All Episodes

September 29, 2025 65 mins

Send me a text! I'd LOVE to hear your feedback on this episode!

Important links:

Get in touch with Dr. Cory Rice & his team here:  https://mymodernmedicine.com/meet-our-team/dr-cory-rice/?srsltid=AfmBOop9IaJVgYBnqGUvjhb0UjRNM8nxMSAJMaaZLt-ark8JH5cwU7jk

Follow me on Instagram:  https://www.instagram.com/sandyknutrition/

Follow me on Substack:  https://sandykruse.substack.com/

Are you considering Ozempic or another GLP-1 medication for weight loss? Before you jump on the bandwagon, this eye-opening conversation with Dr. Corey Rice reveals what your doctor might not be telling you about these popular drugs.

Dr. Rice breaks down the science behind GLP-1 medications with crystal clarity, explaining how they work in your body and who should—and shouldn't—consider using them. Unlike many providers who prescribe medications without adequate monitoring, Dr. Rice advocates for a comprehensive approach that examines gut health, hormone balance, and nutritional status before initiating these powerful medications.

Dr. Rice discusses "the cry box" phenomenon—patients who achieve lower numbers on the scale but suffer from hair loss, brain fog, anxiety, and other symptoms of malnutrition. These are people who come in tired and brain-foggy. They're happy with their weight because their weight has come down, but they're now on three to four different medications to treat energy, to treat anxiety, to treat sleep, he explains. If you're currently taking a GLP-1 medication or considering starting one, this warning alone makes the episode essential listening.

For women in menopause, Dr. Rice offers particularly valuable insights about how hormone balance affects weight management and whether bioidentical hormone replacement might be a better first step than Ozempic. He also delves into fascinating emerging applications of GLP-1s at micro-doses for inflammatory conditions like Alzheimer's and Parkinson's, revealing the broader potential of these medications beyond weight loss.

Whether you're struggling with weight issues, dealing with menopause symptoms, or simply interested in the science behind today's most talked-about medications, this conversation delivers practical wisdom you can use to make better health decisions. Share this episode with someone who needs to hear it—knowledge truly is power when it comes to navigating these complex

Support the show

Please rate & review my podcast with a few kind words on Apple or Spotify. Subscribe wherever you listen, share this episode with a friend, and follow me below. This truly gives back & helps me keep bringing amazing guests & topics every week.

Instagram: https://www.instagram.com/sandyknutrition/
Facebook Page: https://www.facebook.com/sandyknutrition
TikTok: https://www.tiktok.com/@sandyknutrition
YouTube: https://www.youtube.com/channel/UCIh48ov-SgbSUXsVeLL2qAg
Rumble: https://rumble.com/c/c-5461001
Linkedin: https://www.linkedin.com/in/sandyknutrition/
Substack: https://sandykruse.substack.com/
Podcast Website: https://sandykruse.ca



Mark as Played
Transcript

Episode Transcript

Available transcripts are automatically generated. Complete accuracy is not guaranteed.
Sandy Kruse (00:02):
Hi everyone, it's me, sandy Kruse of Sandy K
Nutrition, health and LifestyleQueen.
For years now, I've beenbringing to you conversations
about wellness from incredibleguests from all over the world.
Discover a fresh take onhealthy living for midlife and

(00:26):
beyond, one that embracesbalance and reason, without
letting only science dictateevery aspect of our wellness.
Join me and my guests as weexplore ways that we can age
gracefully, with in-depthconversations about the thyroid,

(00:49):
about hormones and otheralternative wellness options for
you and your family.
True wellness nurtures ahealthy body, mind, spirit and
soul, and we cover all of theseessential aspects to help you
live a balanced, joyful life.

(01:10):
Be sure to follow my show, rateit, review it and share it.
Always remember my friendsbalanced living works.
Remember my friends, balancedliving works.
Hi everyone, welcome to Sandy KNutrition, health and Lifestyle

(01:31):
Queen.
Today with me I have Dr CoreyRice and he's a weight
management specialist and he'svery, very well versed in GLP-1s
.
Yes, we are talking aboutOzempic and Wegovy and any of

(01:52):
the GLP-1s.
We get into so much detail inthis podcast recording.
We basically talk about whatcomes after GLP-1s as well,
because the facts are, you know,this is actually a diabetic
drug, so we even get into someother stuff, like you know, 50

(02:18):
plus women who just want to beskinny again, and what are the
implications of this and what isit even doing to society on
what is beautiful, what is not.
I mean, this is such a bigconversation.

(02:38):
I have talked at great lengthabout weight, about what is
health.
The reason I did that, or dothat, I should say, is because I
don't have a thyroid gland andI'm going through, or have gone
through, menopause without athyroid gland and most of you
who are listening know that thethyroid is like.

(03:01):
The Thyroid is like thethermostat for your body's
metabolism.
It controls everything, andhaving my entire gland removed
definitely changed my lifeforever.
And weight is something thatyou know.
For me, I'm always thinkingabout it, guys, and this is the

(03:28):
truth, and a lot of women obsessof you know that 30 something
body they used to have.
These are definitely my truths.
I'm not that.
You know I'm only five foot twobarely, and you know I can't
chase that 110 pound bodyanymore.
I can't.

(03:49):
And as much as I'd love to bethinner, I also know the
implications of being too thinas we age and that is one of
frailty.
So we get into a lot of this.
This is such a massiveconversation.
I'm going to ask you to please,please, share this.

(04:10):
Share this with a friend, sharethis on social media.
Be sure to tag Sandy KNutrition.
It's kind of the way that weget the word out, because I
don't do any advertising for mypodcast.
It's going to be six years inFebruary since I started this
and I would just reallyappreciate that, and I would

(04:31):
also appreciate it if you can goahead and review my podcast
with a few kind words on Spotifyor on Apple.
Those are the best ways to doit.
And, yeah, follow me onInstagram.
I'm quite active there and, yes, I thank you.
Thank you, thank you so muchfor being here each and every

(04:54):
week.
And now I'll cut on through tothe interview with Dr Cory Rice.
Hi everyone, welcome to Sandy KNutrition, Health and Lifestyle
Queen.
Today, I have a special guestwith me.
His name is Dr Cory Rice, andDr Rice graduated from Baylor
University.
I've heard great things aboutBaylor, by the way.

(05:14):
It's cool, it's cool, greatthings.
And he graduated with abachelor's degree in forensic
science and then completedmedical school at the Arizona
College of Osteopathic Medicinein Glendale, arizona.
He attended Methodist MedicalCenter of Dallas for his
internship and residency ininternal medicine.

(05:38):
Dr Rice's professionalinterests include
nutrition-based chronic diseasemanagement, thyroid management
hey, did you know I don't have athyroid gland?
Maybe you didn't even know that.
Maybe we can talk about that.
We could talk about thatdefinitely.
Longevity, precision medicineand bioidentical hormone

(06:00):
replacement therapy all myfavorite topics.
His main focus in his practiceis on wellness and prevention,
nutrition, therapeutic lifestylechange and appropriate
lifestyle medicine.
Dr Rice also currently servesas the chief clinical advisor
for BioT Medical, the nation'sleading provider of natural

(06:23):
hormone replacement therapyusing subcutaneous pellets, and
today I'm so excited about this.
I have been wanting to do ashow on GLP-1s for a long time
and I've kind of waited for theright person.
And here you are now to talk tous all about GLP-1s and

(06:49):
everything in between, like whatcomes after, who are candidates
.
So I am so excited to welcomeyou, dr Rice, to the podcast.
Thank you for coming.

