedfermentation my method of
prolonged fermentation so thatwe allow the microbe to double
(25:37):
12 times.
Lactobacillus rotari doubles.
They don't have sex, right,they just double themselves
Every three hours at human bodytemperature.
We allow it to do that 12 timesand when we perform a count of
microbes using a method calledflow cytometry, we get around
300 billion microbes per halfcup serving.
(25:58):
That's how we get these bigeffects.
Now the one caution is we don'tknow how safe that is during
pregnancy.
During pregnancy, the uterusincreases its oxytocin receptors
up to 200 fold in the last fewdays to weeks preceding delivery
.
We don't know if getting thesehigh counts of rotari are safe
in the setting of pregnancy, soI would not do this if you are
(26:20):
pregnant.
Instead, if you want to restorerotari because everybody should
have it anyway right, you aresupposed to have it since birth
from your mom, but we've lost it.
So if you want to replacerotari and there may be a modest
boost in oxytocin, don't makethe yogurt like we usually do,
that achieves high count ofextended fermentation.
Instead, I would use a mixedculture yogurt, for instance.
(26:42):
Take your rotari starter.
It could be an osfortis capsule.
It could be tablets of gastristhat you crushed, and if you
don't know what I'm talkingabout, see my super gut book for
the recipe, see mydrdafusinfinitehealthcom blog
that has the recipe also, andthere's also many YouTube videos
by other people not just not mewho show you how to do this.
(27:03):
So take some source of rotariand combine it with other
microbes.
It could be a capsule ofanother commercial probiotic.
It could be some yogurt youbought at the store that has a
mixture of microbes at least twolike lactobacillus bulgaricus,
streptococcus thermophilus,bifidobacterium bifidum and some
others and ferment them alltogether.
(27:25):
So it's just like having abackyard garden.
If all you do is plant tomatoes,you're going to have a lot of
tomatoes at the end of thegrowing season.
But what if instead, at thestart of the season, you grow
tomatoes, an eggplant andzucchini and squash?
How many tomatoes will you have?
Well, far fewer, and you'llhave tomatoes to enjoy.
(27:46):
Likewise here, cultivatelactobacillus rotari in the
company of other microbes thatyou don't get these high counts,
so that you do get the microbe,but not these very high counts,
because we really don't knowwhat happens to a pregnant
woman's uterus.
Now, if you learn somethingfrom this Defiant Health podcast
, I invite you to subscribe toyour favorite podcast directory.
Post a review, post a commentand join the conversation.
(28:10):
Help build this community ofpeople who want to be free to
the health care system yet havemagnificent health.
Thanks for listening.
There are a great many emerging ideas that we can
discuss, but sometimes thesetopics are just not big enough
to fill out an entire podcastepisode.
So I decided to start somethingI call Poperie, a collection of
unconnected but interestingtopics that may be helpful in
guiding you in your healthjourney.
I'd like to say, ask yourdoctor about these issues, but
(00:29):
you and I know that it will morethan likely know absolutely
nothing about these questionsbecause 1.
It's not a pharmaceutical or aprocedure and 2.
It will make no money for them.
But just because your doctormay be indifferent or ignorant
does not mean that they don'tpack a wallop of potential
health benefits for you.
(00:50):
So in this episode of theDefiant Health Podcast, I'd like
to talk about hyaluronic acid,the sweetener allulose, and the
relationship of lactobacillusrhodorite and reproductive
health.
I'd like to also tell you aboutDefiant Health sponsors, paleo
Valley and Biodiquest.
Paleo Valley is our preferredsource for many excellent foods,
(01:10):
such as fermented beef, porkand chicken sticks sourced from
organic pastured animals, bonebroth, protein and delicious low
carb superfood bars.
Biodiquest is my preferredsource of quality probiotics
crafted by academicmicrobiologist Dr Raul Kenno,
probiotics created with theattention to collaborative
(01:33):
metabolic effects among microbesthe only probiotics available
with this built in feature.
So, as I mentioned in theopening comments, this episode
of Defiant Health Podcast willbe a series of shorter
conversations about some issuesthat are still very interesting,
just not big enough, perhaps,to fill out an entire Defiant
(01:54):
Health Podcast episode.
Let's start with this idea ofhyaluronic acid.
So hyaluronic acid is veryinteresting.
It has great potential to addsome major benefits to your
health program, not just in yourphysiology but also in your
appearance.