Dr. Cory Rice (06:59):
Yeah, thanks, sandy, I appreciate it.
This is a hot topic really foranybody, whether you're a
clinician or just a consumer,layman, patient.
What have you so?
Anytime I can spreadinformation and not
misinformation, happy to do it.

Sandy Kruse (07:12):
Yeah, and now I think that you have a very busy
clinic there.
Maybe tell us a little bitabout your background.

Dr. Cory Rice (07:19):
Yeah, love to.
So I think it's important tounderstand I started out not
necessarily knowing or wantingto go into health care.
As you mentioned, I actuallywas the first graduate from
Baylor with a forensic sciencedegree.
So I actually worked in lawenforcement for two or three
years on the forensic side ofthings and dealing with death
honestly, and what that taughtme was how to put puzzles

(07:41):
together.
And what that taught me was howto put puzzles together.
Essentially, what studyingdeath taught me was how to put
people back together and telltheir story.
And the irony is I've kind ofcome full circle in what I do
now.
So I conventionally went intointernal medicine, not knowing
what I wanted to do when I wentinto healthcare, and ultimately

(08:01):
that gave me a ton of options.
So I worked in inpatientmedicine, outpatient medicine,
really dealing with the sickestof the sick, and this was
roughly 13, 14 years ago, twoyears of doing that.
I was pretty disenfranchisedwith medicine and the medical
machine, as I like to call it inthe country, up an outpatient
practice and grew that reallyinto what it is now, which is

(08:24):
truly more of a functionalmedicine, slash lifestyle
medicine type emphasis.
Internal medicine really gaveme the skills and the tools to
understand the breakdown ofglands as they become
chronically diseased, but itdidn't really help me understand
how to fix people or put themback together, and so I started
off in death and now I work inlife putting people back

(08:46):
together.
Um, because every human being,whether you have weight
challenges, whether you haveHashimoto's, whether you have
cancer, whatever you have,there's a reason, um, and if you
can figure that, puzzle out andreconstruct something, um, and
restore function back todysfunction, oh my God.
It's like it's literally noteven a, it's like a hobby for me

(09:08):
to give people back theirhealth, essentially.
And so that's, in a nutshell,what I do.
I have two offices in theDallas area that are busy.
I've got a team of people.
It takes a village.
It's not about Dr Rice, it'sabout the people that support me
and I support, and we have tensof thousands of patients that
we interface with on a dailybasis, from all over the country
, and we treat a myriad ofthings.

(09:29):
Whether you're a professionalathlete, I've got actors, I've
got actresses, I've got peoplethat are sick, I've got people
that have a year to live, youname it, everything in between.
So that's really what I do dayin and day out.

Sandy Kruse (09:42):
Yeah, I love the way that you explain that about
putting people back together and, you know, because I believe
that we all have the chance tomake changes that can really
have an impact and I love thatyou kind of look at it

(10:04):
holistically.
You look at a person's healthholistically.
You don't discount nutrition,you don't just.
You just kind of, like you said, you piece them together.
And one of the big things thatwe're seeing right now and you
know this in your practice yousee this all the time.
I'm sure People think GLP-1sare a quick fix.

(10:27):
Right, let's just lose a fewpounds here and there, Dr Rice,
let's just get it done withoutmaking the changes.
There's a lot of confusion onsocial media because you have so
many different people talkingabout it in different ways, so
maybe let's begin with what areGLP-1s?

(10:48):
That's a good place to start.

Dr. Cory Rice (10:51):
Yeah.
So you know mechanistically.
What's really important, Ithink, for your audience to
understand is you and I, ashumans we all as humans make
GLP-1s in our body.
So a GLP-1 is something we'reproducing inside of our gut.
So that'll come back later whenwe get into the gut.
But ultimately, if you havepoor gut health, you're not
making a lot of GLP-1.
So why I mention this is if yougo on to GLP-1 appropriately,

(11:17):
you should do okay on it if youhave appropriate gut function
period.
If you have a dysfunctional gutand a dysfunctional diet, you're
not going to respond well to aGLP-1 because you're not even
able to make your own GLP-1.
So, to answer your question,what do they do?
Essentially, they increase thesecretion of insulin.

(11:37):
So insulin, as your audiencemay know and tongue-in-cheek I
like to say, we are the UnitedStates of diabetes and we are
the United States ofhyperinsulinemia, or high
insulin.
It is what it is.
We have a lot of people Upwardsof 40% of the human population
in this country has high insulinor insulin resistance.
So GLP-1 specifically helped toforce the body to secrete

(11:58):
insulin, which helps to bringblood sugar down.
So in a way, it's helping tosensitize the cells within the
pancreas that make insulin.
When someone develops diabetes,they lose those cells in the
pancreas to make insulin, so ifyou're not making insulin, your
blood sugar stays way high andyou get diagnosed at some point
with diabetes.
So that's number one.

(12:18):
The other thing it does is itsuppresses what's called
glucagon.
Glucagon is a hormone thatessentially just raises blood
sugar, and so it suppresses theexcretion of glucagon or the
production of glucagon, so, in away, that's a positive thing.
The other thing it does is itpromotes the term satiety or
fullness.
So, essentially, you injectthis compound and you just feel

(12:41):
full, and so those are themechanisms of action of what
they're actually doing.
I think the devil's in thedetails, though, of is that
appropriate for everyone, and isit not?
There are certain people youhave to be careful with on these
things.
I have used these compounds,and I would say, for certain

(13:03):
patients they're miracles, butthese are not, in certain and
most cases, to be forever inperpetuity compounds.
You have to be able to come offof them at some point, for
whatever reason, and if that'sthe case, you want to keep the
weight off, you want to keep thefat off, right, and so,
mechanistically, that'sessentially what these GLP-1s

(13:24):
are doing, and somechanistically.

Sandy Kruse (13:26):
that's essentially what these GLP-1s are doing.
Okay, I have a question aboutthat, because a big piece of
this is it used to be used onlyin diabetics.
Is that right?

Dr. Cory Rice (13:35):
Yes, yes.

Sandy Kruse (13:37):
That's what it was kind of created for.
So let's say we're talkingabout who it's for.
Let's say I'm 55 years old, I'min menopause, I have some.
You know it's not that easy forme to keep weight off.
I have a good lifestyle.
I move my body every day, I eatwhole real foods, that kind of

(14:02):
thing.
My HbA1c and I know you'reprobably going to get into what
that is is decent.
I just had it done.
It was 5.5.
You know, I know you'd probablysay 5.2 is better, but HbA1c is
okay.
My fasting glucose is okay.
My fasting insulin is okay.
Could I even think about goingon it?

(14:23):
Like, who's a candidate for it?

Dr. Cory Rice (14:26):
Okay, so to your point on label, yes, diabetics
and potentially weight losspatients, people that have a BMI
above a certain cutoff wherethey are clinically obese or
overweight.
But I will also tell you, as afunctional medicine person who
essentially all that means isyou're finding the root cause of

(14:47):
someone's illness, you're nottrying to just cover it up with
a bunch of pharmacologic agents.
So that's my whole deal is look, there are lots of things we're
uncovering about thesecompounds, and the two pillars
of treatment are for thediabetics and for people that
need to lose some of thevisceral fat or some of the
inflammatory fat around theirbody.

(15:09):
The real answer here is and alot of this has not been parsed
out completely in the literaturethis is more of anecdotal or
observational because of a lotof us that do this.
But I will use small dosages ofthis in inflammatory
degenerative illnesses, and soyou name it.
I've used it in multiplesclerosis, I've used it in
Alzheimer's, dementia,parkinson's, as a very, very

(15:30):
tiny dose.
This is not for people to loseweight.
This is a compound that appearsto be sweeping the body of
inflammation.
So we do know that it lowersthe amount of beta amyloid
overload, which can be one ofthe mechanisms leading to
degenerative illnesses, whetherthat's Alzheimer's, whether
that's Parkinson's, whetherthat's you know, you name it

(15:51):
multiple sclerosis.
And so I think there's a way andthere's a place to use this.
These aren't going to be FDAapproved, on-label uses.
These are going to be off-labeluses, which I mean 70 to 75% of
medicines used in America areoff-label anyways.
So you know, that's justessentially what we do, and so I

(16:14):
think, yes, if there's someonethat's needing to lose weight,
it's a consideration.
However, I'll just give you myopinion on the use of these.
In the initiation of them, Idon't think anyone should use a
GLP-1 or consider a GLP-1,whether this is an injection or
oral administration, untilyou've objectified what is their

(16:34):
menu plan and nutritionalprofile and their day-to-day
habitual eating schedule?
What do they normally do as faras their diet on a normal basis
?
And two objectify whether theirgut function is even
appropriate to handle the weightthey're about to lose.
So if you don't digest protein,carbs, fats, if you don't break

(16:56):
them down, if you don't absorbthem, if you've got overgrowth,
undergrowth, parasite, pathogen,I mean, if you have things
happening within your gut andyou're not looking at that and
you put someone on a weight lossagent, you are setting yourself
up for a disastrous outcome,and I see this time and time
again.

Sandy Kruse (17:11):
Yeah, there's a lot of symptoms that I've heard
about with GLP-1s in some peopleand then some people are fine.
So what are some of thesymptoms that some might
experience if those things arenot in order that you mentioned?

Dr. Cory Rice (17:27):
Yeah, Two most common side effects, bar none,
are nausea and having reflux orheartburn.
You know, I think doneappropriately, you don't have
many of those side effects.
You don't have many of thoseside effects.
Again, I'm biased to myselfbecause I see what I see every

(17:52):
day, but I just don't see people, Sandy, with side effects very
often, and if they do, it'sgoing to be mild nausea or mild
reflux.
There's some literature outthere about it delaying gastric
emptying or delaying the foodclearance through the stomach
and then ultimately leading to aparalyzed sort of stomach where
things aren't mobile.
And I mean, I have never seenthat.
And I guess, listen, you givethe wrong agent to the wrong

(18:13):
patient.
If the wrong doctor gives thewrong agent to the wrong patient
, you're going to get the wrongoutcome.
So I guess in the realm ofreality, sure, those things can
happen.
But I think, done appropriatelyand this is one big problem, I
think in my profession there'sno real certification, there's
no real licensing, there's no.
If you have a medical license,you have a medical license and
you can sort of like do what youwant and what you feel is

(18:36):
appropriate for your patient.
You don't need to go throughGLP-1 training and unfortunately
we don't have that.
I think it'd be nice becausethere's best practices out there
where patients just do not getthe side effects and they
achieve the results they wantand they keep the weight off.
That's ultimately what I thinkanybody wants.

Sandy Kruse (18:55):
That goes on to this so, because you obviously
have a ton of experience withGLP-1s and not everybody who's
listening is going to come toyou your doors are probably
already pretty busy.
So what would a patient want toask of their practitioner?

(19:15):
You know what questions areimportant for a patient to ask
or even know about.
Like, what do you need to knowof this practitioner before they
put you on it?
Because I'm going to tell you,dr Rice, like I'm not going to
name names, but I know ofdoctors who are just sending

(19:36):
emails saying, hey, have youthought about going on one?
And I'm like, okay, well,what's your process?
How do you know if I'm acandidate?
Yeah, well, I'm going to leadit off.
Simply, you should ask themwhat's your process.

Dr. Cory Rice (19:44):
How do you know if I'm a candidate?
Yeah Well, I'm going to lead itoff.
Simply, you should ask them doyou have a process?
A lot of them do not, so a lotof my colleagues.
It's literally a prescriptiverelationship If you want it, you
get it, and when you don't wantit, just tell me you don't want
it.
There's no, you just call theoffice and we'll fill it for you
and that's it.
I mean, there's no supervision,there's no oversight.
So the first question is do youhave a process?

(20:04):
And if so, what is it?
I know my process, but I'm justsaying you need to have a
process because, ultimately,losing weight is not healthy.
If you're losing healthy weight, so you're trying to drive
unhealthy weight.
You're trying to drive theunhealthy weight that you're
trying to lose correct.
You're trying to sensitize theinsulin.
So this is another veryimportant part of insulin.

(20:25):
Again, this compound inducesthe secretion of insulin so you
can keep blood sugars lower.
Well, insulin is a growthhormone.
So what I would tell yourlisteners is one simple,
ineffective, inexpensive testhave your provider check your
fasting insulin.
What is your insulin?
If someone has an elevatedinsulin level, they have an
elevated growth hormone.

(20:46):
So the more insulin you have,that you're producing, you're
going to grow.
Your belly is going to grow.
Other things in your body, liketumors and cysts and skin tags
and polyps in the colon, theygrow when you have high insulin.
So insulin is an independentrisk factor for cancer.
So I would say always checkyour insulin level if you can.

(21:09):
If they don't, no problem.
But back to okay, let'sdetermine.
You put me on this.
What does this look like?
Well, the most important thing,when you go on to a weight loss
agent like a GLP-1, can youretain muscle?
In my opinion, muscle is thecurrency of life.
If you don't have muscle orlean, dense mass, you don't live
as long, you don't live ashealthy period, you become

(21:30):
disabled more.
So you need to retain muscle.
And as we age, you hit on thehormonal thing and I can hit on
that later.
But we all lose hormones.
As we age, we lose hormones.
So when you lose hormones,things happen right you lose
muscle, your blood sugar goes up, your blood pressure goes up,
your cholesterol goes up.
Everything happens as you losehormones.
And so that's a critical pieceas well.
But I would want to know how doyou ensure that I'm losing the

(21:55):
weight you want me to lose, iethe fat, and I'm retaining my
muscle.
How do you monitor my proteinconsumption?
Right, protein to helpsynthesize muscle protein
synthesis.
I mean, if you don't eat enoughprotein, because this agent, as
I said, is inducing fullness,it's reducing your appetite.
So if you're not wanting to eat, you have to make sure that

(22:16):
when you do eat, you're eatingprotein period, otherwise you
will lose your weight and that'sgoing to just.
I hope we get into this becauseI want to talk to you about
these individuals out there thatare on GLP-1s.
They've been on them foreverand they're now a malnourished
human and they like what I callthe cry box.
The cry box is the square onthe ground.

(22:36):
You step on it and it gives youa number and it makes you cry.
Well, that cry box may begetting better.
What I'm referring to is clearlya scale.
The scale number may be gettingbetter, but you feel awful.
So is it worth it for thatnumber to make you happy, but to
feel completely awful?
And there's real reasons whythey feel awful that you know.