So lots of women know abouthyaluronic acid because they pay
a lot of money for thesehyaluronic acid serums, that is,
(02:17):
these topical products.
They're put around their eyes,for instance around their mouth,
and hyaluronic acid appliedtopically does indeed partially
reduce the depth of wrinkles,especially the finest wrinkles,
such as the crows, feet aroundthe eyes and the smile lines
around the mouth.
But if you apply that to thoseareas, what does it do for the
(02:38):
skin on your neck or the skin onyour thighs or your abdomen?
Nothing, of course, becauseit's a topical, local effect.
There's very little penetrationof that hyaluronic acid beneath
the epidermis.
The epidermis, of course, isthe external part of your skin.
Just below the epidermis is thedermis.
The epidermis is largely deadskin cells.
(02:59):
By the way, the dermis isliving and that's where skin
health is determined in thedermis, because that's where the
cells are that produce thecomponents of skin, like
collagen.
That's where moisture resides.
That's where hormone exertstheir effect, that's where
various inflammatory oranti-inflammatory factors exert
their effect.
All that action occurs in thedermis.
(03:22):
Can we increase the dermalcontent of hyaluronic acid?
Yes, you can, and you can do itdramatically.
But that means takinghyaluronic acid orally.
Now the odd thing, the greatiron about hyaluronic acid is it
is a common component of organmeats, especially brain, skin
and other organs.
(03:42):
Modern people, given the adviceto cut your fat and cholesterol
, have largely abandoned theconsumption of hyaluronic acid
as well as collagen, yet anotherimportant component of diet.
So the modern diet has almostno hyaluronic acid because of
the abandonment of eating suchthings as brain, skin and other
(04:02):
organs.
That means that skin aging isaccelerated.
So a restoration of hyaluronicacid can be very important.
Hyaluronic acid in the dermallayer of skin is responsible for
retaining water.
Hyaluronic acid is unique inits great capacity to retain
water.
Hyaluronic acid in the dermallayer also stimulates production
(04:24):
of collagen, so it stimulatesthe fibroblast cells to produce
more collagen.
So hyaluronic acid is a crucialcomponent of your skin, health
and appearance.
When taken orally, it does itin there, though, so hyaluronic
acid is also an importantcomponent of your joints, such
as your knees and hips, so yourlubricating fluid in your joints
(04:46):
is made largely of hyaluronicacid.
That is, the synovial fluid,that is, the lubricant in your
joints, is largely hyaluronicacid, and you can increase the
moisture and the lubrication ofyour joints by ingesting
hyaluronic acid.
This thing absent from moderndiet, and the increase in
hyaluronic acid also stimulateschondroblasts, cardilage cells,
(05:10):
to produce more cartilage, andso getting hyaluronic acid
orally is a big first step inrebuilding joint cartilage and
thereby preventing or evenreversing, at least in its early
phases, arthritis.
Another very interesting effectof hyaluronic acid is that it is
a component of the so-calledglyco-calix of your arteries.
(05:33):
This is a polysaccharide orsugar coating on your arteries
that determines how relaxed orconstricted your arteries are
the process called endothelialdysfunction.
It's called that because thethin lining of arteries, the
endothelium that contains thisglyco-calix that is the
principle determinant of howconstricted or how relaxed your
(05:56):
arteries are.
Thank you.
Chronic constriction ofarteries is a problem because it
leads to atherosclerosis aswell as hypertension, so we want
our arteries to be relaxed, andgetting hyaluronic acid
ingested orally rebuilds theglyco-calix, restores normal
arterial relaxation and therebyhelps prevent the development of
(06:20):
atherosclerosis.
Atherosclerosis is a processthat leads to such things as
heart attack, sudden cardiacdeath, the need for such things
as stents and bypassing yourarteries.
Now, yet another veryinteresting aspect of hyaluronic
acid is that the woman's uterus, cervix and vagina are largely
made of hyaluronic acid, andthere's emerging evidence to
(06:42):
suggest that a lack ofhyaluronic acid impairs a
woman's reproductive health, maylead to such things as vaginal
atrophy, dryness, irritation,pain upon penetration,
restoration of hyaluronic acidorally.
So remember that hyaluronicacid you put around your eyes
topically has no effect on thereproductive organs, so we're
going to ingest it orally and itincreases moisture in a woman's
(07:05):
reproductive system.