(22:57):
If you want me to get into, Ican, but these are things that
I'm seeing now People that areon these, but on them way too
long, and when you ask them thequestion, what is your goal and
what is your treating provider'sgoal Like?
What are we trying to do here?
They all say the same thingWell, I wanted to lose weight.
They didn't really tell me whattheir goal was.
It was just do you want it ordo you not?
And that's a lot of themajority of the relationships

(23:18):
out there between provider andpatient.

Sandy Kruse (23:21):
I think you raised such an important point just
right there.
I have actually written aboutthis because I am a person who
has, since I had a totalthyroidectomy.
I'm not the same as I once was.
I don't care that every doctorsays, well, it should be,

(23:45):
because you're on this mix andyour thyroid panel looks perfect
.
I'm like I don't care.
It's not my actual thyroidorgan, it's never going to be
the same and I'm also inmenopause at 55.
So I've got a lot of thingsgoing on.
So for me, health is the mostimportant thing.
But guess what I see.
Health is the most importantthing, but guess what I see.

(24:09):
Every TV station you turn on,you see these celebrities, the
real housewives, all of them.
You know they talk aboutozempic face muscle wasting.
They look frail.
To me, these are women that aremy age and I'm like if this is
the example that a lot ofmenopausal women are looking at,
it's very unhealthy In my mind.
As a holistic nutritionist, I'malso a certified metabolic

(24:30):
balance coach I'm like this isnot healthy for everyone.

Dr. Cory Rice (24:35):
Demonstratively true, yes.

Sandy Kruse (24:37):
And, honestly, there's a lot of stuff that goes
on in a woman's brain aroundmenopause and it can really mess
with what you think isbeautiful, what you think is
healthy.
So it's a lot bigger of youknow a subject and you know I
would love for you to get intosome of this.

(25:00):
Get into some of the musclewasting aspect that we see.
The ozempic phase, like howdoes one safely who's a
candidate?
Like am I a candidate?
If I'm, and I and, by the way,I have one of those body
composition scales because Iwant to see what's going on with
my bone, I want to see what'sgoing on with my muscle, I want

(25:21):
to see what's going on with myentire physiology, everything.
So who's a candidate?

Dr. Cory Rice (25:30):
Yeah.
So listen, as before, diabeticsand insulin resistant patients,
people with high insulinthey're candidates.
They're candidates to considerthe compound.
You still have to find someonewho is going to do it safely,
appropriately, I think.
Anyone who is having massiveproblems losing weight you know
these people.
I've tried everything,everything, literally everything

(25:52):
, and I can't lose weight.
Those are considerations to trythis.
I still would strongly recommendyou understand how to eat prior
to this, how to even followthese things, how to follow
nutrient-dense platforms priorto doing a GLP-1, because I'm
going to get into what you callthe ozempic phase and sort of

(26:12):
the other side of it.
But you need to know thesethings beforehand.
I still want to know, in somecapacity, what is your gut
function, basically speaking?
Do you take the trash out everyday?
If you do not take the trashout every day, you're going to
feel like trash when you go onGLP-1s.
It's just that simple.
So if you're not havingadequate bowel function going

(26:34):
into a GLP-1, you need to getadequate bowel function before
you go on to a GLP-1.
These are very basic things butthey're not looked at in
medicine, which is very, veryunfortunate.
So then you get to the otherside of this and the people that
go on to this and you know, arejust raving about their weight

(26:56):
loss and things like this.
What I would tell you is a lotof these people, what they're
not telling you and this is avery, very I'm going to keep
this as basic as I possibly canCellular death within the body
exhibits very concrete symptoms,right?
So I started off in death.
Now I'm working in life and Ican tell you, when someone's

(27:18):
dying, they're, they willexperience everything from hair
loss to brain fog.
They can't remember yesterday,they can't remember this morning
, their energy goes to thetoilet, they don't feel good,
they get anxious, they get panicattacks, they're very depressed

(27:39):
, they're not motivated.
Their nails are starting tobreak.
Their skin is very, very dry.
Motivated their nails arestarting to break.
Their skin is very, very dry.
That is the sign of someone whois, little by little by little,
dying on the inside.
So this is what I see.
These are people that come inthat are like tired and brain
foggy.
They're happy with their weightbecause their weights come down
, but they're now on three tofour different medications to

(28:02):
treat energy, to treat anxiety,to treat sleep.
None of these things work.
None of these bodily functionswork when you're not feeding it.
So what I tell them is you arenutritionally deplete.
You have no basic raw materialto make your machinery run.

(28:24):
It's literally like we ploppedyou on an island with no food.
And we come back and check onyou in four weeks and you're
sitting there and you're like ohmy God, I'm skinnier, but you
can't remember yesterday.
You're so tired and you feelawful.
This is the sign of someone who, on the inside, needs nutrition
.
So these people, what I tellthem is I have to deconstruct

(28:47):
you before we can reconstructyou.
You haven't earned the right tobe on GLP-1.
And they all say the same thing.
Well, if I stop this compoundI've been on it for a year and a
half If I stop it, I'm going togain weight.
I'm like I don't care, you'redying.
I mean, we need to feed youappropriately and then, if you
start storing visceral fat, wecan consider earning a GLP-1

(29:10):
again.
But my goodness, we've got tolike save you right.
And that's what we're seeing ispeople that are now being
medicated on a GLP-1 forsymptoms caused by the GLP-1.
And I'm not saying this is oneor 10 people caused by the GLP-1
.
And I'm not saying this is oneor 10 people.
This is like an army of peopleout there that think it's normal
because they get around otherpatients that are like oh yeah,

(29:31):
girl, I feel the same way, but Ilike how I can fit into my
shirt and I'm like what, do youunderstand what I'm saying?
It's very, very backwards.
So I think you can have thebest of both worlds.
I think you can learn how toeat food appropriately, I think
you can absolutely get adequategut function and I think you can
qualify to go on a GLP-1.
And I think you can lose thefat and I think you can retain
muscle and I think you can getoff the GLP-1.

(29:52):
I think those are the types ofthings I keep coming back to.
Is what I'm saying Iunfortunately feel like is in
the minority.

Sandy Kruse (30:04):
That just isn't how practices are run when they're
using GLP-1s and it's veryunfortunate.
Yeah, you know I actually likeright here I'm looking at it I
have a vitamin and mineralreference guide that shows all
the nutrients and the symptomsof depletion and the foods that
you need to actually restore thebodily functions.

(30:28):
So I love what you're saying,because not enough people are
saying it.
So it's not about the weightloss, it's about really making
your body more efficient andhealthier.
And really, for middle-agedwell, I guess technically I'm
past middle age, unless I liveto 110, which it's always

(30:51):
possible, right?
But for people around 40, 45,when they start to see changes
in their body, if they're noteducated enough in how to
support their body before theygo on it, then that's when you
see all those symptoms.
So I love that you brought thatup.
Now here's a question for you,and I don't think I've ever read

(31:15):
anything about this.
You know, if somebody losesweight too quickly, is it
possible that they can do damageto the gallbladder?

Dr. Cory Rice (31:27):
You know, I think if you lose weight too quickly,
that is induced.
Or if it's, you know,unfortunately in healthcare when
someone loses weightunintentionally it's cancer
until proven otherwise.
It's cancer until provenotherwise.
And so, yeah, if it's from that, if it's from a malignancy that

(31:48):
you don't know you have, thencertainly it can lead to all
sorts of organ dysfunction andorgan problems.
If you're inducing, if you'redoing a caloric restriction and
you're giving a signaling agentthat's telling the brain stop
eating, if every gland is notgetting the raw material it
needs, if it's not getting thenutrition it needs to actually
operate and like just basicthings like protein

(32:08):
transcription and translationand just simple.
You know the Krebs cycle andATP and all that.
If you're not, I mean it standsto reason that whether it's the
gallbladder or whether it's thekidney or whether it's the
liver, the brain is always thefirst to be preserved.
So you know the body will doeverything it can to protect the
brain, and basically at thedetriment of everything else.
But if you're not gettinganything else to the other

(32:30):
organs, then it stands to reasonthat sure you can have issues
there.
Because if you're not feedingthe body, the gallbladder isn't
being used, it's not secretingthe bile acids to help with
digestion, because there'snothing to digest.
So yes, I think that's possible, for sure.

Sandy Kruse (32:48):
Now, another thing that I know a lot of people have
heard about, and I'm sureyou're going to know.
The answer to this is that, oh,just take this Ackermansia
probiotic and it's just like aGLP-1.
What are your thoughts on thatone?

Dr. Cory Rice (33:06):
Yeah.
So this is a great question.
So, to your listeners,acromantia is a microorganism
that essentially to keep itbasic it helps to just feed and
create and restore the biofilm.
So, just as you may know, theintestinal wall is surrounded by

(33:27):
this mucosal layer.
It's this sort of slimy layer.
Well, that slimy layer is whathouses all of what's called the
commensal bacteria.
It's all the bacteria thatsupports the immune system and
fights off everything fromcancer to COVID, to viruses, to
funguses.
What have you?
Ackermansia, historically, hasactually been very difficult to
fix without your diet, withoutdoing prebiotics and fiber and

(33:49):
eating correctly, and all ofthat.
There's particular companiesnow that have invested lots of
money in the ingenuity intoactually getting acromantia
isolated so that you cansupplement with acromantia to
essentially facilitate thecreation of the biofilm, so that
your intestinal wall, ie yourimmune system, which is where

(34:10):
about 70% to 80% of it resides,is now intact.
So things like Hashimoto's orthings like autoimmune disease
or what have you start gettingbetter.
I mean, truly that's how thatworks is you're repairing the
immune system.
So acromantia is a great toolto use to seal the gut if
there's problems.
And you've objectified that theacromantia counts are low.

(34:31):
I think the biggest thing aboutacromantia and you're exactly
right it's now being tied offinto glucose response and GLP-1s
, and I'll get to there.
But what I want to tie off isacromantia is not an in
perpetuity organism.
You can't keep taking thisforever.
It is meant to cycle on, cycleoff.
So 90 days, tops maybe evenless, is enough.
If you keep taking acromancia,you're going to get overgrowth

(34:53):
and that's going to lead toiadefinitely has a role in
inducing the gut to make its ownGLP-1.
Therefore it does stand toreason that there could be some.

(35:14):
There is adult literature thatacromantia can help regulate
with glucose utilization and theglycemic response, so I think
it's something to it, but itstill doesn't change the fact
that you can't be on acromantiain perpetuity period.
So I hope that answers yourquestion.

Sandy Kruse (35:31):
Yeah, yeah, you did , because it's also misleading.
When you see it and if you'renot in the industry you may not
understand You'll be like, ohyeah, all I got to do is take
some acromantia and it is like aGLP-1.
So you've made it very clear,dr Rice, that it will help your

(35:54):
body to make GLP-1s itself, butyou cannot stay on it.
I know I went on a littleacromantia protocol last year.
I only did two months of it, soyou know, but and I haven't
touched it since and I guess Iguess it could be something that

(36:18):
some might try.
Here's another question, thoughI don't want to lose this one
because it's if you know you'retalking about stabilizing
somebody's wellness beforethey're, you know, ready for a
GLP-1, making sure that allthings are in order with
bioidentical hormones Isbioidentical.

(36:39):
Are bioidentical hormones apiece of that puzzle that might
actually help to stabilize evenweight?
Even like let's just say I'm amenopausal woman.
Who knows, maybe if I get onthe right mix of hormones I'm

(37:00):
not gonna.
The weight will come off anyway, like what are your thoughts on
that?

Dr. Cory Rice (37:03):
Exactly, exactly correct.
So the term hormonal imbalanceis real.
It isn't woo-woo, it isn'tconjecture.
The women make three hormones.
To keep it simple, as I keepsaying testosterone,
progesterone and estrogen.
If those are out of balance,your weight is out of balance.
It's that simple.
If one is too much, you gaintoo much weight.

(37:26):
If one is too little, you can'tlose weight.
It's this sort of like.
You have to walk this balanceand I guess the reality maybe
it's unfortunate, maybe it's notthis whole thing we're talking
about is what I callidiosyncratic.
It is very individual to theperson.
It is not a wide.
What works for your friend oryour sister or your mother or
your audience doesn't alwayswork for you.
Everyone needs an individual,personalized assessment to

(37:48):
determine what ratios they needand how much they need of what
Same thing on the male side Very, very synonymous.
And so, to your point, I wouldput this in the category of so
hormones, eating appropriately,peptides, supplements, any of
that stuff.
If you don't optimize thosethings prior to trying a GLP-1,

(38:11):
you will not get to the mostefficient, effective and healthy
response on a GLP-1 thansomeone who doesn't do those
things.
So since we're on the topic ofhormones, people do not respond
to a lot of things as favorablyon the weight loss side if their
hormones are not balancedappropriate.
You use the term bioidentical.

(38:32):
That term is fine.
I like the term isomolecular.
It's essentially a moleculethat is identical in your case
to the ovarian hormones you'vebeen producing, since your
ovaries have been producinghormones, and the same idea on
the male male side.
So I'm just very simple.
Why would I put something in mybody or recommend for my
patient's body something that isnot identifiable from what I've

(38:56):
been producing my entirenatural life or what this
patient has been producing?
I don't think putting asynthetic hormone makes a lot of
like sense just at the receptorlevel, because the receptor
isn't understanding what you'retrying to get it to receive.
And so, yes, I am a fan ofhormones that are
indistinguishable, essentially,from what a human has been

(39:17):
producing their entire naturallife, since they've been
producing hormones.
But balancing these hormonesappropriately are critical if
you're considering going on aGLP-1.
So put that back on thechecklist when your audience is
looking for providers.
I would say do you check myhormones Period, do you at least
start with the labs, and thenit leads to a conversation and

(39:38):
you hit the nail on the head.
That conversation may lead toother service lines and other
modalities that dissuade youfrom ever even wanting a GLP-1.
Like once, you get like theability to lose weight and gain
muscle, and you know this themore muscle you have, the better
your metabolism.
If you don't have much muscle,you don't have a great
metabolism, so you need hormonesto build muscle.

(39:59):
So if you build muscle, youhave better metabolism.
Better metabolism, you loseweight.
You lose weight.
You may not need a GLP-1.
I mean, it's all this sort ofthing, right?
So I hope that's what you'reasking.