Now there's more a woman can doto reestablish vaginal health,
such as supplement the microbelactobacillus crispatus.
That's a conversation foranother day.
But know that the wisdom inmanaging reproductive health in
females, which is terrible.
Ladies have terrible choices,like whether they should take
estrogen in some form, some thatincreases risk for endometrial
(07:27):
cancer and thromboembolicdisease like deep vein
thrombosis.
Well, there are better choicesemerging and among them,
restoration of this factoredloss from the modern diet,
hyaluronic acid.
Now hyaluronic acid is kind of acommodity product.
You don't have to be tooparticular about brands Dose.
Most studies have used 120milligrams.
(07:49):
Those are studies examining theeffect on skin, on the dermal
layer of skin, also on jointpain and joint cartilage.
The few efforts that usedhigher doses don't seem to
suggest that higher doses yieldbetter effects.
So we're sitting with 120milligrams.
We always ask if 120 milligramsis good, is more better?
Well, let's ask how much didprimitive humans obtain when
(08:12):
they consumed organ meats?
Well, if you eat a four-outserving of sheep's brain or
other animal's brain, you getabout seven milligrams of
hyaluronic acid.
So 120 milligrams is reallykind of a very confident dose.
It's the equivalent of eatingfour pounds of an animal's brain
.
So I think 120 milligrams is avery confident dose.
(08:33):
That's subject to future updateas the science becomes better.
But right now if you buyhyaluronic acid as a powder or
as a capsule, 120 milligrams orthereabouts is a very confident
dose.
Another very interesting aspectof hyaluronic acid's behavior is
that it's a fiber.
Even though it's sourced fromanimal organs like brain and
(08:54):
skin, it is a fiber recognizedthat most fibers come from
plants, right from legumes androot vegetables and things like
that.
But hyaluronic acid is sourcedfrom animals, yet it is a fiber.
It's one of the very few fiberssourced from animal products.
When you consume hyaluronic acid, very interesting things happen
in the gastrointestinalmicrobiome.
(09:16):
First of all, there's a bloomin beneficial species.
These are species likefecalobacterium prusnitsii or
acromansium eucinophila, orspecies of lactosepiration or
rheumatic acacia.
Why is that important?
Well, those microbes, whenstimulated, when fed with
hyaluronic acid, in turn producea fatty acid called butyrate or
(09:38):
butyric acid.
And that fatty acid is themediator of multiple beneficial
effects in you, such asfacilitation of weight loss,
especially from abdominal,visceral fat, inflammatory fat,
reduction of blood sugar,reduction of blood pressure,
reduction in some resistance,preservation of cognition,
(09:58):
deeper sleep, vivid dreams.
So that boosts and butyratethat occurs from consumption of
hyaluronic acid is veryimportant.
It goes farther.
Hyaluronic acid also reducesfecal microbes or proteobacteria
in the small intestine andcolon.
Because fecal microbes workagainst us.
They're destructive, so we wantto keep them at bay, we want to
(10:19):
minimize them, and hyaluronicacid reduces the burden of fecal
microbes in the GI tract andthereby reduces endotoxemia.
Remember that when fecalmicrobes, especially when they
inhabit the small intestine,when they die, they release some
of their toxic compounds, suchas endotoxin.
That enters the bloodstreamthrough the very permeable small
(10:41):
intestine and you get a processcalled endotoxemia, which
drives high blood pressure, highblood sugar, weight gain,
especially in the abdomen,cognitive impairment, heart
disease risk, type 2 diabetes,autoimmune diseases, on and on
and on.
Well, hyaluronic acid reducesfecal microbes, reduces
endotoxemia, achieves awonderful panel of benefits.
(11:05):
And then, lastly, hyaluronicacid also reduces multiple
inflammatory mediators, whichprovides even greater advantage
in losing abdominal fat,reducing blood sugar and all
those other effects.
So hyaluronic acid veryimportant, now absent from the
modern dietary experiencerestore it and regain all the
(11:26):
health, shape and bodycomposition advantages that this
natural nutrient can provide.
Let's now shift gears and talkabout the natural sweetener,
alulose.
So those of you who've beenfollowing my conversations know
that we reject the syntheticnon-caloric sweeteners like
aspartame, niotame, acesulfame,saccharin and sucralose, because
(11:48):
they have been shown with goodevidence that they cause
distortions of thegastrointestinal microbiome,
such that it takes themicrobiome of a slender, healthy
person and makes it look morelike the GI microbiome of
someone who's obese and type 2diabetic and it pushes that
normal, slender person closer tobeing obese, closer to becoming
(12:08):
a type 2 diabetic.
So we don't use those syntheticsweeteners.
Now we have been using naturalsweeteners, especially monk
fruit, the various fractions ofstevia, which there are many.
In case you don't like thetaste, try another one.
Rithritol there's some issueswith the Rithritol, we'll
discuss in another time and thenalulose.
Well, we've been using thesethings.
(12:28):
They're delicious, they allowyou to recreate some dishes.
A lot of people in my communitysay well, we've lost our taste
for sweet dishes, we don't needthese things.
I learned long ago that if Ijust tell people eat whole
natural foods like eggs andavocados and salmon, and don't
limit fat and eat no wheat orgrains, holidays come around and
(12:49):
people would come back startingwith wonderful metabolic
markers and being slender andbeing freed of type 2 diabetes
and hypertension, all the otherkinds of common conditions.
They'd come back after, say,thanksgiving, 14 pounds heavier
and absolute disasters.
Maybe they dropped theirtriglycerides from 200 to 47 and
(13:11):
they come back after anindulgent Thanksgiving with
triglycerides of 300 or anexplosion in the small LDL
particles that actually causeheart disease.
So maybe their small LDL was2400 nanomoles per liter, very
high level, dropped to zero withthe program and now it's 1800.
Now you expose yourself toextravagant risk for heart
(13:32):
attack and death that lasts forweeks.
So I learned that in order tohelp people navigate holidays
where you have kids andgrandkids and company and
neighbors and entertaining, that, it helps to provide you with
alternatives, ways to recreate,for instance, a cheesecake or
biscuits and gravy usingalternative ingredients.
(13:54):
So instead of using wheat flour, for instance, we'll use almond
flour, coconut flour, groundgolden flax seed and other
ingredients.
But for sweeteners, in case youwant to make some muffins or
cookies or cheesecake, we'regoing to use safe, non-caloric
or minimally caloric sweetenersand that has worked out very
well for us.
Well, there's been the recentemergence of a new sweetener, a
natural sweetener that you canfind alulose.
(14:16):
You can find it in raisins,maple syrup and some fruits in
small quantities, but it's anaturally occurring sweetener in
many of those sources.
Well, alulose is proven to bedifferent in that it's not just
safe and does not provokeglucose or insulin, as some of
those synthetic sweeteners do,but actually reduces blood
(14:38):
glucose, reduces insulin, not alittle bit, but quite
dramatically.
So several studies, forinstance, have shown that
alulose a dose of approximately8.5 to 10 milliliters or grams
that's about two teaspoons worthof liquid or powder you can get
either form reduces bloodglucose by about 10 to 20
(14:58):
milligrams, which is huge.
It also reduces insulin.
When you consume something thatraises blood glucose it
provokes a rise in insulin andwith alulose in the vicinity it
reduced that rise in insulin byabout a third, about 35%.
So it's dramatic.
And it reduced wastecircumference.
Now it seems to be selective,more for the subcutaneous fat,
(15:21):
fat just below the skin surface,not so much for the more
problematic visceral fat andthat's kind of a curiosity I'm
not sure anyone understands yet.
But it does help you loseabdominal fat and it reduces
triglycerides quite dramaticallyand reduces blood pressure
systolic blood pressure by aboutseven millimeters, diastolic
blood pressure about fivemillimeters, which equals the
(15:44):
effect of most anti-hypertensivemedications with none of the
side effects.
So alulose very benign,non-chloric and has some pretty
surprisingly spectacular effectson reducing body fat, reducing
blood glucose, reducing insulinand reducing blood pressure.
So alulose has become mysweetener of choice and it's
(16:07):
very soft, it has a good flavor,doesn't have funny aftertastes.
If you're interested in takingadvantage of this sweetener for
its beneficial metabolic andbody shaping effects, the intake
is a teaspoon or two per day orper meal.
It's not a supplement, ofcourse, it's a sweetener.
So use it as a sweetener.
Please don't hear that I'mtrying to advocate this part of
(16:28):
our program.
It's just something you have anoption to use for further
advantage.