Sandy Kruse (40:08):
That's exactly what I was asking.
So I haven't startedtestosterone yet or DHEA.
Those levels have been prettygood and I started with
progesterone and estrogen, butyou know that's not to say
things aren't going to change.

(40:29):
And then I'm going to want tobring that in because I know
testosterone can be very helpfulfor a lot of women to help the
building of the muscles, soespecially at my age.
So you mentioned peptides Likewhat kind of peptides do you
like in somebody who's midlifelet's use a woman's body who's

(40:53):
midlife, in menopause trying tolose a bit of weight, maintain
muscle.
How do peptides come into playhere?

Dr. Cory Rice (41:01):
Yeah.
So great question I would startoff with I don't initiate
peptides until hormones areassessed and balanced, because
then, once you get those in theranges where the literature
supports them being so that youdo get optimization on the

(41:22):
symptom side of hormones,whatever's left over that isn't
getting better, whether that'sbody composition, maybe it's
sleep, maybe it's energy, maybeit's cognitive problems, I don't
know.
Hormones usually hit most ofthat, but there's still people
that are going to be like okay,libido's better, sleeping better

(41:42):
, I just can't lose this weight,I can't build this fat, I can't
.
That's where I feel likepeptides, assuming everything
equal, their diet's fine and allof that.
That's where I feel likepeptides can help.
So, whether it's the bodycomposition so there's different
groups and classes of peptideswhich you and your audience may
know and maybe they don't.
But back to my same, before Igo further with this, peptides

(42:05):
are just groups of amino acidsthat are grouped together and
essentially the way I thinkabout it is these exist in our
bodies naturally.
These have been compounded in away that delivers something a
little more concentrated andmore therapeutic therapeutic, so
you can get there quicker thanwaiting for your body to produce

(42:27):
it on its own timeline.
So, whether it's the bodycomposition ones, there are ones
that help with hair loss.
Let's say that you have hormonepostmenopausal hair loss or
hormone-induced hair loss.
There's wonderful peptides thatyou can use as foams, gels and
injections to help fix that andkick that back into place.

(42:48):
There's great peptides forcognition, cellular energy,
which means body energy,cellular health and recovery and
things like that.
So the body composition oneshelp with recovery.
There are great ones for sleep.
So even if progesterone andestrogen and the combination of

(43:08):
testosterone in a woman is nothelping you sleep, there's great
peptides to help you sleep.
And the great thing aboutpeptides is, again, they're not
pharmacologic agents in thesense of synthetic
pharmaceuticals.
They are tolerated very, verywell.
There's very little downside todoing them.
I think the one thing I wouldcaution about peptides,

(43:30):
depending on the ones you use,is those are similar to
acromantia.
You cycle on some of them, youcycle off, because you will
build up your receptors, willbuild up a tolerance, and the
peptide won't work on you as itonce did if you're not careful
there.
So you know, honestly, thedevil's in the details.
It depends on the type of whatyou're looking to do, but

(43:52):
there's usually a peptide formost of these things on the
enhancement, regenerative sideof things.

Sandy Kruse (44:02):
So there's actually a lot of things to consider
before you, you know, decideokay, I'm a candidate for a
GLP-1.
So I think yeah, I meanhonestly, you know this a lot of
times people just want thequick fix.
But if you want a fix, youcan't just not do the work, like

(44:25):
you got to do the investigationand then you got to see what's
out of balance and what is.
You know what are the causativefactors for it?
Sometimes it just might be age,sometimes it might be genetics.
Like there's many, so manyavenues to look through.

(44:58):
There really is, there reallyis to me.
And then you know work withyour practitioner to say, okay,
let's tweak this a little bit,maybe this is what you need,
let's do some tests.
So it's just, you gottaeveryone's individual and I love
that you speak about that.
But I know people who are onGLP-1s and they're going to say,

(45:21):
okay, well, I'm scared to getoff of them now because I'm
going to gain the weight.
So could you get into that withus a little bit?

Dr. Cory Rice (45:31):
Sure, and what I would tell you before I get to
that is you are so correct.
The best patients I see are theones that know their bodies so
well that, quite frankly, whatthey really pay me for is to be
their pattern recognitionspecialist, because they know I
see a lot of other patients andthey really draw upon my
expertise to help them in theirconstellation of presenting

(45:55):
symptoms.
That is not like every otherfemales or every other males,
and so I love people that are soin tune with their body that,
because they make my job mucheasier than going on this wild
goose hunt looking for thingsthat I don't know that are there
.
I would say that my colleaguesmay not feel that way.

(46:16):
Sometimes they may be scared ofthese people that come in and
they're so I need this is what Ifeel on these days, and I'm
like heck.
No, you're your own doctor.
I'm literally just here trying.
You are the captain of yourship.
I am just trying to steer it ina way that's going to get you
to your health goals but,honestly, keep you off out of

(46:36):
the medical machine.
I mean, that's what I'm tryingto do, and so you're just so
right.
I wanted to.
I wanted to say that.
So to the people that arenervous or scared about coming
off of GOP ones, um, I wouldjust tell you this they're not
going anywhere.
So if you just were nervous,understand, if you come off of
it, I'm sure you could go backon it, um, if you had to, but at

(46:59):
some point assuming you don'thave a degenerative illness um,
that I feel like maybe might bepart of your treatment regimen
on the long haul in microdosing.
Now, microdosing isn't aformalized, recognized term, but
microdosing is below the dosingthat has been approved by the
FDA for diabetes and weight loss, and so a very, very small dose

(47:19):
can help sweep the body.
As I said, not lose weight, butsweep the body of that
inflammation.
So there is somewhat of anargument on that side to discuss
it.
But let's not talk about thosepeople.
These are just people straighton GLP-1s, had good success, are
nervous to come off of them.
What I would say is alwaysstrive to get on the lowest dose
you possibly can.
That give you the results,because eventually what you're

(47:40):
going to find is you may notneed to be on this like you
think, because the body has away of adapting.
So if you go on a GLP-1 and youget up to one of the higher
dosages and you lose the 30, 40,50 pounds and then you back off
to 2.5 or the 5, whatever it is, whatever compound we're
talking about.
On the lower end of the dose, ifyou've removed, you've

(48:00):
essentially had a surgicalresection of all that fat.
Hopefully You've essentiallyhad a surgical resection of all
that fat.
Hopefully, if you've removedall of that fat, you've
essentially had an organresection, because fat is an
endocrine organ, right, it'sactivating all sorts of
inflammation and all sorts ofbadness you don't want.
When you remove all thatinflammation, you help clean off
the receptor sites.
So you're making your receptorsnot hide anymore.

(48:22):
They're coming up and they'rereceptive now to receive
anything Vitamin D, they'rereceptive to receive hormones
and thyroid and when yourreceptors become receptive, you
feel so much better.
When you feel so much better,you have more motivation.
When you have more motivation,you exercise.
Yeah, I didn't exercise in 15years.
Well, now you do because youcare and you want to and you
want to look like that person oryou want to feel like that

(48:44):
person.
So you start doing things youdidn't do before, because now
your body has been completelytransformed.
So I feel like it's onlynatural that someone that adapts
that lifestyle and when youadapt that lifestyle, typically
you don't want to eat theinflammatory foods, right, foods
that traditionally causeinflammation.
If you remove the inflammatoryfoods and you add nutrient-dense

(49:04):
foods back in, it's creating ahuman that is now repleted so
that you work and you feel greatand you sleep and you have all
these emotions and all thesefeelings, whereas before you
lived a very numb life becauseyou were so… you were so
inflamed from the excess weight.

(49:24):
And so when you fix this person, I like to remind people what
they used to feel like like inthe rears, like what do you
remember?
When you came to me?
You had migraines every otherday.
Now you don't.
You had eczema all over yourbody, now you don't.
So I don't feel like it's adifficult conversation if you
can get people to adopt those.
Now I'm talking about the waywe do it.

(49:45):
I get it.
I'm the minority.
The majority are not going togo through this like all that
time with patients to explainwhat they should be doing and
all that I mean.
A lot of times they don't dothat, and so I would be nervous
if I was the patient that wasn'tbeing supervised or wasn't
having their muscle looked at orwasn't having someone tell them
how much protein to eat or whatprotein to eat, or, you know,

(50:07):
asking about bowel function andasking about hydration and how
much water are you getting?
Not just fluid, but actual water, like these are things that are
just basic to a weight lossprogram that if someone's not
following it, I would agree theyshould be a little nervous in
coming off of that compound.
So what I've had patients dothey start on one clinic,
they're on a GLP-1, they'llswitch to us because they've

(50:27):
just heard, I guess, that we doa little more monitoring or any
monitoring, and they want to bea part of that.
So I would say stay on theGLP-1,.
Try to find a clinic that knowshow to design the program in a
way that gets you off of it, ina way where you don't gain the
weight back I mean that's reallythe idea in a way where you
don't gain the weight back.
I mean that's really the idea.

Sandy Kruse (50:45):
I like it.
Here's a question.
You mentioned receptor sites.
We talked about producing ourown GLP-1.
If you're on a GLP-1 for a verylong time, you said that those
receptor sites, if you lose theweight they actually wake up, so
they don't weaken as a resultof being.

Dr. Cory Rice (51:08):
Yeah, if you're eating protein, yeah.

Sandy Kruse (51:10):
Oh, okay, if you're eating protein.

Dr. Cory Rice (51:13):
If you're malnourished?
If you're malnourished, thosereceptors hate you.
They hate you.
That's why you lose hair andyou can't sleep and you're
anxious and panicky and, youknow, depressed because they
hate you.
But if you're retaining muscle,eating enough protein, drinking
enough fluid, having regularbowel movements, your receptors
are going to be like it's likefertilizing your lawn.

(51:35):
I mean, they're going to loveyou and now you can give
whatever you can get, like nowwhen you give vitamin D, it
actually will absorb her.
Now, when you put her onestrogen or testosterone, oh my
God, now I feel it.
It's because before you were soblunted, everything was so
blunted because of theinflammation in your body.

Sandy Kruse (51:54):
Okay, and then if you are on a GLP-1 for a really
long time, it also doesn'taffect your own production of
GLP-1s once you get off of it.

Dr. Cory Rice (52:07):
Shouldn't Nope?
Assuming back to the same kindof pillar of what I mentioned
earlier of gut function If yougo into a GLP-1 with poor gut
function, you more than likelyare going to come out with poor
gut function to some degree.
You may not be producing GLP-1as efficiently as you would like
, but assuming all things equalregular bowel movements, no

(52:28):
bloating, you know, no refluxprior to initiation of GLP-1, if
you start the GLP-1 and youcome off of the GLP-1, if you
have great gut function, thenyou should be able to produce
GLP-1.
There's no reason you shouldn'tjust because you were on an
injectable or an exogenous formof it yeah, because you know,
like you know I'm.

Sandy Kruse (52:49):
I'm asking just because you know how, if met, if
a man starts testosteronemidlife, you know eventually
he's the.
The pituitary will no longer.
What is it?
It won't signal to the testesto make testosterone, so you
kind of have to stay on it.

Dr. Cory Rice (53:09):
Isn't that right?
No, that depends on the form oftestosterone.
There are forms out there,synthetic forms, that will
basically necessitate that youstay on it to some degree.
And I'm only telling you thisbecause I have men of fertility
age that tell me they don't wantto have children.

(53:29):
And then they meet Ms Wrightlater in life and realize, ok, I
guess I do want kids, and wehave to figure out how to induce
spermatogenesis.
Spermatogenesis is testosteronemaking sperm.
Testosterone makes sperm, butthat's his testosterone, not the
testosterone he's beeninjecting or taking in his body.
So there's ways to get him backto doing that.

(53:50):
And there are forms oftestosterone on the market that
when you give them tea, theirlevels will come back to their
pre-treatment levels, likevirtually every single time if
they come off of thetestosterone.
There's other forms out therethat if you keep giving it oh my
God, if they start off at 300,they're never going to get back

(54:12):
to that.
If you stop the therapy itcomes back to 100 or 150 or way
low, and so I mean I can tellyou what those are, but
ultimately it isn't like apermanent.
It is possible that TRT caninduce permanent infertility,
but if you know what you'redoing.
There are ways to actuallyrepair that.
Assuming your pre-treatmentsperm counts were intact, right,

(54:37):
if you weren't making themprior to TRT.
We can't make you make them bygiving you testosterone.
But assuming all things equal,things were okay prior to
initiation, absolutely, youdon't have to stay on it
lifelong.
Now most men do because theylike the benefits of it, but
there are certain modalities andways of administering it that
are just not, as they're not aspermanent as some of the other

(55:00):
ones.

Sandy Kruse (55:01):
This is really insightful.
Now I have to get into themicro dosing of GLP-1s for
inflammation, because I haveread that some will take it if
they have heart issues.
Is that right, dr Rice?

Dr. Cory Rice (55:23):
So lots of things , yeah, so microdosing.
First off, there's noestablished protocol for what
that actually means.
There's the formal dosingschedule relative to diabetes
and weight loss.
That's very, very formal.
Anything below the lowest doseof the formal recommended lowest

(55:45):
dose of whatever compound we'rediscussing that's considered
microdosing.
It has to be compounded, so youuse a compounding pharmacy but
you essentially use it.
I'll give you an example.
If you have someone who is thin, great muscle, they don't have
any.
Their insulin is like three,they don't have any excess
insulin.
They don't have any excessadipose, basically very little

(56:07):
fat on their body, but they havedementia or they have one of
these degenerative problems, Iwill use a lower microdose than
someone who has excess insulin,needs to lose weight but also
has a degenerative illness likedementia or something like that.

(56:30):
So microdosing is really a veryindividualized way of fixing an
inflammatory response that'sleading to some endpoint
diagnosis like degenerativeneurologic illnesses and things
like this.
So I can't tell you there's astandard dose or a protocol or
anything like that.
It's just lower than the lowestdose on the weight loss

(56:55):
schedule and it really comesdown to do you want this person
to not lose weight?
Do you want them to lose weight, in combination with the
inflammatory reduction mechanismof action that it does.

Sandy Kruse (57:09):
Yeah, I find it really fascinating that more and
more research is coming outabout that.
Do you know who Dr Tina is?
Dr, it's Tina T-Y-N-A.
Dr Tina, dr Tina, she was thefirst one I heard talk about
using a microdose, a GLP-1.