Now, before I talk aboutlactobacillus rhodorite and
reproductive health, let me tellyou something about Define
Health Podcast sponsors.
The Defiant Health podcast issponsored by Paleo Valley makers
of delicious grass-fed beefsticks, healthy snack bars and
(16:50):
other products.
We're very picky around hereand insist that any product we
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All Paleo Valley productscontain no gluten nor grains.
In fact, I find Paleo Valleyproducts among the cleanest in
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One of the habits I urgeeveryone to get into is to
(17:13):
include at least one, if notseveral, servings of fermented
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Unlike nearly all other beefsticks available, paleo Valley
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(18:20):
And in case you haven't yetheard, biodicwest probiotics are
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I've had numerous conversationswith Biodicwest founders,
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They have formulated uniqueprobiotic products that
(18:40):
incorporate what are calledcollaborative or guild effects,
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(19:03):
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(19:26):
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Now let's get back to ourdiscussion.
Let's now shift gears onceagain and talk about a very
important topic, that is, therelationship of this microbe,
lactobacillus rotari, withfemale reproductive health.
(19:48):
Now, if you're a guy and maynot care too much about female
reproductive health, I urge youstill to listen, because I'm
sure you have a woman close toyou or a female close to you,
such as your wife, your daughter, your girlfriend, your
granddaughter someone who couldbenefit from this information,
because it's not being passed onby the great majority of
gynecologists or primary caredoctors.
(20:09):
Yet these are very, verycrucial issues.
Now, there's more toreproductive health, female
reproductive health andlactobacillus rotari, but let's
start that conversation withthis microbe.
There are other microbes thatare very important for female
health, but lactobacillus rotariplays a central role.
So, one of the effects oflactobacillus rotari as you
recall, this microbe lost by thegreat majority of people
(20:32):
because it's susceptible toantibiotics like amoxicillinate
you may have taken 10, 20, or 30years ago, but thereby lost
this microbe.
Well, lactobacillus rotaritakes up residence in the GI
tract and one of the things itdoes is it stimulates
contraction of the uterus attime of delivery.
That's why, when a woman wantsto deliver a child at a specific
(20:54):
time, she schedules herdelivery, let's say Wednesday,
august 23rd, at 8 am.
She comes into the hospital,they put an IV in and they give
her an infusion of oxytocin,often called pitocin.
It's the same thing that causesa uterus receptive to
contraction to contract and thecervix to relax, and the child
(21:15):
is delivered.
So that for many years wasthought to be the only primary
application of oxytocin.
That couldn't be farthest fromthe truth.
So the higher levels ofoxytocin that develop at time of
delivery, or supposed todevelop at time of delivery,
have largely been lost.
Because if we've lostlactobacillus rotari, we've
thereby lost the capacity to getthis extra high boost of
(21:38):
oxytocin.
What that means is a womandelivers her child, often with
the artificial support ofintravenous oxytocin, and then
relies on breastfeeding.
Well, the process of releasingmilk for breastfeeding requires
oxytocin.
So a common cause of failedbreastfeeding, which is a very
that's a major impairment to achild, because breastfeeding is
(22:00):
a major advantage that child'sdevelopment, especially
neurological maturation andimmunological maturation.
So depriving a child ofbreastfeeding is a major
detriment to that child's health.
So not being able to breastfeed, as often happens in modern
females, is a major problem.
So restoration of rotari, andthereby the boost in oxytocin,
(22:22):
is instrumental in allowing awoman to breastfeed, to release
milk from her breast.
Another factor is that theoxytocin boost that you get from
rotari also increases theno-transcript cultivates the
mother-child relationship.
Ladies who are low in oxytocincan often experience postpartum
depression.
That's a major problem becauseit threatens the survival and
(22:45):
health of the child.
If the mother can't seem togenerate a bond, it doesn't pay
attention to the child's needs.
That can be a major threat tothat child's welfare.
So having lactobacillus rotariand thereby oxytocin at the
postpartum period can be veryimportant in generating that
very important bond betweenmother and child.
Now lactobacillus rotari andoxytocin play roles outside of
(23:08):
the delivery period.
It also plays a role in vaginalmoisture.
So we know that oxytocin isinstrumental in increasing
vaginal moisture and restoring anormal lining to the vagina.
So as women age, as females age, especially into their mid and
late 60s, it becomes very common, virtually universal, for a
(23:29):
woman to experience vaginalatrophy, that is, loss of the
lining of the vagina becomescoarse and dry.
It's prone to developdischarges and odd scents or
smells and also cause pain withpenetration of any sort.
Another aspect of rotari andoxytocin is that as women age,
(23:49):
many lose libido or sexualinterest.
Now that's some that interestyou.
You want to regain.
So not everybody does.
But if you do, the choices arevery poor.
There are two prescription drugsthat purport to restore libido
but hardly provide any effect atall.
There's an oral drug, there'san injectable drug.
The injectable drug, forinstance, called phlebancerin.
(24:10):
You have to inject it into yourthigh 40 minutes before
anticipated sexual activity.
Who knows how to do that right?
Who knows how to anticipatethat precisely sexual activity?
And it increased libido barelyat all.
In fact, these two drugs are soineffective that the FDA is
contemplating withdrawing theirapprovals.
(24:31):
There's also DHEA, which canhelp a little bit, testosterone,
which does help some ladies,but we're talking about not very
good choices If it's estrogen,whether it's intravaginal,
topical or oral.
Once again a woman has to make achoice.
Does she regain libido at thecost of risking endometrial
cancer and thrombombolic disease, blood clot diseases?
(24:54):
So it's a very poor choice thatwomen have.
Well, now we have the choice ofrotari and oxytocin, because we
know that oxytocin boostslibido.
That's true also in males, butit's very true in females.
So now ladies have a key tomany aspects of reproductive
health, whether it'sfacilitating delivery,
(25:15):
breastfeeding, generating lovefor her and attachment for her
infant or whether it'srestoration of vaginal health in
a mature woman.
Now just one caution we restorerotari by fermenting it as a
yogurt.
It's not yogurt, of course, itlooks and smells like yogurt.
But we use prolongedfermentation my method of
prolonged fermentation so thatwe allow the microbe to double
(25:37):
12 times.
Lactobacillus rotari doubles.
They don't have sex, right,they just double themselves
Every three hours at human bodytemperature.
We allow it to do that 12 timesand when we perform a count of
microbes using a method calledflow cytometry, we get around
300 billion microbes per halfcup serving.
(25:58):
That's how we get these bigeffects.
Now the one caution is we don'tknow how safe that is during
pregnancy.
During pregnancy, the uterusincreases its oxytocin receptors
up to 200 fold in the last fewdays to weeks preceding delivery
.
We don't know if getting thesehigh counts of rotari are safe
in the setting of pregnancy, soI would not do this if you are
(26:20):
pregnant.
Instead, if you want to restorerotari because everybody should
have it anyway right, you aresupposed to have it since birth
from your mom, but we've lost it.
So if you want to replacerotari and there may be a modest
boost in oxytocin, don't makethe yogurt like we usually do,
that achieves high count ofextended fermentation.
Instead, I would use a mixedculture yogurt, for instance.
(26:42):
Take your rotari starter.
It could be an osfortis capsule.
It could be tablets of gastristhat you crushed, and if you
don't know what I'm talkingabout, see my super gut book for
the recipe, see mydrdafusinfinitehealthcom blog
that has the recipe also, andthere's also many YouTube videos
by other people not just not mewho show you how to do this.
(27:03):
So take some source of rotariand combine it with other
microbes.
It could be a capsule ofanother commercial probiotic.
It could be some yogurt youbought at the store that has a
mixture of microbes at least twolike lactobacillus bulgaricus,
streptococcus thermophilus,bifidobacterium bifidum and some
others and ferment them alltogether.
(27:25):
So it's just like having abackyard garden.
If all you do is plant tomatoes,you're going to have a lot of
tomatoes at the end of thegrowing season.
But what if instead, at thestart of the season, you grow
tomatoes, an eggplant andzucchini and squash?
How many tomatoes will you have?
Well, far fewer, and you'llhave tomatoes to enjoy.
(27:46):
Likewise here, cultivatelactobacillus rotari in the
company of other microbes thatyou don't get these high counts,
so that you do get the microbe,but not these very high counts,
because we really don't knowwhat happens to a pregnant
woman's uterus.
Now, if you learn somethingfrom this Defiant Health podcast
, I invite you to subscribe toyour favorite podcast directory.
Post a review, post a commentand join the conversation.
(28:10):
Help build this community ofpeople who want to be free to
the health care system yet havemagnificent health.
Thanks for listening.
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