(57:32):
This was like a while ago,about a year and a half ago, and
she noticed that in menopause,despite the fact that she works
out, she takes bioidentical orwhat did you call it?
Again, you said so molecular,yes, um, and she does all the

(57:53):
right things, but she noticedthat it's like her body's still
like.
I do think that, as a woman, wego through an inflammatory
process, despite all the work wemight be doing.
No, question.
Things are not working.
The same doctor.

Dr. Cory Rice (58:10):
Yeah, not a question, women have a very hard
fight.
Men, the way it is, it's justmen are more machine-like in
being able to take on toxins,pollution and what have you, and
get rid of it.
Women store things.
They store things.
You touch it, you drink it, youbreathe it, you eat it.
It is on you, in you, andsometimes it takes a while to

(58:39):
get it out of you, unless youare doing well.
There's a lot you can do to getit out of you, but that's a
whole nother discussion.

Sandy Kruse (58:44):
But yeah, women, you need to be a little
sensitive, if you're not a woman, to what they're going through,
our bodies and our uniqueness,in order to have a good

(59:05):
practitioner to work with tohelp us navigate some of the
things Like for me, for example,not having a thyroid gland and
understanding that thesehormones don't work in isolation
, and so if my estrogen drops,it's going to affect my
medications for my thyroid andthe whole thing can be

(59:29):
complicated.
If my estrogen drops, it'sgoing to affect my medications
for my thyroid, and you know thewhole thing can be complicated,
and so I just want to mentionthat.
So I love that you talk aboutGLP-1s for people in a very
bio-individual way.
So one last question, becausewe certainly covered a lot in

(59:51):
this hour, but have you everworked with a patient where it
is strictly for inflammation andthat's it?

Dr. Cory Rice (01:00:01):
100%.
I see that on the weekly, Ifeel like sometimes on the daily
.
So when people establish withus, the very the most important
thing is not what their lab showor their gut microbiome.
It's what they want, period.
And what a lot of people willtell me is I feel inflamed.
Now that may mean their sexdrive's gone or they don't sleep

(01:00:26):
, but they're focused on.
My body feels like it'sinflamed.
I'm swollen.
I just don't feel healthy.
Help me feel healthy again.
Great, once we know that westart to go to work and we start
to look at all the data and westart to just analyze the data,
we do a data reveal party and weultimately start fixing that.

(01:00:47):
I mean that's it so.
So, yeah, yeah, that's that's.
That's pretty critical.

Sandy Kruse (01:00:54):
I love that.
Do you?
Do you only work with Americanpatients?

Dr. Cory Rice (01:00:59):
You know I work with patients almost in every
state.
I have a Texas license and Idon't know, honestly, don't know
how that works internationally,because I have patients that
are in the states and then theygo live somewhere overseas or
wherever, but they're still mypatient because they established
with me in my state lines.
So I can only speak for Texasand Texas really requires that

(01:01:22):
at least one time you're withinthe borders of where I'm
licensed to practice.
You can even just I've had thishappen.
I've had doctors fromCalifornia who are my patients
will go to the border, fly andthen fly home.
They don't come all the way toDallas and see me in person.
So I can do Zoom with patientsas long as they're somewhere in

(01:01:45):
Texas.
Once, everything.
After that we can do virtualEverything Unless this is why I
do such a comprehensive initialvisit If you get a new symptom
that you didn't talk to me abouton the first visit, technically
by law you have to fly to thestate, to my state border, and

(01:02:07):
tell me okay, now I haveheadaches, can you help me?
It's silly but it's true.
But at least in Texas that'sthe rules.

Sandy Kruse (01:02:17):
Okay, that's good to know.
I mean because I'm sure a lotof people are going to listen to
this and want to know how theycan see you or your team.
Well, you're very sweet and Ithey can see you or your team.

Dr. Cory Rice (01:02:26):
So Well, you're very sweet and I mean this
sincerely when I say this.
This is not about me.
I would love to see myproviders, we would love to help
anybody in your audience, butone of my biggest callings in
the world is to train mycolleagues.
So I do so much teaching Sandythat it just that's like my
passion, because I learned longago.

(01:02:47):
It is not about my abilities infront of a human, it is my
abilities in front of mycolleagues to change the way
they look at pathologic diseaseand how can they fix it, how do
they put the genie back in thebottle without having a patient
leave on 10 prescription pills.
And I absolutely love doingthat and I'm so blessed to be

(01:03:07):
able to do it.
But, that said, I still lovepracticing medicine because what
makes me really good at onemakes me really good at the
other when you're training yourproviders or teaching your
colleagues.
If you're not doing this in thetrenches, you lose the
legitimacy of the experience.
So, but yes, we would be happyto help anybody.

Sandy Kruse (01:03:26):
Can I send my husband to Dallas?
I'm just kidding.
I'm just kidding.
Yes, yeah, sure I mean hedoesn't listen to my podcast, so
don't tell him.
I said that Somebody might tellhim.
He knows I always slam him allthe time.
You know he doesn't listen tome.

Dr. Cory Rice (01:03:41):
But he might listen to you.
Selective hearing.
All spouses have it.
You can't judge it.

Sandy Kruse (01:03:47):
Exactly All right.
So what is your website?
Where can people find out more?

Dr. Cory Rice (01:03:52):
Yeah, so website is mymodernmedicinecom, so
mymodernmedicinecom, that's it.

Sandy Kruse (01:04:00):
Okay, that's perfect.
Thank you so much.
Really is such a blessing foryou to share your wisdom with us
on GLP-1s.
We got through a lot and I willhave a transcription for
anybody who wants to see thetranscription, and everything
else will be in the show notes.
Thank you so much, dr Rice.

(01:04:21):
Thank you, sandy.

Dr. Cory Rice (01:04:21):
Very, very much.
I really enjoyed this Me too.
Thank you, sandy, very, verymuch.
I really enjoyed this Me too.

Sandy Kruse (01:04:27):
I hope you enjoyed this episode.
Be sure to share it withsomeone you know might benefit,
and always remember when yourate, review, subscribe, you
help to support my content andhelp me to keep going and
bringing these conversations toyou each and every week.

(01:04:50):
Join me next week for a newtopic, new guest, new exciting
conversations to help you liveyour best life.
Advertise With Us

Popular Podcasts

On Purpose with Jay Shetty

On Purpose with Jay Shetty

I’m Jay Shetty host of On Purpose the worlds #1 Mental Health podcast and I’m so grateful you found us. I started this podcast 5 years ago to invite you into conversations and workshops that are designed to help make you happier, healthier and more healed. I believe that when you (yes you) feel seen, heard and understood you’re able to deal with relationship struggles, work challenges and life’s ups and downs with more ease and grace. I interview experts, celebrities, thought leaders and athletes so that we can grow our mindset, build better habits and uncover a side of them we’ve never seen before. New episodes every Monday and Friday. Your support means the world to me and I don’t take it for granted — click the follow button and leave a review to help us spread the love with On Purpose. I can’t wait for you to listen to your first or 500th episode!

Stuff You Should Know

Stuff You Should Know

If you've ever wanted to know about champagne, satanism, the Stonewall Uprising, chaos theory, LSD, El Nino, true crime and Rosa Parks, then look no further. Josh and Chuck have you covered.

The Joe Rogan Experience

The Joe Rogan Experience

The official podcast of comedian Joe Rogan.

Music, radio and podcasts, all free. Listen online or download the iHeart App.

Connect

© 2025 iHeartMedia, Inc.